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    • 3. 发明申请
    • METHOD AND SYSTEM FOR NON-INVASIVE OPTICAL BLOOD GLUCOSE DETECTION UTILIZING SPECTRAL DATA ANALYSIS
    • 用于非侵入式光学血糖检测的方法和系统利用光谱数据分析
    • US20130006071A1
    • 2013-01-03
    • US13610256
    • 2012-09-11
    • Zhi Xu
    • Zhi Xu
    • A61B5/1455
    • A61B5/14532A61B5/1455A61B5/6826A61B5/6838A61B5/7225A61B2562/0238A61B2576/00G06F19/00
    • Systems and methods are disclosed for non-invasively measuring blood glucose levels in a biological sample based on spectral data. This includes utilizing at least one light source configured to strike a target area of a sample, utilizing at least one light filter positioned to receive light transmitted through the target area of the sample from the at least one light source, utilizing at least one light detector positioned to receive light from the at least one light source and filtered by the at least one light filter, and to generate an output signal, having a time dependent current, which is indicative of the power of light detected, receiving the output signal from the at least one light detector with a processor, calculating the attenuance attributable to blood with a ratio factor based on the received output signal, and determining a blood glucose level based on the calculated attenuance.
    • 公开了基于光谱数据非生物地测量生物样品中的血糖水平的系统和方法。 这包括利用至少一个光源,其被配置成撞击样品的目标区域,利用至少一个光过滤器,其定位成通过至少一个光检测器接收透射来自所述至少一个光源的样品的目标区域的光 定位成从所述至少一个光源接收光并被所述至少一个滤光器滤波,并且产生具有时间相关电流的输出信号,所述时间相关电流指示所检测的光的功率,从所述至少一个光滤波器接收来自所述至少一个光滤波器的输出信号 具有处理器的至少一个光检测器,基于所接收的输出信号以比例因子计算归因于血液的衰减,以及基于所计算的衰减来确定血糖水平。
    • 4. 发明申请
    • METHOD AND SYSTEM FOR NON-INVASIVE OPTICAL BLOOD GLUCOSE DETECTION UTILIZING SPECTRAL DATA ANALYSIS
    • 用于非侵入式光学血糖检测的方法和系统利用光谱数据分析
    • US20130006070A1
    • 2013-01-03
    • US13610140
    • 2012-09-11
    • Zhi Xu
    • Zhi Xu
    • A61B5/1455
    • A61B5/14532A61B5/1455A61B5/6826A61B5/6838A61B5/7225A61B2562/0238A61B2576/00G06F19/00
    • Systems and methods are disclosed for non-invasively measuring blood glucose levels in a biological sample based on spectral data. This includes utilizing at least one light source configured to strike a target area of a sample, utilizing at least one light filter positioned to receive light transmitted through the target area from the at least one light source, utilizing at least one light detector positioned to receive light from the at least one light source and filtered by the at least one light filter, and to generate an output signal, having a time dependent current, which is indicative of the power of light detected, receiving the output signal from the at least one light detector with a processor and based on the received output signal, calculating the attenuance attributable to blood in a sample with a signal-to-noise ratio of at least 20-to-1; and determining a blood glucose level.
    • 公开了基于光谱数据非生物地测量生物样品中的血糖水平的系统和方法。 这包括利用构造成撞击样品的目标区域的至少一个光源,利用至少一个光过滤器,其定位成从至少一个光源接收透射通过目标区域的光,利用至少一个光检测器定位成接收 来自所述至少一个光源的光并由所述至少一个滤光器滤波,并且产生输出信号,所述输出信号具有指示所检测的光的功率的时间相关电流,所述输出信号从所述至少一个光滤波器接收所述输出信号 光检测器,具有处理器并基于接收的输出信号,计算信噪比至少为20比1的样品中归因于血液的衰减; 并确定血糖水平。
    • 6. 发明授权
    • Optical device components
    • 光器件组件
    • US07809418B2
    • 2010-10-05
    • US12245298
    • 2008-10-03
    • Zhi Xu
    • Zhi Xu
    • A61B5/1455
    • G01N21/359A61B5/14532A61B5/1455G01N21/474
    • Embodiments of the invention relate to an apparatus including a light source to generate a plurality of light beams with each of the plurality of light beams having a different wavelength range. The apparatus also includes a light funnel to direct the plurality of light beams to the target area, an aperture to direct the plurality of light beams emitting from the target area to a lens, the lens configured to collect the light beams emitting from the target area. Further, the apparatus includes a detector including a plurality of light-sensing devices each configured to detect a light beam and configured to generate an output signal indicative of an intensity of light detected and a processor for determining the blood characteristic as a function of each generated output signal.
    • 本发明的实施例涉及一种包括用于产生多个光束的光源的装置,其中多个光束中的每一个具有不同的波长范围。 该装置还包括一个光漏斗,用于将多个光束引导到目标区域,一个孔径,用于将从目标区域发射的多个光束引导到透镜,该透镜被配置成收集从目标区域发射的光束 。 此外,该装置包括检测器,其包括多个光感测装置,每个光感测装置被配置为检测光束并且被配置为产生指示所检测到的光的强度的输出信号,以及用于根据每个生成的功能确定血液特性的处理器 输出信号。
    • 7. 发明申请
    • Light Scattering Detector
    • 光散射检测器
    • US20100002229A1
    • 2010-01-07
    • US12325890
    • 2008-12-01
    • David W. LarsenZhi Xu
    • David W. LarsenZhi Xu
    • G01N21/53
    • G01N30/74G01N21/0303G01N21/53G01N2030/847G01N2030/8494G01N2201/0642G01N21/47
    • The invention concerns high sensitivity light scattering detection and its application to evaporative light scattering detection in liquid chromatography. The exemplary embodiment includes a detection cell to accept particles suspended in a gas stream and permit a polarized light beam to pass through a trajectory of the particles and gas stream. A sample light detector is disposed to detect light scattered in the detection cell. A light trap accepts the polarized beam after it passes through the detection cell. The light trap includes an elongated housing through which the polarized beam passes, and light absorptive material within the elongated housing. An absorptive filter is aligned such that the angle of incidence of the light beam upon the filter approximates Brewster's angle and the electric field vector of the beam is aligned with the plane of incidence between the beam and the filter. Other embodiments of the invention provide increased light collection. Embodiments of the invention include temperature-controlled entrance and exit ports that control particle trajectory. Embodiments of the invention include a reference cell disposed between a detection cell and a light trap, and the reference cell includes lensing and a spherical mirror to direct light toward a reference light detector. The reference light detector provides a reference signal that may be used with noise cancellation circuitry, operating in either voltage or current mode, to reduce light source noise in the sample signal.
    • 本发明涉及高灵敏度光散射检测及其在液相色谱中的蒸发光散射检测中的应用。 该示例性实施例包括接收悬浮在气流中的颗粒并允许偏振光束通过颗粒和气流的轨迹的检测单元。 设置采样光检测器以检测在检测单元中散射的光。 光阱在其通过检测单元之后接受偏振光束。 光阱包括通过偏振光束通过的细长壳体和细长壳体内的光吸收材料。 对准吸收滤光器,使得光束在滤光片上的入射角近似于布鲁斯特角,并且光束的电场矢量与光束与滤光片之间的入射平面对准。 本发明的其它实施例提供增加的光收集。 本发明的实施例包括控制粒子轨迹的温度控制的入口和出口。 本发明的实施例包括设置在检测单元和光阱之间的参考单元,并且参考单元包括透镜和球面镜,以将光引向参考光检测器。 参考光检测器提供可用于噪声消除电路的参考信号,其以电压或电流模式工作,以减少采样信号中的光源噪声。
    • 9. 发明授权
    • Light scattering detector
    • 光散射检测器
    • US07268881B2
    • 2007-09-11
    • US10780278
    • 2004-02-17
    • David W. LarsenZhi Xu
    • David W. LarsenZhi Xu
    • G01N21/00
    • G01N30/74G01N21/0303G01N21/53G01N2030/847G01N2030/8494G01N2201/0642G01N21/47
    • The invention concerns high sensitivity light scattering detection and its application to evaporative light scattering detection in liquid chromatography. The exemplary embodiment includes a detection cell to accept particles suspended in a gas stream and permit a polarized light beam to pass through a trajectory of the particles and gas stream. A sample light detector is disposed to detect light scattered in the detection cell. A light trap accepts the polarized beam after it passes through the detection cell. The light trap includes an elongated housing through which the polarized beam passes, and light absorptive material within the elongated housing. An absorptive filter is aligned such that the angle of incidence of the light beam upon the filter approximates Brewster's angle and the electric field vector of the beam is aligned with the plane of incidence between the beam and the filter. Other embodiments of the invention provide increased light collection. Embodiments of the invention include temperature-controlled entrance and exit ports that control particle trajectory. Embodiments of the invention include a reference cell disposed between a detection cell and a light trap, and the reference cell includes lensing and a spherical mirror to direct light toward a reference light detector. The reference light detector provides a reference signal that may be used with noise cancellation circuitry, operating in either voltage or current mode, to reduce light source noise in the sample signal.
    • 本发明涉及高灵敏度光散射检测及其在液相色谱中的蒸发光散射检测中的应用。 该示例性实施例包括接收悬浮在气流中的颗粒并允许偏振光束通过颗粒和气流的轨迹的检测单元。 设置采样光检测器以检测在检测单元中散射的光。 光阱在其通过检测单元之后接受偏振光束。 光阱包括通过偏振光束通过的细长壳体和细长壳体内的光吸收材料。 对准吸收滤光器,使得光束在滤光片上的入射角近似于布鲁斯特角,并且光束的电场矢量与光束与滤光片之间的入射平面对准。 本发明的其它实施例提供增加的光收集。 本发明的实施例包括控制粒子轨迹的温度控制的入口和出口。 本发明的实施例包括设置在检测单元和光阱之间的参考单元,并且参考单元包括透镜和球面镜,以将光引向参考光检测器。 参考光检测器提供可用于噪声消除电路的参考信号,其以电压或电流模式工作,以减少采样信号中的光源噪声。
    • 10. 发明申请
    • Light scattering detector
    • 光散射检测器
    • US20050179904A1
    • 2005-08-18
    • US10780278
    • 2004-02-17
    • David LarsenZhi Xu
    • David LarsenZhi Xu
    • G01N21/00G01N21/03G01N21/53G01N30/74G01N30/84
    • G01N30/74G01N21/0303G01N21/53G01N2030/847G01N2030/8494G01N2201/0642G01N21/47
    • The invention concerns high sensitivity light scattering detection and its application to evaporative light scattering detection in liquid chromatography. The exemplary embodiment includes a detection cell to accept particles suspended in a gas stream and permit a polarized light beam to pass through a trajectory of the particles and gas stream. A sample light detector is disposed to detect light scattered in the detection cell. A light trap accepts the polarized beam after it passes through the detection cell. The light trap includes an elongated housing through which the polarized beam passes, and light absorptive material within the elongated housing. An absorptive filter is aligned such that the angle of incidence of the light beam upon the filter approximates Brewster's angle and the electric field vector of the beam is aligned with the plane of incidence between the beam and the filter. Other embodiments of the invention provide increased light collection. Embodiments of the invention include temperature-controlled entrance and exit ports that control particle trajectory. Embodiments of the invention include a reference cell disposed between a detection cell and a light trap, and the reference cell includes lensing and a spherical mirror to direct light toward a reference light detector. The reference light detector provides a reference signal that may be used with noise cancellation circuitry, operating in either voltage or current mode, to reduce light source noise in the sample signal.
    • 本发明涉及高灵敏度光散射检测及其在液相色谱中的蒸发光散射检测中的应用。 该示例性实施例包括接收悬浮在气流中的颗粒并允许偏振光束通过颗粒和气流的轨迹的检测单元。 设置采样光检测器以检测在检测单元中散射的光。 光阱在其通过检测单元之后接受偏振光束。 光阱包括通过偏振光束通过的细长壳体和细长壳体内的光吸收材料。 对准吸收滤光器,使得光束在滤光片上的入射角近似于布鲁斯特角,并且光束的电场矢量与光束与滤光片之间的入射平面对准。 本发明的其它实施例提供增加的光收集。 本发明的实施例包括控制粒子轨迹的温度控制的入口和出口。 本发明的实施例包括设置在检测单元和光阱之间的参考单元,并且参考单元包括透镜和球面镜,以将光引向参考光检测器。 参考光检测器提供可用于噪声消除电路的参考信号,其以电压或电流模式工作,以减少采样信号中的光源噪声。