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1. 发明申请

US20070275975A1 3-QUINUCLIDINYL AMINO-SUBSTITUTED BIARYL DERIVATIVES 审中-公开
标题翻译： 3-喹啉基氨基取代的二价衍生物
公开(公告)号：US20070275975A1
公开(公告)日：2007-11-29
申请号：US11749779
申请日：2007-05-17
申请人： Jianguo Ji , Tao Li , Ying Wang
发明人： Jianguo Ji , Tao Li , Ying Wang
IPC分类号： C07D453/00 , A61K31/4427 , A61K31/50 , C07D471/08 , A61P25/00 , C07D403/02
CPC分类号： C07D453/02
摘要： Compounds of formula (I) wherein A is N or N+—O−; n is 0, 1, or 2; Y is O, S, —NH—, and —N-alkyl-; Ar1 is both 6-membered aromatic rings; Ar2 is 5- or 6-membered aromatic rings with a —NR8R9 group, as defined herein. The compounds are useful in treating conditions or disorders prevented by or ameliorated by α7 nAChR ligands. Also disclosed are pharmaceutical compositions having compounds of formula (I) and methods for using such compounds and compositions.
摘要翻译：式（I）的化合物，其中A是N或N +，-O - n为0,1或2; Y是O，S，-NH-和-N-烷基 - ; Ar 1是两个6元芳环; Ar 2是如本文所定义的具有-NR 8 R 9 R 9基团的5-或6-元芳环。该化合物可用于治疗由α7nAChR配体预防或改善的病症或病症。还公开了具有式（I）化合物的药物组合物和使用这些化合物和组合物的方法。

2. 发明申请

US20050159597A1 3-Quinuclidinyl amino-substituted biaryl derivatives 有权
标题翻译： 3-喹啉基氨基取代的联芳基衍生物
公开(公告)号：US20050159597A1
公开(公告)日：2005-07-21
申请号：US11015158
申请日：2004-12-17
申请人： Jianguo Ji , Tao Li , Ying Wang
发明人： Jianguo Ji , Tao Li , Ying Wang
IPC分类号： C07D453/02 , C07D487/04
CPC分类号： C07D453/02
摘要： Compounds of formula (I) wherein A is N or N+—O−; n is 0, 1, or 2; Y is O, S, —NH—, and —N-alkyl-; Ar1 is both 6-membered aromatic rings; Ar2 is 5- or 6-membered aromatic rings with a —NR8R9 group, as defined herein. The compounds are useful in treating conditions or disorders prevented by or ameliorated by α7 nAChR ligands. Also disclosed are pharmaceutical compositions having compounds of formula (I) and methods for using such compounds and compositions.
摘要翻译：式（I）的化合物，其中A是N或N +，-O - n为0,1或2; Y是O，S，-NH-和-N-烷基 - ; Ar 1是两个6元芳环; Ar 2是如本文所定义的具有-NR 8 R 9 R 9基团的5-或6-元芳环。该化合物可用于治疗由α7nAChR配体预防或改善的病症或病症。还公开了具有式（I）化合物的药物组合物和使用这些化合物和组合物的方法。

3. 发明授权

US07309699B2 3-Quinuclidinyl amino-substituted biaryl derivatives 有权
标题翻译： 3-喹啉基氨基取代的联芳基衍生物
公开(公告)号：US07309699B2
公开(公告)日：2007-12-18
申请号：US11015158
申请日：2004-12-17
申请人： Jianguo Ji , Tao Li , Ying Wang
发明人： Jianguo Ji , Tao Li , Ying Wang
IPC分类号： C07D453/02 , C07D487/04
CPC分类号： C07D453/02
摘要： Compounds of formula (I) wherein A is N or N+—O−; n is 0, 1, or 2; Y is O, S, —NH—, and —N-alkyl-; Ar1 is both 6-membered aromatic rings; Ar2 is 5- or 6-membered aromatic rings with a —NR8R9 group, as defined herein. The compounds are useful in treating conditions or disorders prevented by or ameliorated by α7 nAChR ligands. Also disclosed are pharmaceutical compositions having compounds of formula (I) and methods for using such compounds and compositions.
摘要翻译：式（I）的化合物，其中A是N或N +，-O - n为0,1或2; Y是O，S，-NH-和-N-烷基 - ; Ar 1是两个6元芳环; Ar 2是如本文所定义的具有-NR 8 R 9 R 9基团的5-或6-元芳环。该化合物可用于治疗由α7nAChR配体预防或改善的病症或病症。还公开了具有式（I）化合物的药物组合物和使用这些化合物和组合物的方法。

4. 发明申请

US20100305086A1 Pharmaceutical Compositions for the Treatment of Pain 有权
标题翻译：用于治疗疼痛的药物组合物
公开(公告)号：US20100305086A1
公开(公告)日：2010-12-02
申请号：US12787937
申请日：2010-05-26
申请人： Murali Gopalakrishnan , Chih-Hung Lee , Jianguo Ji , Tao Li , Kevin B. Sippy
发明人： Murali Gopalakrishnan , Chih-Hung Lee , Jianguo Ji , Tao Li , Kevin B. Sippy
IPC分类号： A61K31/397 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/501 , A61P19/02 , A61P29/00 , A61P9/10 , A61P35/00
CPC分类号： A61K45/06 , A61K31/4245 , A61K31/4427 , A61K2300/00
摘要： This invention discloses a method of treatment of osteoarthritis pain by administration of a composition containing a nicotinic acetylcholine receptor ligand and a nicotinic acetylcholine receptor subtype α4β2 allosteric modulator. The present application also relates to compositions comprising such compounds for use in treating pain and related disorders mediated by controlling neurotransmitter release in a subject.
摘要翻译：本发明公开了一种通过施用含有烟碱乙酰胆碱受体配体和烟碱乙酰胆碱受体亚型α4和bgr2变构调节剂的组合物治疗骨关节炎疼痛的方法。本申请还涉及包含用于治疗疼痛和通过控制受试者中的神经递质释放介导的相关病症的化合物的组合物。

5. 发明授权

US07365193B2 Amino-substituted tricyclic derivatives and methods of use 有权
标题翻译：氨基取代的三环衍生物和使用方法
公开(公告)号：US07365193B2
公开(公告)日：2008-04-29
申请号：US11051437
申请日：2005-02-04
申请人： Michael R. Schrimpf , Kevin B. Sippy , Jianguo Ji , Tao Li , Jennifer M. Frost , Clark A. Briggs , William H. Bunnelle
发明人： Michael R. Schrimpf , Kevin B. Sippy , Jianguo Ji , Tao Li , Jennifer M. Frost , Clark A. Briggs , William H. Bunnelle
IPC分类号： C07D245/00 , A01N43/00 , A61K31/33 , A61K31/397 , A61K31/407
CPC分类号： C07D453/02 , C07D205/04 , C07D207/08 , C07D207/12 , C07D207/14 , C07D209/88 , C07D211/14 , C07D243/08 , C07D333/76 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D451/06 , C07D487/04 , C07D487/08
摘要： Compounds of formula (I) wherein A and B are amine-substituted sidechains, Y1 and Y2 form various tricyclic cores, Xa and Xb are C, CH, or N, as defined herein, and Rx is an optional substituent. Compounds and compositions of formula (I) are contemplated as well as methods for treating conditions or disorders prevented by or ameliorated by α7nAChR ligands that encompass compounds of formula (I) and other tricyclic derivatives. Methods of using amino-substituted tricyclic derivatives also are described herein.
摘要翻译：其中A和B是胺取代的侧链，Y 1和Y 2的式（I）化合物形成各种三环核，X 1和如本文所定义，C 1-6烷基是C，CH或N，并且R x是任选的取代基。考虑式（I）的化合物和组合物以及用于治疗由包括式（I）化合物和其它三环衍生物的α7nAChR配体防止或改善的病症或病症的方法。使用氨基取代的三环衍生物的方法也在本文中描述。

6. 发明申请

US20050137398A1 3-Quinuclidinyl heteroatom bridged biaryl derivatives 审中-公开
标题翻译： 3-奎宁环基杂原子桥连的联芳基衍生物
公开(公告)号：US20050137398A1
公开(公告)日：2005-06-23
申请号：US10744484
申请日：2003-12-22
申请人： Jianguo Ji , Tao Li
发明人： Jianguo Ji , Tao Li
IPC分类号： A61K31/439 , C07D453/00 , C07D453/02
CPC分类号： C07D453/02
摘要： Compounds of formula (I) or a pharmaceutically acceptable salt, amide, or prodrug thereof, wherein: n is 0, 1, or 2; X1 is O, S, —N(R1)—, —N(Ar2)—, and N(R2)C(O)—; Ar1 is a six-membered aromatic ring; Ar2 is cyclohexyl or a mono- or bicyclic aromatic ring, as defined herein. The compounds are useful in treating conditions or disorders prevented by or ameliorated by nAChR ligands. Also disclosed are pharmaceutical compositions having compounds of formula (I) and methods for using such compounds and compositions.
摘要翻译：式（I）化合物或其药学上可接受的盐，酰胺或前药，其中：n为0,1或2; X 1是O，S，-N（R 1） - ， - N（Ar 2） - 和N（R 0） > 2）C（O） - ; Ar 1是6元芳环; Ar 2是如本文所定义的环己基或单环或双环芳环。该化合物可用于治疗由nAChR配体预防或改善的病症或病症。还公开了具有式（I）化合物的药物组合物和使用这些化合物和组合物的方法。

7. 发明申请

US20050137226A1 3-Quinuclidinyl heteroatom bridged biaryl derivatives 有权
标题翻译： 3-奎宁环基杂原子桥连的联芳基衍生物
公开(公告)号：US20050137226A1
公开(公告)日：2005-06-23
申请号：US11015157
申请日：2004-12-17
申请人： Jianguo Ji , Tao Li
发明人： Jianguo Ji , Tao Li
IPC分类号： A61K31/4745 , C07D453/02
CPC分类号： C07D453/02
摘要： Compounds of formula: or pharmaceutically acceptable salts, esters, amides, or prodrugs thereof, wherein: A and G are each independently N or N+—O−; m and n are each independently 0, 1, or 2; X1 and X3 are each independently O, S, and —N(R1)—; X2 is O, S, —N(R1)—, —N(Ar2)—, and —N(R2)C(O)—; Ar1 is a six-membered aromatic ring; Ar2 is cyclohexyl or a mono- or bicyclic aromatic ring, and R13 is hydrogen, alkyl, or halogen, as defined herein. The compounds are useful in treating conditions or disorders prevented by or ameliorated by nAChR ligands. Also disclosed are pharmaceutical compositions having compounds of formulas (I) and (II) and methods for using such compounds and compositions.
摘要翻译：式：或其药学上可接受的盐，酯，酰胺或前药的化合物，其中：A和G各自独立地为N或N +， - O - m和n各自独立地为0,1或2; X 1和X 3各自独立地为O，S和-N（R 1） - ; X 2是O，S，-N（R 1） - ， - N（Ar 2） - 和-N（R' （O） - ; Ar 1是6元芳环; Ar 2是环己基或单环或双环芳环，R 13是如本文所定义的氢，烷基或卤素。该化合物可用于治疗由nAChR配体预防或改善的病症或病症。还公开了具有式（I）和（II）化合物的药物组合物以及使用这些化合物和组合物的方法。

8. 发明申请

US20050137184A1 Fused bicycloheterocycle substituted quinuclidine derivatives 有权
标题翻译：稠合双环杂环取代的奎宁环衍生物
公开(公告)号：US20050137184A1
公开(公告)日：2005-06-23
申请号：US10744208
申请日：2003-12-22
申请人： Jianguo Ji , Tao Li
发明人： Jianguo Ji , Tao Li
IPC分类号： A61K31/501 , A61K31/506 , A61K31/55 , C07D453/02
CPC分类号： A61K31/506 , A61K31/501 , A61K31/55 , C07D453/02
摘要： Compounds of formula (I) wherein n is 0, 1, or 2; X is O, S, —NH—, and —N-alkyl-; Ar1 is a 6-membered aromatic ring; and Ar2 is a fused bicycloheterocycle. The compounds are useful in treating conditions or disorders prevented by or ameliorated by α7 nAChR ligands. Also disclosed are pharmaceutical compositions having compounds of formula (I) and methods for using such compounds and compositions.
摘要翻译：其中n为0,1或2的式（I）化合物; X是O，S，-NH-和-N-烷基 - ; Ar 1是6元芳环; 并且Ar 2是稠合的双环杂环。该化合物可用于治疗由α7nAChR配体预防或改善的病症或病症。还公开了具有式（I）化合物的药物组合物和使用这些化合物和组合物的方法。

9. 发明申请

US20050065178A1 Substituted diazabicycloakane derivatives 审中-公开
标题翻译：取代的二氮杂双环戊烷衍生物
公开(公告)号：US20050065178A1
公开(公告)日：2005-03-24
申请号：US10666884
申请日：2003-09-19
申请人： Anwer Basha , William Bunnelle , Michael Dart , Megan Gallagher , Jianguo Ji , Tao Li , Jennifer Pace , Keith Ryther , Karin Tietje
发明人： Anwer Basha , William Bunnelle , Michael Dart , Megan Gallagher , Jianguo Ji , Tao Li , Jennifer Pace , Keith Ryther , Karin Tietje
IPC分类号： A61K31/435 , A61P25/00 , C07D471/04 , C07D471/08 , C07D487/04 , C07D487/08 , C07D471/02 , A61K31/4745
CPC分类号： C07D487/08 , C07D471/04 , C07D471/08 , C07D487/04
摘要： Compounds of formula (I) Z-Ar1—Ar2 (I) wherein Z is a diazabicyclic amine, Ar1 is a 5- or 6-membered aromatic ring, and Ar2 is selected from an unsubstituted or substituted 5-membered heteroaryl ring; an unsubstituted or substituted 6-membered heteroaryl ring; 3,4-(methylenedioxy)phenyl; and phenyl substituted with 0, 1, 2, or 3 substituents in the meta- or para-positions. The compounds are useful in treating conditions or disorders prevented by or ameliorated by α7 nAChR ligands. Also disclosed are pharmaceutical compositions comprising compounds of formula (I) and methods for using such compounds and compositions.
摘要翻译：式（I）Z-Ar1-Ar2（Ⅰ）化合物其中Z是二氮杂双环胺，Ar1是5-或6-元芳环，Ar2选自未取代或取代的5元杂芳基环; 未取代或取代的6元杂芳基环; 3,4-（亚甲二氧基）苯基; 和在间位或对位取代有0,1,2或3个取代基的苯基。该化合物可用于治疗由α7nAChR配体预防或改善的病症或病症。还公开了包含式（I）化合物和使用这些化合物和组合物的方法的药物组合物。

10. 发明授权

US09186407B2 Pharmaceutical compositions and their methods of use 有权
标题翻译：药物组合物及其使用方法
公开(公告)号：US09186407B2
公开(公告)日：2015-11-17
申请号：US13080071
申请日：2011-04-05
申请人： Murali Gopalakrishnan , Marie P. Honore , Chih-Hung Lee , John Malysz , Jianguo Ji , Tao Li , Michael R. Schrimpf , Kevin B. Sippy , David J. Anderson
发明人： Murali Gopalakrishnan , Marie P. Honore , Chih-Hung Lee , John Malysz , Jianguo Ji , Tao Li , Michael R. Schrimpf , Kevin B. Sippy , David J. Anderson
IPC分类号： A01N43/82 , A61K31/41 , A01N43/40 , A61K31/44 , C07D413/00 , C07D413/04 , C07D413/14 , A61K31/4245 , A61K31/443 , A61K31/444 , A61K45/06
CPC分类号： A61K31/4439 , A61K31/4245 , A61K31/4427 , A61K31/443 , A61K31/444 , A61K31/4709 , A61K45/06 , C07D413/04 , C07D413/14 , G01N33/944 , G01N2333/70571 , A61K2300/00
摘要： The invention relates to a composition comprising a neuronal nicotinic receptor ligand and an α4β2 positive allosteric modulator, a method of using the same, and a related article of manufacture.
摘要翻译：本发明涉及包含神经元烟碱性受体配体和α4和bgr2阳性变构调节剂，其使用方法和相关制品的组合物。

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