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1. 发明授权

US08121686B2 Cardiac rhythm management system selecting between multiple same-chamber electrodes for delivering cardiac therapy 有权
标题翻译：心脏节律管理系统选择多个相同室电极之间进行心脏治疗
公开(公告)号：US08121686B2
公开(公告)日：2012-02-21
申请号：US13026917
申请日：2011-02-14
申请人： Jiang Ding , Julio C. Spinelli , Andrew P. Kramer
发明人： Jiang Ding , Julio C. Spinelli , Andrew P. Kramer
IPC分类号： A61N1/362
CPC分类号： A61N1/3684 , A61N1/3627 , A61N1/36514 , A61N1/368
摘要： A cardiac rhythm management system selects one of multiple electrodes associated with a particular heart chamber based on a relative timing between detection of a depolarization fiducial point at the multiple electrodes, or based on a delay between detection of a depolarization fiducial point at the multiple electrodes and detection of a reference depolarization fiducial point at another electrode associated with the same or a different heart chamber. Subsequent contraction-evoking stimulation therapy is delivered from the selected electrode.
摘要翻译：心脏节律管理系统基于在多个电极处的去极化基准点的检测之间的相对定时或基于在多个电极之间的去极化基准点的检测之间的延迟来选择与特定心室相关联的多个电极中的一个，以及在与相同或不同的心室相关联的另一电极处检测参考去极化基准点。随后的收缩诱导刺激疗法从所选择的电极递送。

2. 发明授权

US06622040B2 Automatic selection of stimulation chamber for ventricular resynchronization therapy 有权
公开(公告)号：US06622040B2
公开(公告)日：2003-09-16
申请号：US09738407
申请日：2000-12-15
申请人： Jiang Ding , Julio C. Spinelli , Yinghong Yu , Andrew P. Kramer
发明人： Jiang Ding , Julio C. Spinelli , Yinghong Yu , Andrew P. Kramer
IPC分类号： A61N1362
CPC分类号： A61N1/36592 , A61B5/0472 , A61N1/3627 , A61N1/3684
摘要： A method and apparatus for selection of one or more ventricular chambers to stimulate for ventricular resynchronization therapy. Intrinsic intracardia electrograms that include QRS complexes, are recorded from a left and right ventricle. A timing relationship between the intrinsic intracardia electrograms recorded from the left and right ventricle is then determined. In one embodiment, the timing relationship is determined using a delay between a left ventricular and a right ventricular sensed intrinsic ventricular depolarizations and a duration interval of one or more QRS complexes. In one embodiment, the duration of QRS complexes is determined from either intracardiac electrograms or from surface ECG recordings. One or more ventricular chambers in which to provide pacing pulses are then selected based on the timing relationship between intrinsic intracardia electrograms recorded from the right and left ventricle, and the duration of one or more QRS complexes.

3. 发明授权

US08818511B2 Automatic selection of stimulation chamber for ventricular resynchronization therapy 有权
标题翻译：自动选择刺激室进行心室再同步治疗
公开(公告)号：US08818511B2
公开(公告)日：2014-08-26
申请号：US12480485
申请日：2009-06-08
申请人： Jiang Ding , Julio C. Spinelli , Yinghong Yu , Andrew P. Kramer
发明人： Jiang Ding , Julio C. Spinelli , Yinghong Yu , Andrew P. Kramer
IPC分类号： A61N1/362
CPC分类号： A61N1/36592 , A61B5/0472 , A61N1/3627 , A61N1/3684
摘要： A method and apparatus for selection of one or more ventricular chambers to stimulate for ventricular resynchronization therapy. Intrinsic intracardia electrograms that include QRS complexes, are recorded from a left and right ventricle. A timing relationship between the intrinsic intracardia electrograms recorded from the left and right ventricle is then determined. In one embodiment, the timing relationship is determined using a delay between a left ventricular and a right ventricular sensed intrinsic ventricular depolarizations and a duration interval of one or more QRS complexes. In one embodiment, the duration of QRS complexes is determined from either intracardiac electrograms or from surface ECG recordings. One or more ventricular chambers in which to provide pacing pulses are then selected based on the timing relationship between intrinsic intracardia electrograms recorded from the right and left ventricle, and the duration of one or more QRS complexes.
摘要翻译：用于选择一个或多个心室以刺激心室再同步治疗的方法和装置。包括QRS复合物在内的心内膜电图从左心室和右心室记录。然后确定从左心室和右心室记录的内在心内电图之间的时间关系。在一个实施例中，使用左心室和右心室感测的内心室去极化之间的延迟和一个或多个QRS复合物的持续时间间隔来确定时间关系。在一个实施方案中，QRS复合物的持续时间由心脏内电刺激图或从表面心电图记录确定。然后基于从右心室和左心室记录的内在心内电图之间的时间关系和一个或多个QRS复合物的持续时间来选择其中提供起搏脉冲的一个或多个心室。

4. 发明申请

US20090248104A1 AUTOMATIC SELECTION OF STIMULATION CHAMBER FOR VENTRICULAR RESYNCHRONIZATION THERAPY 有权
标题翻译：自体选择刺激室进行心脏再生治疗
公开(公告)号：US20090248104A1
公开(公告)日：2009-10-01
申请号：US12480485
申请日：2009-06-08
申请人： Jiang Ding , Julio C. Spinelli , Yinghong Yu , Andrew P. Kramer
发明人： Jiang Ding , Julio C. Spinelli , Yinghong Yu , Andrew P. Kramer
IPC分类号： A61N1/08 , A61N1/362
CPC分类号： A61N1/36592 , A61B5/0472 , A61N1/3627 , A61N1/3684
摘要： A device and method for programming an implantable pulse generator. In one embodiment, commands are entered designating implantable pulse generator programming variables into programmer memory. At least some of the commands are transformed into an executable macro. The macro is stored in the programmer memory. The macro is executed to transmit the programming variables to the implantable pulse generator.
摘要翻译：一种用于编程可植入脉冲发生器的装置和方法。在一个实施例中，命令被指定为可植入脉冲发生器编程变量到编程器存储器中。至少一些命令被转换成可执行宏。宏存储在编程器存储器中。执行宏以将编程变量发送到可植入脉冲发生器。

5. 发明授权

US07529585B2 Method and apparatus for optimizing ventricular synchrony during DDD resynchronization therapy using adjustable atrio-ventricular delays 有权
标题翻译：在使用可调节心室延迟的DDD再同步治疗期间优化心室同步的方法和装置
公开(公告)号：US07529585B2
公开(公告)日：2009-05-05
申请号：US11463176
申请日：2006-08-08
申请人： Yinghong Yu , Jiang Ding , Julio C. Spinelli , Andrew P. Kramer
发明人： Yinghong Yu , Jiang Ding , Julio C. Spinelli , Andrew P. Kramer
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61N1/056 , A61N1/36564 , A61N1/368 , A61N1/3682
摘要： A pacing system for providing optimal hemodynamic cardiac function for parameters such as ventricular synchrony or contractility (peak left ventricle pressure change during systole or LV+dp/dt), or stroke volume (aortic pulse pressure) using system for calculating atrio-ventricular delays for optimal timing of a ventricular pacing pulse. The system providing an option for near optimal pacing of multiple hemodynamic parameters. The system deriving the proper timing using electrical or mechanical events having a predictable relationship with an optimal ventricular pacing timing signal.
摘要翻译：用于为诸如心室同步或收缩性（收缩期左心室压力峰值或LV + dp / dt）之间的参数提供最佳血液动力学心脏功能或行程体积（主动脉脉压）的起搏系统，用于计算心室间期延迟心室起搏脉冲的最佳时机。该系统为多个血液动力学参数的近似最佳起搏提供了选择。该系统使用与最佳心室起搏定时信号具有可预测关系的电或机械事件导出适当的定时。

6. 发明申请

US20130030485A1 CARDIAC RHYTHM MANAGEMENT SYSTEM SELECTING BETWEEN MULTIPLE SAME-CHAMBER ELECTRODES FOR DELIVERING CARDIAC THERAPY 有权
标题翻译： CARDIAC RHYTHM管理系统选择用于提供心脏治疗的多个相同电极
公开(公告)号：US20130030485A1
公开(公告)日：2013-01-31
申请号：US13646720
申请日：2012-10-07
申请人： Jiang Ding , Julio C. Spinelli , Andrew P. Kramer
发明人： Jiang Ding , Julio C. Spinelli , Andrew P. Kramer
IPC分类号： A61N1/365
CPC分类号： A61N1/3684 , A61N1/3627 , A61N1/36514 , A61N1/368
摘要： A cardiac rhythm management system selects one of multiple electrodes associated with a particular heart chamber based on a relative timing between detection of a depolarization fiducial point at the multiple electrodes, or based on a delay between detection of a depolarization fiducial point at the multiple electrodes and detection of a reference depolarization fiducial point at another electrode associated with the same or a different heart chamber. Subsequent contraction-evoking stimulation therapy is delivered from the selected electrode.
摘要翻译：心脏节律管理系统基于在多个电极处的去极化基准点的检测之间的相对定时或基于在多个电极之间的去极化基准点的检测之间的延迟来选择与特定心室相关联的多个电极中的一个，以及在与相同或不同的心室相关联的另一电极处检测参考去极化基准点。随后的收缩诱导刺激疗法从所选择的电极递送。

7. 发明授权

US08301253B2 Cardiac rhythm management system selecting between multiple same-chamber electrodes for delivering cardiac therapy 有权
公开(公告)号：US08301253B2
公开(公告)日：2012-10-30
申请号：US13369189
申请日：2012-02-08
申请人： Jiang Ding , Julio C. Spinelli , Andrew P. Kramer
发明人： Jiang Ding , Julio C. Spinelli , Andrew P. Kramer
IPC分类号： A61N1/362
CPC分类号： A61N1/3684 , A61N1/3627 , A61N1/36514 , A61N1/368
摘要： A cardiac rhythm management system selects one of multiple electrodes associated with a particular heart chamber based on a relative timing between detection of a depolarization fiducial point at the multiple electrodes, or based on a delay between detection of a depolarization fiducial point at the multiple electrodes and detection of a reference depolarization fiducial point at another electrode associated with the same or a different heart chamber. Subsequent contraction-evoking stimulation therapy is delivered from the selected electrode.

8. 发明授权

US07974695B2 Method and apparatus for optimizing stroke volume during DDD resynchronization therapy using adjustable atrio-ventricular delays 有权
标题翻译：使用可调节的心房延迟在DDD再同步治疗期间优化卒中量的方法和装置
公开(公告)号：US07974695B2
公开(公告)日：2011-07-05
申请号：US11567933
申请日：2006-12-07
申请人： Yinghong Yu , Jiang Ding , Julio C. Spinelli , Andrew P. Kramer
发明人： Yinghong Yu , Jiang Ding , Julio C. Spinelli , Andrew P. Kramer
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/36564 , A61N1/3682
摘要： A pacing system for providing optimal hemodynamic cardiac function for parameters such as ventricular synchrony or contractility (peak left ventricle pressure change during systole or LV+dp/dt), or stroke volume (aortic pulse pressure) using system for calculating atrio-ventricular delays for optimal timing of a ventricular pacing pulse. The system providing an option for near optimal pacing of multiple hemodynamic parameters. The system deriving the proper timing using electrical or mechanical events having a predictable relationship with an optimal ventricular pacing timing signal.
摘要翻译：用于为诸如心室同步或收缩性（收缩期左心室压力峰值或LV + dp / dt）之间的参数提供最佳血液动力学心脏功能或行程体积（主动脉脉压）的起搏系统，用于计算心室间期延迟心室起搏脉冲的最佳时机。该系统为多个血液动力学参数的近似最佳起搏提供了选择。该系统使用与最佳心室起搏定时信号具有可预测关系的电或机械事件导出适当的定时。

9. 发明授权

US07239913B2 Cardiac rhythm management system selecting between multiple same-chamber electrodes for delivering cardiac therapy 有权
标题翻译：心脏节律管理系统选择多个相同室电极之间进行心脏治疗
公开(公告)号：US07239913B2
公开(公告)日：2007-07-03
申请号：US10706436
申请日：2003-11-12
申请人： Jiang Ding , Julio C. Spinelli , Andrew P. Kramer
发明人： Jiang Ding , Julio C. Spinelli , Andrew P. Kramer
IPC分类号： A61N1/365
CPC分类号： A61N1/3684 , A61N1/3627 , A61N1/36514 , A61N1/368
摘要： A cardiac rhythm management system selects one of multiple electrodes associated with a particular heart chamber based on a relative timing between detection of a depolarization fiducial point at the multiple electrodes, or based on a delay between detection of a depolarization fiducial point at the multiple electrodes and detection of a reference depolarization fiducial point at another electrode associated with the same or a different heart chamber. Subsequent contraction-evoking stimulation therapy is delivered from the selected electrode.
摘要翻译：心脏节律管理系统基于在多个电极处的去极化基准点的检测之间的相对定时或基于在多个电极之间的去极化基准点的检测之间的延迟来选择与特定心室相关联的多个电极中的一个，以及在与相同或不同的心室相关联的另一电极处检测参考去极化基准点。随后的收缩诱导刺激疗法从所选择的电极递送。

10. 发明授权

US07110817B2 Method and apparatus for optimizing ventricular synchrony during DDD resynchronization therapy using adjustable atrio-ventricular delays 有权
公开(公告)号：US07110817B2
公开(公告)日：2006-09-19
申请号：US10314910
申请日：2002-12-09
申请人： Yinghong Yu , Jiang Ding , Julio C. Spinelli , Andrew P. Kramer
发明人： Yinghong Yu , Jiang Ding , Julio C. Spinelli , Andrew P. Kramer
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/056 , A61N1/36564 , A61N1/368 , A61N1/3682
摘要： A pacing system for providing optimal hemodynamic cardiac function for parameters such as ventricular synchorny or contractility (peak left ventricle pressure change during systole or LV+dp/dt), or stroke volume (aortic pulse pressure) using system for calculating atrio-ventricular delays for optimal timing of a ventricular pacing pulse. The system providing an option for near optimal pacing of multiple hemodynamic parameters. The system deriving the proper timing using electrical or mechanical events having a predictable relationship with an optimal ventricular pacing timing signal.

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