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1. 发明授权

US07923486B2 Bio-polymer and scaffold-sheet method for tissue engineering 有权
标题翻译：生物聚合物和支架组织工程方法
公开(公告)号：US07923486B2
公开(公告)日：2011-04-12
申请号：US11906962
申请日：2007-10-04
申请人： Jian Yang , Jagannath Dey
发明人： Jian Yang , Jagannath Dey
IPC分类号： A61F2/00 , A61L24/00
CPC分类号： A61L27/507 , A61L27/18 , B33Y80/00 , C08L67/00
摘要： A method of making a new type of biomaterials, biodegrable crosslinked urethane-containing polyester (CUPE) elastomers and a scaffold-sheet engineering method for tissue engineering applications is provided. CUPEs can be synthesized by forming a linear pre-polymer, which is a polyester, introducing the urethane bonds into polyester using a diisocyanate as a linker, and crosslinking the resulting urethane containing linear polymers to form CUPEs via post-polymerization. This family of polymers, CUPEs, exhibit excellent biocompatibility with desired degradation. Tissue engineering scaffolds made of CUPEs are soft and elastic, and have good mechanical strength. Complex tissue grafts can be constructed by a novel layer-by-layer (LBL) scaffold-sheet engineering design using CUPE sheets. CUPE scaffolds can provide openings for cell to cell communication across scaffold layers and angiogenesis into the depth of the construct. Biomolecules, such as anticoagulants, can be incorporated into the CUPE polymers, increasing their viability as vascular graft scaffolds.
摘要翻译：提供了一种新型生物材料的制备方法，可生物降解的含交联聚氨酯的聚酯（CUPE）弹性体和用于组织工程应用的支架工程方法。可以通过形成作为聚酯的线性预聚物来形成CUPE，使用二异氰酸酯作为接头将氨基甲酸酯键引入聚酯中，并通过后聚合将所得的含氨基甲酸酯的线性聚合物交联以形成CUPE。这种聚合物系列CUPE具有优异的生物相容性和所需的降解性。由CUPE制成的组织工程支架柔软弹性，机械强度好。复合组织移植物可以通过使用CUPE片材的新型逐层（LBL）支架工程设计来构建。 CUPE支架可以提供穿过支架层的细胞与细胞之间的通道和血管发生进入构建体深度的开口。生物分子，如抗凝剂，可加入到CUPE聚合物中，增加其作为血管移植支架的活力。

2. 发明申请

US20090093565A1 Bio-polymer and scaffold-sheet method for tissue engineering 有权
标题翻译：生物聚合物和支架组织工程方法
公开(公告)号：US20090093565A1
公开(公告)日：2009-04-09
申请号：US11906962
申请日：2007-10-04
申请人： Jian Yang , Jagannath Dey
发明人： Jian Yang , Jagannath Dey
IPC分类号： A61F2/06 , A61F2/00
CPC分类号： A61L27/507 , A61L27/18 , B33Y80/00 , C08L67/00
摘要： A method of making a new type of biomaterials, biodegrable crosslinked urethane-containing polyester (CUPE) elastomers and a scaffold-sheet engineering method for tissue engineering applications is provided. CUPEs can be synthesized by forming a linear pre-polymer, which is a polyester, introducing the urethane bonds into polyester using a diisocyanate as a linker, and crosslinking the resulting urethane containing linear polymers to form CUPEs via post-polymerization. This family of polymers, CUPEs, exhibit excellent biocompatibility with desired degradation. Tissue engineering scaffolds made of CUPEs are soft and elastic, and have good mechanical strength. Complex tissue grafts can be constructed by a novel layer-by-layer (LBL) scaffold-sheet engineering design using CUPE sheets. CUPE scaffolds can provide openings for cell to cell communication across scaffold layers and angiogenesis into the depth of the construct. Biomolecules, such as anticoagulants, can be incorporated into the CUPE polymers, increasing their viability as vascular graft scaffolds.
摘要翻译：提供了一种制备新型生物材料，可生物降解的含交联聚氨酯的聚酯（CUPE）弹性体的方法和用于组织工程应用的支架片工程方法。可以通过形成作为聚酯的线性预聚物来形成CUPE，使用二异氰酸酯作为接头将氨基甲酸酯键引入聚酯中，并通过后聚合将所得的含氨基甲酸酯的线性聚合物交联以形成CUPE。这种聚合物系列CUPE具有优异的生物相容性和所需的降解性。由CUPE制成的组织工程支架柔软弹性，机械强度好。复合组织移植物可以通过使用CUPE片材的新型逐层（LBL）支架工程设计来构建。 CUPE支架可以提供穿过支架层的细胞与细胞之间的通道和血管发生进入构建体深度的开口。生物分子，如抗凝剂，可加入到CUPE聚合物中，增加其作为血管移植支架的活力。

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