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1. 发明申请

US20130131699A1 POROUS METAL DEVICE FOR REGENERATING SOFT TISSUE-TO-BONE INTERFACE 有权
公开(公告)号：US20130131699A1
公开(公告)日：2013-05-23
申请号：US13679041
申请日：2012-11-16
申请人： Tao Jiang , Jian Q. Yao , Hali Wang , Timothy A. Hoeman , Ray Zubok , John Chernosky , Keith A. Roby
发明人： Tao Jiang , Jian Q. Yao , Hali Wang , Timothy A. Hoeman , Ray Zubok , John Chernosky , Keith A. Roby
IPC分类号： A61B17/68
CPC分类号： A61F2/0811 , A61B17/68 , A61F2002/0858 , A61F2002/0888 , A61F2250/0021 , A61F2250/0023 , A61F2250/0026 , A61L27/04 , A61L27/56
摘要： The present disclosure relates, in some aspects, to orthopaedic implants for securing soft tissue to bone and methods for using the same. One particular implant comprises a first exposed porous surface region, having pores for promoting bone ingrowth, and a second exposed porous surface, having pores for promoting soft tissue ingrowth. At least some of the pores of the first exposed porous surface region may be seeded with osteocytic factors and at least some of the pores of the second exposed porous surface region may be seeded with fibrocytic factors. Such orthopaedic implants can advantageously facilitate regeneration of the soft tissue to bone interface.

2. 发明申请

US20080306610A1 TISSUE PROCESSING FOR NONIMMUNOGENIC IMPLANTS 审中-公开
标题翻译：非发育性植入物的组织加工
公开(公告)号：US20080306610A1
公开(公告)日：2008-12-11
申请号：US11759679
申请日：2007-06-07
申请人： Hali Wang , Hui Liu , Hai-Qing Xian , Jian Q. Yao , Victor Zaporojan
发明人： Hali Wang , Hui Liu , Hai-Qing Xian , Jian Q. Yao , Victor Zaporojan
IPC分类号： A61F2/02 , C12N5/02
CPC分类号： A61L27/3654 , A61K35/32 , A61K35/34 , A61K35/44 , A61L27/3633 , A61L27/3687 , A61L2430/40
摘要： Methods for processing tissues to render them suitable for implantation, e.g. in an orthopedic site. Tissues are rendered substantially acellular and substantially nonimmunogenic by exposure to processes that result in cell lysis, increasing permeability of the extracellular matrix, degrading the debris from lysis, and removing the debris. Methods of forming tissue implants, kits for processing tissue implants, and methods of using tissue implants are also disclosed.
摘要翻译：用于处理组织以使其适合植入的方法，例如，在矫形部位。组织通过暴露于导致细胞裂解，增加细胞外基质的渗透性，降解碎裂从裂解中除去碎屑的过程而基本上是非细胞的并且基本上是非免疫原性的。还公开了形成组织植入物的方法，用于处理组织植入物的试剂盒和使用组织植入物的方法。

3. 发明授权

US08608759B2 Medical devices for suturing biological tissue 有权
标题翻译：用于缝合生物组织的医疗装置
公开(公告)号：US08608759B2
公开(公告)日：2013-12-17
申请号：US13426167
申请日：2012-03-21
申请人： Victor Zaporojan , Jian Q. Yao , Rodney E. Bristol , Hui Liu , Hali Wang , Hai-Qing Xian
发明人： Victor Zaporojan , Jian Q. Yao , Rodney E. Bristol , Hui Liu , Hali Wang , Hai-Qing Xian
IPC分类号： A61B17/04
CPC分类号： A61B17/0469 , A61B17/0467 , A61B17/0482 , A61B17/06066 , A61B17/320016 , A61B2017/00353 , A61B2017/06042 , A61B2017/320052
摘要： Medical devices for cutting and suturing biological tissue generally include a shaft and first and second guide members each including a first portion coupled to the shaft at a first location and a second portion coupled to the shaft at a second location. The first portions are movable along the shaft relative to the second portions, and the first and second guide members define an arcuate profile and are configured to flex in response to such movement. When used to cut tissue, the medical device may further include a blade positioned between the first and second guide members. When used to suture tissue, one or more suture guides may be provided on the first guide member for directing a suture needle through tissue proximate the first guide member. Methods of repairing and replacing a meniscus using the medical devices are also provided.
摘要翻译：用于切割和缝合生物组织的医疗装置通常包括轴和第一和第二引导构件，每个引导构件包括在第一位置处联接到所述轴的第一部分和在第二位置处联接到所述轴的第二部分。第一部分可相对于第二部分沿着轴可移动，并且第一和第二引导构件限定弓形轮廓并且构造成响应于这种移动而弯曲。当用于切割组织时，医疗装置还可以包括位于第一和第二引导构件之间的刀片。当用于缝合组织时，可以在第一引导构件上设置一个或多个缝合线引导件，用于引导缝合针穿过靠近第一引导构件的组织。还提供了使用医疗装置修复和替换弯液面的方法。

4. 发明授权

US08162961B2 Medical devices and methods for cutting and suturing biological tissue 有权
标题翻译：用于切割和缝合生物组织的医疗装置和方法
公开(公告)号：US08162961B2
公开(公告)日：2012-04-24
申请号：US11781517
申请日：2007-07-23
申请人： Victor Zaporojan , Jian Q. Yao , Rodney Bristol , Hui Liu , Hali Wang , Hai-Qing Xian
发明人： Victor Zaporojan , Jian Q. Yao , Rodney Bristol , Hui Liu , Hali Wang , Hai-Qing Xian
IPC分类号： A61B17/04
CPC分类号： A61B17/0469 , A61B17/0467 , A61B17/0482 , A61B17/06066 , A61B17/320016 , A61B2017/00353 , A61B2017/06042 , A61B2017/320052
摘要： Medical devices for cutting and suturing biological tissue generally include a shaft and first and second guide members each including a first portion coupled to the shaft at a first location and a second portion coupled to the shaft at a second location. The first portions are movable along the shaft relative to the second portions, and the first and second guide members define an arcuate profile and are configured to flex in response to such movement. When used to cut tissue, the medical device may further include a blade positioned between the first and second guide members. When used to suture tissue, one or more suture guides may be provided on the first guide member for directing a suture needle through tissue proximate the first guide member. Methods of repairing and replacing a meniscus using the medical devices are also provided.
摘要翻译：用于切割和缝合生物组织的医疗装置通常包括轴和第一和第二引导构件，每个引导构件包括在第一位置处联接到所述轴的第一部分和在第二位置处联接到所述轴的第二部分。第一部分可相对于第二部分沿着轴可移动，并且第一和第二引导构件限定弓形轮廓并且构造成响应于这种移动而弯曲。当用于切割组织时，医疗装置还可以包括位于第一和第二引导构件之间的刀片。当用于缝合组织时，可以在第一引导构件上设置一个或多个缝合线引导件，用于引导缝合针穿过靠近第一引导构件的组织。还提供了使用医疗装置修复和替换弯液面的方法。

5. 发明申请

US20140178343A1 SUPPORTS AND METHODS FOR PROMOTING INTEGRATION OF CARTILAGE TISSUE EXPLANTS 审中-公开
公开(公告)号：US20140178343A1
公开(公告)日：2014-06-26
申请号：US13799452
申请日：2013-03-13
申请人： Jian Q. Yao , Hali Wang
发明人： Jian Q. Yao , Hali Wang
IPC分类号： A61L27/36 , C12N5/077 , A61L27/38
CPC分类号： C12N5/0655 , A61L27/3612 , A61L27/3852 , A61L27/54 , A61L2300/414 , A61L2300/426 , A61L2300/43 , A61L2430/06 , C12N2500/90 , C12N2501/10 , C12N2501/20 , C12N2501/30
摘要： The present disclosure provides tissue supports and methods for preparing a cartilage composition for repairing cartilage defects, which is prepared by expanding and integrating small cartilage tissue pieces derived from donor or engineered tissue. The methods and supports described herein promote cell migration and integration of neighboring tissue pieces in culture to form the cartilage composition. Methods of cartilage repair using the cartilage composition are also described.

6. 发明申请

US20110111028A1 Composition and Methods For Repair of Connective Tissue 有权
标题翻译：组合和修复结缔组织的方法
公开(公告)号：US20110111028A1
公开(公告)日：2011-05-12
申请号：US12736314
申请日：2008-12-22
申请人： Hali Wang , Jian Q. Yao
发明人： Hali Wang , Jian Q. Yao
IPC分类号： A61K38/18 , A61K9/14 , A61K47/42 , A61P19/04
CPC分类号： A61L27/24 , A61L27/52 , A61L27/54 , A61L2300/414
摘要： Compositions and methods for repairing a ruptured connective tissue are disclosed. The composition may include a first biocompatible material to provide a scaffold for connective tissue cell growth and tissue repair. This first biocompatible material may withstand a tensile load of up to 250 N. The composition may also include a second biocompatible material including at least one bioactive agent that can stimulate connective tissue cell growth and tissue repair. The method may include positioning a first end of the first biocompatible material adjacent a first end of a ruptured connective tissue, positioning a second end of the first biocompatible material adjacent a second end of the ruptured connective tissue, and anchoring the first biocompatible material to the first and second tendon ends. The method may alternatively comprise or further include positioning a second biocompatible material between the first and second ends of the ruptured connective tissue.
摘要翻译：公开了用于修复破裂的结缔组织的组合物和方法。组合物可以包括第一生物相容性材料，以提供用于结缔组织细胞生长和组织修复的支架。该第一生物相容性材料可以承受高达250N的拉伸载荷。组合物还可以包括第二生物相容性材料，其包括至少一种可刺激结缔组织细胞生长和组织修复的生物活性剂。该方法可以包括将第一生物相容性材料的第一端邻近破裂的结缔组织的第一端定位，将第一生物相容性材料的第二端邻近破裂的结缔组织的第二端定位，并将第一生物相容性材料锚定到第一和第二肌腱末端。该方法可以可选地包括或进一步包括将第二生物相容性材料定位在破裂的结缔组织的第一和第二端之间。

7. 发明申请

US20080294270A1 DIFFERENTIALLY PROCESSED TISSUE AND PROCESSING METHODS THEREOF 审中-公开
标题翻译：不同加工组织及其加工方法
公开(公告)号：US20080294270A1
公开(公告)日：2008-11-27
申请号：US11753102
申请日：2007-05-24
申请人： Jian Q. Yao , Hai-Qing Xian , Jizong Gao , Rodney Bristol , Victor Zaporojan , Hali Wang , Hui Liu
发明人： Jian Q. Yao , Hai-Qing Xian , Jizong Gao , Rodney Bristol , Victor Zaporojan , Hali Wang , Hui Liu
IPC分类号： A61L27/38 , A61F2/28 , D01C3/00
CPC分类号： A61L27/3608 , A61L27/3604 , A61L27/3683
摘要： A method of preparing an implantable biological device having a first tissue part and a second tissue part includes exposing the first tissue part to a first preparation method and preventing exposure of the second biological tissue part to the first preparation method. Preventing exposure of the second biological tissue part to the first preparation method may be achieved using an embedding technique, a coating technique, a covering technique, or physical isolation. The method may further include exposing the second tissue part to a second preparation method and preventing exposure of the first biological tissue part to the second preparation method. An apparatus for preparing an implantable biologic device includes an enclosure having first and second chambers separated by a partition member wherein a substantial portion of the first tissue part is within the first chamber and a substantial portion of the second tissue part is within the second chamber.
摘要翻译：制备具有第一组织部分和第二组织部分的可植入生物装置的方法包括将第一组织部分暴露于第一制备方法并防止第二生物组织部分暴露于第一制备方法。可以使用嵌入技术，涂覆技术，覆盖技术或物理隔离来防止第二生物组织部分暴露于第一制备方法。该方法可以进一步包括将第二组织部分暴露于第二制备方法并防止第一生物组织部分暴露于第二制备方法。一种用于制备可植入生物装置的装置，包括具有由分隔构件分开的第一和第二腔室的外壳，其中所述第一组织部分的大部分位于所述第一腔室内，并且所述第二组织部分的大部分位于所述第二腔室内。

8. 发明申请

US20120179173A1 MEDICAL DEVICES AND METHODS FOR CUTTING AND SUTURING BIOLOGICAL TISSUE 有权
标题翻译：用于切割和修复生物组织的医疗装置和方法
公开(公告)号：US20120179173A1
公开(公告)日：2012-07-12
申请号：US13426167
申请日：2012-03-21
申请人： Victor Zaporojan , Jian Q. Yao , Rodney Bristol , Hui Liu , Hali Wang , Hai-Qing Xian
发明人： Victor Zaporojan , Jian Q. Yao , Rodney Bristol , Hui Liu , Hali Wang , Hai-Qing Xian
IPC分类号： A61B17/04
CPC分类号： A61B17/0469 , A61B17/0467 , A61B17/0482 , A61B17/06066 , A61B17/320016 , A61B2017/00353 , A61B2017/06042 , A61B2017/320052
摘要： Medical devices for cutting and suturing biological tissue generally include a shaft and first and second guide members each including a first portion coupled to the shaft at a first location and a second portion coupled to the shaft at a second location. The first portions are movable along the shaft relative to the second portions, and the first and second guide members define an arcuate profile and are configured to flex in response to such movement. When used to cut tissue, the medical device may further include a blade positioned between the first and second guide members. When used to suture tissue, one or more suture guides may be provided on the first guide member for directing a suture needle through tissue proximate the first guide member. Methods of repairing and replacing a meniscus using the medical devices are also provided.
摘要翻译：用于切割和缝合生物组织的医疗装置通常包括轴和第一和第二引导构件，每个引导构件包括在第一位置处联接到所述轴的第一部分和在第二位置处联接到所述轴的第二部分。第一部分可相对于第二部分沿着轴可移动，并且第一和第二引导构件限定弓形轮廓并且构造成响应于这种移动而弯曲。当用于切割组织时，医疗装置还可以包括位于第一和第二引导构件之间的刀片。当用于缝合组织时，可以在第一引导构件上设置一个或多个缝合线引导件，用于引导缝合针穿过靠近第一引导构件的组织。还提供了使用医疗装置修复和替换弯液面的方法。

9. 发明申请

US20100297766A1 Method of Removing Undesired Tissue from Connective Tissue 审中-公开
标题翻译：从结缔组织中去除不需要的组织的方法
公开(公告)号：US20100297766A1
公开(公告)日：2010-11-25
申请号：US12864207
申请日：2009-02-03
申请人： Hai-Qing Xian , Hali Wang , Hui Liu , Jian Q. Yao , Jizong Gao
发明人： Hai-Qing Xian , Hali Wang , Hui Liu , Jian Q. Yao , Jizong Gao
IPC分类号： C12N5/02
CPC分类号： A61K38/4826 , A61K38/465 , C12Y301/01003 , C12Y304/21004
摘要： A method of removing undesired tissue from a connective tissue is provided that includes stretching the connective tissue and peeling away the undesired tissue. Some methods include soaking the connective tissue in a solution prior to and/or subsequent to stretching and peeling away the undesired tissue. The solution may include a detergent, an enzyme, a salt solution, an organic solvent, and combinations thereof.
摘要翻译：提供从结缔组织中去除不想要的组织的方法，其包括拉伸结缔组织并剥离不想要的组织。一些方法包括在拉伸和/或剥离不想要的组织之前和/或之后将结缔组织浸泡在溶液中。溶液可以包括洗涤剂，酶，盐溶液，有机溶剂及其组合。

10. 发明申请

US20090030431A1 MEDICAL DEVICES AND METHODS FOR CUTTING AND SUTURING BIOLOGICAL TISSUE 有权
标题翻译：用于切割和修复生物组织的医疗装置和方法
公开(公告)号：US20090030431A1
公开(公告)日：2009-01-29
申请号：US11781517
申请日：2007-07-23
申请人： Victor Zaporojan , Jian Q. Yao , Rodney Bristol , Hui Liu , Hali Wang , Hai-Qing Xian
发明人： Victor Zaporojan , Jian Q. Yao , Rodney Bristol , Hui Liu , Hali Wang , Hai-Qing Xian
IPC分类号： A61B17/04 , A61B17/32
CPC分类号： A61B17/0469 , A61B17/0467 , A61B17/0482 , A61B17/06066 , A61B17/320016 , A61B2017/00353 , A61B2017/06042 , A61B2017/320052
摘要： Medical devices for cutting and suturing biological tissue generally include a shaft and first and second guide members each including a first portion coupled to the shaft at a first location and a second portion coupled to the shaft at a second location. The first portions are movable along the shaft relative to the second portions, and the first and second guide members define an arcuate profile and are configured to flex in response to such movement. When used to cut tissue, the medical device may further include a blade positioned between the first and second guide members. When used to suture tissue, one or more suture guides may be provided on the first guide member for directing a suture needle through tissue proximate the first guide member. Methods of repairing and replacing a meniscus using the medical devices are also provided.
摘要翻译：用于切割和缝合生物组织的医疗装置通常包括轴和第一和第二引导构件，每个引导构件包括在第一位置处联接到所述轴的第一部分和在第二位置处联接到所述轴的第二部分。第一部分可相对于第二部分沿着轴可移动，并且第一和第二引导构件限定弓形轮廓并且构造成响应于这种移动而弯曲。当用于切割组织时，医疗装置还可以包括位于第一和第二引导构件之间的刀片。当用于缝合组织时，可以在第一引导构件上设置一个或多个缝合线引导件，用于引导缝合针穿过靠近第一引导构件的组织。还提供了使用医疗装置修复和替换弯液面的方法。

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