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1. 发明申请

US20130237432A1 APPLICATION OF A PCR SEQUENCING METHOD, BASED ON DNA BARCODING TECHNIQUE AND DNA INCOMPLETE SHEARING STRATEGY, IN HLA GENOTYPING 有权
标题翻译：基于DNA测序技术的PCR测序方法的应用和HLA基因组DNA的不完全剪切策略
公开(公告)号：US20130237432A1
公开(公告)日：2013-09-12
申请号：US13807660
申请日：2011-06-30
申请人： Jian Li , Shiping Chen , Xiandong Zhang , Ying Liu , Calfen Zhang , Tao Liu , Meiru Zhao
发明人： Jian Li , Shiping Chen , Xiandong Zhang , Ying Liu , Calfen Zhang , Tao Liu , Meiru Zhao
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6881 , C12Q1/6844 , C12Q1/6869 , C12Q2600/156 , C12Q2600/16 , C12Q2600/172 , C12Q2525/191
摘要： The invention provides a PCR sequencing method, wherein the combination of primer indexes, DNA incomplete shearing strategy and the second generation sequencing technique (Paired-End sequencing technique) can make the length of PCR products that can be sequenced by a sequencer longer than the maximum sequencing length of the sequencer whilst making full use of the characteristics of the second generation sequencing technique such as high throughput and low cost, thereby greatly broadening its applicable scope. In addition, the present invention also provides primer indexes for the PCR sequencing method and the use of the method in genotyping, particularly in HLA analysis, and also provides the PCR primers used, particularly the PCR primers for HLA-A, B, HLA-C and HLA-DQB1 gene.
摘要翻译：本发明提供了一种PCR测序方法，其中引物指数，DNA不完全剪切策略和第二代测序技术（配对终点测序技术）的组合可以使序列长度超过最大序列的PCR产物的序列长度定序器的测序长度，同时充分利用第二代测序技术的特点，如高吞吐量和低成本，从而大大拓宽了其适用范围。另外，本发明还提供了PCR测序方法的引物指标和基因分型方法的使用，特别是在HLA分析中，还提供了使用的PCR引物，特别是HLA-A，B，HLA- C和HLA-DQB1基因。

2. 发明授权

US09957564B2 Application of a PCR sequencing method, based on DNA barcoding technique and DNA incomplete shearing strategy, in HLA genotyping 有权
公开(公告)号：US09957564B2
公开(公告)日：2018-05-01
申请号：US13807660
申请日：2011-06-30
申请人： Jian Li , Shiping Chen , Xiandong Zhang , Ying Liu , Caifen Zhang , Tao Liu , Meiru Zhao
发明人： Jian Li , Shiping Chen , Xiandong Zhang , Ying Liu , Caifen Zhang , Tao Liu , Meiru Zhao
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6881 , C12Q1/6844 , C12Q1/6869 , C12Q2600/156 , C12Q2600/16 , C12Q2600/172 , C12Q2525/191
摘要： The invention provides a PCR sequencing method, wherein the combination of primer indexes, DNA incomplete shearing strategy and the second generation sequencing technique (Paired-End sequencing technique) can make the length of PCR products that can be sequenced by a sequencer longer than the maximum sequencing length of the sequencer while making full use of the characteristics of the second generation sequencing technique such as high throughput and low cost, thereby greatly broadening its applicable scope. In addition, the present invention also provides primer indexes for the PCR sequencing method and the use of the method in genotyping, particularly in HLA analysis, and also provides the PCR primers used, particularly the PCR primers for HLA-A, B, HLA-C and HLA-DQB1 gene.

3. 发明申请

US20160147778A1 APPLYING A DATABASE TRANSACTION LOG RECORD DIRECTLY TO A DATABASE TABLE CONTAINER 有权
标题翻译：应用数据库交易日志直接记录到数据库表容器
公开(公告)号：US20160147778A1
公开(公告)日：2016-05-26
申请号：US14552914
申请日：2014-11-25
申请人： Ivan SCHRETER , Shiping Chen , David Wein , Steffen Geißinger
发明人： Ivan SCHRETER , Shiping Chen , David Wein , Steffen Geißinger
IPC分类号： G06F17/30
CPC分类号： G06F17/30371 , G06F17/30368
摘要： Disclosed herein are system, method, and computer program product embodiments for directly restoring a database from a log volume. An embodiment operates by reading one or more database transaction log records from a log volume. The embodiment then loads from a database table persistent storage one or more pages containing rows in the database table that will be read from or written to by the one or more database transaction log records. The embodiment then loads a dictionary for each column associated with the one or more database transaction log records. The embodiment then applies the one or more database transaction log records directly into the one or more loaded pages and the one or more dictionaries. Each dictionary and page modified in memory is then written to the database table persistent storage when a savepoint operation is performed.
摘要翻译：这里公开了用于从日志卷直接恢复数据库的系统，方法和计算机程序产品实施例。实例通过从日志卷读取一个或多个数据库事务日志记录来操作。然后，该实施例从数据库表加载包含数据库表中将由一个或多个数据库事务日志记录读取或写入的行的一个或多个页面。该实施例然后加载与一个或多个数据库事务日志记录相关联的每个列的字典。然后，该实施例将一个或多个数据库事务日志记录直接应用于一个或多个加载的页面和一个或多个字典。当执行保存点操作时，将内存中修改的每个字典和页面随后写入数据库表永久存储。

4. 发明申请

US20080080558A1 Packet Flow Side Channel 有权
标题翻译：分组流侧边信道
公开(公告)号：US20080080558A1
公开(公告)日：2008-04-03
申请号：US11556220
申请日：2006-11-03
申请人： Xinyuan Wang , Shiping Chen , Sushil Jajodia
发明人： Xinyuan Wang , Shiping Chen , Sushil Jajodia
IPC分类号： H04L5/00
CPC分类号： H04L65/607
摘要： A packet flow side channel encoder and decoder embeds and extracts a side channel communication in an overt communication data stream transmitted over a network. The encoder selects more than one group of related packets being transmitted on the network, relates a packet of one group to a packet of another group to form a pair of packets; and delays the timing of at least one packet from each pair of packets The decoder determines inter-packet delays that are the difference in timing between two packets in a pair of packets; determines at least one inter-packet delay difference between two or more determined inter-packet delays; and extracts a bit using the at least one interpacket delay difference.
摘要翻译：分组流侧信道编码器和解码器在通过网络传输的公开通信数据流中嵌入和提取侧信道通信。编码器选择在网络上发送的多组相关数据包，将一组数据包与另一组数据包相连，形成一对数据包; 并且延迟来自每对分组的至少一个分组的定时。解码器确定作为一对分组中的两个分组之间的定时差的分组间延迟; 确定两个或多个确定的分组间延迟之间的至少一个分组间延迟差异; 并且使用所述至少一个间隔延迟差提取位。

5. 发明授权

US09811549B2 Applying a database transaction log record directly to a database table container 有权
公开(公告)号：US09811549B2
公开(公告)日：2017-11-07
申请号：US14552914
申请日：2014-11-25
申请人： Ivan Schreter , Shiping Chen , David Wein , Steffen Geiβinger
发明人： Ivan Schreter , Shiping Chen , David Wein , Steffen Geiβinger
IPC分类号： G06F17/30
CPC分类号： G06F17/30371 , G06F17/30368
摘要： Disclosed herein are system, method, and computer program product embodiments for directly restoring a database from a log volume. An embodiment operates by reading one or more database transaction log records from a log volume. The embodiment then loads from a database table persistent storage one or more pages containing rows in the database table that will be read from or written to by the one or more database transaction log records. The embodiment then loads a dictionary for each column associated with the one or more database transaction log records. The embodiment then applies the one or more database transaction log records directly into the one or more loaded pages and the one or more dictionaries. Each dictionary and page modified in memory is then written to the database table persistent storage when a savepoint operation is performed.

6. 发明授权

US09779104B2 Efficient database undo / redo logging 有权
公开(公告)号：US09779104B2
公开(公告)日：2017-10-03
申请号：US14553833
申请日：2014-11-25
申请人： Mihnea Andrei , Ivan Schreter , David Wein , Shiping Chen , Panfeng Zhou , Steffen Geissinger
发明人： Mihnea Andrei , Ivan Schreter , David Wein , Shiping Chen , Panfeng Zhou , Steffen Geissinger
IPC分类号： G06F17/30 , G06F11/14
CPC分类号： G06F17/30162 , G06F11/1402 , G06F17/30185 , G06F17/30336 , G06F17/30368
摘要： Log records are accessed as part of a database operation in a database. The log records log insert, update, and delete operations in the database and include, for each row, a row position, a fragment identifier (ID), and a row ID. Thereafter, as part of the database operation, rows specified by the log records are located by: using the fragment identifier and the row position within the corresponding record of the log if the fragment with the corresponding fragment identifier is still available, otherwise, using the row identifier within the corresponding record of the log to look up the row position in an index of a corresponding row identifier column. The database operation is then finalized using the located rows. Related apparatus, systems, techniques and articles are also described.

7. 发明授权

US09158933B2 Protection of encryption keys in a database 有权
标题翻译：保护数据库中的加密密钥
公开(公告)号：US09158933B2
公开(公告)日：2015-10-13
申请号：US12464617
申请日：2009-05-12
申请人： Barbara Jane Banks , Rajnish Kumar Chitkara , Shiping Chen
发明人： Barbara Jane Banks , Rajnish Kumar Chitkara , Shiping Chen
IPC分类号： H04L9/08 , H04L9/00 , G06F21/00 , G06F7/04 , H04L29/06 , G06F21/62
CPC分类号： G06F21/6227 , H04L9/085 , H04L9/0863 , H04L9/0891 , H04L9/0894
摘要： System, method, computer program product embodiments and combinations and sub-combinations thereof for protection of encryption keys in a database are described herein. An embodiment includes a master key and a dual master key, both of which are used to encrypt encryption keys in a database. To access encrypted data, the master key and dual master key must be supplied to a database server by two separate entities, thus requiring dual control of the master and dual master keys. Furthermore, passwords for the master and dual master keys must be supplied separately and independently, thus requiring split knowledge to access the master and dual master keys. In another embodiment, a master key and a key encryption key derived from a user password is used for dual control. An embodiment also includes supplying the secrets for the master key and dual master key through server-private files.
摘要翻译：这里描述了用于保护数据库中的加密密钥的系统，方法，计算机程序产品实施例及其组合和子组合。一个实施例包括主密钥和双主密钥，它们都用于加密数据库中的加密密钥。要访问加密数据，主密钥和双主密钥必须由两个单独的实体提供给数据库服务器，因此需要双重控制主密钥和双主密钥。此外，主主密钥和双主密钥的密码必须单独和独立提供，因此需要拆分知识以访问主密钥和双主密钥。在另一个实施例中，将主密钥和从用户密码导出的密钥加密密钥用于双重控制。实施例还包括通过服务器专用文件提供主密钥和双主密钥的秘密。

8. 发明申请

US20100195819A1 Interval Centroid Based Watermark Decoder 有权
标题翻译：基于间隔心脏的水印解码器
公开(公告)号：US20100195819A1
公开(公告)日：2010-08-05
申请号：US12758053
申请日：2010-04-12
申请人： Xinyuan Wang , Shiping Chen
发明人： Xinyuan Wang , Shiping Chen
IPC分类号： H04L9/00
CPC分类号： H04L63/0428 , H04L2463/103
摘要： An interval centroid-based watermark encoder encodes a watermark into a packet flow. Intervals are defined for the packet flow. Some of the intervals are selected as group A intervals while other intervals are selected as group B intervals. Group A and group B intervals are paired and assigned to watermark bits. A first or second value may be encoded by increasing the relative packet time between packets in either the group A (for the first bit value) or group B (for the second bit value) interval(s) of the interval pair(s) assigned to the watermark bits that are to represent the first or second bit value and the beginning of the same group interval(s). The relative packet times may be measured by a decoder and used to calculate a centroid difference for each interval pair. The centroid differences may be used to reconstruct the watermark.
摘要翻译：基于间隔质心的水印编码器将水印编码成分组流。为数据包流定义了间隔。选择一些间隔作为组A间隔，而选择其他间隔作为组B间隔。 A组和B组间隔配对并分配给水印位。第一或第二值可以通过增加在分配的间隔对（分组）的组A（用于第一比特值）或组B（对于第二比特值）间隔的分组之间的分组之间的相对分组时间来进行编码涉及要表示第一或第二位值和相同组间隔的开始的水印位。相对分组时间可以由解码器测量，并用于计算每个间隔对的质心差。质心差异可用于重建水印。

9. 发明申请

US20080038725A1 Methods of detecting nucleic acids in individual cells and of identifying rare cells from large heterogeneous cell populations 审中-公开
标题翻译：检测单个细胞中的核酸并鉴定来自大异质细胞群体的稀有细胞的方法
公开(公告)号：US20080038725A1
公开(公告)日：2008-02-14
申请号：US11471278
申请日：2006-06-19
申请人： Yuling Luo , Shiping Chen
发明人： Yuling Luo , Shiping Chen
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6837 , C12Q1/682 , C12Q1/6841 , C12Q2537/143 , C12Q2537/125 , C12Q2565/543 , C12Q2525/313
摘要： Methods of detecting multiple nucleic acid targets in single cells through indirect capture of labels to the nucleic acids are provided. Methods of assaying the relative levels of nucleic acid targets through normalization to levels of reference nucleic acids are also provided. Methods of detecting individual cells, particularly rare cells from large heterogeneous cell populations, through detection of nucleic acids are described. Related compositions, systems, and kits are also provided.
摘要翻译：提供了通过间接捕获标记到核酸来检测单个细胞中的多个核酸靶的方法。还提供了通过归一化到参考核酸水平来测定核酸靶的相对水平的方法。描述了通过检测核酸检测单个细胞，特别是来自大异质细胞群体的罕见细胞的方法。还提供了相关的组合物，系统和试剂盒。

10. 发明授权

US06953551B2 Microarray fabrication techniques and apparatus 失效
标题翻译：微阵列制造技术和装置
公开(公告)号：US06953551B2
公开(公告)日：2005-10-11
申请号：US09791998
申请日：2001-02-22
申请人： Shiping Chen , Yuling Luo
发明人： Shiping Chen , Yuling Luo
IPC分类号： G01N33/53 , B01J4/00 , B01J19/00 , B01L3/02 , B81B1/00 , C12M1/00 , C12N15/09 , C40B40/06 , C40B40/10 , C40B60/14 , G01N21/25 , G01N21/64 , G01N35/10 , G01N37/00 , B41K1/38
CPC分类号： B01L3/0268 , B01J19/0046 , B01J2219/00369 , B01J2219/00382 , B01J2219/00385 , B01J2219/00418 , B01J2219/00527 , B01J2219/00529 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00648 , B01J2219/00659 , B01J2219/00707 , B01J2219/00722 , B01J2219/00725 , B01L3/0262 , C40B40/06 , C40B40/10 , C40B60/14 , G01N21/253 , G01N21/6452 , G01N35/1074 , G01N2021/6484 , G01N2035/1037
摘要： Disclosed is a microarray printing system and methods of printing probe microarrays. The system has a print-head formed of one or more capillary bundle, such as light-guiding capillaries. The bundles may especially be bundles of capillaries that provide a large number of probes on the surface of a substrate. Methods of registering or correlating the distal and proximal ends of the capillaries are also provided. Further, the invention provides methods and equipment for identifying defective microarrays that are missing one or more probes from the surface of the microarray.
摘要翻译：公开了一种微阵列打印系统和打印探针微阵列的方法。该系统具有由一个或多个毛细管束形成的打印头，例如导光毛细管。束可以特别地是在基底表面上提供大量探针的毛细管束。也提供了注射或关联毛细管的远端和近端的方法。此外，本发明提供了用于鉴定从微阵列表面缺少一个或多个探针的有缺陷的微阵列的方法和设备。

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