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    • 3. 发明申请
    • USE OF TRIM72 AS A TARGET FOR MUSCLE AND HEART ENHANCER
    • 使用TRIM72作为肌肉和心脏增强剂的目标
    • US20110251256A1
    • 2011-10-13
    • US12733484
    • 2008-09-04
    • Young-Gyu KoJae-Sung YiChang-Seok Lee
    • Young-Gyu KoJae-Sung YiChang-Seok Lee
    • A61K31/7105A61P9/00C12Q1/02
    • C07K14/4703A61K31/7105A61K38/00C12N15/113C12N2310/14C12Q1/6883C12Q2600/136C12Q2600/158G01N33/5008G01N33/5061
    • The present invention relates to a new use of TRIM72 as a target for muscle enhancer and heart enhancer, more particularly to a composition for enhancing muscle or heart comprising an expression or action inhibitor of TRIM72 protein. The present invention further relates to a new TRIM mutant protein inducing muscle differentiation and hypertrophy and its gene. The inventors of the present invention have identified that TRIM72 overexpression inhibits myogenesis whereas TRIM72 knockdown enhances myogenesis, and first elucidated that TRIM72 is a negative regulator of skeletal muscle differentiation. Accordingly, the inhibition of TRIM72 acts exclusively on skeletal muscle and heart muscle, but does not affect IGF-I signaling pathway in other tissues. Therefore, a drug or gene therapy using TRIM72 as a target may be helpful in treating obesity and type 2 diabetes by promoting skeletal muscle differentiation, hypertrophy and energy consumption in adipose tissue and inducing strong muscle by promoting physiological hypertrophy of heart muscle, without cancer or other side effects.
    • 本发明涉及TRIM72作为肌肉增强剂和心脏增强剂的靶的新用途,更具体地说涉及用于增强肌肉或心脏的组合物,其包含TRIM72蛋白的表达或作用抑制剂。 本发明还涉及一种诱导肌肉分化和肥大的新型TRIM突变蛋白及其基因。 本发明的发明人已经发现TRIM72过表达抑制肌细胞生成,而TRIM72敲低增强肌发生,首先阐明了TRIM72是骨骼肌分化的负调节因子。 因此,TRIM72的抑制仅在骨骼肌和心肌上起作用,但不影响其他组织中的IGF-I信号通路。 因此,使用TRIM72作为靶标的药物或基因治疗可能有助于通过促进骨骼肌分化,脂肪组织中的肥大和能量消耗以及通过促进心肌的生理肥大而诱发强力的肌肉而不致癌症或治疗肥胖和2型糖尿病 其他副作用。
    • 4. 发明授权
    • Use of TRIM72 as a target for muscle and heart enhancer
    • 使用TRIM72作为肌肉和心脏增强剂的目标
    • US08383602B2
    • 2013-02-26
    • US12733484
    • 2008-09-04
    • Young-Gyu KoJae-Sung YiChang-Seok Lee
    • Young-Gyu KoJae-Sung YiChang-Seok Lee
    • A61P9/00A61K31/70C12Q1/68
    • C07K14/4703A61K31/7105A61K38/00C12N15/113C12N2310/14C12Q1/6883C12Q2600/136C12Q2600/158G01N33/5008G01N33/5061
    • The present invention relates to a new use of TRIM72 as a target for muscle enhancer and heart enhancer, more particularly to a composition for enhancing muscle or heart comprising an expression or action inhibitor of TRIM72 protein. The present invention further relates to a new TRIM mutant protein inducing muscle differentiation and hypertrophy and its gene. The inventors of the present invention have identified that TRIM72 overexpression inhibits myogenesis whereas TRIM72 knockdown enhances myogenesis, and first elucidated that TRIM72 is a negative regulator of skeletal muscle differentiation. Accordingly, the inhibition of TRIM72 acts exclusively on skeletal muscle and heart muscle, but does not affect IGF-I signaling pathway in other tissues. Therefore, a drug or gene therapy using TRIM72 as a target may be helpful in treating obesity and type 2 diabetes by promoting skeletal muscle differentiation, hypertrophy and energy consumption in adipose tissue and inducing strong muscle by promoting physiological hypertrophy of heart muscle, without cancer or other side effects.
    • 本发明涉及TRIM72作为肌肉增强剂和心脏增强剂的靶的新用途,更具体地说涉及用于增强肌肉或心脏的组合物,其包含TRIM72蛋白的表达或作用抑制剂。 本发明还涉及一种诱导肌肉分化和肥大的新型TRIM突变蛋白及其基因。 本发明的发明人已经发现TRIM72过表达抑制肌细胞生成,而TRIM72敲低增强肌发生,首先阐明了TRIM72是骨骼肌分化的负调节因子。 因此,TRIM72的抑制仅在骨骼肌和心肌上起作用,但不影响其他组织中的IGF-I信号通路。 因此,使用TRIM72作为靶标的药物或基因治疗可能有助于通过促进骨骼肌分化,脂肪组织中的肥大和能量消耗以及通过促进心肌的生理肥大而诱发强力的肌肉而不致癌症或治疗肥胖和2型糖尿病 其他副作用。