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1. 发明申请

US20080188723A1 Sensor For Detection Of Carbohydrate 有权
标题翻译：碳水化合物检测传感器
公开(公告)号：US20080188723A1
公开(公告)日：2008-08-07
申请号：US11791924
申请日：2005-12-07
申请人： Jesper Svennin Kristensen , Klaus Gregorius , Casper Struve , John Myhre Frederiksen , Yihua Yu
发明人： Jesper Svennin Kristensen , Klaus Gregorius , Casper Struve , John Myhre Frederiksen , Yihua Yu
IPC分类号： A61B5/1455
CPC分类号： C08B37/0063 , A61B5/145 , A61B5/14532 , G01N33/54373 , G01N33/66
摘要： A sensor for the detection or measurement of carbohydrate analyte (such as glucose) in fluid comprises components of a competitive binding assay the readout of which is a detectable or measurable optical signal (such as FRET assay) retained by a material that permits diffusion of analyte but not the assay components, the assay components comprising: an animal lectin; and an analyte analogue capable of competing with analyte for binding to the lectin.
摘要翻译：用于检测或测量流体中碳水化合物分析物（例如葡萄糖）的传感器包括竞争性结合测定的组分，其读出是可检测或可测量的光学信号（例如FRET测定），其由允许分析物扩散的材料保留但不是测定组分，测定组分包含：动物凝集素; 以及能够与分析物竞争结合凝集素的分析物类似物。

2. 发明授权

US08700113B2 Sensor for detection of carbohydrate 有权
标题翻译：用于检测碳水化合物的传感器
公开(公告)号：US08700113B2
公开(公告)日：2014-04-15
申请号：US11791924
申请日：2005-12-07
申请人： Jesper Svenning Kristensen , Klaus Gregorius , Casper Struve , John Myhre Frederiksen , Yihua Yu
发明人： Jesper Svenning Kristensen , Klaus Gregorius , Casper Struve , John Myhre Frederiksen , Yihua Yu
IPC分类号： A61B5/1455
CPC分类号： C08B37/0063 , A61B5/145 , A61B5/14532 , G01N33/54373 , G01N33/66
摘要： A sensor for the detection or measurement of carbohydrate analyte (such as glucose) in fluid comprises components of a competitive binding assay the readout of which is a detectable or measurable optical signal (such as FRET assay) retained by a material that permits diffusion of analyte but not the assay components, the assay components comprising: an animal lectin; and an analyte analogue capable of competing with analyte for binding to the lectin.
摘要翻译：用于检测或测量流体中碳水化合物分析物（例如葡萄糖）的传感器包括竞争性结合测定的组分，其读出是可检测或可测量的光学信号（例如FRET测定），其由允许分析物扩散的材料保留但不是测定组分，测定组分包含：动物凝集素; 以及能够与分析物竞争结合凝集素的分析物类似物。

3. 发明授权

US08691517B2 Flexible carbohydrate-bearing polymer 有权
标题翻译：柔性含碳水化合物聚合物
公开(公告)号：US08691517B2
公开(公告)日：2014-04-08
申请号：US12085961
申请日：2006-12-06
申请人： Jesper Svenning Kristensen , Klaus Gregorius , Casper Struve , Yihua Yu
发明人： Jesper Svenning Kristensen , Klaus Gregorius , Casper Struve , Yihua Yu
IPC分类号： G01N33/543 , G01N33/542 , G01N33/66 , A61B5/145
CPC分类号： C08B37/0063 , A61B5/145 , A61B5/14532 , G01N33/54373 , G01N33/66
摘要： A sensor for the detection or measurement of a carbohydrate analyte in fluid comprises components of a competitive binding assay the readout of which is a detectable or measurable optical signal retained by a material that permits diffusion of the analyte but not the assay components, the assay components comprising: a carbohydrate binding molecule labelled with one of a proximity based signal generating/modulating moiety pair; and a carbohydrate analogue capable of competing with the analyte for binding to the carbohydrate binding molecule, the carbohydrate analogue being a flexible water-soluble polymer comprising: polymerized or co-polymerised residues of monomer units, the monomer unit residues bearing pendant carbohydrate or carbohydrate mimetic moieties and pendant moieties which are the other of the proximity based signal generating/modulating moiety pair.
摘要翻译：用于检测或测量流体中的碳水化合物分析物的传感器包括竞争性结合测定的组分，其读出是由允许分析物扩散但不含测定组分的测定组分保留的可检测或可测量的光学信号，测定组分包括：用接近度信号产生/调节部分对之一标记的碳水化合物结合分子; 碳水化合物类似物是柔性水溶性聚合物，其包含：单体单元的聚合或共聚残基，带有碳水化合物或碳水化合物模拟物的单体单元残基部分和侧基部分，其是基于邻近的信号产生/调节部分对中的另一个。

4. 发明申请

US20090187084A1 Flexible Carbohydrate-Bearing Polymer 有权
标题翻译：柔性碳水化合物承载聚合物
公开(公告)号：US20090187084A1
公开(公告)日：2009-07-23
申请号：US12085961
申请日：2006-12-06
申请人： Jesper Svenning Kristensen , Klaus Gregorius , Casper Struve , Yihua Yu
发明人： Jesper Svenning Kristensen , Klaus Gregorius , Casper Struve , Yihua Yu
IPC分类号： A61B5/1455 , G01N33/53 , C07H15/00
CPC分类号： C08B37/0063 , A61B5/145 , A61B5/14532 , G01N33/54373 , G01N33/66
摘要： A sensor for the detection or measurement of a carbohydrate analyte in fluid comprises components of a competitive binding assay the readout of which is a detectable or measurable optical signal retained by a material that permits diffusion of the analyte but not the assay components, the assay components comprising: a carbohydrate binding molecule labelled with one of a proximity based signal generating/modulating moiety pair; and a carbohydrate analogue capable of competing with the analyte for binding to the carbohydrate binding molecule, the carbohydrate analogue being a flexible water-soluble polymer comprising: polymerized or co-polymerised residues of monomer units, the monomer unit residues bearing pendant carbohydrate or carbohydrate mimetic moieties and pendant moieties which are the other of the proximity based signal generating/modulating moiety pair.
摘要翻译：用于检测或测量流体中的碳水化合物分析物的传感器包括竞争性结合测定的组分，其读出是由允许分析物扩散但不含测定组分的测定组分保留的可检测或可测量的光学信号，测定组分包括：用接近度信号产生/调节部分对之一标记的碳水化合物结合分子; 碳水化合物类似物是柔性水溶性聚合物，其包含：单体单元的聚合或共聚残基，带有碳水化合物或碳水化合物模拟物的单体单元残基部分和侧基部分，其是基于邻近的信号产生/调节部分对中的另一个。

5. 发明申请

US20090131773A1 Sensor for Detection of Carbohydrate 有权
标题翻译：碳水化合物检测传感器
公开(公告)号：US20090131773A1
公开(公告)日：2009-05-21
申请号：US11792046
申请日：2005-12-07
申请人： Casper Struve , Jesper Svenning Kristensen , Klaus Gregorius , Yihua Yu
发明人： Casper Struve , Jesper Svenning Kristensen , Klaus Gregorius , Yihua Yu
IPC分类号： A61B5/1459 , A61B5/145
CPC分类号： G01N33/54373
摘要： A sensor for sensing analyte concentration comprises at least two different variants of an appropriate competitive binding assay, the sensor being capable of sensing accurately a required range of analyte concentrations by means of the variants of the assay each being capable of sensing accurately a part only of the required range of analyte concentrations and the variants of the assay being chosen to sense overlapping or adjoining ranges of concentration covering the whole of the required range.
摘要翻译：用于感测分析物浓度的传感器包括适当竞争性结合测定的至少两种不同变体，所述传感器能够通过所述测定的变体精确地感测分析物浓度的所需范围，所述变体各自能够精确地仅感测部分分析物浓度的所需范围和测定的变体被选择以感测覆盖整个所需范围的重叠或相邻的浓度范围。

6. 发明授权

US08478375B2 Sensor for detection of carbohydrate 有权
标题翻译：用于检测碳水化合物的传感器
公开(公告)号：US08478375B2
公开(公告)日：2013-07-02
申请号：US11792046
申请日：2005-12-07
申请人： Casper Struve , Jesper Svenning Kristensen , Klaus Gregorius , Yihua Yu
发明人： Casper Struve , Jesper Svenning Kristensen , Klaus Gregorius , Yihua Yu
IPC分类号： A61B5/1455 , C12Q1/68
CPC分类号： G01N33/54373
摘要： A sensor for sensing analyte concentration comprises at least two different variants of an appropriate competitive binding assay, the sensor being capable of sensing accurately a required range of analyte concentrations by means of the variants of the assay each being capable of sensing accurately a part only of the required range of analyte concentrations and the variants of the assay being chosen to sense overlapping or adjoining ranges of concentration covering the whole of the required range.
摘要翻译：用于感测分析物浓度的传感器包括适当竞争性结合测定的至少两种不同变体，所述传感器能够通过所述测定的变体精确地感测分析物浓度的所需范围，所述变体各自能够精确地仅感测部分分析物浓度的所需范围和测定的变体被选择以感测覆盖整个所需范围的重叠或相邻的浓度范围。

7. 发明授权

US07087748B2 Process 失效
标题翻译：处理
公开(公告)号：US07087748B2
公开(公告)日：2006-08-08
申请号：US10380686
申请日：2001-09-17
申请人： Klaus Mosbach , Lei Ye , Yihua Yu
发明人： Klaus Mosbach , Lei Ye , Yihua Yu
IPC分类号： C07D503/18
CPC分类号： B01J20/26 , B01J20/268 , C07D503/00 , C12P17/188
摘要： A novel process for the removal of impurities from clavulanic acid using a selective adsorption material, in particular a molecularly imprinted polymer. Novel selective adsorption materials suitable for the process, and a process for the preparation of such selective adsorption materials, are also disclosed.
摘要翻译：使用选择性吸附材料，特别是分子印迹聚合物从克拉维酸中去除杂质的新方法。还公开了适用于该方法的新型选择性吸附材料，以及制备这种选择性吸附材料的方法。

8. 发明授权

US08252778B2 Highly fluorinated oils and surfactants and methods of making and using same 有权
标题翻译：高氟化油和表面活性剂及其制备和使用方法
公开(公告)号：US08252778B2
公开(公告)日：2012-08-28
申请号：US12294424
申请日：2007-03-26
申请人： Yihua Yu , Zhong-Xing Jiang
发明人： Yihua Yu , Zhong-Xing Jiang
IPC分类号： A61K31/33 , A61K49/04
CPC分类号： A61K51/065 , A61K41/0038 , A61K47/6905 , A61K47/6953 , A61K49/0002 , A61K49/085 , A61K49/124 , A61K49/14 , A61K49/1809 , A61K49/1818 , A61K51/122 , B82Y5/00 , C08G83/003 , C08G83/004
摘要： Disclosed are compounds comprising the structure: In one aspect, the compounds exhibit maximum symmetric branching. Also disclosed are bilayers, micelles, coatings, and nanoparticles comprising the disclosed compounds. Also disclosed are processes for the preparation of the disclosed compounds and methods of using the disclosed compounds. Also disclosed are highly fluorinated dendrons and methods for making same. Also disclosed are methods for Fluorous Mixture Synthesis and tagging. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
摘要翻译：公开的是包含以下结构的化合物：一方面，化合物表现出最大对称支化。还公开了包含所公开的化合物的双层，胶束，涂层和纳米颗粒。还公开了制备所公开的化合物的方法和使用所公开的化合物的方法。还公开了高度氟化的树枝状化合物及其制备方法。还公开了氟混合物合成和标记的方法。该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。

9. 发明申请

US20090264397A1 HIGHLY FLUORINATED OILS AND SURFACTANTS AND METHODS OF MAKING AND USING SAME 有权
标题翻译：高度氟化油和表面活性剂及其制备方法和使用方法
公开(公告)号：US20090264397A1
公开(公告)日：2009-10-22
申请号：US12294424
申请日：2007-03-26
申请人： Yihua Yu , Zhong-Xing Jiang
发明人： Yihua Yu , Zhong-Xing Jiang
IPC分类号： A61K31/395 , C07D225/02 , A61P43/00
CPC分类号： A61K51/065 , A61K41/0038 , A61K47/6905 , A61K47/6953 , A61K49/0002 , A61K49/085 , A61K49/124 , A61K49/14 , A61K49/1809 , A61K49/1818 , A61K51/122 , B82Y5/00 , C08G83/003 , C08G83/004
摘要： Disclosed are compounds comprising the structure: In one aspect, the compounds exhibit maximum symmetric branching. Also disclosed are bilayers, micelles, coatings, and nanoparticles comprising the disclosed compounds. Also disclosed are processes for the preparation of the disclosed compounds and methods of using the disclosed compounds. Also disclosed are highly fluorinated dendrons and methods for making same. Also disclosed are methods for Fluorous Mixture Synthesis and tagging. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
摘要翻译：公开的是包含以下结构的化合物：一方面，化合物表现出最大对称支化。还公开了包含所公开的化合物的双层，胶束，涂层和纳米颗粒。还公开了制备所公开的化合物的方法和使用所公开的化合物的方法。还公开了高度氟化的树枝状化合物及其制备方法。还公开了氟混合物合成和标记的方法。该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。

10. 发明授权

US09399076B2 Optical sensor for in vivo detection of analyte 有权
标题翻译：用于体内检测分析物的光学传感器
公开(公告)号：US09399076B2
公开(公告)日：2016-07-26
申请号：US11596589
申请日：2005-05-17
申请人： Yihua Yu , Jesper S. Kristensen
发明人： Yihua Yu , Jesper S. Kristensen
IPC分类号： A61B5/00 , A61K49/00 , A61B5/145
CPC分类号： A61K49/0004 , A61B5/14532
摘要： A sensor for the in vivo detection of glucose comprises:components of an assay for glucose, a readout of which is a detectable optical signal which can be interrogated transcutaneously by external optical means when the sensor is implanted in vivo; anda shell of biodegradable material encapsulating the assay components while allowing analyte to contact the assay components, wherein the biodegradable material comprises a co-polymer having hydrophobic and hydrophilic units.A method of preparing such a sensor preferably comprises coacervation, solvent evaporation and/or extraction, spray drying, spray coating, spray chilling, rotary disk atomisation, fluid bed coating, coextrusion and/or pan coating.A method of detecting glucose using such a sensor suitably comprises implantation of the sensor into the skin of a mammal, transdermal detection or measurement of glucose using external optical means and degradation of the biodegradable material.
摘要翻译：用于体内检测葡萄糖的传感器包括：葡萄糖测定的组分，其读出是可检测的光学信号，当传感器植入体内时，可以通过外部光学装置经皮询问; 以及包封测定组分同时允许分析物接触测定组分的可生物降解材料的壳，其中所述可生物降解材料包含具有疏水和亲水单元的共聚物。制备这种传感器的方法优选包括凝聚，溶剂蒸发和/或提取，喷雾干燥，喷涂，喷雾冷却，旋转盘雾化，流化床涂覆，共挤出和/或泛涂。使用这种传感器检测葡萄糖的方法适当地包括将传感器植入哺乳动物的皮肤，使用外部光学手段进行透皮检测或测量葡萄糖并降解可生物降解材料。

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