专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20080207687A1 Quinoline Derivatives as Antibacterial Agents 有权
公开(公告)号：US20080207687A1
公开(公告)日：2008-08-28
申请号：US11997173
申请日：2006-07-31
申请人： Jerome Emile Georges Guillemont , Elisabeth Therese Jeanne Pasquier , David Francis Alain Lancois , Koenraad Jozef Lodewijk Marcel Andries , Anil Koul , Leo Jacobus Jozef Backx , Lieven Meerpoel
发明人： Jerome Emile Georges Guillemont , Elisabeth Therese Jeanne Pasquier , David Francis Alain Lancois , Koenraad Jozef Lodewijk Marcel Andries , Anil Koul , Leo Jacobus Jozef Backx , Lieven Meerpoel
IPC分类号： A61K31/47 , A61P31/04 , C07D215/227
CPC分类号： C07D215/227 , A61K31/47
摘要： Use of a compound for the manufacture of a medicament for the treatment of a bacterial infection provided that the bacterial infection is other than a Mycobacterial infection, said compound being a compound of formula (I) a pharmaceutically acceptable acid or base addition salt, a quaternary amine, a stereochemically isomeric form, a tautomeric form or a N-oxide form thereof, wherein R1 is hydrogen, halo, haloalkyl, cyano, hydroxy, Ar, Het, alkyl, alkyloxy, alkylthio, alkyloxyalkyl, alkylthioalkyl, Ar-alkyl or di(Ar)alkyl; p is 1 to 3; s is 0 to 4; R2 is hydrogen; halo; alkyl; hydroxy; mercapto; optionally substituted alkyloxy; alkyloxyalkyloxy; alkylthio; mono or di(alkyl)amino wherein alkyl may optionally be substituted; Ar; Het or a radical of formula R3 is alkyl, Ar, Ar-alkyl, Het or Het-alkyl; q is 0 to 4; R4 and R5 each independently are hydrogen, alkyl or benzyl; or R4 and R5 may be taken together including the N to which they are attached; R6 is hydrogen, halo, haloalkyl, hydroxy, Ar, alkyl, alkyloxy, alkylthio, alkyloxyalkyl, alkylthioalkyl, Ar-alkyl or di(Ar)alkyl; or two vicinal R6 radicals may be taken together to form together with the phenyl ring to which they are attached a naphthyl; r is 1 to 5; R7 is hydrogen, alkyl, Ar or Het; R8 is hydrogen, alkyl, hydroxyl, aminocarbonyl, mono- or di(alkyl)aminocarbonyl, Ar, Het, alkyl substituted with one or two Het, alkyl substituted with one or two Ar, Het-C(═O)— or Ar—C(═O)—; provided that when the R3 bearing radical is placed in position 3 of the quinoline moiety; R7 is placed in position 4 and R2 is placed in position 2 and represents hydrogen, hydroxy, mercapto, alkyloxy, alkyloxyalkyloxy, alkylthio, mono or di(alkyl)amino or a radical of formula then s is 1 to 4.

2. 发明申请

US20100048585A1 QUINOLINE DERIVATIVES AS ANTIBACTERIAL AGENTS 有权
标题翻译：喹诺酮衍生物作为抗菌剂
公开(公告)号：US20100048585A1
公开(公告)日：2010-02-25
申请号：US11993145
申请日：2006-06-26
申请人： Koenraad Jozef Lodewijk Marcel Andries , Anil Koul , Jérôme Emile Georges Guilliemont , David Francis Alain Lancois , Magali Madeleine Simone Motte , Ismet Dorange , Leo Jacobus Jozef Backx , Lieven Meerpoel
发明人： Koenraad Jozef Lodewijk Marcel Andries , Anil Koul , Jérôme Emile Georges Guilliemont , David Francis Alain Lancois , Magali Madeleine Simone Motte , Ismet Dorange , Leo Jacobus Jozef Backx , Lieven Meerpoel
IPC分类号： A61K31/497 , C07D215/20 , C07D401/10 , C07D405/10 , C07D213/02 , A61K31/47 , A61K31/4439 , A61K31/443 , A61K31/4545 , A61P31/04
CPC分类号： A61K31/47 , C07D215/227
摘要： Use of a compound for the manufacture of a medicament for the treatment of a bacterial infection provided that the bacterial infection is other than a Mycobacterial infection, said compound being a compound of formula (Ia) or (Ib) a pharmaceutically acceptable acid or base addition salt thereof, a stereochemically isomeric form thereof, a tautomeric form thereof or a N-oxide form thereof, wherein R1 is hydrogen, halo, haloalkyl, cyano, hydroxy, Ar, Het, alkyl, alkyloxy, alkylthio, alkyloxyalkyl, alkylthioalkyl, Ar-alkyl or di(Ar)alkyl; p is 1, 2, 3 or 4; R2 is hydrogen, hydroxy, mercapto, alkyloxy, alkyloxyalkyloxy, alkylthio, mono or di(alkyl)amino or a radical of formula; R3 is alkyl, Ar, Ar-alkyl, Het or Het-alkyl; q is 1, 2 or 3; R4 and R5 are hydrogen, alkyl or benzyl; or R4 and R5 together and including the N to which they are attached may form a ring; R6 is hydrogen, halo, haloalkyl, hydroxy, Ar, alkyl, alkyloxy, alkylthio, alkyloxyalkyl, alkythioalkyl, Ar-alkyl or di(Ar)alkyl; or two vicinal R6 radicals may be taken together to form a bivalent radical of formula —CH═CH—CH═CH—; r is 1, 2, 3, 4 or 5; R7 is hydrogen, alkyl, Ar or Het; R8 is hydrogen or alkyl; R9 is oxo; or R8 and R9 together form the radical —CH═CH—N═.
摘要翻译：使用化合物制造用于治疗细菌感染的药物，只要细菌感染不是分枝杆菌感染，所述化合物是式（Ia）或（Ib）的化合物，其药学上可接受的酸或碱加成其盐，其立体化学异构形式，其互变异构形式或其N-氧化物形式，其中R 1是氢，卤素，卤代烷基，氰基，羟基，Ar，Het，烷基，烷氧基，烷硫基，烷氧基烷基，烷硫基烷基，烷基或二（Ar）烷基; p为1,2,3或4; R2是氢，羟基，巯基，烷氧基，烷氧基烷氧基，烷硫基，一或二（烷基）氨基或式的基团; R3是烷基，Ar，Ar-烷基，Het或Het-烷基; q为1,2或3; R4和R5是氢，烷基或苄基; 或R 4和R 5一起并包括它们所连接的N可以形成环; R 6是氢，卤素，卤代烷基，羟基，Ar，烷基，烷氧基，烷硫基，烷氧基烷基，链仲烷基，芳烷基或二（Ar）或两个连位的R6基团可以一起形成式-CH = CH-CH = CH-的二价基团; r为1,2,3,4或5; R7是氢，烷基，Ar或Het; R8是氢或烷基; R9是氧代; 或R8和R9一起形成基团-CH = CH-N =。

3. 发明授权

US08841321B2 Quinoline derivatives as antibacterial agents 有权
标题翻译：喹啉衍生物作为抗菌剂
公开(公告)号：US08841321B2
公开(公告)日：2014-09-23
申请号：US11993145
申请日：2006-06-26
申请人： Koenraad Jozef Lodewijk Marcel Andries , Anil Koul , Jérôme Emile Georges Guillemont , David Francis Alain Lançois , Magali Madeleine Simone Motte , Ismet Dorange , Leo Jacobus Jozef Backx , Lieven Meerpoel
发明人： Koenraad Jozef Lodewijk Marcel Andries , Anil Koul , Jérôme Emile Georges Guillemont , David Francis Alain Lançois , Magali Madeleine Simone Motte , Ismet Dorange , Leo Jacobus Jozef Backx , Lieven Meerpoel
IPC分类号： A01N43/42 , A61K31/47 , A01N43/40 , A61K31/445 , A61K31/44 , C07D215/227
CPC分类号： A61K31/47 , C07D215/227
摘要： Use of a compound for the manufacture of a medicament for the treatment of a bacterial infection provided that the bacterial infection is other than a Mycobacterial infection, said compound being a compound of formula (Ia) or (Ib) a pharmaceutically acceptable acid or base addition salt thereof, a stereochemically isomeric form thereof, a tautomeric form thereof or a N-oxide form thereof, wherein R1 is hydrogen, halo, haloalkyl, cyano, hydroxy, Ar, Het, alkyl, alkyloxy, alkylthio, alkyloxyalkyl, alkylthioalkyl, Ar-alkyl or di(Ar)alkyl; p is 1, 2, 3 or 4; R2 is hydrogen, hydroxy, mercapto, alkyloxy, alkyloxyalkyloxy, alkylthio, mono or di(alkyl)amino or a radical of formula; R3 is alkyl, Ar, Ar-alkyl, Het or Het-alkyl; q is 1, 2 or 3; R4 and R5 are hydrogen, alkyl or benzyl; or R4 and R5 together and including the N to which they are attached may form a ring; R6 is hydrogen, halo, haloalkyl, hydroxy, Ar, alkyl, alkyloxy, alkylthio, alkyloxyalkyl, alkythioalkyl, Ar-alkyl or di(Ar)alkyl; or two vicinal R6 radicals may be taken together to form a bivalent radical of formula —CH═CH—CH═CH—; r is 1, 2, 3, 4 or 5; R7 is hydrogen, alkyl, Ar or Het; R8 is hydrogen or alkyl; R9 is oxo; or R8 and R9 together form the radical —CH═CH—N═.
摘要翻译：使用化合物制造用于治疗细菌感染的药物，只要细菌感染不是分枝杆菌感染，所述化合物是式（Ia）或（Ib）的化合物，其药学上可接受的酸或碱加成其盐，其立体化学异构形式，其互变异构形式或其N-氧化物形式，其中R 1是氢，卤素，卤代烷基，氰基，羟基，Ar，Het，烷基，烷氧基，烷硫基，烷氧基烷基，烷硫基烷基，烷基或二（Ar）烷基; p为1,2,3或4; R2是氢，羟基，巯基，烷氧基，烷氧基烷氧基，烷硫基，一或二（烷基）氨基或式的基团; R3是烷基，Ar，Ar-烷基，Het或Het-烷基; q为1,2或3; R4和R5是氢，烷基或苄基; 或R 4和R 5一起并包括它们所连接的N可以形成环; R 6是氢，卤素，卤代烷基，羟基，Ar，烷基，烷氧基，烷硫基，烷氧基烷基，链仲烷基，芳烷基或二（Ar）或两个连位的R6基团可以一起形成式-CH = CH-CH = CH-的二价基团; r为1,2,3,4或5; R7是氢，烷基，Ar或Het; R8是氢或烷基; R9是氧代; 或R8和R9一起形成基团-CH = CH-N =。

4. 发明授权

US08802671B2 Quinoline derivatives as antibacterial agents 有权
标题翻译：喹啉衍生物作为抗菌剂
公开(公告)号：US08802671B2
公开(公告)日：2014-08-12
申请号：US11997173
申请日：2006-07-31
申请人： Jérôme Emile Georges Guillemont , Elisabeth Thérèse Jeanne Pasquier , David Francis Alain Lançois , Koenraad Jozef Lodewijk Marcel Andries , Anil Koul , Leo Jacobus Jozef Backx , Lieven Meerpoel
发明人： Jérôme Emile Georges Guillemont , Elisabeth Thérèse Jeanne Pasquier , David Francis Alain Lançois , Koenraad Jozef Lodewijk Marcel Andries , Anil Koul , Leo Jacobus Jozef Backx , Lieven Meerpoel
IPC分类号： A61K31/535
CPC分类号： C07D215/227 , A61K31/47
摘要： Use of a compound for the manufacture of a medicament for the treatment of a bacterial infection provided that the bacterial infection is other than a Mycobacterial infection, said compound being a compound of formula (I) a pharmaceutically acceptable acid or base addition salt, a quaternary amine, a stereochemically isomeric form, a tautomeric form or a N-oxide form thereof, wherein R1 is hydrogen, halo, haloalkyl, cyano, hydroxy, Ar, Het, alkyl, alkyloxy, alkylthio, alkyloxyalkyl, alkylthioalkyl, Ar-alkyl or di(Ar)alkyl; p is 1 to 3; s is 0 to 4; R2 is hydrogen; halo; alkyl; hydroxy; mercapto; optionally substituted alkyloxy; alkyloxyalkyloxy; alkylthio; mono or di(alkyl)amino wherein alkyl may optionally be substituted; Ar; Het or a radical of formula R3 is alkyl, Ar, Ar-alkyl, Het or Het-alkyl; q is 0 to 4; R4 and R5 each independently are hydrogen, alkyl or benzyl; or R4 and R5 may be taken together including the N to which they are attached; R6 is hydrogen, halo, haloalkyl, hydroxy, Ar, alkyl, alkyloxy, alkylthio, alkyloxyalkyl, alkylthioalkyl, Ar-alkyl or di(Ar)alkyl; or two vicinal R6 radicals may be taken together to form together with the phenyl ring to which they are attached a naphthyl; r is 1 to 5; R7 is hydrogen, alkyl, Ar or Het; R8 is hydrogen, alkyl, hydroxyl, aminocarbonyl, mono- or di(alkyl)aminocarbonyl, Ar, Het, alkyl substituted with one or two Het, alkyl substituted with one or two Ar, Het-C(═O)— or Ar—C(═O)—; provided that when the R3 bearing radical is placed in position 3 of the quinoline moiety; R7 is placed in position 4 and R2 is placed in position 2 and represents hydrogen, hydroxy, mercapto, alkyloxy, alkyloxyalkyloxy, alkylthio, mono or di(alkyl)amino or a radical of formula then s is 1 to 4.
摘要翻译：使用化合物制造用于治疗细菌感染的药物，只要细菌感染不是分枝杆菌感染，所述化合物是式（I）化合物，其药学上可接受的酸或碱加成盐，季铵盐胺，立体化学异构形式，互变异构形式或其N-氧化物形式，其中R 1是氢，卤素，卤代烷基，氰基，羟基，Ar，Het，烷基，烷氧基，烷硫基，烷氧基烷基，烷硫基烷基，（Ar）烷基; p为1〜3; s为0〜4; R2是氢; 光环; 烷基; 羟基; 巯基任选取代的烷氧基; 烷氧基烷氧基; 烷硫基; 单或二（烷基）氨基，其中烷基可任选被取代; Ar; Het或式R3的基团是烷基，Ar，Ar-烷基，Het或Het-烷基; q为0〜4; R4和R5各自独立地为氢，烷基或苄基; 或R4和R5可以一起包括它们所连接的N; R 6是氢，卤素，卤代烷基，羟基，Ar，烷基，烷氧基，烷硫基，烷氧基烷基，烷硫基烷基，芳烷基或二（Ar）或两个连位的R6基团可以与它们所连接的苯环一起形成萘基; r为1〜5; R7是氢，烷基，Ar或Het; R8是氢，烷基，羟基，氨基羰基，单或二（烷基）氨基羰基，Ar，Het，被一个或两个Het取代的烷基，被一个或两个Ar，Het-C（= O） - 或Ar- C（= O） - ; 条件是当将带有R3的自由基置于喹啉部分的位置3时; R7位于4位，R2位于2位，代表氢，羟基，巯基，烷氧基，烷氧基烷氧基，烷硫基，单或二（烷基）氨基或式基团，其中s为1至4。

5. 发明授权

US08258304B2 N-aryl piperidine substituted biphenylcarboxamides 有权
标题翻译： N-芳基哌啶取代的联苯基甲酰胺
公开(公告)号：US08258304B2
公开(公告)日：2012-09-04
申请号：US12351385
申请日：2009-01-09
申请人： Lieven Meerpoel , Leo Jacobus Jozef Backx , Peter Walter Maria Roevens
发明人： Lieven Meerpoel , Leo Jacobus Jozef Backx , Peter Walter Maria Roevens
IPC分类号： A61K31/454 , A61K31/451 , C07D211/62 , C07D213/75
CPC分类号： C07D401/04 , C07D211/34 , C07D211/62
摘要： N-aryl piperidine substituted biphenylcarboxamides compounds of formula (I) methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use of said compounds as a medicine for the treatment of hyperlipidemia, obesity and type II diabetes.
摘要翻译：式（I）的N-芳基哌啶取代的联苯甲酰胺化合物制备此类化合物的方法，包含所述化合物的药物组合物以及所述化合物作为治疗高脂血症，肥胖症和II型糖尿病的药物的用途。

6. 发明申请

US20090156623A1 N-ARYL PIPERIDINE SUBSTITUTED BIPHENYLCARBOXAMIDES 有权
标题翻译： N-ARYL哌啶取代的联苯基胆红素
公开(公告)号：US20090156623A1
公开(公告)日：2009-06-18
申请号：US12351385
申请日：2009-01-09
申请人： Lieven Meerpoel , Leo Jacobus Jozef Backx , Peter Walter Maria Roevens
发明人： Lieven Meerpoel , Leo Jacobus Jozef Backx , Peter Walter Maria Roevens
IPC分类号： A61K31/4545 , C07D211/32 , C07D401/04 , A61P3/10 , A61P9/10 , A61P3/04 , A61K31/506 , A61K31/451
CPC分类号： C07D401/04 , C07D211/34 , C07D211/62
摘要： N-aryl piperidine substituted biphenylcarboxamides compounds of formula (I) methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use of said compounds as a medicine for the treatment of hyperlipidemia, obesity and type II diabetes.
摘要翻译：式（I）的N-芳基哌啶取代的联苯甲酰胺化合物制备此类化合物的方法，包含所述化合物的药物组合物以及所述化合物作为治疗高脂血症，肥胖症和II型糖尿病的药物的用途。

7. 发明申请

US20080275087A1 BIPHENYLCARBOXAMIDES USEFUL AS LIPID LOWERING AGENTS 有权
公开(公告)号：US20080275087A1
公开(公告)日：2008-11-06
申请号：US12144962
申请日：2008-06-24
申请人： Lieven Meerpoel , Leo Jacobus Jozef Backx
发明人： Lieven Meerpoel , Leo Jacobus Jozef Backx
IPC分类号： A61K31/451 , C07C229/44 , C07C237/28 , A61K31/40 , A61K31/167 , A61K31/216 , C07D211/58 , C07D207/14
CPC分类号： C07C237/20 , C07C233/80 , C07C2601/08 , C07C2601/14 , C07D207/14 , C07D211/58
摘要： Biphenylcarboxamide compounds of formula (I) methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use of said compounds as a medicine for the treatment of hyperlipidemia, obesity and type II diabetes.

8. 发明申请

US20080125412A1 POLYARYLCARBOXAMIDES USEFUL AS LIPID LOWERING AGENTS 审中-公开
标题翻译：有益于脂肪降低剂的多元醇
公开(公告)号：US20080125412A1
公开(公告)日：2008-05-29
申请号：US11928942
申请日：2007-10-30
申请人： Lieven Meerpoel , Peter Walter Maria Roevens , Leo Jacobus Jozef Backx , Louis Jozef Elisabeth Van der Veken , Marcel Viellevoye
发明人： Lieven Meerpoel , Peter Walter Maria Roevens , Leo Jacobus Jozef Backx , Louis Jozef Elisabeth Van der Veken , Marcel Viellevoye
IPC分类号： A61K31/55 , A61K31/495 , C07D243/08 , C07D211/10 , C07D241/04 , A61K31/451
CPC分类号： C07D213/40 , C07D211/26 , C07D211/34 , C07D211/70 , C07D213/55 , C07D213/56 , C07D241/04 , C07D243/08 , C07D295/15 , C07D307/54 , C07D333/24
摘要： Polyarylcarboxamide compounds of formula (I) are useful as lipid lowering agents.
摘要翻译：式（I）的聚芳基酰胺化合物可用作降脂剂。

9. 发明授权

US07253157B2 Polyarylcarboxamides useful as lipid lowering agents 有权
标题翻译：可用作降脂剂的聚芳酰胺酰胺
公开(公告)号：US07253157B2
公开(公告)日：2007-08-07
申请号：US11474911
申请日：2006-06-26
申请人： Lieven Meerpoel , Peter Walter Maria Roevens , Leo Jacobus Jozef Backx , Louis Jozef Elisabeth Van der Veken , Marcel Viellevoye
发明人： Lieven Meerpoel , Peter Walter Maria Roevens , Leo Jacobus Jozef Backx , Louis Jozef Elisabeth Van der Veken , Marcel Viellevoye
IPC分类号： A61K31/5513 , C07D243/08
CPC分类号： C07D213/40 , C07D211/26 , C07D211/34 , C07D211/70 , C07D213/55 , C07D213/56 , C07D241/04 , C07D243/08 , C07D295/15 , C07D307/54 , C07D333/24
摘要： Polyarylcarboxamide compounds of formula (I) are useful as lipid lowering agents.
摘要翻译：式（I）的聚芳基酰胺化合物可用作降脂剂。

10. 发明申请

US20110269747A1 POLYARYLCARBOXAMIDES USEFUL AS LIPID LOWERING AGENTS 有权
标题翻译：有益于脂肪降低剂的多元醇
公开(公告)号：US20110269747A1
公开(公告)日：2011-11-03
申请号：US13181624
申请日：2011-07-13
申请人： Lieven Meerpoel , Peter Walter Maria Roevens , Leo Jacobus Jozef Backx , Louis Jozef Elisabeth Van der Veken , Marcel Viellevoye
发明人： Lieven Meerpoel , Peter Walter Maria Roevens , Leo Jacobus Jozef Backx , Louis Jozef Elisabeth Van der Veken , Marcel Viellevoye
IPC分类号： A61K31/495 , C07D211/34 , C07D401/12 , C07D211/32 , C07D243/08 , C07D211/58 , C07D409/12 , C07D405/12 , A61K31/451 , A61K31/496 , A61K31/4545 , A61K31/5513 , A61P3/06 , A61P3/04 , A61P3/10 , A61P9/10 , A61P7/00 , A61P1/18 , A61P9/00 , C07D241/04
CPC分类号： C07D213/40 , C07D211/26 , C07D211/34 , C07D211/70 , C07D213/55 , C07D213/56 , C07D241/04 , C07D243/08 , C07D295/15 , C07D307/54 , C07D333/24
摘要： Polyarylcarboxamide compounds of formula (I) are useful as lipid lowering agents.
摘要翻译：式（I）的聚芳基酰胺化合物可用作降脂剂。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式