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1. 发明授权

US08545407B2 Method and device for measuring a mean value of visco-elasticity of a region of interest 有权
标题翻译：用于测量感兴趣区域的粘弹性平均值的方法和装置
公开(公告)号：US08545407B2
公开(公告)日：2013-10-01
申请号：US12599260
申请日：2007-05-16
申请人： Jeremy Bercoff , David Savery , Mickaël Tanter , Jean-Luc Gennisson , Mathias Fink , Claude Cohen-Bacrie
发明人： Jeremy Bercoff , David Savery , Mickaël Tanter , Jean-Luc Gennisson , Mathias Fink , Claude Cohen-Bacrie
IPC分类号： A61B8/00
CPC分类号： A61B8/485 , A61B5/0051 , A61B8/08 , A61B8/4483 , G01S7/52036 , G01S7/52042 , G01S15/8927
摘要： The invention relates to a method for measuring a mean visco-elasticity value for a soft material. The method uses a single probe carrying at least one transducer and includes the steps of: (a) inducing, in a constraint zone, at least one burst of mechanical vibrations in order to generate internal shear waves in the tissue propagating from the constraint zone into the tissue, (b1) measuring, with the transducer, the transient tissue displacements in at least one first measurement zone in the tissue, and wherein the first measurement zone is located away from the constraint zone, and (c) estimating a mean visco-elasticity of the region of the tissue situated between the constraint zone and the first measurement zone from the measured transient tissue displacements of the tissue in the first measurement zone.
摘要翻译：本发明涉及一种用于测量软材料的平均粘弹性值的方法。该方法使用携带至少一个换能器的单个探针，并且包括以下步骤：（a）在约束区域中诱导至少一个机械振动的爆发，以便在从约束区域传播的组织中产生内部剪切波，（b1）用传感器测量组织中至少一个第一测量区域中的瞬时组织位移，并且其中第一测量区域远离约束区域，以及（c）估计平均粘度 - 位于约束区域和第一测量区域之间的组织区域的弹性，来自第一测量区域中组织的测量的瞬时组织位移。

2. 发明申请

US20100222678A1 METHOD AND DEVICE FOR MEASURING A MEAN VALUE OF VISCO-ELASTICITY OF A REGION OF INTEREST 有权
标题翻译：用于测量感兴趣区域的粘弹性的平均值的方法和装置
公开(公告)号：US20100222678A1
公开(公告)日：2010-09-02
申请号：US12599260
申请日：2007-05-16
申请人： Jeremy Bercoff , David Savery , Mickaël Tanter , Jean-Luc Gennisson , Mathias Fink , Claude Cohen-Bacrie
发明人： Jeremy Bercoff , David Savery , Mickaël Tanter , Jean-Luc Gennisson , Mathias Fink , Claude Cohen-Bacrie
IPC分类号： A61B8/00
CPC分类号： A61B8/485 , A61B5/0051 , A61B8/08 , A61B8/4483 , G01S7/52036 , G01S7/52042 , G01S15/8927
摘要： The invention relates to a method for measuring a mean visco-elasticity value for a soft material. Said method using a single probe carrying at least one transducer comprises the steps of: a) inducing, in a constraint zone, at least one burst of mechanical vibrations in order to generate internal shear waves in the tissue propagating from said constraint zone into the tissue, b1) measuring, with said transducer, the transient tissue displacements in at least one first measurement zone in the tissue, said first measurement zone being located away from said constraint zone, c) estimating a mean visco-elasticity of the region of the tissue situated between the constraint zone and the first measurement zone from said measured transient tissue displacements of the tissue in the first measurement zone.
摘要翻译：本发明涉及一种用于测量软材料的平均粘弹性值的方法。使用携带至少一个换能器的单个探针的所述方法包括以下步骤：a）在约束区域中诱导至少一个机械振动爆发，以便在从所述约束区传播到组织中的组织中产生内部剪切波，b1）用所述换能器测量组织中的至少一个第一测量区域中的瞬时组织位移，所述第一测量区域位于远离所述约束区域，c）估计组织区域的平均粘弹性位于所述约束区域和所述第一测量区域之间，所述第一测量区域中的所述组织的测量的瞬时组织位移。

3. 发明申请

US20080276709A1 Method for Generation Mechanical Waves by Generation of Interfacial Acoustic Radiation Force 有权
标题翻译：通过生成界面声辐射力产生机械波的方法
公开(公告)号：US20080276709A1
公开(公告)日：2008-11-13
申请号：US12092406
申请日：2007-10-25
申请人： Jeremy Bercoff , Claude Cohen-Bacrie , Mathieu Pernot , David Savery
发明人： Jeremy Bercoff , Claude Cohen-Bacrie , Mathieu Pernot , David Savery
IPC分类号： G01N29/00
CPC分类号： G10K11/30
摘要： The present invention relates to a method for generating mechanical waves within a viscoelastic medium (11) comprising a step of generating an acoustic radiation force (15) within the viscoelastic medium (11) by application of acoustic waves focussed on an interface (13) delimiting two zones (11, 14) having distinct acoustic properties.
摘要翻译：技术领域本发明涉及一种用于在粘弹性介质（11）内产生机械波的方法，包括通过施加聚焦在界面（13）上的声波来在粘弹性介质（11）内产生声辐射力（15）的步骤具有不同声学特性的两个区域（11,14）。

4. 发明申请

US20100170342A1 Method for Rheological Characterization of a Viscoelastic Medium 有权
标题翻译：粘弹性介质流变特性的方法
公开(公告)号：US20100170342A1
公开(公告)日：2010-07-08
申请号：US12666240
申请日：2008-06-23
申请人： Ralph Sinkus , Mickaël Tanter , Matthias Fink , Jeremy Bercoff , David Savery
发明人： Ralph Sinkus , Mickaël Tanter , Matthias Fink , Jeremy Bercoff , David Savery
IPC分类号： G01N29/024 , G01N29/032
CPC分类号： G01N29/032 , A61B8/08 , A61B8/485 , G01N29/024 , G01N29/06 , G01N29/07 , G01N29/11 , G01N2203/0094 , G01N2291/02475 , G01N2291/02483 , G01N2291/02491 , G01N2291/02827 , G01S7/52038 , G01S15/8906
摘要： Method for rheological characterization of a viscoelastic medium, comprising the following steps: (a) an excitation step during which a vibratory excitation is generated in the viscoelastic medium leading to a deformation of the medium, (b) a deformation measurement step during which the deformation of the medium caused by the excitation is observed, (c) and a characterization step during which at least one non-zero power parameter y is determined such that a rheological parameter of the medium x is equal to x (f)=a+b.fy, where f is the frequency, a is a real number and b a non-zero scale parameter. It is thus possible to obtain mapping of the power parameter y.
摘要翻译：粘弹性介质的流变学表征方法，包括以下步骤：（a）在粘弹性介质中产生振动激发导致介质变形的激发步骤，（b）变形测量步骤，观察到由激励引起的介质的（c）和表征步骤，其中确定至少一个非零功率参数y，使得介质x的流变参数等于x（f）= a + b .fy，其中f是频率，a是实数和ba非零比例参数。因此，可以获得功率参数y的映射。

5. 发明授权

US08347692B2 Method for rheological characterization of a viscoelastic medium 有权
标题翻译：粘弹性介质的流变学表征方法
公开(公告)号：US08347692B2
公开(公告)日：2013-01-08
申请号：US12666240
申请日：2008-06-23
申请人： Ralph Sinkus , Michaël Tanter , Mathias Fink , Jeremy Bercoff , David Savery
发明人： Ralph Sinkus , Michaël Tanter , Mathias Fink , Jeremy Bercoff , David Savery
IPC分类号： G01N11/16 , G01N29/04
CPC分类号： G01N29/032 , A61B8/08 , A61B8/485 , G01N29/024 , G01N29/06 , G01N29/07 , G01N29/11 , G01N2203/0094 , G01N2291/02475 , G01N2291/02483 , G01N2291/02491 , G01N2291/02827 , G01S7/52038 , G01S15/8906
摘要： Method for rheological characterization of a viscoelastic medium, with the following steps: (a) an excitation step during which a vibratory excitation is generated in the viscoelastic medium leading to a deformation of the medium, (b) a deformation measurement step during which the deformation of the medium caused by the excitation is observed, (c) and a characterization step during which at least one non-zero power parameter y is determined such that a rheological parameter of the medium x is equal to x(f)=a+b·fy, where f is the frequency, a is a real number and b a non-zero scale parameter. It is thus possible to obtain mapping of the power parameter y.
摘要翻译：粘弹性介质的流变学表征方法，具有以下步骤：（a）在粘弹性介质中产生振动激发导致介质变形的激发步骤，（b）变形测量步骤，其中变形观察到由激励引起的介质的（c）和表征步骤，其中确定至少一个非零功率参数y，使得介质x的流变参数等于x（f）= a + b ·fy，其中f是频率，a是实数和ba非零比例参数。因此，可以获得功率参数y的映射。

6. 发明授权

US10795007B2 Method and a device for imaging a visco-elastic medium 有权
公开(公告)号：US10795007B2
公开(公告)日：2020-10-06
申请号：US12294898
申请日：2007-03-22
申请人： Jérémy Bercoff , David Savery , Claude Cohen-Bacrie , Jacques Souquet
发明人： Jérémy Bercoff , David Savery , Claude Cohen-Bacrie , Jacques Souquet
IPC分类号： G01S7/52 , G01S15/89 , A61B8/08 , A61B5/00 , A61N7/00
摘要： The invention relates to a method and a device for imaging a visco-elastic medium (2). The method comprises an excitation step during which an internal mechanical stress is generated in an excitation zone [A] and an imaging step of acquiring signals during the movements generated by the mechanical stress in the visco-elastic medium (2) in response to the internal mechanical stress in an imaging zone [B] that includes the excitation zone [A]. According to the invention, the method further comprises a step of calculating a quantitative index [Cij] associated with the rheological properties of the visco-elastic medium (2) at at least one point [Bij] of the imaging zone situated at a given depth outside the excitation zone [A].

7. 发明申请

US20100168566A1 METHOD AND A DEVICE FOR IMAGING A VISCO-ELASTIC MEDIUM 审中-公开
标题翻译：用于成像VISCO-ELASTIC介质的方法和装置
公开(公告)号：US20100168566A1
公开(公告)日：2010-07-01
申请号：US12294898
申请日：2007-03-22
申请人： Jérémy Bercoff , David Savery , Claude Cohen-Bacrie , Jacques Souquet
发明人： Jérémy Bercoff , David Savery , Claude Cohen-Bacrie , Jacques Souquet
IPC分类号： A61B8/00
CPC分类号： G01S7/52036 , A61B5/0051 , A61B8/08 , A61B8/0825 , A61B8/0833 , A61B8/485 , A61N7/00 , G01S7/52042 , G01S15/8961 , G01S15/8977
摘要： The invention relates to a method and a device for imaging a visco-elastic medium. The method comprises an excitation step during which an internal mechanical stress is generated in excitation zone and an imaging step of acquiring signals during the movements generated by the mechanical stress in the visco-elastic medium in response to the internal mechanical stress in an imaging zone that includes the excitation zone. According to the invention, the method further comprises a step of calculating a quantitative index associated with the rheological properties of the visco-elastic medium at at least one point of the imaging zone situated at a given depth outside the excitation zone. The quantitative index is representative of a comparison between signals acquired during the movements generated in response to the mechanical stress at at least one point of the excitation zone situated at the given depth, and signals acquired during the movements generated in response to the mechanical stress at at least the point of the imaging zone situated outside the excitation zone.
摘要翻译：本发明涉及一种用于成像粘弹性介质的方法和装置。该方法包括激发步骤，在激励步骤期间在激发区域中产生内部机械应力，以及成像步骤，其响应于成像区域中的内部机械应力，在由粘弹性介质中的机械应力产生的移动期间获取信号，包括激发区。根据本发明，该方法还包括在位于激发区外的给定深度处的成像区的至少一个点处计算与粘弹性介质的流变特性相关的定量指标的步骤。定量指标代表响应于位于给定深度处的激发区的至少一个点处的机械应力而产生的运动期间获取的信号与响应于机械应力产生的运动期间获得的信号之间的比较至少成像区域位于激发区域外。

8. 发明授权

US08037766B2 Method for generation mechanical waves by generation of interfacial acoustic radiation force 有权
标题翻译：通过产生界面声辐射力产生机械波的方法
公开(公告)号：US08037766B2
公开(公告)日：2011-10-18
申请号：US12092406
申请日：2007-10-25
申请人： Jérémy Bercoff , Claude Cohen-Bacrie , Mathieu Pernot , David Savery
发明人： Jérémy Bercoff , Claude Cohen-Bacrie , Mathieu Pernot , David Savery
IPC分类号： G01N29/06 , G01N29/28
CPC分类号： G10K11/30
摘要： The present invention relates to a method for generating mechanical waves within a viscoelastic medium (11) comprising a step of generating an acoustic radiation force (15) within the viscoelastic medium (11) by application of acoustic waves focused on an interface (13) delimiting two zones (11, 14) having distinct acoustic properties.
摘要翻译：本发明涉及一种用于在粘弹性介质（11）内产生机械波的方法，包括通过施加聚焦在界面（13）上的声波在声粘弹介质（11）内产生声辐射力（15）的步骤具有不同声学特性的两个区域（11,14）。

9. 发明申请

US20100168571A1 IMAGE-BASED POWER FEEDBACK FOR OPTIMAL ULTRASOUND IMAGING OR RADIO FREQUENCY TISSUE ABLATION 审中-公开
标题翻译：基于图像的功率反馈优化超声成像或无线电频率组织消除
公开(公告)号：US20100168571A1
公开(公告)日：2010-07-01
申请号：US12377060
申请日：2007-08-02
申请人： David Savery , Christopher Hall
发明人： David Savery , Christopher Hall
IPC分类号： A61B8/14 , A61B18/18
CPC分类号： A61B18/1206 , A61B8/08 , A61B8/0833 , A61B8/0841 , A61B34/10 , A61B90/36 , A61B2017/00026 , A61B2017/00092 , A61B2018/00577 , A61B2018/00642 , A61B2090/378
摘要： Methods and systems are provided for monitoring and regulating radiofrequency (RF) ablation therapy to improve quality of ultrasound imaging. Feedback is provided from real-time ultrasound imaging, and RF power is altered in response to a feedback signal to improve image quality.
摘要翻译：提供了用于监测和调节射频（RF）消融治疗以提高超声成像质量的方法和系统。从实时超声成像提供反馈，并且响应于反馈信号改变RF功率以提高图像质量。

10. 发明申请

US20100043557A1 ULTRASONIC DETERMINATION OF OPTICAL ABSORPTION COEFFICIENTS 有权
标题翻译：光学吸收系数的超声波测定
公开(公告)号：US20100043557A1
公开(公告)日：2010-02-25
申请号：US12442729
申请日：2007-09-18
申请人： David Savery , Ladislav Jankovic , Ajay Anand
发明人： David Savery , Ladislav Jankovic , Ajay Anand
IPC分类号： G01N29/024 , G01N21/17 , G01N21/47
CPC分类号： G01N29/2418 , A61B5/0059 , A61B5/0095 , A61B8/08 , G01N21/1702 , G01N21/4795 , G01N2021/1706 , G01N2291/02466 , G01N2291/02475
摘要： The invention relates to an examination apparatus and a method for the determination of optical coefficients, particularly of the optical absorption coefficient (μa) in an object (1) like the body of a patient. The apparatus comprises an ultrasonic scanner (20) for recording first and second pulse echoes before and after the object (1) has been illuminated with a heating light beam (11) from a (e.g. laser) light source (10). An evaluation unit (30) determines a map of temperature increase (ΔT(r)) caused by the heating light beam (11) inside the object (1) based on apparent displacements showing up between the second and first pulse echoes. Furthermore, the evaluation of locally adjacent temperature increases inside the object (1) allows to determine a map of the effective scattering coefficient (μeff(r)), from which the distribution of light intensity (I(r)) inside the object (1) can be calculated. Finally, the desired optical absorption coefficient (μa) at a measuring location (r) can be determined from the light intensity and the temperature increase at this location.
摘要翻译：本发明涉及一种用于确定像患者身体的物体（1）中的光学系数，特别是光学吸收系数（μa）的检查装置和方法。该装置包括用于在来自（例如激光）光源（10）的加热光束（11）照射物体（1）之前和之后记录第一和第二脉冲回波的超声波扫描器（20）。评估单元（30）基于在第二和第一脉冲回波之间显示的表观位移来确定由对象（1）内部的加热光束（11）引起的温度升高（＆Dgr; T（r））的映射。此外，物体（1）内的局部相邻温度升高的评估允许确定物体（1）内的光强度（I（r））的分布的有效散射系数（μeff（r））的映射）可以计算。最后，测量位置（r）所需的光学吸收系数（μa）可以从光强度和该位置的温度升高来确定。

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