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1. 发明授权

US5082851A Pharmaceutical composition for protecting the heart comprising a heterocyclic ethylenediamine derivative and methods for the use thereof 失效
标题翻译：用于保护心脏的药物组合物，其包含杂环乙二胺衍生物及其使用方法
公开(公告)号：US5082851A
公开(公告)日：1992-01-21
申请号：US477046
申请日：1990-02-07
申请人： Jerachmiel Y. Appelbaum , Mordechai Chevion , Gideon Uretzky
发明人： Jerachmiel Y. Appelbaum , Mordechai Chevion , Gideon Uretzky
IPC分类号： A61K31/44
CPC分类号： A61K31/44
摘要： The invention provides a composition for protecting the heart from myocardial ischemia and reperfusion injury as well as for reducing post-ischemic damage, improving cardiac function and serving as a hypothermic cardiac preservative solution comprising N,N,N'N'-tetrakis-(2-pyridylmethyl)-ethylenediamine (TPEN) as active ingredient therein.
摘要翻译：本发明提供了一种用于保护心脏免受心肌缺血和再灌注损伤以及减少缺血后损伤，改善心脏功能并用作包含N，N，N'-不饱和（2） - 吡啶甲基） - 乙二胺（TPEN）作为活性成分。

2. 发明授权

US4826945A Biodegradable polymeric materials based on polyether glycols, processes for the preparation thereof and surgical articles made therefrom 失效
标题翻译：基于聚醚二醇的可生物降解的聚合物材料，其制备方法和由其制备的外科用品
公开(公告)号：US4826945A
公开(公告)日：1989-05-02
申请号：US201403
申请日：1988-06-02
申请人： Daniel Cohn , Hani Younes , Gideon Uretzky
发明人： Daniel Cohn , Hani Younes , Gideon Uretzky
IPC分类号： A61L17/00 , A61K9/22 , A61K47/34 , A61L17/12 , A61L27/00 , A61L27/18 , A61L27/58 , A61L31/06 , C08G18/42 , C08G63/66 , C08G18/34
CPC分类号： C08G63/66 , A61K47/34 , A61L17/12 , A61L27/18 , A61L27/58 , A61L31/06 , C08G18/4283 , C08G2230/00 , Y10T428/31565 , Y10T428/31786
摘要： The invention provides poly(.alpha.-hydroxy-carboxylic acid)/poly(oxyalkylene) polymers selected from multiblock polymers of the following repeating unit I ##STR1## wherein R is an alkylene group, R.sub.1 is hydrogen or methyl groups, m is a positive integer, and a and b are zero or positive integers, the case where a and b are simultaneously zero being excluded, and chain extended multiblock polymers which polymers are bioabsorbable and biodegradable, these polymeric materials being derived from reacting diols in the form of polyether glycols with .alpha.-hydroxy-carboxylic acids. The invention also provides methods for the preparation of such polymeric materials and bioabsorbable surgical articles made therefrom.

3. 发明授权

US5098370A Heart assist device 失效
标题翻译：心脏辅助装置
公开(公告)号：US5098370A
公开(公告)日：1992-03-24
申请号：US504472
申请日：1990-04-04
申请人： Shumel Rahat , Joe Borman , Dan Rottenberg , Gideon Uretzky
发明人： Shumel Rahat , Joe Borman , Dan Rottenberg , Gideon Uretzky
IPC分类号： A61M1/10
CPC分类号： A61M1/1086 , A61M1/1037
摘要： There is provided a heart assist system aimed at saving lives of patients who's heart is failing temporarily. The assist system comprises means for continuously monitoring the hemodynamic parameter which define the demand of the body for blood to be circulated by the heart, means to define the heart's actual performance and provides means to draw the excess blood not provided by the failing heart at that beat. That blood is reintroduced during the systolic phase of the same beat. Thus the system establishes the supply of blood required, which is supplied at rate and at a shape as close as possible to that expected by the body. The main parameter monitored is the entire atrial pressure function during the diastolic phase of the heart beat which provides the indication of the real time heart performance thus making it possible to define and provide the required assistance to be provided by the system of the invention.
摘要翻译：提供了一个心脏辅助系统，旨在挽救心脏暂时失败的患者的生命。辅助系统包括连续监测血液动力学参数的装置，该血流动力学参数定义了心脏要循环血液的需求，用于定义心脏的实际表现的手段，并提供了在失败的心脏中抽取未提供的多余血液的手段击败。在同一节拍的收缩阶段再次引入血液。因此，该系统建立所需血液的供应，其以尽可能接近身体预期的速度和形状提供。监测的主要参数是在心跳的舒张期期间的整个心房压力功能，其提供实时心脏性能的指示，从而使得可以限定和提供由本发明的系统提供的所需的辅助。

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