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1. 发明申请

US20070148262A1 Bactericidal and virucidal composition containing natural products 审中-公开
标题翻译：含有天然产物的杀菌和杀病毒组合物
公开(公告)号：US20070148262A1
公开(公告)日：2007-06-28
申请号：US11318871
申请日：2005-12-27
申请人： Jeong Ra , Yong Park , Bong Park
发明人： Jeong Ra , Yong Park , Bong Park
IPC分类号： A61K36/752 , A61K36/736 , A61K31/19
CPC分类号： A61K36/534 , A61K31/194 , A61K36/736 , A61K36/752 , A61K2300/00
摘要： A bactericidal and virucidal composition containing the natural products malic acid and grapefruit seed extract. Such compositions exhibit disinfectant effects on a broad spectrum of bacteria and viruses, and are particularly useful for disinfection of stalls, domestic animals and drinking water.
摘要翻译：含有天然产物苹果酸和葡萄柚籽提取物的杀菌和杀病毒组合物。这样的组合物对广谱的细菌和病毒表现出消毒作用，并且特别适用于对档位，家畜和饮用水进行消毒。

2. 发明申请

US20050208159A1 Phytoestrogenic composition comprising an extract of chinese licorice root, liquiritin or isoliquiritin 审中-公开
标题翻译：含有甘草根，甘草苷或异喹啉的提取物的植物雌激素组合物
公开(公告)号：US20050208159A1
公开(公告)日：2005-09-22
申请号：US11018363
申请日：2004-12-20
申请人： Kyung Kang , Jeong Ra , Eun Jo
发明人： Kyung Kang , Jeong Ra , Eun Jo
IPC分类号： A23C9/13 , A23C15/00 , A23C19/06 , A23L1/30 , A23L2/02 , A23L2/52 , A61K36/484 , A61K35/78
CPC分类号： A23C19/06 , A23C9/13 , A23C15/00 , A23L2/02 , A23L2/52 , A23L33/105 , A61K36/484
摘要： A phytoestrogen composition comprising an extract of Chinese licorice root (Glycyrrhiza uralensis Fisch), liquiritin or isoliquiritin isolated therefrom, which show estrogen activity and inhibitory effect on proliferation of cancer cells, as an effective ingredient. The Chinese licorice root extract, as well as liquiritin or isoliquiritin isolated therefrom, show estrogenicity but not androgenicity, suppress activity of the endocrine disrupter bisphenol-A and inhibit proliferation of cancer cells, e.g., breast cancer cells. The composition is usefully employed as a phytoestrogen for hormone replacement therapy and/or prevention and treatment of breast cancer.
摘要翻译：作为有效成分的植物雌激素组合物，其含有中国甘草根（甘草），从其分离的甘草苷或异喹喔啉的提取物，其显示雌激素活性和对癌细胞增殖的抑制作用。中国甘草根提取物以及从其分离的甘草苷或异喹喔啉显示出雌激素而不是雄激素活性，抑制内分泌干扰物双酚A的活性并抑制癌细胞例如乳腺癌细胞的增殖。该组合物有用地用作激素替代疗法的植物雌激素和/或乳腺癌的预防和治疗。

3. 发明申请

US20070243172A1 MULTIPOTENT STEM CELLS DERIVED FROM PLACENTA TISSUE AND CELLULAR THERAPEUTIC AGENTS COMPRISING THE SAME 审中-公开
标题翻译：来自PLACENTA组织的多个干细胞和包含其的细胞治疗药物
公开(公告)号：US20070243172A1
公开(公告)日：2007-10-18
申请号：US11734262
申请日：2007-04-11
申请人： Jeong Ra , Bong Kim , Hang Lee , Sang Woo , Hanna Park , Hyoeun Kim
发明人： Jeong Ra , Bong Kim , Hang Lee , Sang Woo , Hanna Park , Hyoeun Kim
IPC分类号： A61K35/39 , A61K35/34 , C12N5/08
CPC分类号： C12N5/0605 , C12N5/0607 , C12N2501/115 , C12N2506/02
摘要： The present invention relates to placenta tissue-derived multipotent stem cells and cell therapeutic agents containing the same. More specifically, to a method for producing placenta stem cells having the following characteristics, the method comprising culturing amnion, chorion, decidua or placenta tissue in a medium containing collagenase and bFGF and collecting the cultured cells: (a) showing a positive immunological response to CD29, CD44, CD73, CD90 and CD105, and showing a negative immunological response to CD31, CD34, CD45 and HLA-DR; (b) showing a positive immunological response to Oct4 and SSEA4; (c) growing attached to plastic, showing a round-shaped or spindle-shaped morphology, and forming spheres in an SFM medium so as to be able to be maintained in an undifferentiated state for a long period of time; and (d) having the ability to differentiate into mesoderm-, endoderm- and ectoderm-derived cells. Also the present invention relates to placenta stem cells obtained using the production method. The inventive multipotent stem cells have the ability to differentiate into muscle cells, vascular endothelial cells, osteogenic cells, nerve cells, satellite cells, fat cells, cartilage-forming cells, osteogenic cells, or insuline-secreting pancreatic β-cells, and thus are effective for the treatment of muscular diseases, osteoporosis, osteoarthritis, nervous diseases, diabetes and the like, and are useful for the formation of breast tissue.
摘要翻译：本发明涉及胎盘组织衍生的多能干细胞和含有其的细胞治疗剂。更具体地，涉及具有以下特征的胎盘干细胞的制造方法，其特征在于，在含有胶原酶和bFGF的培养基中培养羊膜，绒毛膜，蜕膜或胎盘组织，并收集培养的细胞：（a）显示出阳性免疫应答 CD29，CD44，CD73，CD90和CD105，并显示对CD31，CD34，CD45和HLA-DR的消极免疫反应; （b）对Oct4和SSEA4显示出阳性免疫应答; （c）生长附着在塑料上，显示出圆形或纺锤形的形态，并在SFM培养基中形成球体，以便能够长时间保持在未分化状态; 和（d）具有分化成中胚层，内胚层和外胚层衍生细胞的能力。本发明还涉及使用该制备方法获得的胎盘干细胞。本发明的多能干细胞具有分化成肌肉细胞，血管内皮细胞，成骨细胞，神经细胞，卫星细胞，脂肪细胞，软骨形成细胞，成骨细胞或胰岛素分泌胰腺β-细胞的能力，因此是有效治疗肌肉疾病，骨质疏松症，骨关节炎，神经疾病，糖尿病等，并且可用于形成乳房组织。

4. 发明申请

US20070134353A1 PHYTOESTROGENIC COMPOSITION COMPRISING AN EXTRACT OF CHINESE LICORICE ROOT, ISOLIQUIRITIN OR LIQUIRITIN 审中-公开
标题翻译：包含中华荔枝提取物，异烟肼或液体的植物组织成分
公开(公告)号：US20070134353A1
公开(公告)日：2007-06-14
申请号：US11673562
申请日：2007-02-10
申请人： Kyung Kang , Jeong Ra , Eun Jo
发明人： Kyung Kang , Jeong Ra , Eun Jo
IPC分类号： A61K36/48 , A61K36/484 , A61K31/704
CPC分类号： A23C19/06 , A23C9/13 , A23C15/00 , A23L2/02 , A23L2/52 , A23L33/105 , A61K36/484
摘要： A phytoestrogen composition comprising an extract of Chinese licorice root (Glycyrrhiza uralensis Fisch), liquiritin or isoliquiritin isolated therefrom, which show estrogen activity and inhibitory effect on proliferation of cancer cells, as an effective ingredient. The Chinese licorice root extract, as well as liquiritin or isoliquiritin isolated therefrom, show estrogenicity but not androgenicity, suppress activity of the endocrine disruptor bisphenol-A and inhibit proliferation of cancer cells, e.g., breast cancer cells. The composition is usefully employed as a phytoestrogen for hormone replacement therapy and/or prevention and treatment of breast cancer.
摘要翻译：作为有效成分的植物雌激素组合物，其含有中国甘草根（甘草），从其分离的甘草苷或异喹喔啉的提取物，其显示雌激素活性和对癌细胞增殖的抑制作用。中国甘草根提取物以及从其分离的甘草苷或异喹喔啉显示出雌激素而不是雄激素，抑制内分泌干扰物双酚A的活性并抑制癌细胞例如乳腺癌细胞的增殖。该组合物有用地用作激素替代疗法的植物雌激素和/或乳腺癌的预防和治疗。

5. 发明申请

US20070110729A1 Multipotent stem cells derived from human adipose tissue and cellular therapeutic agents comprising the same 有权
标题翻译：衍生自人类脂肪组织的多能干细胞和包含其的细胞治疗剂
公开(公告)号：US20070110729A1
公开(公告)日：2007-05-17
申请号：US11313083
申请日：2005-12-20
申请人： Kyung Kang , Jeong Ra , Jung Park
发明人： Kyung Kang , Jeong Ra , Jung Park
IPC分类号： A61K35/39 , A61K35/30 , C12N5/08
CPC分类号： C12N5/0667 , C12N2500/14 , C12N2500/20 , C12N2500/32 , C12N2500/44 , C12N2500/84 , C12N2501/11 , C12N2501/115 , C12N2501/33 , C12N2501/39
摘要： This invention relates to human adipose tissue-derived multipotent adult stem cells. More particularly, the invention relates to human adipose tissue-derived multipotent stem cells, which can be maintained in an undifferentiated state for a long period of time by forming spheres and have high proliferation rates, as well as methods for isolating and maintaining the adult stem cells, and methods for differentiating the multipotent adult stem cells into nerve cells, fat cells, cartilage cells, osteogenic cells and insulin-releasing pancreatic beta-cells. Also, the invention relates to cellular therapeutic agents for treating osteoarthritis, osteoporosis and diabetes and for forming breast tissue, which contain the differentiated cells or the adult stem cells. Although the multipotent stem cells are adult stem cells, they have the ability to differentiate into osteogenic cells, nerve cells, astrocytes, fat cells, chrondrogenic cells or insulin-releasing pancreatic beta-cells, and so are effective in treating osteoporosis, osteoarthritis, nerve disease, diabetes, etc. Also, the stem cells form spheres in a serum-free medium containing CORM-2, and thus can be maintained in an undifferentiated state for a long period of time. Also, the stem cells have very high proliferation rates. Accordingly, the stem cells are useful as cellular therapeutic agents.
摘要翻译：本发明涉及人脂肪组织衍生的多潜能成体干细胞。更具体地说，本发明涉及人类脂肪组织衍生的多潜能干细胞，其可以通过形成球体并且具有高增殖率而长时间维持在未分化状态，以及分离和维持成体干细胞的方法细胞和用于将多能成体干细胞分化成神经细胞，脂肪细胞，软骨细胞，成骨细胞和胰岛素释放胰腺β-细胞的方法。此外，本发明涉及用于治疗骨关节炎，骨质疏松症和糖尿病以及形成含有分化细胞或成体干细胞的乳腺组织的细胞治疗剂。虽然多能干细胞是成体干细胞，但它们具有分化成成骨细胞，神经细胞，星形胶质细胞，脂肪细胞，成纤维细胞或胰岛素释放胰腺β-细胞的能力，因此有效治疗骨质疏松症，骨关节炎，神经疾病，糖尿病等。此外，干细胞在含有CORM-2的无血清培养基中形成球，因此可以长时间维持在未分化状态。此外，干细胞具有非常高的增殖率。因此，干细胞可用作细胞治疗剂。

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