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1. 发明申请

US20090153130A1 FIELD EFFECT TRANSISTOR-BASED BIOSENSOR WITH INORGANIC FILM, METHOD OF MANUFACTURING THE BIOSENSOR, AND METHOD OF DETECTING BIOMOLECULE USING THE BIOSENSOR 审中-公开
标题翻译：基于场效应晶体管的无机膜生物传感器，生物传感器的制造方法和使用生物传感器检测生物分子的方法
公开(公告)号：US20090153130A1
公开(公告)日：2009-06-18
申请号：US11556783
申请日：2006-11-06
申请人： Jeo-young SHIM , Kyu-sang LEE , Chang-eun YOO , Kyu-youn HWANG , Young-a KIM , Kyu-tae YOO , Yeon-ja CHO
发明人： Jeo-young SHIM , Kyu-sang LEE , Chang-eun YOO , Kyu-youn HWANG , Young-a KIM , Kyu-tae YOO , Yeon-ja CHO
IPC分类号： G01N27/00 , H01L29/772 , H01L21/335
CPC分类号： G01N33/54373 , B01J2219/00529 , B01J2219/00596 , B01J2219/00612 , B01J2219/00617 , B01J2219/00621 , B01J2219/00637 , B01J2219/00653 , B01J2219/00659 , B01J2219/00722 , G01N27/4145
摘要： Provided is a Field-Effect Transistor (FET)-based biosensor including: a substrate; a source and a drain, disposed on the substrate, having opposite polarity to the substrate; a gate, disposed on the substrate, contacting the source and the drain; and an inorganic film capable of binding with a biomolecule, disposed on a surface of the gate. A method of manufacturing the FET-based biosensor and a method of detecting a biomolecule using the FET-based biosensor is also provided. The FET-based biosensor can be manufactured using a semiconductor fabrication process without performing an additional process. Therefore, the inorganic film can be selectively deposited on a surface of a specific gate of a single FET, or on the surfaces of some gates of a plurality of FETs using patterning. Furthermore, the FET-based biosensor can be used to effectively detect trace amounts of a target biomolecule in a sample.
摘要翻译：提供了一种基于场效应晶体管（FET）的生物传感器，包括：基板; 源极和漏极，设置在衬底上，具有与衬底相反的极性; 栅极，设置在基板上，与源极和漏极接触; 以及能够与生物分子结合的无机膜，其设置在栅极的表面上。还提供了制造基于FET的生物传感器的方法和使用基于FET的生物传感器检测生物分子的方法。基于FET的生物传感器可以使用半导体制造工艺制造而不执行额外的工艺。因此，无机膜可以选择性地沉积在单个FET的特定栅极的表面上，或者使用图案化沉积在多个FET的一些栅极的表面上。此外，基于FET的生物传感器可以用于有效地检测样品中痕量的目标生物分子。

2. 发明申请

US20110043213A1 FET-BASED SENSOR FOR DETECTING IONIC MATERIAL, IONIC MATERIAL DETECTING DEVICE USING THE FET-BASED SENSOR, AND METHOD OF DETECTING IONIC MATERIAL USING THE FET-BASED SENSOR 有权
标题翻译：用于检测离子材料的基于FET的传感器，使用基于FET的传感器的离子材料检测装置以及使用基于FET的传感器检测离子材料的方法
公开(公告)号：US20110043213A1
公开(公告)日：2011-02-24
申请号：US12912191
申请日：2010-10-26
申请人： Kyu-sang LEE , Kyu-tae YOO , Jeo-young SHIM , Jin-tae KIM , Yeon-ja CHO
发明人： Kyu-sang LEE , Kyu-tae YOO , Jeo-young SHIM , Jin-tae KIM , Yeon-ja CHO
IPC分类号： G01N27/62
CPC分类号： G01N33/54373 , C12Q1/6825 , G01N27/4145
摘要： Provided are a FET-based sensor for detecting an ionic material, an ionic material detecting device including the FET-based sensor, and a method of detecting an ionic material using the FET-based sensor. The FET-based sensor includes: a sensing chamber including a reference electrode and a plurality of sensing FETs; and a reference chamber including a reference electrode and a plurality of reference FETs. The method includes: flowing a first solution into and out of the sensing chamber and the reference chamber of the FET-based sensor; flowing a second solution expected to contain an ionic material into and out of the sensing chamber while continuously flowing the first solution into and out of the reference chamber; measuring a current in a channel region between the source and drain of each of the sensing and reference FETs; and correcting the current of the sensing FETs.
摘要翻译：提供了一种用于检测离子材料的基于FET的传感器，包括基于FET的传感器的离子材料检测装置，以及使用基于FET的传感器检测离子材料的方法。基于FET的传感器包括：感测室，包括参考电极和多个感测FET; 以及包括参考电极和多个参考FET的参考室。该方法包括：使第一溶液流入和流出基于FET的传感器的感测室和参考室; 使预期含有离子材料的第二溶液流入和流出感测室，同时使第一溶液持续流入和移出参考室; 测量每个感测和参考FET的源极和漏极之间的沟道区域中的电流; 并校正感测FET的电流。

3. 发明申请

US20090322354A1 METHOD OF DETECTING BIO-MOLECULES USING FIELD EFFECT TRANSISTOR WITHOUT FIXING PROBE BIO-MOLECULES ON THE GATE SENSING SURFACE 有权
标题翻译：使用场效应晶体管检测生物分子的方法，没有在门传感表面上固定探针生物分子
公开(公告)号：US20090322354A1
公开(公告)日：2009-12-31
申请号：US11695905
申请日：2007-04-03
申请人： Kyu-tae YOO , Kyu-sang LEE , Won-seok CHUNG , Jeo-young SHIM , Yeon-ja CHO
发明人： Kyu-tae YOO , Kyu-sang LEE , Won-seok CHUNG , Jeo-young SHIM , Yeon-ja CHO
IPC分类号： G01R27/08
CPC分类号： G01N33/54373
摘要： A method of detecting a presence of bio-molecules, or a concentration of the target bio-molecules using a field effect transistor, includes allowing a first sample including a first target bio-molecule to contact a sensing surface of the field effect transistor and measuring a change in an electric signal of the field effect transistor, the field effect transistor including a substrate, a source region and a drain region, the source region and the drain region formed apart from each other on the substrate, the source region and the drain region each doped to having an opposite polarity than a polarity of the substrate, a channel region disposed between the source region and the drain region and an insulating layer including the sensing surface, the insulating layer disposed on the channel region.
摘要翻译：使用场效应晶体管检测生物分子的存在或靶生物分子的浓度的方法包括允许包含第一靶生物分子的第一样品接触场效应晶体管的感测表面并测量场效应晶体管的电信号的变化，所述场效应晶体管包括基板，源极区和漏极区，在所述基板上彼此分离形成的所述源极区和漏极区，所述源极区和漏极每个被掺杂为具有与衬底的极性相反的极性，设置在源区和漏区之间的沟道区和包括感测表面的绝缘层，绝缘层设置在沟道区上。

4. 发明申请

US20070251301A1 METHOD AND APPARATUS FOR SIMULTANEOUSLY DETECTING SIZE AND CONCENTRATION OF IONIC MATERIAL 有权
标题翻译：同时检测离子材料的尺寸和浓度的方法和装置
公开(公告)号：US20070251301A1
公开(公告)日：2007-11-01
申请号：US11619650
申请日：2007-01-04
申请人： Kyu-sang LEE , Kyu-tae YOO , Jeo-young SHIM , Won-seok CHUNG , Yeon-ja CHO
发明人： Kyu-sang LEE , Kyu-tae YOO , Jeo-young SHIM , Won-seok CHUNG , Yeon-ja CHO
IPC分类号： G01N11/00
CPC分类号： G01N27/4145 , G01N27/27
摘要： A method for simultaneously detecting a size and concentration of ionic materials includes measuring voltage drop values of at least three ionic materials of which sizes and concentrations are known using each of at least two FET-based sensors having different electrical characteristics, determining at least three points in a three-dimensional plot from the known sizes, concentrations and the measured voltage drop values, approximating the at least three points into a single plane, measuring a voltage drop value of an ionic material of which size and concentration are unknown using the at least two FET-based sensors, determining equipotential lines existing on the plane using the voltage drop value of the unknown ionic material and determining a cross point between each of the equipotential lines.
摘要翻译：用于同时检测离子材料的尺寸和浓度的方法包括测量至少三种离子材料的电压降值，其中尺寸和浓度已知使用具有不同电特性的至少两个基于FET的传感器中的每一个，确定至少三个点在已知尺寸，浓度和测量的电压降值的三维图中，将至少三个点近似为单个平面，测量其尺寸和浓度未知的离子材料的电压降值，至少使用至少两个基于FET的传感器，使用未知离子材料的电压降值确定在平面上存在的等电位线，并确定每个等电位线之间的交叉点。

5. 发明申请

US20070159216A1 FET-BASED SENSOR FOR DETECTING IONIC MATERIAL, IONIC MATERIAL DETECTING DEVICE USING THE FET-BASED SENSOR, AND METHOD OF DETECTING IONIC MATERIAL USING THE FET-BASED SENSOR 有权
标题翻译：用于检测离子材料的基于FET的传感器，使用基于FET的传感器的离子材料检测装置以及使用基于FET的传感器检测离子材料的方法
公开(公告)号：US20070159216A1
公开(公告)日：2007-07-12
申请号：US11621191
申请日：2007-01-09
申请人： Kyu-sang LEE , Kyu-tae YOO , Jeo-young SHIM , Jin-tae KIM , Yeon-ja CHO
发明人： Kyu-sang LEE , Kyu-tae YOO , Jeo-young SHIM , Jin-tae KIM , Yeon-ja CHO
IPC分类号： H03F3/45
CPC分类号： G01N33/54373 , C12Q1/6825 , G01N27/4145
摘要： Provided are a FET-based sensor for detecting an ionic material, an ionic material detecting device including the FET-based sensor, and a method of detecting an ionic material using the FET-based sensor. The FET-based sensor includes: a sensing chamber including a reference electrode and a plurality of sensing FETs; and a reference chamber including a reference electrode and a plurality of reference FETs. The method includes: flowing a first solution into and out of the sensing chamber and the reference chamber of the FET-based sensor; flowing a second solution expected to contain an ionic material into and out of the sensing chamber while continuously flowing the first solution into and out of the reference chamber; measuring a current in a channel region between the source and drain of each of the sensing and reference FETs; and correcting the current of the sensing FETs.
摘要翻译：提供了一种用于检测离子材料的基于FET的传感器，包括基于FET的传感器的离子材料检测装置以及使用基于FET的传感器检测离子材料的方法。基于FET的传感器包括：感测室，包括参考电极和多个感测FET; 以及包括参考电极和多个参考FET的参考室。该方法包括：使第一溶液流入和流出基于FET的传感器的感测室和参考室; 使预期含有离子材料的第二溶液流入和流出感测室，同时使第一溶液持续流入和移出参考室; 测量每个感测和参考FET的源极和漏极之间的沟道区域中的电流; 并校正感测FET的电流。

6. 发明申请

US20070252176A1 FIELD EFFECT TRANSISTOR FOR DETECTING IONIC MATERIAL AND METHOD OF DETECTING IONIC MATERIAL USING THE SAME 有权
标题翻译：用于检测离子材料的场效应晶体管及其检测离子材料的方法
公开(公告)号：US20070252176A1
公开(公告)日：2007-11-01
申请号：US11613258
申请日：2006-12-20
申请人： Jeo-young SHIM , Kyu-sang LEE , Kyu-tae YOO , Won-seok CHUNG
发明人： Jeo-young SHIM , Kyu-sang LEE , Kyu-tae YOO , Won-seok CHUNG
IPC分类号： H01L29/76
CPC分类号： G01N27/4145
摘要： A field effect transistor for detecting ionic material and a method of detecting ionic material using the field effect transistor. The field effect transistor for detecting ionic material includes a substrate formed of a semiconductor material, a source region and a drain region spaced apart from each other in the substrate and doped with an opposite conductivity type to that of the substrate, a channel region interposed between the source region and the drain region, an insulating layer disposed on the channel region and formed of an electrically insulating material, a first reference electrode disposed at an edge of the upper portion of the insulating layer and a second reference electrode disposed to be spaced apart from the insulating layer.
摘要翻译：用于检测离子材料的场效应晶体管和使用场效应晶体管检测离子材料的方法。用于检测离子材料的场效应晶体管包括由衬底形成的衬底，源极区和漏极区，在衬底中彼此间隔开并且掺杂有与衬底相反的导电类型，沟道区介于源极区域和漏极区域，设置在沟道区域上并由电绝缘材料形成的绝缘层，设置在绝缘层的上部的边缘处的第一参考电极和设置成间隔开的第二参考电极从绝缘层。

7. 发明申请

US20100329931A1 SENSING SWITCH AND DETECTING METHOD USING THE SAME 有权
标题翻译：感应开关及其检测方法
公开(公告)号：US20100329931A1
公开(公告)日：2010-12-30
申请号：US12833095
申请日：2010-07-09
申请人： Kyu-tae YOO , Joon-ho KIM , Jun-hong MIN , Sung-ouk JUNG , Ji-na NAMGOONG , Kui-hyun KIM , Jeo-young SHIM , Kak NAMKOONG
发明人： Kyu-tae YOO , Joon-ho KIM , Jun-hong MIN , Sung-ouk JUNG , Ji-na NAMGOONG , Kui-hyun KIM , Jeo-young SHIM , Kak NAMKOONG
IPC分类号： G01N27/00
CPC分类号： G01N33/54373
摘要： Provided are a sensing switch and a sensing method using the same. The sensing switch includes: a substrate; a supporter on the substrate; a sensing plate that is connected to a side of the supporter and is in parallel with the substrate by a predetermined distance; a receptor binding region on an upper surface of an end portion of the sensing plate; an electric or magnetic field generation device that induces deflection of the sensing plate when a receptor bound to the receptor binding region is selectively bound to an electrically or magnetically active ligand; and a pair of switching electrodes that are separated by a predetermined distance and is connected when the sensing plate contacts the substrate due to the deflection of the sensing plate. A target material need not be labelled, a signal processing of a fluorescent or electrical detection signal using an analysis apparatus is not required, and a signal can be directly decoded by confirming whether a current flows through the switch.
摘要翻译：提供了一种感测开关和使用该感测开关的感测方法。感测开关包括：基板; 底物上的支撑物; 感测板，其与所述支撑体的一侧连接并且与所述基板平行预定距离; 在感测板的端部的上表面上的受体结合区域; 当与受体结合区结合的受体选择性地结合到电或磁性活性配体时，引起感测板偏转的电场或磁场产生装置; 以及一对分离预定距离的开关电极，并且当感测板由于感测板的偏转而与基板接触时被连接。目标材料不需要标注，不需要使用分析装置的荧光或电检测信号的信号处理，并且可以通过确认电流是否流过开关直接解码信号。

8. 发明申请

US20090170211A1 SENSING SWITCH AND DETECTING METHOD USING THE SAME 有权
标题翻译：感应开关及其检测方法
公开(公告)号：US20090170211A1
公开(公告)日：2009-07-02
申请号：US12272183
申请日：2008-11-17
申请人： Kyu-tae YOO , Joon-ho KIM , Jun-hong MIN , Sung-ouk JUNG , Ji-na NAMGOONG , Kui-hyun KIM , Jeo-young SHIM , Kak NAMKOONG
发明人： Kyu-tae YOO , Joon-ho KIM , Jun-hong MIN , Sung-ouk JUNG , Ji-na NAMGOONG , Kui-hyun KIM , Jeo-young SHIM , Kak NAMKOONG
IPC分类号： G01N27/00
CPC分类号： G01N33/54373
摘要： Provided are a sensing switch and a sensing method using the same. The sensing switch includes: a substrate; a supporter on the substrate; a sensing plate that is connected to a side of the supporter and is in parallel with the substrate by a predetermined distance; a receptor binding region on an upper surface of an end portion of the sensing plate; an electric or magnetic field generation device that induces deflection of the sensing plate when a receptor bound to the receptor binding region is selectively bound to an electrically or magnetically active ligand; and a pair of switching electrodes that are separated by a predetermined distance and is connected when the sensing plate contacts the substrate due to the deflection of the sensing plate. A target material need not be labelled, a signal processing of a fluorescent or electrical detection signal using an analysis apparatus is not required, and a signal can be directly decoded by confirming whether a current flows through the switch.
摘要翻译：提供了一种感测开关和使用该感测开关的感测方法。感测开关包括：基板; 底物上的支撑物; 感测板，其与所述支撑体的一侧连接并且与所述基板平行预定距离; 在感测板的端部的上表面上的受体结合区域; 当与受体结合区结合的受体选择性地结合到电或磁性活性配体时，引起感测板偏转的电场或磁场产生装置; 以及一对分离预定距离的开关电极，并且当感测板由于感测板的偏转而与基板接触时被连接。目标材料不需要标注，不需要使用分析装置的荧光或电检测信号的信号处理，并且可以通过确认电流是否流过开关直接解码信号。

9. 发明申请

US20100181209A1 METHOD OF ELECTRICALLY DETECTING BIOMOLECULE 审中-公开
标题翻译：电生物分析方法
公开(公告)号：US20100181209A1
公开(公告)日：2010-07-22
申请号：US12637245
申请日：2009-12-14
申请人： Kyu-tae YOO , Sung-ouk JUNG , Jun-hong MIN , Ji-na NAMGOONG , Soo-hyung CHOI , Jeo-young SHIM
发明人： Kyu-tae YOO , Sung-ouk JUNG , Jun-hong MIN , Ji-na NAMGOONG , Soo-hyung CHOI , Jeo-young SHIM
IPC分类号： G01N27/26
CPC分类号： G01N33/54306
摘要： Provided is a method of sensing biomolecules using a bioFET, the method including: forming a layer including Au on a gate of the bioFET; forming a probe immobilized on a substrate separated from the gate by a predetermined distance, and a biomolecule having a thiol group (—SH) which is incompletely bonded to the probe; reacting the probe with a sample including a target molecule; and measuring a current flowing in a channel region between a source and a drain of the bioFET.
摘要翻译：提供了一种使用bioFET感测生物分子的方法，该方法包括：在bioFET的栅极上形成包含Au的层; 形成固定在与栅极分离预定距离的基板上的探针，以及具有与探针不完全结合的硫醇基（-SH）的生物分子; 使探针与包含靶分子的样品反应; 以及测量在bioFET的源极和漏极之间的沟道区域中流动的电流。

10. 发明申请

US20100088118A1 METHOD AND APPARATUS FOR MANAGING PATIENT 审中-公开
标题翻译：治疗患者的方法和装置
公开(公告)号：US20100088118A1
公开(公告)日：2010-04-08
申请号：US12573360
申请日：2009-10-05
申请人： Woo-young JANG , Yun-sun NAM , Kyu-tae YOO
发明人： Woo-young JANG , Yun-sun NAM , Kyu-tae YOO
IPC分类号： G06Q50/00
CPC分类号： G06F19/3418 , G06Q50/24
摘要： A patient management method includes; collecting initial information about a patient, monitoring the collected initial information to determine whether the collected initial information corresponds to an event indicating an abnormal condition of the patient, selectively collecting additional information about the patient based on a result of the monitoring, and performing medical processing with regard to the patient based on at least one of the collected initial information and the additional information.
摘要翻译：患者管理方法包括：收集关于患者的初始信息，监测所收集的初始信息以确定所收集的初始信息是否对应于指示患者的异常状况的事件，基于监测结果有选择地收集关于患者的附加信息，并执行医疗处理基于所收集的初始信息和附加信息中的至少一个，关于患者。

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