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1. 发明授权

US08811706B2 System, method and computer accessible medium for providing real-time diffusional kurtosis imaging and for facilitating estimation of tensors and tensor-derived measures in diffusional kurtosis imaging 有权
标题翻译：系统，方法和计算机可访问介质，用于提供实时扩散峰度成像，并有助于估计扩张峰度成像中的张量和张量推导测量
公开(公告)号：US08811706B2
公开(公告)日：2014-08-19
申请号：US13022488
申请日：2011-02-07
申请人： Jens Jensen , Joseph Helpern , Ali Tabesh , Els Fieremans
发明人： Jens Jensen , Joseph Helpern , Ali Tabesh , Els Fieremans
IPC分类号： G06T7/00 , A61B5/055
CPC分类号： G01R33/56341
摘要： Exemplary method, system, and computer-accessible medium can be provided for determining a measure of diffusional kurtosis by receiving data relating to at least one diffusion weighted image, and determining a measure of a diffusional kurtosis as a function of the received data using a closed form solution procedure. In accordance with certain exemplary embodiments of the present disclosure, provided herein are computer-accessible medium, systems and methods for, e.g., imaging in an MRI system, and, more particularly for facilitating estimation of tensors and tensor-derived measures in diffusional kurtosis imaging (DKI). For example, DKI can facilitate a characterization of non-Gaussian diffusion of water molecules in biological tissues. The diffusion and kurtosis tensors parameterizing the DKI model can typically be estimated via unconstrained least squares (LS) methods. In the presence of noise, motion, and imaging artifacts, these methods can be prone to producing physically and/or biologically implausible tensor estimates. The exemplary embodiments of the present disclosure can address at least this deficiency by formulating an exemplary estimation problem, e.g., as linearly constrained linear LS, where the constraints can ensure acceptable tensor estimates.
摘要翻译：可以提供示例性方法，系统和计算机可访问介质，用于通过接收与至少一个扩散加权图像相关的数据来确定扩散峰度的度量，并且使用闭合的方法确定作为接收数据的函数的扩散峰度的度量形式解决程序。根据本公开的某些示例性实施例，本文提供了用于例如在MRI系统中成像的计算机可访问介质，系统和方法，并且更具体地，用于促进扩散峭度成像中的张量和张量导出测量的估计（DKI）。例如，DKI可以促进水分子在生物组织中的非高斯扩散的表征。参数化DKI模型的扩散和峰度张量通常可以通过非约束最小二乘法（LS）方法估计。在存在噪声，运动和成像伪像的情况下，这些方法可能容易产生物理和/或生物学不可信的张量估计。本公开的示例性实施例可以通过制定示例性估计问题（例如线性约束线性LS）来解决至少该缺陷，其中约束可以确保可接受的张量估计。

2. 发明申请

US20120002851A1 System, Method and Computer Accessible Medium for Providing Real-Time Diffusional Kurtosis Imaging and for Facilitating Estimation of Tensors and Tensor- Derived Measures in Diffusional Kurtosis Imaging 有权
标题翻译：系统，方法和计算机可访问介质，用于提供实时扩散性血液饱和成像和促进传感器估计和弥漫性高血压成像中的传感器测量
公开(公告)号：US20120002851A1
公开(公告)日：2012-01-05
申请号：US13022488
申请日：2011-02-07
申请人： Jens Jensen , Joseph Helpern , Ali Tabesh , Els Fieremans
发明人： Jens Jensen , Joseph Helpern , Ali Tabesh , Els Fieremans
IPC分类号： G06K9/00
CPC分类号： G01R33/56341
摘要： Exemplary method, system, and computer-accessible medium can be provided for determining a measure of diffusional kurtosis by receiving data relating to at least one diffusion weighted image, and determining a measure of a diffusional kurtosis as a function of the received data using a closed form solution procedure. In accordance with certain exemplary embodiments of the present disclosure, provided herein are computer-accessible medium, systems and methods for, e.g., imaging in an MRI system, and, more particularly for facilitating estimation of tensors and tensor-derived measures in diffusional kurtosis imaging (DKI). For example, DKI can facilitate a characterization of non-Gaussian diffusion of water molecules in biological tissues. The diffusion and kurtosis tensors parameterizing the DKI model can typically be estimated via unconstrained least squares (LS) methods. In the presence of noise, motion, and imaging artifacts, these methods can be prone to producing physically and/or biologically implausible tensor estimates. The exemplary embodiments of the present disclosure can address at least this deficiency by formulating an exemplary estimation problem, e.g., as linearly constrained linear LS, where the constraints can ensure acceptable tensor estimates.
摘要翻译：可以提供示例性方法，系统和计算机可访问介质，用于通过接收与至少一个扩散加权图像相关的数据来确定扩散峰度的度量，并且使用闭合的方法确定作为接收数据的函数的扩散峰度的度量形式解决程序。根据本公开的某些示例性实施例，本文提供了用于例如在MRI系统中成像的计算机可访问介质，系统和方法，并且更具体地，用于促进扩散峭度成像中的张量和张量导出测量的估计（DKI）。例如，DKI可以促进水分子在生物组织中的非高斯扩散的表征。参数化DKI模型的扩散和峰度张量通常可以通过非约束最小二乘法（LS）方法估计。在存在噪声，运动和成像伪像的情况下，这些方法可能容易产生物理和/或生物学不可信的张量估计。本公开的示例性实施例可以通过制定示例性估计问题（例如线性约束线性LS）来解决至少该缺陷，其中约束可以确保可接受的张量估计。

3. 发明申请

US20120095700A1 SYSTEM, METHOD AND COMPUTER-ACCESSIBLE MEDIUM FOR DETERMINING MEMBRANE PROPERTIES RELATING TO DIFFUSION 有权
标题翻译：用于确定与扩散相关的膜性质的系统，方法和计算机可访问介质
公开(公告)号：US20120095700A1
公开(公告)日：2012-04-19
申请号：US13260445
申请日：2010-03-26
申请人： Dmitry S. Novikov , Jens Jensen , Joseph A. Helpern , Els Fieremans
发明人： Dmitry S. Novikov , Jens Jensen , Joseph A. Helpern , Els Fieremans
IPC分类号： G06F19/00
CPC分类号： B01D65/10 , G01R33/56341
摘要： Exemplary embodiments of a methodology, procedure, system, method and computer-accessible medium can be provided to obtain particular information relating to at least one transport property of a material containing at least one membrane, and to determine, e.g., a permeability of the membrane of the material and/or a surface area of the membrane of the material, as a function of, e.g., the obtained particular information.
摘要翻译：可以提供方法，程序，系统，方法和计算机可访问介质的示例性实施例，以获得与含有至少一个膜的材料的至少一种输送性质相关的特定信息，并且确定例如膜的渗透性的材料和/或材料的膜的表面积，作为例如所获得的特定信息的函数。

4. 发明授权

US09295948B2 System, method and computer-accessible medium for determining membrane properties relating to diffusion 有权
标题翻译：用于确定与扩散相关的膜性质的系统，方法和计算机可访问介质
公开(公告)号：US09295948B2
公开(公告)日：2016-03-29
申请号：US13260445
申请日：2010-03-26
申请人： Dmitry S. Novikov , Jens Jensen , Joseph A. Helpern , Els Fieremans
发明人： Dmitry S. Novikov , Jens Jensen , Joseph A. Helpern , Els Fieremans
IPC分类号： G01N3/30 , G01B9/04 , G01B9/06 , G01B9/08 , B01D65/10 , G01R33/563
CPC分类号： B01D65/10 , G01R33/56341
摘要： Exemplary embodiments of a methodology, procedure, system, method and computer-accessible medium can be provided to obtain particular information relating to at least one transport property of a material containing at least one membrane, and to determine, e.g., a permeability of the membrane of the material and/or a surface area of the membrane of the material, as a function of, e.g., the obtained particular information.
摘要翻译：可以提供方法，程序，系统，方法和计算机可访问介质的示例性实施例，以获得与含有至少一个膜的材料的至少一种输送性质相关的特定信息，并且确定例如膜的渗透性的材料和/或材料的膜的表面积，作为例如所获得的特定信息的函数。

5. 发明授权

US09916654B2 System, method and computer accessible mediums for determining neurodegeneration 有权
公开(公告)号：US09916654B2
公开(公告)日：2018-03-13
申请号：US14358785
申请日：2012-11-16
申请人： NEW YORK UNIVERSITY , Els Fieremans , Dmitry S. Novikov
发明人： Els Fieremans , Dmitry S. Novikov
IPC分类号： G06K9/00 , G06T7/00 , G01R33/563 , A61B5/055 , G01R33/56 , G06F19/00
CPC分类号： G06T7/0012 , A61B5/055 , G01R33/5608 , G01R33/56341 , G06K9/00147 , G06T2207/10088 , G06T2207/30024 , G16H50/50
摘要： Method, system and computer-accessible medium for determining at least one of axonal loss or myelin degradation can be provided. For example, it is possible to receive data based on at least one of a measure of diffusion of an axonal structure or a measure of a density of axons, and determine axonal loss and/or myelin degradation based on the data. The determination can be based on axonal geometry of at least one parallel tube.

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