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1. 发明申请

US20120082732A1 MEDICINE FOR TREATMENT OF A CARCINOMA 审中-公开
标题翻译：治疗癌症的药物
公开(公告)号：US20120082732A1
公开(公告)日：2012-04-05
申请号：US13313664
申请日：2011-12-07
申请人： JENS FEHRE , Ralf Nanke , Martin Stetter
发明人： JENS FEHRE , Ralf Nanke , Martin Stetter
IPC分类号： A61K38/17 , A61K9/14 , A61K31/7088 , A61P37/04 , A61K35/76 , A61K39/395 , A61P35/00
CPC分类号： A61K9/1676 , A61K9/0009
摘要： In a method for treating a carcinoma in a patient, a medicine is administered via the blood stream of the patient that appears, to the patient's immune system, that tissue of the carcinoma is an inflammation source. The medicine employs two active components that are coupled to each other in a form allowing administration of the two active components to the carcinoma via the blood stream of the patient. A first of the active components is at least one coupling molecule that specifically tethers to a target molecule formed by cancer tissue of the carcinoma. A second of the active ingredients is at least one signal molecule typical to inflammation, or at least one originating molecule encoding such a signal molecule, that induces the immune system of the body to attack the cancer cells.
摘要翻译：在用于治疗患者癌症的方法中，药物通过出现在患者的免疫系统中的患者的血流中被施用，癌的组织是炎症源。药物使用两种活性组分，其以允许经由患者的血液将两种活性成分施用于癌的形式彼此偶联。活性组分中的第一个是至少一个特异性地连接到由癌的癌组织形成的靶分子的偶联分子。活性成分中的第二种是至少一种典型的炎症信号分子，或至少一种编码这种信号分子的起始分子，其诱导身体的免疫系统侵袭癌细胞。

2. 发明授权

US08002718B2 Shockwave system control dependent on patient's blood pressure 有权
标题翻译：冲击波系统控制取决于患者的血压
公开(公告)号：US08002718B2
公开(公告)日：2011-08-23
申请号：US11479347
申请日：2006-06-30
申请人： Gerhard Buchholtz , Jens Fehre , Bernd Granz , Martin Hoheisel , Werner Kruft , Markus Lanski , Matthias Mahler , Christian Meinert , Thomas Mertelmeier , Ralf Nanke , Manfred Rattner
发明人： Gerhard Buchholtz , Jens Fehre , Bernd Granz , Martin Hoheisel , Werner Kruft , Markus Lanski , Matthias Mahler , Christian Meinert , Thomas Mertelmeier , Ralf Nanke , Manfred Rattner
IPC分类号： A61N5/02
CPC分类号： A61B17/2251 , A61B5/021 , A61B17/22004 , A61B2017/00022 , A61B2017/00044 , A61B2017/00119 , A61B2017/00194
摘要： In a shockwave system with a shockwave source for treatment of a patient with shockwaves, a control and evaluation unit for evaluating an input signal supplied directly thereto that is correlated with a blood pressure value of the patient determined during the treatment, and controls the shockwave source dependent on the input signal.
摘要翻译：在具有用于治疗患有冲击波的患者的冲击波源的冲击波系统中，用于评估与其直接供应的输入信号相关联的控制和评估单元，其与在治疗期间确定的患者的血压值相关联，并且控制冲击波源取决于输入信号。

3. 发明申请

US20090180586A1 UROLOGICAL X-RAY WORKSTATION WITH ORBITING X-RAY IMAGING COMPONENTS 有权
标题翻译：具有对位X射线成像组件的尿路X射线工作台
公开(公告)号：US20090180586A1
公开(公告)日：2009-07-16
申请号：US11943786
申请日：2007-11-21
申请人： Jens Fehre , Ralf Nanke , Monika Schwarz
发明人： Jens Fehre , Ralf Nanke , Monika Schwarz
IPC分类号： H05G1/60 , A61B6/04
CPC分类号： A61B6/4429 , A61B6/587
摘要： A urological x-ray workstation has an x-ray source and an x-ray receiver that are respectively supported on device retainers of a device carrier located at the longitudinal side of a patient positioning table such that they can be positioned opposite one another and independently of one another in various positions on an orbit proceeding around a common center in a working plane oriented perpendicular to the longitudinal axis.
摘要翻译：泌尿x射线工作站具有分别支撑在位于患者定位台的纵向侧的装置载体的装置保持器上的x射线源和x射线接收器，使得它们可以彼此相对定位并且独立地定位在垂直于纵向轴线定向的工作平面中的公共中心周围的轨道上的各种位置。

4. 发明申请

US20090060926A1 MEDICINE FOR TREATMENT OF CARCINOMA 审中-公开
标题翻译：药物治疗药物
公开(公告)号：US20090060926A1
公开(公告)日：2009-03-05
申请号：US12203204
申请日：2008-09-03
申请人： Jens Fehre , Ralf Nanke , Martin Stetter
发明人： Jens Fehre , Ralf Nanke , Martin Stetter
IPC分类号： A61K39/395 , A61P35/00
CPC分类号： A61K9/1676 , A61K9/0009
摘要： A medicine for treatment of a carcinoma which can be supplied to the carcinoma via the circulatory system, contains two active components coupled to one another. The first active component is formed of at least one coupling molecule that specifically tethers to a target molecule formed by the cancer tissue. The second active component is formed of at least one signal molecule typical to inflammation, or of at least originating molecule encoding such a signal molecule.
摘要翻译：用于治疗可以通过循环系统供应给癌症的癌症药物含有彼此偶联的两种活性成分。第一活性成分由至少一个特异性地束缚于由癌组织形成的靶分子的偶联分子形成。第二活性成分由至少一种典型的炎症信号分子或至少起码分子编码这种信号分子形成。

5. 发明授权

US07438695B2 Shockwave system and method for operation of such a shockwave system 失效
标题翻译：冲击波系统和这种冲击波系统的运行方法
公开(公告)号：US07438695B2
公开(公告)日：2008-10-21
申请号：US11478992
申请日：2006-06-30
申请人： Gerhard Buchholtz , Jens Fehre , Bernd Granz , Martin Hoheisel , Werner Kruft , Markus Lanski , Matthias Mahler , Christian Meinert , Thomas Mertelmeier , Ralf Nanke , Manfred Rattner
发明人： Gerhard Buchholtz , Jens Fehre , Bernd Granz , Martin Hoheisel , Werner Kruft , Markus Lanski , Matthias Mahler , Christian Meinert , Thomas Mertelmeier , Ralf Nanke , Manfred Rattner
IPC分类号： A61H1/00
CPC分类号： A61B17/22004 , A61B5/00 , A61B17/2251 , A61B17/2255 , A61B90/37 , A61B2017/00022
摘要： A shockwave system for treatment of a patient has a detection unit for detection of an indicator correlated with the calmness of the patient, and a device that is operable dependent on the indicator that increases the calmness of the patient. In a method for operation of a shockwave system for treatment of a patient, an indicator correlated with the calmness of the patient is detected and a measure to increase the calmness of the patient is taken dependent on the indicator.
摘要翻译：用于治疗患者的冲击波系统具有用于检测与患者的平静相关的指示器的检测单元，以及依赖于增加患者平静度的指示器可操作的装置。在用于治疗患者的冲击波系统的操作方法中，检测到与患者的平静度相关的指标，并且取决于指标来采取增加患者平静度的措施。

6. 发明申请

US20070038159A1 Shockwave system and method for operation of such a shockwave system 失效
标题翻译：冲击波系统和这种冲击波系统的运行方法
公开(公告)号：US20070038159A1
公开(公告)日：2007-02-15
申请号：US11478992
申请日：2006-06-30
申请人： Gerhard Buchholtz , Jens Fehre , Bernd Granz , Martin Hoheisel , Werner Kruft , Markus Lanski , Matthias Mahler , Christian Meinert , Thomas Mertelmeier , Ralf Nanke , Manfred Rattner
发明人： Gerhard Buchholtz , Jens Fehre , Bernd Granz , Martin Hoheisel , Werner Kruft , Markus Lanski , Matthias Mahler , Christian Meinert , Thomas Mertelmeier , Ralf Nanke , Manfred Rattner
IPC分类号： A61H1/00
CPC分类号： A61B17/22004 , A61B5/00 , A61B17/2251 , A61B17/2255 , A61B90/37 , A61B2017/00022
摘要： A shockwave system for treatment of a patient has a detection unit for detection of an indicator correlated with the calmness of the patient, and a device that is operable dependent on the indicator that increases the calmness of the patient. In a method for operation of a shockwave system for treatment of a patient, an indicator correlated with the calmness of the patient is detected and a measure to increase the calmness of the patient is taken dependent on the indicator.
摘要翻译：用于治疗患者的冲击波系统具有用于检测与患者的平静相关的指示器的检测单元，以及依赖于增加患者平静度的指示器可操作的装置。在用于治疗患者的冲击波系统的操作方法中，检测到与患者的平静度相关的指标，并且取决于指标来采取增加患者平静度的措施。

7. 发明申请

US20070025510A1 Method and apparatus for x-ray imaging of a patient during a shockwave treatment 审中-公开
标题翻译：冲击波治疗期间患者的x射线成像的方法和装置
公开(公告)号：US20070025510A1
公开(公告)日：2007-02-01
申请号：US11479905
申请日：2006-06-30
申请人： Gerhard Buchholtz , Jens Fehre , Bernd Granz , Martin Hoheisel , Werner Kruft , Markus Lanski , Matthias Mahler , Christian Meinert , Thomas Mertelmeier , Ralf Nanke , Manfred Rattner
发明人： Gerhard Buchholtz , Jens Fehre , Bernd Granz , Martin Hoheisel , Werner Kruft , Markus Lanski , Matthias Mahler , Christian Meinert , Thomas Mertelmeier , Ralf Nanke , Manfred Rattner
IPC分类号： A61N5/10
CPC分类号： A61B17/2256 , A61B6/12 , A61B90/39 , A61B2090/376 , G06T7/33 , G06T7/38 , G06T2207/30004
摘要： In a method for x-ray imaging given a patient containing a subject to be represented during a shockwave treatment, an image data set containing the subject and a marker is generated at a first point in time; an x-ray image showing essentially only the subject (14) and the marker is acquired at a second point in time, the x-ray image is correctly spatially associated with the image data set using the marker, the x-ray image is displayed together with information extracted from the image data set during the shockwave treatment. An apparatus for x-ray imaging a patient containing a subject to be represented during a shockwave treatment has a memory for an image data set generated at a first point in time and containing the subject and a marker, an x-ray system for acquisition of an x-ray image showing essentially only the subject and the marker at a second point in time; an evaluation unit for spatially-accurate association of the x-ray image with the image data set using the marker and for extraction of information from the image data set, and a display unit for display of the x-ray image together with the information during the shockwave treatment.
摘要翻译：在给予包含在冲击波治疗期间被表示的受试者的患者的x射线成像的方法中，在第一时间点产生包含受试者和标记的图像数据集; 基本上只显示对象（14）的X射线图像，并且在第二时间点获取标记，X射线图像与使用标记的图像数据组正确空间相关联，显示x射线图像以及在冲击波处理期间从图像数据中提取的信息。用于在冲击波治疗期间包含要表示的受试者的患者的x射线成像的装置具有用于在第一时间点生成并包含受试者和标记的图像数据集的存储器，用于获取在第二时间点基本上只显示受试者和标记物的X射线图像; 用于使用所述标记将所述X射线图像与所述图像数据集进行空间准确关联的评估单元，以及用于从所述图像数据组提取信息的评估单元，以及用于显示所述X射线图像以及所述X射线图像的信息的显示单元冲击波治疗。

8. 发明授权

US09162080B2 Device for X-ray brachytherapy, and method for positioning a probe introduced into a body for X-ray brachytherapy 有权
标题翻译：用于X射线近距离放射治疗的装置，以及引入体内用于X射线近距离放射治疗的探针定位方法
公开(公告)号：US09162080B2
公开(公告)日：2015-10-20
申请号：US12094891
申请日：2006-09-28
申请人： Jens Fehre , Bernd Granz , Markus Lanski , Ralf Nanke
发明人： Jens Fehre , Bernd Granz , Markus Lanski , Ralf Nanke
IPC分类号： A61B8/12 , A61B18/00 , A61N5/10 , A61B19/00 , A61B8/00 , A61B8/08
CPC分类号： A61N5/1002 , A61B8/4416 , A61B8/5261 , A61B34/20 , A61B2090/378 , A61B2090/3925 , A61B2090/3983 , A61N5/1049 , A61N2005/1058 , A61N2005/1094
摘要： In a system and method for x-ray brachytherapy, a probe is introduced into the body of a subject, the probe carrying an x-ray source that radiates x-rays into an exposure area outside of the probe within the body of the subject. A number of markers are located in or on the probe, that are detectable in an image generated by an imaging device. The markers are located in or on the probe in a known spatial relation to the exposure area, so that the position of the exposure area can be determined by identifying the markers in the displayed image.
摘要翻译：在用于x射线近距离放射疗法的系统和方法中，将探针引入受试者的身体，探头携带将X射线照射到受试者身体内的探针外部的暴露区域中的x射线源。多个标记物位于探针中或探针上，可由成像装置产生的图像中检测到。标记以与曝光区域的已知空间关系位于探头中或探针上，从而可以通过识别显示图像中的标记来确定曝光区域的位置。

9. 发明申请

US20130253485A1 MEDICAL EXAMINATION SYSTEM 审中-公开
标题翻译：医学检查系统
公开(公告)号：US20130253485A1
公开(公告)日：2013-09-26
申请号：US13615292
申请日：2012-09-13
申请人： Jens Fehre , Andreas Limmer , Ralf Nanke , Manfred Sechser
发明人： Jens Fehre , Andreas Limmer , Ralf Nanke , Manfred Sechser
IPC分类号： A61B18/26 , H02P29/04
CPC分类号： A61B18/26 , A61B6/0407 , A61B6/102 , A61B6/4405 , A61B6/4441 , A61B6/46 , A61B6/547 , A61B6/548 , A61B17/225 , A61B2017/00017 , A61B2090/0801 , A61B2090/0807 , A61B2090/0808 , A61B2090/0811 , H02P29/04
摘要： A system includes at least one device that includes at least one device component. For a defined movement of the at least one device component, a movement axis and/or a movement direction may be selected by a selection element and may be identified by an activatable lighting element. The identified movement axis and/or the identified movement direction may be released by at least one actuation element, so that a desired movement of the at least one device component may be performed.
摘要翻译：系统包括至少一个包括至少一个设备组件的设备。对于所述至少一个装置部件的确定的运动，可以通过选择元件选择运动轴和/或运动方向，并且可以由可激活的照明元件来识别。所确定的运动轴线和/或所识别的移动方向可以由至少一个致动元件释放，使得可以执行至少一个设备部件的期望的移动。

10. 发明申请

US20120252057A1 METHOD AND DEVICE FOR DETECTING TUMOROUS LIVING CELL TISSUE 有权
标题翻译：用于检测肿瘤生殖细胞组织的方法和装置
公开(公告)号：US20120252057A1
公开(公告)日：2012-10-04
申请号：US13320610
申请日：2010-05-12
申请人： Juergen Schrelber , Joerg Opitz , Carola Gerich , Jens Fehre , Georg Salomon , Ralf Nanke
发明人： Juergen Schrelber , Joerg Opitz , Carola Gerich , Jens Fehre , Georg Salomon , Ralf Nanke
IPC分类号： G01N21/64 , C12M1/34
CPC分类号： G01N21/6486 , A61B5/0059 , G01N21/6408
摘要： The invention relates to a method and to an apparatus for recognizing tumorous living cell tissue. It furthermore relates to a method and to an apparatus for recognizing tumorous cell tissue at collected living cell tissue samples. In the method, electromagnetic radiation is emitted with local definition onto cell tissue by a radiation source and, after deactivation of the radiation source, the decay behavior of the inherent fluorescence intensity of the cell tissue excited by the electromagnetic radiation is detected at the cell tissue in a time resolved and spectrally resolved manner at known sampling rate(s) for at least one wavelength using a detector. The difference autocorrelation function C(t) of the intensity decay behavior is determined using the determined measured intensity values, the fractal dimension DF for the respective irradiated cell tissue is calculated from this and the value of the fractal dimension DF is used for a classification with respect to a presence of a tumor in the respective irradiated cell tissue.
摘要翻译：本发明涉及用于识别肿瘤活细胞组织的方法和装置。此外，本发明还涉及用于在收集的活细胞组织样品处识别肿瘤细胞组织的方法和装置。在该方法中，电磁辐射通过辐射源以局部定义发射到细胞组织上，并且在放射源失活之后，在细胞组织处检测由电磁辐射激发的细胞组织的固有荧光强度的衰变行为以使用检测器的至少一个波长的已知采样速率以时间分辨和频谱分辨的方式。使用确定的测量强度值确定强度衰减行为的差分自相关函数C（t），并从其计算相应的照射细胞组织的分形维数DF，并且使用分形维数DF的值进行分类，相对于各自照射的细胞组织中肿瘤的存在。

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