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1. 发明申请

US20060019244A1 Planar optical waveguide based sandwich assay sensors and processes for the detection of biological targets including protein markers, pathogens and cellular debris 有权
公开(公告)号：US20060019244A1
公开(公告)日：2006-01-26
申请号：US11172246
申请日：2005-06-29
申请人： Jennifer Martinez , Basil Swanson , Karen Grace , Wyane Grace , Andrew Shreve
发明人： Jennifer Martinez , Basil Swanson , Karen Grace , Wyane Grace , Andrew Shreve
IPC分类号： C12Q1/70 , C12Q1/68 , G01N33/554 , C12M1/34 , G01N33/569
CPC分类号： G01N21/648 , B01J2219/00497 , B01J2219/00527 , B01J2219/00576 , B01J2219/00605 , B01J2219/00612 , B01J2219/0063 , B01J2219/00637 , B01J2219/00725 , B01J2219/00743 , B82Y15/00 , B82Y30/00 , C12Q1/6825 , G01N21/6428 , G01N33/54373 , G01N2610/00 , Y10S436/805
摘要： An assay element is described including recognition ligands bound to a film on a single mode planar optical waveguide, the film from the group of a membrane, a polymerized bilayer membrane, and a self-assembled monolayer containing polyethylene glycol or polypropylene glycol groups therein and an assay process for detecting the presence of a biological target is described including injecting a biological target-containing sample into a sensor cell including the assay element, with the recognition ligands adapted for binding to selected biological targets, maintaining the sample within the sensor cell for time sufficient for binding to occur between selected biological targets within the sample and the recognition ligands, injecting a solution including a reporter ligand into the sensor cell; and, interrogating the sample within the sensor cell with excitation light from the waveguide, the excitation light provided by an evanescent field of the single mode penetrating into the biological target-containing sample to a distance of less than about 200 nanometers from the waveguide thereby exciting the fluorescent-label in any bound reporter ligand within a distance of less than about 200 nanometers from the waveguide and resulting in a detectable signal.

2. 发明申请

US20050078903A1 Waveguide-based optical chemical sensor 有权
标题翻译：基于波导的光学化学传感器
公开(公告)号：US20050078903A1
公开(公告)日：2005-04-14
申请号：US10958965
申请日：2004-10-04
申请人： Karen Grace , Basil Swanson , Seppo Honkanen
发明人： Karen Grace , Basil Swanson , Seppo Honkanen
IPC分类号： G01N21/21 , G01N21/77 , G02B6/10 , G02B6/122 , G02B6/00
CPC分类号： G02B6/1221 , G01N21/21 , G01N21/7703 , G01N2021/7709 , G01N2021/7776 , G02B6/105
摘要： The invention provides an apparatus and method for highly selective and sensitive chemical sensing. Two modes of laser light are transmitted through a waveguide, refracted by a thin film host reagent coating on the waveguide, and analyzed in a phase sensitive detector for changes in effective refractive index. Sensor specificity is based on the particular species selective thin films of host reagents which are attached to the surface of the planar optical waveguide. The thin film of host reagents refracts laser light at different refractive indices according to what species are forming inclusion complexes with the host reagents.
摘要翻译：本发明提供了一种用于高选择性和敏感的化学感测的装置和方法。激光的两种模式通过波导传输，由波导上的薄膜主体试剂涂层折射，并在相敏检测器中分析有效折射率的变化。传感器的特异性是基于附着于平面光波导表面的主体试剂的特定种类的选择性薄膜。主体试剂的薄膜根据与宿主试剂形成包合配合物的物质折射不同折射率的激光。

3. 发明申请

US20050088648A1 Integrated optical biosensor system (IOBS) 有权
标题翻译：集成光学生物传感器系统（IOBS）
公开(公告)号：US20050088648A1
公开(公告)日：2005-04-28
申请号：US10842750
申请日：2004-05-11
申请人： Karen Grace , Martin Sweet , Roy Goeller , Leland Morrison , Wynne Grace , Jerome Kolar
发明人： Karen Grace , Martin Sweet , Roy Goeller , Leland Morrison , Wynne Grace , Jerome Kolar
IPC分类号： G01J3/30 , G01N21/64 , G01N21/77 , G01N33/543
CPC分类号： G01N21/6428 , B82Y10/00 , B82Y15/00 , B82Y30/00 , G01N33/54373 , G01N2021/6423
摘要： An optical biosensor has a first enclosure with a pathogen recognition surface, including a planar optical waveguide and grating located in the first enclosure. An aperture is in the first enclosure for insertion of sample to be investigated to a position in close proximity to the pathogen recognition surface. A laser in the first enclosure includes means for aligning and means for modulating the laser, the laser having its light output directed toward said grating. Detection means are located in the first enclosure and in optical communication with the pathogen recognition surface for detecting pathogens after interrogation by the laser light and outputting the detection. Electronic means is located in the first enclosure and receives the detection for processing the detection and outputting information on the detection, and an electrical power supply is located in the first enclosure for supplying power to the laser, the detection means and the electronic means.
摘要翻译：光学生物传感器具有带有病原体识别表面的第一外壳，包括位于第一外壳中的平面光波导和光栅。在第一外壳中有一个孔，用于将待研究的样品插入到病原体识别表面附近的位置。第一外壳中的激光器包括用于对准的装置和用于调制激光器的装置，激光器具有指向所述光栅的光输出。检测装置位于第一外壳中并与病原体识别表面光学通信，用于通过激光询问后检测病原体并输出检测。电子装置位于第一外壳中，并且接收检测以处理检测和输出关于检测的信息，并且电源位于第一外壳中，用于向激光，检测装置和电子装置供电。

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