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1. 发明授权

US08660628B2 Analyte sensors comprising blended membrane compositions and methods for making and using them 有权
标题翻译：分析物传感器包括混合膜组合物和制备和使用它们的方法
公开(公告)号：US08660628B2
公开(公告)日：2014-02-25
申请号：US12643790
申请日：2009-12-21
申请人： Jenn-Hann Larry Wang , Tri T. Dang , Brooks B. Cochran , John J. Mastrototaro , Rajiv Shah
发明人： Jenn-Hann Larry Wang , Tri T. Dang , Brooks B. Cochran , John J. Mastrototaro , Rajiv Shah
IPC分类号： A61B5/05
CPC分类号： G01N33/5438 , G01N27/307 , G01N33/54393
摘要： Embodiments of the invention provide analyte sensors having elements designed to modulate their chemical reactions as well as methods for making and using such sensors. In certain embodiments of the invention, the sensor includes an analyte modulating membrane that comprises a blended mixture of a linear polyurethane/polyurea polymer, and a branched acrylate polymer.
摘要翻译：本发明的实施例提供了分析物传感器，其具有被设计成调节其化学反应的元件以及用于制造和使用这些传感器的方法。在本发明的某些实施方案中，传感器包括分析物调节膜，其包含线性聚氨酯/聚脲聚合物和支化丙烯酸酯聚合物的共混混合物。

2. 发明申请

US20130178726A1 STABILIZED POLYMERS FOR USE WITH ANALYTE SENSORS AND METHODS FOR MAKING AND USING THEM 审中-公开
标题翻译：用于分析传感器的稳定聚合物及其制备和使用方法
公开(公告)号：US20130178726A1
公开(公告)日：2013-07-11
申请号：US13344343
申请日：2012-01-05
申请人： Jenn-Hann Larry Wang , Brooks B. Cochran , Tri T. Dang , Rajiv Shah
发明人： Jenn-Hann Larry Wang , Brooks B. Cochran , Tri T. Dang , Rajiv Shah
IPC分类号： A61B5/1477 , C08G77/388 , A61K49/00
CPC分类号： C08G77/458 , C08K5/13 , C12Q1/002 , C08L75/00
摘要： Embodiments of the invention provide analyte sensors having elements designed to modulate their chemical reactions as well as methods for making and using such sensors. In certain embodiments of the invention, the sensor includes an analyte modulating membrane that comprises a linear polyurethane/polyurea polymer comprising one or more agents selected for their ability to stabilize the polymers against thermal and/or oxidative degradation.
摘要翻译：本发明的实施例提供了分析物传感器，其具有被设计成调节其化学反应的元件以及用于制造和使用这些传感器的方法。在本发明的某些实施方案中，传感器包括分析物调节膜，其包含线性聚氨酯/聚脲聚合物，其包含一种或多种选自其稳定聚合物抵抗热和/或氧化降解的能力的试剂。

3. 发明申请

US20110152654A1 ANALYTE SENSORS COMPRISING BLENDED MEMBRANE COMPOSITIONS AND METHODS FOR MAKING AND USING THEM 有权
标题翻译：包含混合膜组合物的分析仪传感器及其制备和使用方法
公开(公告)号：US20110152654A1
公开(公告)日：2011-06-23
申请号：US12643790
申请日：2009-12-21
申请人： Jenn-Hann Larry Wang , Tri T. Dang , Brooks B. Cochran , John J. Mastrototaro , Rajiv Shah
发明人： Jenn-Hann Larry Wang , Tri T. Dang , Brooks B. Cochran , John J. Mastrototaro , Rajiv Shah
IPC分类号： A61B5/1473 , G01N27/26 , C12Q1/26 , B05D1/36
CPC分类号： G01N33/5438 , G01N27/307 , G01N33/54393
摘要： Embodiments of the invention provide analyte sensors having elements designed to modulate their chemical reactions as well as methods for making and using such sensors. In certain embodiments of the invention, the sensor includes an analyte modulating membrane that comprises a blended mixture of a linear polyurethane/polyurea polymer, and a branched acrylate polymer.
摘要翻译：本发明的实施例提供了分析物传感器，其具有被设计成调节其化学反应的元件以及用于制造和使用这些传感器的方法。在本发明的某些实施方案中，传感器包括分析物调节膜，其包含线性聚氨酯/聚脲聚合物和支化丙烯酸酯聚合物的共混混合物。

4. 发明申请

US20080026473A1 Analyte sensors and methods for making and using them 有权
标题翻译：分析物传感器和制造和使用它们的方法
公开(公告)号：US20080026473A1
公开(公告)日：2008-01-31
申请号：US11492273
申请日：2006-07-25
申请人： Yunbing Wang , Udo Hoss , Rajiv Shah , Jenn-Hann Larry Wang , William P. Van Antwerp , Brooks B. Cochran
发明人： Yunbing Wang , Udo Hoss , Rajiv Shah , Jenn-Hann Larry Wang , William P. Van Antwerp , Brooks B. Cochran
IPC分类号： G01N33/48 , A61B5/05 , C08G77/04
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/14546 , C12Q1/006 , Y10T29/49002
摘要： Embodiments of the invention provide analyte sensors having elements designed to modulate their chemical reactions as well as methods for making and using such sensors. In certain embodiments of the invention, the sensor includes a hydrophilic comb-copolymer having a central chain and a plurality of side chains coupled to the central chain, wherein at least one side chain comprises a silicone moiety.
摘要翻译：本发明的实施例提供了分析物传感器，其具有被设计成调节其化学反应的元件以及用于制造和使用这些传感器的方法。在本发明的某些实施方案中，传感器包括具有中心链和耦合到中心链的多个侧链的亲水梳状共聚物，其中至少一个侧链包含硅氧烷部分。

5. 发明授权

US09237865B2 Analyte sensors and methods for making and using them 有权
标题翻译：分析物传感器和制造和使用它们的方法
公开(公告)号：US09237865B2
公开(公告)日：2016-01-19
申请号：US11492273
申请日：2006-07-25
申请人： Yunbing Wang , Rajiv Shah , Jenn-Hann Larry Wang , William P. Van Antwerp , Brooks B. Cochran
发明人： Yunbing Wang , Udo Hoss , Rajiv Shah , Jenn-Hann Larry Wang , William P. Van Antwerp , Brooks B. Cochran
IPC分类号： G01N33/48 , A61B5/05 , A61B5/1486 , A61B5/145 , C12Q1/00
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/14546 , C12Q1/006 , Y10T29/49002
摘要： Embodiments of the invention provide analyte sensors having elements designed to modulate their chemical reactions as well as methods for making and using such sensors. In certain embodiments of the invention, the sensor includes a hydrophilic comb-copolymer having a central chain and a plurality of side chains coupled to the central chain, wherein at least one side chain comprises a silicone moiety.
摘要翻译：本发明的实施例提供了分析物传感器，其具有被设计成调节其化学反应的元件以及用于制造和使用这些传感器的方法。在本发明的某些实施方案中，传感器包括具有中心链和耦合到中心链的多个侧链的亲水梳状共聚物，其中至少一个侧链包含硅氧烷部分。

6. 发明授权

US06642015B2 Hydrophilic polymeric material for coating biosensors 有权
标题翻译：用于涂覆生物传感器的亲水性聚合材料
公开(公告)号：US06642015B2
公开(公告)日：2003-11-04
申请号：US09753095
申请日：2000-12-29
申请人： David J. Vachon , Brooks B. Cochran , Bill C. Ponder
发明人： David J. Vachon , Brooks B. Cochran , Bill C. Ponder
IPC分类号： C12Q154
CPC分类号： C08G18/61 , C08G18/5024 , C08G18/6685 , C09D175/02 , C12Q1/002 , Y10T428/31551 , Y10T428/31663
摘要： Disclosed is a biocompatible membrane comprising a hydrophilic polyurea composition. The hydrophilic polyurea composition comprises the product of a reaction mixture comprising (a) an amino terminated polysiloxane, (b) a hydrophilic polymer selected from the group consisting of a diamino terminated copolymer of polypropylene glycol and polyethylene glycol, polyethylene glycol, polypropylene glycol and diamino polyethylene glycol having an average molecular weight of from about 400 to about 2000, and (c) a diisocyanate selected from the group consisting of hexamethylene-1,6-diisocyanate, dicyclohexylmethane 4,4′-diisocyanate, and isophorone diisocyanate, and constituting about 50 mole % of the reaction mixture. In this mixture, (a) and (b) constitute a polymeric portion of the reaction mixture, and the hydrophilic polyurea composition has a ratio of its diffusion coefficient for oxygen to its diffusion coefficient for glucose of from about 2,000 to about 10,000. Also provided are biosensors coated with a membrane of the invention, and methods of using such biosensors to measure an analyte in a tissue of a subject.
摘要翻译：公开了包含亲水性聚脲组合物的生物相容性膜。亲水性聚脲组合物包含反应混合物的产物，该反应混合物包含（a）氨基封端的聚硅氧烷，（b）亲水性聚合物，其选自聚丙二醇与聚乙二醇的二氨基封端的共聚物，聚乙二醇，聚丙二醇和二氨基平均分子量为约400至约2000的聚乙二醇和（c）选自六亚甲基-1,6-二异氰酸酯，二环己基甲烷4,4'-二异氰酸酯和异佛尔酮二异氰酸酯的二异氰酸酯，并且构成约 50摩尔％的反应混合物。在该混合物中，（a）和（b）构成反应混合物的聚合物部分，亲水性聚脲组合物的氧扩散系数与其对葡萄糖的扩散系数的比例为约2,000至约10,000。还提供了涂覆有本发明的膜的生物传感器，以及使用这种生物传感器来测量受试者组织中的分析物的方法。

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