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1. 发明申请

US20080213406A1 Compositions and methods for enhancing cognitive function 有权
标题翻译：用于增强认知功能的组合和方法
公开(公告)号：US20080213406A1
公开(公告)日：2008-09-04
申请号：US11890278
申请日：2007-08-03
申请人： Jeffry Stock , Maxwell Stock , Haoming Gu , Gregory Stock , Zhu Li , Peter Wolanin
发明人： Jeffry Stock , Maxwell Stock , Haoming Gu , Gregory Stock , Zhu Li , Peter Wolanin
IPC分类号： A61K36/25 , A61K36/16 , A61K36/8962 , A61K36/38 , A61K36/81 , A61P25/00 , A61K36/82 , A61K36/87 , A61K36/55
CPC分类号： A23F5/24 , A23F3/16 , A23F5/36 , A23G3/36 , A23G3/48 , A23G4/06 , A23G4/068 , A23L2/02 , A23L2/38 , A23L33/105 , A23L33/40 , A61K31/355 , A61K36/16 , A61K36/185 , A61K36/258 , A61K36/28 , A61K36/38 , A61K36/55 , A61K36/74 , A61K36/81 , A61K36/82 , A61K36/87 , A61K36/8962 , A61K45/06 , A61K2300/00
摘要： Disclosed are compositions for promoting general health and well-being, comprising an extract of a botanical raw material, wherein said extract inhibits the carboxyl demethylating activity of a protein phosphatase, and methods of making and using same.
摘要翻译：公开了用于促进一般健康和幸福的组合物，其包含植物原料的提取物，其中所述提取物抑制蛋白质磷酸酶的羧基去甲基化活性，以及制备和使用它们的方法。

2. 发明授权

US07923041B2 Compositions and methods for enhancing cognitive function 有权
标题翻译：用于增强认知功能的组合和方法
公开(公告)号：US07923041B2
公开(公告)日：2011-04-12
申请号：US11890278
申请日：2007-08-03
申请人： Jeffry Stock , Maxwell Stock , Haoming Gu , Zhu Li , Peter Wolanin
发明人： Jeffry Stock , Maxwell Stock , Haoming Gu , Zhu Li , Peter Wolanin
IPC分类号： A61K36/00 , A61K36/254 , A61K9/00 , A61K47/00
CPC分类号： A23F5/24 , A23F3/16 , A23F5/36 , A23G3/36 , A23G3/48 , A23G4/06 , A23G4/068 , A23L2/02 , A23L2/38 , A23L33/105 , A23L33/40 , A61K31/355 , A61K36/16 , A61K36/185 , A61K36/258 , A61K36/28 , A61K36/38 , A61K36/55 , A61K36/74 , A61K36/81 , A61K36/82 , A61K36/87 , A61K36/8962 , A61K45/06 , A61K2300/00
摘要： Disclosed are compositions for promoting general health and well-being, comprising an extract of a botanical raw material, wherein said extract inhibits the carboxyl demethylating activity of a protein phosphatase, and methods of making and using same.
摘要翻译：公开了用于促进一般健康和幸福的组合物，其包含植物原料的提取物，其中所述提取物抑制蛋白质磷酸酶的羧基去甲基化活性，以及制备和使用它们的方法。

3. 发明申请

US20060171938A1 Compositions and methods for enhancing cognitive function 有权
标题翻译：用于增强认知功能的组合和方法
公开(公告)号：US20060171938A1
公开(公告)日：2006-08-03
申请号：US11346706
申请日：2006-02-03
申请人： Jeffry Stock , Maxwell Stock , Gu Haoming , Gregory Stock , Zhu Li , Peter Wolanin
发明人： Jeffry Stock , Maxwell Stock , Gu Haoming , Gregory Stock , Zhu Li , Peter Wolanin
IPC分类号： A61K38/46 , A61K36/16 , A61K36/8962
CPC分类号： A61K31/355 , A23F5/24 , A23F5/267 , A23G3/36 , A23G3/48 , A23G4/06 , A23G4/068 , A23L2/02 , A23L2/38 , A23L33/105 , A23L33/40 , A23V2002/00 , A61K36/16 , A61K36/185 , A61K36/258 , A61K36/28 , A61K36/38 , A61K36/55 , A61K36/74 , A61K36/81 , A61K36/82 , A61K36/87 , A61K36/8962 , A61K45/06 , A61K2300/00 , A23V2200/322 , A23V2250/21
摘要： The invention encompasses novel compositions containing a methylation modifying compound isolated from botanical raw materials, including a fruit of the genus Coffea, and microbial raw materials, methods of making such compositions, and methods of treating or preventing human disease using such compositions. The methylation modifying compound in botanical extracts of the present invention can dramatically increase the level of methylation of PP2A, thus increasing cognitive function, particularly in persons suffering from or prone to developing Alzheimer's disease.
摘要翻译：本发明包括含有从植物原料分离的甲基化修饰化合物的新型组合物，其包括咖啡属的果实，微生物原料，制备这种组合物的方法，以及使用这些组合物治疗或预防人类疾病的方法。本发明的植物提取物中的甲基化修饰化合物可以显着增加PP2A的甲基化水平，从而增加认知功能，特别是在患有或易于发生阿尔茨海默病的人中。

4. 发明授权

US08221804B2 Compositions and methods for enhancing cognitive function 有权
标题翻译：用于增强认知功能的组合和方法
公开(公告)号：US08221804B2
公开(公告)日：2012-07-17
申请号：US11346706
申请日：2006-02-03
申请人： Jeffry B. Stock , Maxwell Stock , Haoming Gu , Gregory B Stock , Zhu Li , Peter Michael Wolanin
发明人： Jeffry B. Stock , Maxwell Stock , Haoming Gu , Gregory B Stock , Zhu Li , Peter Michael Wolanin
IPC分类号： A61K36/258 , A61K36/82 , A61K36/81 , A61K36/16 , A61K36/87
CPC分类号： A61K31/355 , A23F5/24 , A23F5/267 , A23G3/36 , A23G3/48 , A23G4/06 , A23G4/068 , A23L2/02 , A23L2/38 , A23L33/105 , A23L33/40 , A23V2002/00 , A61K36/16 , A61K36/185 , A61K36/258 , A61K36/28 , A61K36/38 , A61K36/55 , A61K36/74 , A61K36/81 , A61K36/82 , A61K36/87 , A61K36/8962 , A61K45/06 , A61K2300/00 , A23V2200/322 , A23V2250/21
摘要： The invention encompasses novel compositions containing a methylation modifying compound isolated from botanical raw materials, including a fruit of the genus Coffea, and microbial raw materials, methods of making such compositions, and methods of treating or preventing human disease using such compositions. The methylation modifying compound in botanical extracts of the present invention can dramatically increase the level of methylation of PP2A, thus increasing cognitive function, particularly in persons suffering from or prone to developing Alzheimer's disease.
摘要翻译：本发明包括含有从植物原料分离的甲基化修饰化合物的新型组合物，其包括咖啡属的果实，微生物原料，制备这种组合物的方法，以及使用这些组合物治疗或预防人类疾病的方法。本发明的植物提取物中的甲基化修饰化合物可以显着增加PP2A的甲基化水平，从而增加认知功能，特别是在患有或易于发生阿尔茨海默病的人中。

5. 发明授权

US09486441B2 Compounds, compositions and methods for making the same 有权
标题翻译：化合物，组合物和制备方法
公开(公告)号：US09486441B2
公开(公告)日：2016-11-08
申请号：US12427743
申请日：2009-04-21
申请人： Scott Vafai , Michael Voronkov , Maxwell Stock , Jeffry B. Stock , Seung-Yub Lee , Zhu Li , Haoming Gu
发明人： Scott Vafai , Michael Voronkov , Maxwell Stock , Jeffry B. Stock , Seung-Yub Lee , Zhu Li , Haoming Gu
IPC分类号： A61K31/405
CPC分类号： A61K31/405
摘要： The present invention provides compounds and/or compositions that modulate PP2A methylation and/or activity and methods for preparing the same, which are useful for modulating the demethylation of PP2A, modulating the methylation of PP2A and/or modulating the activity of PP2A.
摘要翻译：本发明提供调节PP2A甲基化和/或活性的化合物和/或组合物及其制备方法，其可用于调节PP2A的去甲基化，调节PP2A的甲基化和/或调节PP2A的活性。

6. 发明申请

US20090264496A1 Compounds, Compositions and Methods for Making the Same 有权
标题翻译：化合物，组合物和制备方法
公开(公告)号：US20090264496A1
公开(公告)日：2009-10-22
申请号：US12427743
申请日：2009-04-21
申请人： Scott Vafai , Michael Voronkov , Maxwell Stock , Jeffry B. Stock , Seung-Yub Lee , Zhu Li , Haoming Gu
发明人： Scott Vafai , Michael Voronkov , Maxwell Stock , Jeffry B. Stock , Seung-Yub Lee , Zhu Li , Haoming Gu
IPC分类号： A61K31/405
CPC分类号： A61K31/405
摘要： The present invention provides compounds and/or compositions that modulate PP2A methylation and/or activity and methods for preparing the same, which are useful for modulating the demethylation of PP2A, modulating the methylation of PP2A and/or modulating the activity of PP2A.
摘要翻译：本发明提供调节PP2A甲基化和/或活性的化合物和/或组合物及其制备方法，其可用于调节PP2A的去甲基化，调节PP2A的甲基化和/或调节PP2A的活性。

7. 发明申请

US20070031909A1 Modulation of protein methylation and phosphoprotein phosphate 失效
标题翻译：蛋白质甲基化和磷酸蛋白磷酸调节
公开(公告)号：US20070031909A1
公开(公告)日：2007-02-08
申请号：US10579369
申请日：2003-03-13
申请人： Gregory Stock , Jeffry Stock , Maxwell Stock , Scott Vafai
发明人： Gregory Stock , Jeffry Stock , Maxwell Stock , Scott Vafai
IPC分类号： A61K36/00 , C12Q1/42
CPC分类号： G01N33/6896 , C12Q1/42 , C12Q1/48 , G01N2500/00
摘要： The invention relates to methylated proteins that control protein phosphorylation, particularly phosphoesterases, such as PP2A. It relates to screening methods for determining agents that affect methylation of these proteins and thus also modulate the level of phosphorylation of phosphoproteins. It relates as well to the agents and to compositions comprising the agents. In a particular aspect in this regard the invention relates to agents that alter PP2A methylation and that thereby affect phosphorylation of phosphoproteins that play an important role in health or disease, such as the tau protein which is implicated in the etiology of Alzheimer's Disease. The invention further relates to diagnostic methods based on protein methylation levels, to compositions comprising agents for affecting methylation of proteins and for controlling the phosphate complement of phosphoproteins. Additionally, the invention relates to methods for administering the agents and compositions to affect methylation of proteins physiologically and to modulate the phosphate complement of phosphoproteins. Examples in this regard include agents and compositions that affect physiological activity of PP2A and alter the phosphate complement of phosphoproteins that are altered in disease.
摘要翻译：本发明涉及控制蛋白磷酸化的甲基化蛋白质，特别是磷酸酯酶，例如PP2A。它涉及用于确定影响这些蛋白质甲基化的试剂的筛选方法，因此也调节磷酸化蛋白的磷酸化水平。它还涉及试剂和包含试剂的组合物。在这方面的一个特定方面，本发明涉及改变PP2A甲基化并因此影响在健康或疾病中发挥重要作用的磷酸化蛋白质的磷酸化的试剂，例如与阿尔茨海默病病因有关的tau蛋白。本发明进一步涉及基于蛋白质甲基化水平的诊断方法，包括影响蛋白质甲基化和控制磷酸蛋白磷酸化补体的试剂的组合物。此外，本发明涉及用于施用影响蛋白质生理学上的甲基化并调节磷酸蛋白的磷酸盐补体的试剂和组合物的方法。在这方面的实例包括影响PP2A的生理活性并改变在疾病中改变的磷酸蛋白的磷酸盐补体的药剂和组合物。

8. 发明申请

US20050277694A1 Topical compositions and methods for epithelial-related conditions 有权
标题翻译：上皮组织和上皮相关病症的方法
公开(公告)号：US20050277694A1
公开(公告)日：2005-12-15
申请号：US11151174
申请日：2005-06-13
申请人： Jeffry Stock , Joel Gordon , Maxwell Stock , Greg Stock
发明人： Jeffry Stock , Joel Gordon , Maxwell Stock , Greg Stock
IPC分类号： A61K31/198 , A61K31/20
CPC分类号： A61K31/198 , A61K8/46 , A61K31/20 , A61K45/06 , A61K2800/75 , A61K2800/782 , A61Q19/00 , C07C323/59
摘要： The present invention relates to pharmaceutical, cosmetic and cosmeceutical topical compositions containing polyisoprenyl-protein inhibitor compounds and methods useful in the promotion of healthy epithelium and the treatment of epithelial-related conditions
摘要翻译：本发明涉及含有聚异戊二烯基蛋白抑制剂化合物的药物，化妆品和药妆外用组合物以及用于促进健康上皮和治疗上皮相关病症的方法

9. 发明申请

US20110070296A1 TOPICAL COMPOSITIONS AND METHODS FOR UTILIZING PEPTIDES CONTAINING LIPID-MODIFIED CYSTEINE-CONTAINING PEPTIDES 审中-公开
标题翻译：用于使用含脂肪改性的含有CYPTS的肽的肽的局部组合物和方法
公开(公告)号：US20110070296A1
公开(公告)日：2011-03-24
申请号：US12919449
申请日：2009-02-25
申请人： Seung-Yub Lee , Eduardo Perez , Gopal Sarngadharan , Jeffry B. Stock , Maxwell Stock , Michael Voronkov , Peter Wolanin
发明人： Seung-Yub Lee , Eduardo Perez , Gopal Sarngadharan , Jeffry B. Stock , Maxwell Stock , Michael Voronkov , Peter Wolanin
IPC分类号： A61K9/127 , A61K38/02 , A61K38/16 , A61K8/64 , A61K38/22 , A61Q11/00 , A61P17/00 , A61P17/10 , A61P39/00 , A61P17/12 , A61Q17/04 , A61P31/00 , A61P31/10 , A61P31/12 , A61P33/02 , A61P23/00 , A61P29/00 , A61P17/04 , A61P39/06 , A61P3/02 , A61Q19/00 , A61Q19/10
CPC分类号： C07K1/1077 , A61K8/64 , A61K9/0014 , A61K9/006 , A61K9/127 , A61K9/7023 , A61Q19/007
摘要： Described are compositions for topical application to keratinous tissues or substrates such as skin, or mucosal surfaces. The composition may be used to treat a skin condition or disease. The composition comprises at least one polypeptide and/or lipidated peptide and a carrier.
摘要翻译：描述了用于局部施用于角质组织或底物如皮肤或粘膜表面的组合物。该组合物可用于治疗皮肤状况或疾病。该组合物包含至少一种多肽和/或脂化肽和载体。

10. 发明申请

US20090170917A1 Acid Mimic Compounds for the Inhibition of Isoprenyl-S-Cysteinyl Methyltransferase 审中-公开
标题翻译：用于抑制异戊二烯基-S-半胱氨酰甲基转移酶的酸性模拟化合物
公开(公告)号：US20090170917A1
公开(公告)日：2009-07-02
申请号：US12326746
申请日：2008-12-02
申请人： Seung-Yub Lee , Eduardo Perez , Keshava Rapole , Gopal Sarngadharan , Gregory B. Stock , Jeffry B. Stock , Maxwell Stock , Michael Voronkov , Peter Wolanin
发明人： Seung-Yub Lee , Eduardo Perez , Keshava Rapole , Gopal Sarngadharan , Gregory B. Stock , Jeffry B. Stock , Maxwell Stock , Michael Voronkov , Peter Wolanin
IPC分类号： A61K31/41 , A61K31/27 , C07C271/22 , A61K31/16 , C07C243/34 , C07D257/04 , A61P11/00
CPC分类号： C07D231/12 , C07C323/60 , C07D233/61 , C07D235/14 , C07D249/04 , C07D249/08 , C07D257/04
摘要： Among other things, the present invention provides novel compounds capable of effectively inhibiting inflammatory responses that are mediated by G-proteins or GPCRs in neutrophils, macrophages and platelets. In particular, compounds of the present invention act as inhibitors of edema, inhibitors of erythema and inhibitors of MPO (myeloperoxidase), pharmaceutical compositions containing the same compounds and the use thereof for the treatment of diseases that may benefit from edema, erythema and MPO inhibition, such as inflammation (acute or chronic), asthma, autoimmune diseases, and chronic obstructive pulmonary disease (COPD) (e.g., emphysema, chronic bronchitis and small airways disease, etc.), inflammatory responses of the immune system, skin diseases (e.g., reducing acute skin irritation for patients suffering from rosacea, atopic dermatitis, seborrheic dermatitis, psoriasis), irritable bowel syndrome (e.g., Chron's disease and ulcerative colitis, etc.), and central nervous system disorders (e.g., Parkinson's disease).
摘要翻译：除此之外，本发明提供能够有效抑制嗜中性粒细胞，巨噬细胞和血小板中G蛋白或GPCR介导的炎症反应的新型化合物。特别地，本发明的化合物作为水肿抑制剂，红斑抑制剂和MPO抑制剂（髓过氧化物酶），含有相同化合物的药物组合物及其用于治疗可能受益于水肿，红斑和MPO抑制的疾病的用途例如炎症（急性或慢性），哮喘，自身免疫疾病和慢性阻塞性肺病（COPD）（例如肺气肿，慢性支气管炎和小气道疾病等），免疫系统的炎症反应，皮肤疾病（例如对于患有酒渣鼻，特应性皮炎，脂溢性皮炎，牛皮癣的患者，肠易激综合征（例如，Chron氏病和溃疡性结肠炎等）以及中枢神经系统疾病（例如帕金森氏病））减少急性皮肤刺激。

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