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1. 发明申请

US20060270781A1 SYSTEMS AND METHODS FOR CONTROLLING AND FORMING POLYMER GELS 有权
标题翻译：用于控制和形成聚合物凝胶的系统和方法
公开(公告)号：US20060270781A1
公开(公告)日：2006-11-30
申请号：US11462799
申请日：2006-08-07
申请人： Jeffrey Ruberti , Gavin Braithwaite
发明人： Jeffrey Ruberti , Gavin Braithwaite
IPC分类号： A61F2/44 , C08L29/04
CPC分类号： A61F2/442 , A61F2002/444 , A61L27/16 , A61L27/52 , A61L2430/38 , C08J3/09 , C08J2329/04 , C08L29/04 , Y10S516/902 , Y10S524/916 , C08L2666/26
摘要： In preferred embodiments, the present invention provides methods of controllably making a vinyl polymer hydrogel having desired physical properties without chemical cross links or radiation. The gelation process is modulated by controlling, for example, the temperature of a resultant vinyl polymer mixture having a gellant or using active ingredients provided in an inactive gellant complex. In accordance with a preferred embodiment, the method of manufacturing a vinyl polymer hyrodgel includes the steps of providing a vinyl polymer solution comprising a vinyl polymer dissolved in a first solvent; heating the vinyl polymer solution to a temperature elevated above the melting point of the physical associations of the vinyl polymer, mixing the vinyl polymer solution with a gellant, wherein the resulting mixture has a higher Flory interaction parameter than the vinyl polymer solution; inducing gelation of the mixture of vinyl polymer solution and gellant; and controlling the gelation rate to form a viscoelastic solution, wherein workability is maintained for a predetermined period, thereby making a vinyl polymer hydrogel having the desired physical property. In further preferred embodiments, the present invention provides physically crosslinked hydrogels produced by controlled gellation of viscoelastic solution wherein workability is maintained for a predetermined period. In another aspect, the present invention provides kits for use in repairing intervertebral disks or articulated joints including components that form the vinyl polymer hydrogel and a dispenser.
摘要翻译：在优选的实施方案中，本发明提供了可控地制备具有所需物理性质而没有化学交联或辐射的乙烯基聚合物水凝胶的方法。通过控制例如具有胶凝剂的所得乙烯基聚合物混合物的温度或使用在非活性胶凝剂络合物中提供的活性成分来调节凝胶化过程。根据优选实施方案，制备乙烯基聚合物凝胶的方法包括以下步骤：提供包含溶解在第一溶剂中的乙烯基聚合物的乙烯基聚合物溶液; 将乙烯基聚合物溶液加热到高于乙烯基聚合物的物理缔合的熔点的温度，将乙烯基聚合物溶液与胶凝剂混合，其中所得混合物具有比乙烯基聚合物溶液更高的Flory相互作用参数; 引起乙烯基聚合物溶液和胶凝剂混合物的凝胶化; 并控制凝胶化速率以形成粘弹性溶液，其中可加工性保持预定时间，从而制备具有所需物理性能的乙烯基聚合物水凝胶。在进一步优选的实施方案中，本发明提供了通过可控制的粘弹性溶液凝胶制备的物理交联水凝胶，其中可操作性保持预定时间。另一方面，本发明提供了用于修复椎间盘或关节连接的试剂盒，其包括形成乙烯基聚合物水凝胶的组分和分配器。

2. 发明申请

US20060228401A1 LAYERED ALIGNED POLYMER STRUCTURES AND METHODS OF MAKING SAME 审中-公开
标题翻译：层状对准的聚合物结构及其制备方法
公开(公告)号：US20060228401A1
公开(公告)日：2006-10-12
申请号：US11419918
申请日：2006-05-23
申请人： Gavin BRAITHWAITE , Jeffrey Ruberti
发明人： Gavin BRAITHWAITE , Jeffrey Ruberti
IPC分类号： A61K9/70 , A61K38/39
CPC分类号： A61L27/24 , A61L27/38 , A61L27/50 , A61L2400/18 , B29C41/045 , B29C41/22 , B29C41/36 , B29C41/52 , B29C48/022 , B29C48/08 , B29C67/0003 , B29C67/24 , B29C2037/90 , B29K2089/00 , B29K2995/005 , C08L89/06 , D01D5/18 , D01D5/38 , D01F4/00
摘要： This invention includes a method of producing a thin, oriented layer of polymer material. The material is preferably produced by the method of introducing a shearing flow to a free surface in a predominantly monomeric solution of the self-assembling polymer sub-units, and inducing polymerization or growth of the monomer while in this shearing flow. The system for forming the oriented layer of material provides relative movement between a delivery system and the substrate on or over which the material is deposited. The rate of flow of the material from the delivery system and the relative velocity between the deposition surface and the material as it is developed to the surface are controlled to properly orient the material and desired thickness. These rates can be adjusted to vary the properties of the film in a controlled manner. Preferred embodiments include either angular or linear relative movement between the delivery system and the substrate.
摘要翻译：本发明包括一种制备薄的取向层的聚合物材料的方法。该材料优选通过将剪切流引入自组装聚合物子单元的主要单体溶液中的自由表面并在该剪切流中引发单体的聚合或生长的方法来制备。用于形成材料的定向层的系统提供在材料沉积物上或其上的输送系统和基底之间的相对运动。控制来自输送系统的材料的流动速率以及沉积表面和材料在其被发展到表面时的相对速度，以适当地定向材料和期望的厚度。可以调整这些速率以便以受控的方式改变胶片的性质。优选实施例包括在输送系统和基底之间的角度或线性的相对运动。

3. 发明申请

US20050019488A1 Layered aligned polymer structures and methods of making same 审中-公开
标题翻译：分层对准的聚合物结构及其制备方法
公开(公告)号：US20050019488A1
公开(公告)日：2005-01-27
申请号：US10611674
申请日：2003-06-30
申请人： Gavin Braithwaite , Jeffrey Ruberti
发明人： Gavin Braithwaite , Jeffrey Ruberti
IPC分类号： A61L27/24 , A61L27/38 , A61L27/50 , B29C41/04 , B29C41/22 , B29C41/36 , B29C41/52 , B29C47/00 , B29C67/00 , B29C67/24 , C08L89/06 , D01D5/38 , D01F4/00 , B05D3/00
CPC分类号： A61L27/3813 , A61L27/24 , A61L27/3633 , A61L27/3641 , A61L27/3645 , A61L27/3804 , A61L27/3808 , A61L27/3843 , A61L27/50 , A61L2400/18 , B29C41/045 , B29C41/22 , B29C41/36 , B29C41/52 , B29C48/022 , B29C48/05 , B29C67/0003 , B29C67/24 , B29C2037/90 , B29K2089/00 , B29K2995/005 , C08L89/06 , D01D5/18 , D01D5/38 , D01F4/00
摘要： This invention includes a method of producing a nanostructured artificial template comprising more than one thin, oriented layer of polymer material. The material is preferably produced by the method of introducing a shearing flow to a free surface in a predominantly monomeric solution of the self-assembling polymer sub-units, and inducing polymerization or growth of the monomer while in this shearing flow. The system for forming the oriented layer of material provides relative movement between a delivery system and the substrate on or over which the material is deposited. The rate of flow of the material from the delivery system and the relative velocity between the deposition surface and the material as it is delivered to the surface are controlled to properly orient the material at the desired thickness. These rates can be adjusted to vary the properties of the film in a controlled manner. Preferred embodiments include either angular or linear relative movement between the delivery system and the substrate. The nanostructured artificial template is useful for inducing the production of a templated extracellular matrix by a population of cells.
摘要翻译：本发明包括一种制备纳米结构人造模板的方法，其包含多于一个薄的取向层的聚合物材料。该材料优选通过将剪切流引入自组装聚合物子单元的主要单体溶液中的自由表面并在该剪切流中引发单体的聚合或生长的方法来制备。用于形成材料的定向层的系统提供在材料沉积物上或其上的输送系统和基底之间的相对运动。控制来自输送系统的材料的流动速率以及在将其输送到表面时沉积表面和材料之间的相对速度被控制以使材料适当地定向在期望的厚度。可以调整这些速率以便以受控的方式改变胶片的性质。优选实施例包括在输送系统和基底之间的角度或线性的相对运动。纳米结构人造模板可用于诱导由细胞群产生模板的细胞外基质。

4. 发明申请

US20070167541A1 Systems and methods for controlling and forming polymer gels 审中-公开
标题翻译：用于控制和形成聚合物凝胶的系统和方法
公开(公告)号：US20070167541A1
公开(公告)日：2007-07-19
申请号：US10566263
申请日：2004-02-04
申请人： Jeffrey Ruberti , Gavin Braithwaite
发明人： Jeffrey Ruberti , Gavin Braithwaite
IPC分类号： C08K5/15
CPC分类号： C08J3/09 , A61K9/0024 , C08J2329/04
摘要： In preferred embodiments, the present invention provides methods of controllably making a vinyl polymer hydrogel having desired physical properties without chemical cross links or radiation. The gelation process is modulated by controlling, for example the temperature of a resultant vinyl polymer mixture having a gellant or using active ingredients provided in an inactive gellant complex. In accordance with a preferred embodiment the method of manufacturing a vinyl polymer hydrogel includes the steps of providing a vinyl polymer solution comprising a vinyl polymer dissolved in a first solvent; heating the vinyl polymer solution to a temperature elevated above the melting point of the physical associations of the vinyl polymer, mixing the vinyl polymer solution with a gellant wherein the resulting mixture has a higher Flory interaction parameter than the vinyl polymer solution: inducing gelation of the mixture of vinyl polymer solution and gellant; and controlling the gelation rate to form a viscoelastic solution wherein workability is maintained for a predetermined period thereby making a vinyl polymer hydrogel having the desired physical property. In further preferred embodiments the present invention provides physically crosslinked hydrogels produced by controlled gelation of viscoelastic solution wherein workability is maintained for a predetermined period. In another aspect, the present invention provides kits for use in repairing intervertebral disks or articulated joints including components that form the vinyl polymer hydrogel and a dispenser.
摘要翻译：在优选的实施方案中，本发明提供了可控地制备具有所需物理性质而没有化学交联或辐射的乙烯基聚合物水凝胶的方法。通过控制例如具有胶凝剂的所得乙烯基聚合物混合物的温度或使用在非活性胶凝剂络合物中提供的活性成分来调节凝胶化过程。根据优选实施方案，制备乙烯基聚合物水凝胶的方法包括以下步骤：提供包含溶解在第一溶剂中的乙烯基聚合物的乙烯基聚合物溶液; 将乙烯基聚合物溶液加热到高于乙烯基聚合物的物理缔合的熔点的温度，将乙烯基聚合物溶液与胶凝胶混合，其中所得混合物具有比乙烯基聚合物溶液更高的Flory相互作用参数：引起凝胶化乙烯基聚合物溶液和胶凝剂的混合物; 并控制凝胶化速率以形成粘弹性溶液，其中可加工性保持预定时间，从而制备具有所需物理性能的乙烯基聚合物水凝胶。在进一步优选的实施方案中，本发明提供通过粘弹性溶液的受控凝胶化产生的物理交联水凝胶，其中可操作性保持预定时间。另一方面，本发明提供了用于修复椎间盘或关节连接的试剂盒，其包括形成乙烯基聚合物水凝胶的组分和分配器。

5. 发明申请

US20060159722A1 Layered aligned polymer structures and methods of making same 审中-公开
标题翻译：分层对准的聚合物结构及其制备方法
公开(公告)号：US20060159722A1
公开(公告)日：2006-07-20
申请号：US10536409
申请日：2003-11-26
申请人： Gavin Braithwaite , Jeffrey Ruberti
发明人： Gavin Braithwaite , Jeffrey Ruberti
IPC分类号： C12N5/08 , A61K9/70 , A61K35/44
CPC分类号： A61L27/3813 , A61L27/24 , A61L27/3633 , A61L27/3641 , A61L27/3645 , A61L27/3804 , A61L27/3808 , A61L27/3843 , A61L27/50 , A61L2400/18 , B29C41/045 , B29C41/22 , B29C41/36 , B29C41/52 , B29C48/022 , B29C48/05 , B29C67/0003 , B29C67/24 , B29C2037/90 , B29K2089/00 , B29K2995/005 , C08L89/06 , D01D5/18 , D01D5/38 , D01F4/00
摘要： This invention includes a method of producing a nanostructured artificial template comprising one or more thin, oriented layer of polymer material. The material is preferably produced by the method of introducing a shearing flow in a predominantly monomeric solution of the self-assembling polymer sub-units to the free surface of a substrate and inducing polymerization or growth of the monomer while in this shearing flow. The rate of flow of the material from the delivery system and the relative velocity between the deposition surface and the material as it is delivered to the surface are controlled to properly orient the material at the desired thickness. These rates can be adjusted to vary the properties of the film in a controlled manner. The nanostructured artificial template is useful for inducing the production of a templated extracellular matrix by a population of cells. The invention further includes a method of remodeling collagen constructs by alternating application of proteases and collagen monomers while the construct is stressed.
摘要翻译：本发明包括一种制备纳米结构人造模板的方法，其包括一个或多个薄的取向层的聚合物材料。该材料优选通过将剪切流引入自组装聚合物子单元的主要单体溶液到基材的自由表面并在该剪切流中引发单体的聚合或生长的方法来制备。控制来自输送系统的材料的流动速率以及在将其输送到表面时沉积表面和材料之间的相对速度被控制以使材料适当地定向在期望的厚度。可以调整这些速率以便以受控的方式改变胶片的性质。纳米结构人造模板可用于诱导由细胞群产生模板的细胞外基质。本发明还包括通过交替施用蛋白酶和胶原单体来改造胶原构建体的方法，同时构造物被应激。

6. 发明申请

US20090019877A1 Systems, Methods and Devices for Frozen Sample Distribution 有权
标题翻译：用于冷冻样品分配的系统，方法和设备
公开(公告)号：US20090019877A1
公开(公告)日：2009-01-22
申请号：US12087695
申请日：2007-01-16
申请人： Dale Larson , Jeffrey Ruberti , John Slusarz , Nicholas Goulas , Erin Rush , Trevor Ehret
发明人： Dale Larson , Jeffrey Ruberti , John Slusarz , Nicholas Goulas , Erin Rush , Trevor Ehret
IPC分类号： F25C5/00
CPC分类号： A01N1/0252 , A01N1/02 , A01N1/0242 , F25D31/00 , G01N1/08 , G01N1/42 , G01N2001/368
摘要： A drilling system including a motor that produces a sonic, linear oscillatory motion is provided for removing a frozen biological sample from a stored frozen specimen and methods of use thereof without thawing the remainder of the specimen. The stator and slider assembly is operated by a servo controller which can communicate and be programmed through a port of a PC equipped with software.
摘要翻译：提供了一种包括产生声音线性振荡运动的电动机的钻井系统，用于从存储的冷冻样品中除去冷冻的生物样品及其使用方法，而不融化样品的其余部分。定子和滑块组件由伺服控制器操作，该伺服控制器可以通过装有软件的PC的端口进行通信和编程。

7. 发明授权

US08448456B2 Systems, methods and devices for frozen sample distribution 有权
标题翻译：用于冷冻样品分配的系统，方法和装置
公开(公告)号：US08448456B2
公开(公告)日：2013-05-28
申请号：US12087695
申请日：2007-01-16
申请人： Dale Larson , Jeffrey Ruberti , John Slusarz , Nicholas Goulas , Erin Rush , Trevor Ehret
发明人： Dale Larson , Jeffrey Ruberti , John Slusarz , Nicholas Goulas , Erin Rush , Trevor Ehret
IPC分类号： F25D25/00
CPC分类号： A01N1/0252 , A01N1/02 , A01N1/0242 , F25D31/00 , G01N1/08 , G01N1/42 , G01N2001/368
摘要： A drilling system including a motor that produces a sonic, linear oscillatory motion is provided for removing a frozen biological sample from a stored frozen specimen and methods of use thereof without thawing the remainder of the specimen. The stator and slider assembly is operated by a servo controller which can communicate and be programmed through a port of a PC equipped with software.
摘要翻译：提供了一种包括产生声音线性振荡运动的电动机的钻井系统，用于从存储的冷冻样品中除去冷冻的生物样品及其使用方法，而不融化样品的其余部分。定子和滑块组件由伺服控制器操作，该伺服控制器可以通过装有软件的PC的端口进行通信和编程。

8. 发明申请

US20060079597A1 PVA hydrogel 失效
标题翻译： PVA水凝胶
公开(公告)号：US20060079597A1
公开(公告)日：2006-04-13
申请号：US10962975
申请日：2004-10-12
申请人： Orhun Muratoglu , Stephen Spiegelberg , Jeffrey Ruberti , Niels Abt
发明人： Orhun Muratoglu , Stephen Spiegelberg , Jeffrey Ruberti , Niels Abt
IPC分类号： B29D11/00
CPC分类号： C08J3/28 , C08J2329/04 , Y10S524/916
摘要： The present invention provides methods of making covalently crosslinked vinyl polymer hydrogels having advantageous physical properties, and covalently crosslinked vinyl polymer hydrogel compositions made by such methods, as well as articles of manufacture comprising such covalently crosslinked vinyl polymer hydrogel compositions. The physical properties of the produced hydrogels can be adjusted by varying controlled parameters such as the proportion of physical associations, the concentration of polymer and the amount of radiation applied. Such covalently crosslinked vinyl polymer hydrogels can be made translucent, preferably transparent, or opaque depending on the processing conditions. The stability of the physical properties of the produced vinyl polymer hydrogel can be enhanced by controlling the amount of covalent crosslinks.
摘要翻译：本发明提供了制备具有有利物理性质的共价交联的乙烯基聚合物水凝胶和通过这些方法制备的共价交联的乙烯基聚合物水凝胶组合物的方法，以及包含这种共价交联的乙烯基聚合物水凝胶组合物的制品。所产生的水凝胶的物理性质可以通过改变受控参数来调节，例如物理缔合的比例，聚合物的浓度和施加的辐射量。根据加工条件，这种共价交联的乙烯基聚合物水凝胶可以制成半透明的，优选透明的或不透明的。所制备的乙烯基聚合物水凝胶的物理性质的稳定性可以通过控制共价交联剂的量来增强。

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