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    • 3. 发明授权
    • Calibration apparatus and method for fluorescent imaging
    • 用于荧光成像的校准装置和方法
    • US08107696B2
    • 2012-01-31
    • US11863345
    • 2007-09-28
    • Jeffrey PoteGregory PayonkNikiforos KolliasDick Jackson
    • Jeffrey PoteGregory PayonkNikiforos KolliasDick Jackson
    • G06K9/00
    • A61B5/441A61B5/0071A61B2560/0233G01N21/278G01N21/6456G01N21/6486G03B15/06G06K9/00255G06K9/2018
    • A fluorescence standard for identifying variations in illumination during imaging has a composite fluorescent laminar structure, which fluoresces in response to light in the approximate wavelength range of 375 nm to 430 nm. The fluorescent object has at least two areas with different fluorescent response, e.g., a first made from a strongly luminescing material, such as GG420 filter glass. A portion of the GG420 glass is covered by filter glass having an attenuating effect on the fluorescent response. In accordance with a method of the present invention, variations in illumination during imaging with a camera are detected by placing the standard before the camera during imaging. Each captured image may contain the image of the standard and the fluorescent response of the standard in different images can be compared to identify any response changes due to variations in illumination. The variations in illumination can then be remediated by adjusting the source of illumination, the camera or ambient lighting. Alternatively, the images can be normalized through digital image processing.
    • 用于识别成像期间照明变化的荧光标准具有复合荧光层状结构,其响应于375nm至430nm的近似波长范围内的光而发荧光。 荧光物体具有至少两个具有不同荧光响应的区域,例如由强烈发光材料制成的第一区域,例如GG420过滤玻璃。 GG420玻璃的一部分被对荧光反应具有衰减作用的滤光玻璃覆盖。 根据本发明的方法,通过在成像期间将标准放置在相机之前来检测通过摄像机成像期间的照明变化。 每个拍摄的图像可以包含标准的图像,并且可以比较不同图像中的标准的荧光响应以识别由于照明变化引起的任何响应变化。 然后可以通过调整照明源,照相机或环境照明来修正照明变化。 或者,可以通过数字图像处理来对图像进行归一化。
    • 4. 发明申请
    • Calibration Apparatus and Method for Fluorescent Imaging
    • 荧光成像的校准装置和方法
    • US20080080781A1
    • 2008-04-03
    • US11863345
    • 2007-09-28
    • Jeffrey PoteGregory PayonkNikiforos KolliasDick Jackson
    • Jeffrey PoteGregory PayonkNikiforos KolliasDick Jackson
    • G06K9/40A61B1/06G03B17/08
    • A61B5/441A61B5/0071A61B2560/0233G01N21/278G01N21/6456G01N21/6486G03B15/06G06K9/00255G06K9/2018
    • A fluorescence standard for identifying variations in illumination during imaging has a composite fluorescent laminar structure, which fluoresces in response to light in the approximate wavelength range of 375 nm to 430 nm. The fluorescent object has at least two areas with different fluorescent response, e.g., a first made from a strongly luminescing material, such as GG420 filter glass. A portion of the GG420 glass is covered by filter glass having an attenuating effect on the fluorescent response. In accordance with a method of the present invention, variations in illumination during imaging with a camera are detected by placing the standard before the camera during imaging. Each captured image may contain the image of the standard and the fluorescent response of the standard in different images can be compared to identify any response changes due to variations in illumination. The variations in illumination can then be remediated by adjusting the source of illumination, the camera or ambient lighting. Alternatively, the images can be normalized through digital image processing.
    • 用于识别成像期间照明变化的荧光标准具有复合荧光层状结构,其响应于375nm至430nm的近似波长范围内的光而发荧光。 荧光物体具有至少两个具有不同荧光响应的区域,例如由强烈发光材料制成的第一区域,例如GG420过滤玻璃。 GG420玻璃的一部分被对荧光反应具有衰减作用的滤光玻璃覆盖。 根据本发明的方法,通过在成像期间将标准放置在相机之前来检测通过摄像机成像期间的照明变化。 每个拍摄的图像可以包含标准的图像,并且可以比较不同图像中的标准的荧光响应以识别由于照明变化引起的任何响应变化。 然后可以通过调整照明源,照相机或环境照明来修正照明变化。 或者,可以通过数字图像处理来对图像进行归一化。
    • 5. 发明申请
    • Apparatus for and method of taking and viewing images of the skin
    • 用于拍摄和观看皮肤图像的装置和方法
    • US20050195316A1
    • 2005-09-08
    • US10978284
    • 2004-10-29
    • Nikiforos KolliasKenneth MerolaJeffrey PoteGregory Payonk
    • Nikiforos KolliasKenneth MerolaJeffrey PoteGregory Payonk
    • G03B29/00H04N5/222
    • G03B29/00A61B5/0071A61B5/441G06F19/00
    • A self-contained, portable apparatus and corresponding method for capturing, displaying and analyzing images of a person includes a housing for containing a digital camera, a light source capable of providing at least two different wavelengths of light, a touch-screen display and a computer for controlling the camera, the light source and the display. The apparatus selectively captures and displays a plurality of digital images using different wavelengths of illuminating light. The light source may include a plurality of flashes and filters, some of which may be adjustable to adjust the angle of incidence of the illuminating light on the subject. Preferably, the apparatus is self-serve, allowing any person to capture, review and analyze the images. To that end, the apparatus may provide a moving image and verbal instructions to a user to aid in positioning themselves relative to the camera. Instruction may further be provided by text or internet connection for using the apparatus and/or interpreting the captured images. An intuitive graphic user interface with thumbnail images is employed. Focus control, zoom and synchronized side-by side comparison of images are available.
    • 用于捕获,显示和分析人的图像的独立的便携式设备和相应的方法包括用于容纳数字照相机的外壳,能够提供至少两种不同波长的光的光源,触摸屏显示器和 用于控制摄像机,光源和显示器的计算机。 该装置选择性地捕获和显示使用不同波长的照明光的多个数字图像。 光源可以包括多个闪光和滤光器,其中一些可以是可调节的,以调节被摄体上的照明光的入射角。 优选地,该装置是自助服务的,允许任何人捕获,查看和分析图像。 为此,设备可以向用户提供运动图像和口头指令,以帮助相对于照相机自己定位。 可以通过文本或因特网连接进一步提供使用该设备和/或解释所捕获的图像的指令。 使用具有缩略图的直观的图形用户界面。 焦点控制,缩放和同步并排比较图像可用。
    • 8. 发明授权
    • Imaging standard apparatus and method
    • 成像标准仪器和方法
    • US08189887B2
    • 2012-05-29
    • US12201044
    • 2008-08-29
    • Nikiforos KolliasJeffrey PoteGregory Payonk
    • Nikiforos KolliasJeffrey PoteGregory Payonk
    • G06K9/00H04N17/00H04N5/228
    • A61B5/441A61B5/0071A61B2560/0233G03B15/06G06K9/00255G06K9/2018
    • A standard used to test imaging systems is imaged by a digital camera which expresses the image of the standard as a plurality of pixels having associated intensities. A computer automatically finds the image of the standard in the image and quantitatively compares intensities of pixels of a subsequent image of the standard to the first image to discern changes indicative of malfunction. A set of images of the standard may be collected and compiled to develop standard data, such as average of median values, that can be used to test imaging apparatus. The standard may be provided with a plurality of types of imaging standards occupying sub-areas that produce a different photoresponse to a plurality of different light sources. A fluorescent standard may be included that has a plurality of different fluorescence levels. Multiple sub-areas of the same type may be distributed over the surface area of the standard to measure the photoresponse in several areas and also to facilitate locating all sub-areas of the standard, e.g., multiple white squares may be distributed over the standard that may be identified by thresholding. The results of testing via the standard may be graphically displayed.
    • 用于测试成像系统的标准由数字照相机成像,数字照相机将标准的图像表示为具有相关联的强度的多个像素。 计算机自动找到图像中的标准图像,并且定量地比较标准的后续图像的像素强度与第一图像,以辨别指示故障的变化。 可以收集和编辑一组标准的图像以开发可用于测试成像装置的标准数据,例如中值的平均值。 该标准可以设置有多种类型的成像标准,占据对多个不同光源产生不同光响应的子区域。 可以包括具有多个不同荧光水平的荧光标准。 相同类型的多个子区域可以分布在标准的表面区域上以测量几个区域中的光响应,并且还有助于定位标准的所有子区域,例如,可以在标准上分布多个白色正方形 可以通过阈值来识别。 可以图形显示通过标准测试的结果。
    • 9. 发明申请
    • Imaging Standard Apparatus and Method
    • 成像标准装置及方法
    • US20090059028A1
    • 2009-03-05
    • US12201044
    • 2008-08-29
    • Nikiforos KolliasJeffrey PoteGregory Payonk
    • Nikiforos KolliasJeffrey PoteGregory Payonk
    • H04N5/228H04N17/00
    • A61B5/441A61B5/0071A61B2560/0233G03B15/06G06K9/00255G06K9/2018
    • A standard used to test imaging systems is imaged by a digital camera which expresses the image of the standard as a plurality of pixels having associated intensities. A computer automatically finds the image of the standard in the image and quantitatively compares intensities of pixels of a subsequent image of the standard to the first image to discern changes indicative of malfunction. A set of images of the standard may be collected and compiled to develop standard data, such as average of median values, that can be used to test imaging apparatus. The standard may be provided with a plurality of types of imaging standards occupying sub-areas that produce a different photoresponse to a plurality of different light sources. A fluorescent standard may be included that has a plurality of different fluorescence levels. Multiple sub-areas of the same type may be distributed over the surface area of the standard to measure the photoresponse in several areas and also to facilitate locating all sub-areas of the standard, e.g., multiple white squares may be distributed over the standard that may be identified by thresholding. The results of testing via the standard may be graphically displayed.
    • 用于测试成像系统的标准由数字照相机成像,数字照相机将标准的图像表示为具有相关联的强度的多个像素。 计算机自动找到图像中的标准图像,并且定量地比较标准的后续图像的像素强度与第一图像,以辨别指示故障的变化。 可以收集和编辑一组标准的图像以开发可用于测试成像装置的标准数据,例如中值的平均值。 该标准可以设置有多种类型的成像标准,占据对多个不同光源产生不同光响应的子区域。 可以包括具有多个不同荧光水平的荧光标准。 相同类型的多个子区域可以分布在标准的表面区域上以测量几个区域中的光响应,并且还有助于定位标准的所有子区域,例如,可以在标准上分布多个白色正方形 可以通过阈值来识别。 可以图形显示通过标准测试的结果。