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1. 发明申请

US20100113463A1 PTERIDINONE DERIVATIVES FOR USE AS STEAROYL CoA DESATURASE INHIBITORS 审中-公开
标题翻译：用作硬脂酰辅酶A消化酶抑制剂的蝶啶酮衍生物
公开(公告)号：US20100113463A1
公开(公告)日：2010-05-06
申请号：US12684007
申请日：2010-01-07
申请人： Jeffrey Chisholm , Dmitry Koltun , Jeff Zablocki , Eric Parkhill , Andrey Glushkov , Natalya Vasilevich , Timur Zilbershtein , Andrew Cole , Tsung Lin , Ian Henderson
发明人： Jeffrey Chisholm , Dmitry Koltun , Jeff Zablocki , Eric Parkhill , Andrey Glushkov , Natalya Vasilevich , Timur Zilbershtein , Andrew Cole , Tsung Lin , Ian Henderson
IPC分类号： A61K31/519 , C07D475/00 , A61P9/12 , A61P9/10 , A61P35/00 , A61P3/04 , A61P3/10
CPC分类号： C07D487/04
摘要： The present invention discloses pteridinone derivatives for use as inhibitors of stearoyl-CoA desaturase having the structure of Formula I: The compounds are useful in treating and/or preventing various human diseases, mediated by stearoyl-CoA desaturase (SCD) enzymes, especially diseases related to abnormal lipid levels, cardiovascular disease, diabetes, obesity, metabolic syndrome and the like.
摘要翻译：本发明公开了用作具有式I结构的硬脂酰CoA去饱和酶抑制剂的蝶啶酮衍生物：该化合物可用于治疗和/或预防由硬脂酰辅酶A去饱和酶（SCD）酶介导的各种人类疾病，特别是疾病相关心血管疾病，糖尿病，肥胖症，代谢综合症等。

2. 发明授权

US07662819B2 Pteridinone derivatives for use as stearoyl CoA desaturase inhibitors 失效
标题翻译：用作硬脂酰CoA去饱和酶抑制剂的蝶啶酮衍生物
公开(公告)号：US07662819B2
公开(公告)日：2010-02-16
申请号：US11868407
申请日：2007-10-05
申请人： Jeffrey Chisholm , Dmitry Koltun , Jeff Zablocki , Eric Parkhill , Andrey Glushkov , Natalya Vasilevich , Timur Zilbershtein , Andrew Cole , Tsung Lin , Ian Henderson
发明人： Jeffrey Chisholm , Dmitry Koltun , Jeff Zablocki , Eric Parkhill , Andrey Glushkov , Natalya Vasilevich , Timur Zilbershtein , Andrew Cole , Tsung Lin , Ian Henderson
IPC分类号： A61K31/519 , C07D475/00 , A61P35/00 , A61P3/10 , A61P9/00
CPC分类号： C07D487/04
摘要： The present invention discloses pteridinone derivatives for use as inhibitors of stearoyl-CoA desaturase having the structure of Formula I: The compounds are useful in treating and/or preventing various human diseases, mediated by stearoyl-CoA desaturase (SCD) enzymes, especially diseases related to abnormal lipid levels, cardiovascular disease, diabetes, obesity, metabolic syndrome and the like.
摘要翻译：本发明公开了用作具有式I结构的硬脂酰CoA去饱和酶抑制剂的蝶啶酮衍生物：该化合物可用于治疗和/或预防由硬脂酰辅酶A去饱和酶（SCD）酶介导的各种人类疾病，特别是疾病相关心血管疾病，糖尿病，肥胖症，代谢综合症等。

3. 发明申请

US20080249100A1 PTERIDINONE DERIVATIVES FOR USE AS STEAROYL CoA DESATURASE INHIBITORS 失效
标题翻译：用作硬脂酰辅酶A消化酶抑制剂的蝶啶酮衍生物
公开(公告)号：US20080249100A1
公开(公告)日：2008-10-09
申请号：US11868407
申请日：2007-10-05
申请人： Jeffrey Chisholm , Dmitry Koltun , Jeff Zablocki , Eric Parkhill , Andrey Glushkov , Natalya Vasilevich , Timur Zilbershtein , Andrew Cole , Tsung Lin , Ian Henderson
发明人： Jeffrey Chisholm , Dmitry Koltun , Jeff Zablocki , Eric Parkhill , Andrey Glushkov , Natalya Vasilevich , Timur Zilbershtein , Andrew Cole , Tsung Lin , Ian Henderson
IPC分类号： A61K31/519 , A61P9/00 , A61P25/00 , A61P35/00 , A61P3/00 , C07D487/04
CPC分类号： C07D487/04
摘要： The present invention discloses pteridinone derivatives for use as inhibitors of stearoyl-CoA desaturase having the structure of Formula I: The compounds are useful in treating and/or preventing various human diseases, mediated by stearoyl-CoA desaturase (SCD) enzymes, especially diseases related to abnormal lipid levels, cardiovascular disease, diabetes, obesity, metabolic syndrome and the like.
摘要翻译：本发明公开了用作具有式I结构的硬脂酰CoA去饱和酶抑制剂的蝶啶酮衍生物：该化合物可用于治疗和/或预防由硬脂酰辅酶A去饱和酶（SCD）酶介导的各种人类疾病，特别是疾病相关心血管疾病，糖尿病，肥胖症，代谢综合症等。

4. 发明申请

US20080255161A1 3-HYDROQUINAZOLIN-4-ONE DERIVATIVES FOR USE AS STEAROYL CoA DESATURASE INHIBITORS 审中-公开
标题翻译：用作硬脂酸CoA去饱和酶抑制剂的3-羟基喹啉-4-酮衍生物
公开(公告)号：US20080255161A1
公开(公告)日：2008-10-16
申请号：US12100399
申请日：2008-04-09
申请人： Dmitry Koltun , Eric Parkhill , Melanie Boze , Jeff Zablocki , Natalya Vasilevich , Elena Mayboroda , Andrei Glushkov , Andrew Cole , Jeffrey Chisholm
发明人： Dmitry Koltun , Eric Parkhill , Melanie Boze , Jeff Zablocki , Natalya Vasilevich , Elena Mayboroda , Andrei Glushkov , Andrew Cole , Jeffrey Chisholm
IPC分类号： A61K31/519 , C07D239/80 , C07D471/04 , A61P9/10 , A61K31/517
CPC分类号： C07D239/91 , C07D471/04
摘要： The present invention discloses 3-hydroquinazolin-4-one derivatives for use as inhibitors of stearoyl-CoA desaturase. The compounds are useful in treating and/or preventing various human diseases, mediated by stearoyl-CoA desaturase (SCD) enzymes, especially diseases related to abnormal lipid levels, cancer, cardiovascular disease, diabetes, obesity, metabolic syndrome and the like.
摘要翻译：本发明公开了用作硬脂酰辅酶A去饱和酶抑制剂的3-氢喹唑啉-4-酮衍生物。该化合物可用于治疗和/或预防由硬脂酰辅酶A去饱和酶（SCD）酶介导的各种人类疾病，特别是与异常脂质水平，癌症，心血管疾病，糖尿病，肥胖症，代谢综合征等相关的疾病。

5. 发明申请

US20070225304A1 AMINOPURINE DERIVATIVES FOR TREATING NEURODEGENERATIVE DISEASES 审中-公开
标题翻译：用于治疗神经损伤性疾病的氨基嘌呤衍生物
公开(公告)号：US20070225304A1
公开(公告)日：2007-09-27
申请号：US11470347
申请日：2006-09-06
申请人： Andrew Cole , Marc-Raleigh Brescia , Gulzar Ahmed , Ian Henderson
发明人： Andrew Cole , Marc-Raleigh Brescia , Gulzar Ahmed , Ian Henderson
IPC分类号： A61K31/52 , C07D473/12
CPC分类号： C07D473/32
摘要： The invention relates to aminopurine derivatives useful in treating disorders that are mediated by adenosine receptor function, including neurodegenerative diseases and inflammation. The compounds are of the general formula:
摘要翻译：本发明涉及可用于治疗由腺苷受体功能介导的疾病（包括神经变性疾病和炎症）的氨基嘌呤衍生物。该化合物具有以下通式：

6. 发明申请

US20080032971A1 8-HETEROARYLPURINE MNK2 INHIBITORS FOR TREATING METABOLIC DISORDERS 有权
标题翻译： 8-HETEROARYLPURINE MNK2用于治疗代谢性疾病的抑制剂
公开(公告)号：US20080032971A1
公开(公告)日：2008-02-07
申请号：US11684262
申请日：2007-03-09
申请人： Andrew Cole , Marc-Raleigh Brescia , Joan Zhang , Zahid Hussain , David Diller , Axel Metzger , Gulzar Ahmed , Ian Henderson
发明人： Andrew Cole , Marc-Raleigh Brescia , Joan Zhang , Zahid Hussain , David Diller , Axel Metzger , Gulzar Ahmed , Ian Henderson
IPC分类号： A61K31/535 , A61K31/519 , A61P25/00 , A61P3/00 , A61P35/00 , C07D413/14 , C07D487/04 , C12N5/06
CPC分类号： C07D473/32
摘要： Compounds of the formula are disclosed as Mnk2 inhibitors which are useful for the treatment and prevention of metabolic disorders such as obesity and diabetes.
摘要翻译：公开的化合物作为可用于治疗和预防代谢性疾病如肥胖症和糖尿病的Mnk2抑制剂。

7. 发明授权

US07750695B2 Phase-locked loop circuitry using charge pumps with current mirror circuitry 失效
标题翻译：使用带电流镜电路的电荷泵的锁相环电路
公开(公告)号：US07750695B2
公开(公告)日：2010-07-06
申请号：US11264283
申请日：2005-10-31
申请人： Randy J. Caplan , Steven P. Hardy , Andrew Cole
发明人： Randy J. Caplan , Steven P. Hardy , Andrew Cole
IPC分类号： H03L7/06
CPC分类号： H03L7/0895 , H03L7/0898 , H03L7/18
摘要： A system and method for performing phase-locked loop is disclosed. The system includes phase frequency detector circuitry, charge pump circuitry having first current mirror circuitry and second current mirror circuitry, loop filter circuitry, and voltage controlled oscillator circuitry. The phase frequency detector circuitry generates an up signal and a down signal based on the phase difference of an input signal and a feedback signal. The charge pump circuitry includes the first current mirror circuitry and the second mirror circuitry and generates a charge pump output signal based on the up and down signals. The loop filter circuitry generates a filtered control signal based on the charge pump output signal. The voltage controlled oscillator circuitry generates the feedback signal with a repeating waveform based on the filtered control signal.
摘要翻译：公开了一种用于执行锁相环的系统和方法。该系统包括相位频率检测器电路，电荷泵电路具有第一电流镜电路和第二电流镜电路，环路滤波器电路和压控振荡器电路。相位频率检测器电路基于输入信号和反馈信号的相位差产生上行信号和下降信号。电荷泵电路包括第一电流镜电路和第二镜电路，并且基于上下信号产生电荷泵输出信号。环路滤波器电路基于电荷泵输出信号产生滤波的控制信号。压控振荡器电路基于滤波的控制信号产生具有重复波形的反馈信号。

8. 发明授权

US07443197B2 Low leakage and data retention circuitry 有权
公开(公告)号：US07443197B2
公开(公告)日：2008-10-28
申请号：US11998725
申请日：2007-11-30
申请人： Barry A. Hoberman , Daniel L. Hillman , William G. Walker , John M. Callahan , Michael A. Zampaglione , Andrew Cole
发明人： Barry A. Hoberman , Daniel L. Hillman , William G. Walker , John M. Callahan , Michael A. Zampaglione , Andrew Cole
IPC分类号： H03K19/173
CPC分类号： H03K19/0016 , G11C5/14 , G11C5/144 , G11C5/148 , H02M3/07 , H03K3/0372 , H03K3/356086 , H03K3/356113 , H03K5/14 , H03K17/102 , H03K19/00315
摘要： An integrated circuit includes first circuitry and sleep transistor circuitry. The first circuitry receives input signals and processes the input signals. The first circuitry also retains data in a sleep state that has low leakage. The sleep transistor circuitry is coupled to the first circuitry and receives a sleep signal. The sleep circuitry reduces power consumption of the first circuitry in the sleep state to have low leakage based on the sleep signal while retaining the data in the first circuitry.

9. 发明申请

US20060125535A1 Phase-locked loop circuitry using charge pumps with current mirror circuitry 失效
标题翻译：使用带电流镜电路的电荷泵的锁相环电路
公开(公告)号：US20060125535A1
公开(公告)日：2006-06-15
申请号：US11264283
申请日：2005-10-31
申请人： Randy Caplan , Steven Hardy , Andrew Cole
发明人： Randy Caplan , Steven Hardy , Andrew Cole
IPC分类号： H03L7/06
CPC分类号： H03L7/0895 , H03L7/0898 , H03L7/18
摘要： A system and method for performing phase-locked loop is disclosed. The system includes phase frequency detector circuitry, charge pump circuitry having first current mirror circuitry and second current mirror circuitry, loop filter circuitry, and voltage controlled oscillator circuitry. The phase frequency detector circuitry generates an up signal and a down signal based on the phase difference of an input signal and a feedback signal. The charge pump circuitry includes the first current mirror circuitry and the second mirror circuitry and generates a charge pump output signal based on the up and down signals. The loop filter circuitry generates a filtered control signal based on the charge pump output signal. The voltage controlled oscillator circuitry generates the feedback signal with a repeating waveform based on the filtered control signal.
摘要翻译：公开了一种用于执行锁相环的系统和方法。该系统包括相位频率检测器电路，电荷泵电路具有第一电流镜电路和第二电流镜电路，环路滤波器电路和压控振荡器电路。相位频率检测器电路基于输入信号和反馈信号的相位差产生上行信号和下降信号。电荷泵电路包括第一电流镜电路和第二镜电路，并且基于上下信号产生电荷泵输出信号。环路滤波器电路基于电荷泵输出信号产生滤波的控制信号。压控振荡器电路基于滤波的控制信号产生具有重复波形的反馈信号。

10. 发明申请

US20050061704A1 Package for a water-soluble capsule 审中-公开
标题翻译：水溶性胶囊包装
公开(公告)号：US20050061704A1
公开(公告)日：2005-03-24
申请号：US10497595
申请日：2002-09-17
申请人： Andrew Cole , Claire Robins , Rahul Vas-Bhat
发明人： Andrew Cole , Claire Robins , Rahul Vas-Bhat
IPC分类号： B65D75/00 , C11D17/04 , B65D85/84
CPC分类号： B65D75/008 , C11D17/042
摘要： One or more water-soluble capsules (3) containing a detergent composition in combination with a package (1) containing the one or more water-soluble capsules, characterised in that the package is formed from a material which has a Moisture Vapour Transfer Rate (M.V.T.R) of between 0.25 g/m2/day to 10 g/m2/day at 38° C. and 90% relative humidity. The Moisture Vapour Transfer Rate is between 0.25 g/m2/day to 5 g/m2/day at 38° C. and 90% relative humidity. In a preferred embodiment, the package is self-standing by means of a collapsible base (16) portion which expands from a collapsed position to an expanded position when one or more capsules is/are placed on the base, and is collapsible when empty so as to make the package substantially flat.
摘要翻译：一种或多种含有洗涤剂组合物与含有一种或多种水溶性胶囊的包装（1）的组合的水溶性胶囊（3），其特征在于，所述包装由具有水分蒸气转移速率 MVTR）在38℃和90％相对湿度下为0.25g / m 2 /天至10g / m 2 /天。在38℃和90％相对湿度下，水蒸汽转移速率为0.25g / m 2 /天至5g / m 2 /天。在优选实施例中，当一个或多个胶囊被放置在基座上时，通过可折叠的底座（16）部分自动展开包装，该折叠部分从折叠位置膨胀到展开位置，并且当空的时可折叠以使包装基本上平坦。

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