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1. 发明授权

US07125840B2 Substituted dipeptides as growth hormone secretagogues 失效
标题翻译：取代的二肽作为生长激素促分泌素
公开(公告)号：US07125840B2
公开(公告)日：2006-10-24
申请号：US10380867
申请日：2001-10-09
申请人： Jeffrey Alan Dodge , Britta Evers , Louis Nickolaus Jungheim , Brian Stephen Muehl , Gerd Ruehter , Kenneth Jeff Thrasher
发明人： Jeffrey Alan Dodge , Britta Evers , Louis Nickolaus Jungheim , Brian Stephen Muehl , Gerd Ruehter , Kenneth Jeff Thrasher
IPC分类号： A01N37/18
CPC分类号： C07D275/06 , A61K31/4015 , A61K31/4025 , A61K31/404 , A61K31/425 , C07D209/54 , C07D401/10 , C07D409/04 , C07D409/10 , C07D417/04 , C07D417/06 , C07D417/10
摘要： This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for use in the synthesis of said compounds, as well as novel processes employed in these syntheses. Also included are methods of treating a mammal which include the administration of said compounds.
摘要翻译：本发明涉及可用于调节哺乳动物内源性生长激素水平的新化合物。本发明还涉及用于合成所述化合物的新中间体，以及在这些合成中使用的新方法。还包括治疗哺乳动物的方法，其包括施用所述化合物。

2. 发明授权

US06992097B2 Growth hormone secretagogues 失效
标题翻译：生长激素促分泌素
公开(公告)号：US06992097B2
公开(公告)日：2006-01-31
申请号：US10453833
申请日：2003-06-03
申请人： Kenneth Lee Hauser , Jeffrey Alan Dodge , Mark Louis Heiman , Scott Alan Jones , Charles Arthur Alt , Henry Uhlman Bryant , Jeffrey Daniel Cohen , James Densmore Copp , Kennan Joseph Fahey , William Harlan Gritton , Louis Nickolaus Jungheim , Joseph Henry Kennedy , Charles Willis Lugar, III , Brian Stephen Muehl , Alan David Palkowitz , Andrew Michael Ratz , Gary Anthony Rhodes , Roger Lewis Robey , David Edward Seyler , Timothy Alan Shepherd , Kenneth Jeff Thrasher , William George Trankle
发明人： Kenneth Lee Hauser , Jeffrey Alan Dodge , Mark Louis Heiman , Scott Alan Jones , Charles Arthur Alt , Henry Uhlman Bryant , Jeffrey Daniel Cohen , James Densmore Copp , Kennan Joseph Fahey , William Harlan Gritton , Louis Nickolaus Jungheim , Joseph Henry Kennedy , Charles Willis Lugar, III , Brian Stephen Muehl , Alan David Palkowitz , Andrew Michael Ratz , Gary Anthony Rhodes , Roger Lewis Robey , David Edward Seyler , Timothy Alan Shepherd , Kenneth Jeff Thrasher , William George Trankle
IPC分类号： A61K31/415 , C07D233/44
CPC分类号： C07D207/416 , A61K45/06 , C07D207/16 , C07D207/42 , C07D231/40 , C07D233/88 , C07D401/06 , C07D403/06 , C07D403/12 , C07D409/12 , C07D417/06 , C07D487/08
摘要： This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for use in the synthesis of said compounds, as well as novel processes employed in these syntheses. Also included are methods of treating a mammal which include the administration of said compounds.
摘要翻译：本发明涉及可用于调节哺乳动物内源性生长激素水平的新化合物。本发明还涉及用于合成所述化合物的新中间体，以及在这些合成中使用的新方法。还包括治疗哺乳动物的方法，其包括施用所述化合物。

3. 发明授权

US06639076B1 Growth hormone secretagogues 失效
标题翻译：生长激素促分泌素
公开(公告)号：US06639076B1
公开(公告)日：2003-10-28
申请号：US09762529
申请日：2001-04-17
申请人： Kenneth Lee Hauser , Jeffrey Alan Dodge , Mark Louis Heiman , Scott Alan Jones , Charles Arthur Alt , Henry Uhlman Bryant , James Densmore Copp , William Harlan Gritton , Charles Willis Lugar, III , Brian Stephen Muehl , Alan David Palkowitz , Andrew Michael Ratz , Gary Anthony Rhodes , Roger Lewis Robey , Timothy Alan Shepherd , Kenneth Jeff Thrasher , William George Trankle
发明人： Kenneth Lee Hauser , Jeffrey Alan Dodge , Mark Louis Heiman , Scott Alan Jones , Charles Arthur Alt , Henry Uhlman Bryant , James Densmore Copp , William Harlan Gritton , Charles Willis Lugar, III , Brian Stephen Muehl , Alan David Palkowitz , Andrew Michael Ratz , Gary Anthony Rhodes , Roger Lewis Robey , Timothy Alan Shepherd , Kenneth Jeff Thrasher , William George Trankle
IPC分类号： C07D40112
CPC分类号： C07D207/416 , A61K45/06 , C07D207/16 , C07D207/42 , C07D231/40 , C07D233/88 , C07D401/06 , C07D403/06 , C07D403/12 , C07D409/12 , C07D417/06 , C07D487/08
摘要： This invention relates to novel compounds of formula I wherein A, B, D, E, G, J, L, X, V are as defined in the specification, and the compounds are useful in the modulation of endogenous growth hormone levels in a mammal.
摘要翻译：本发明涉及式I的新化合物，其中A，B，D，E，G，J，L，X，V如说明书中所定义，并且该化合物可用于调节哺乳动物内源性生长激素水平。

4. 发明申请

US20090069400A1 Indole Sulfonamide Modulators of Progesterone Receptors 失效
标题翻译：吲哚磺酰胺调节剂孕激素受体
公开(公告)号：US20090069400A1
公开(公告)日：2009-03-12
申请号：US12160460
申请日：2007-01-17
申请人： Thomas John Bleisch , Christian Alexander Clarke , Jeffrey Alan Dodge , Scott Alan Jones , Jose Eduardo Lopez , Charles Willis Lugar, III , Brian Stephen Muehl , Timothy Ivo Richardson , Ying Kwong Yee , Kuo-Long Yu
发明人： Thomas John Bleisch , Christian Alexander Clarke , Jeffrey Alan Dodge , Scott Alan Jones , Jose Eduardo Lopez , Charles Willis Lugar, III , Brian Stephen Muehl , Timothy Ivo Richardson , Ying Kwong Yee , Kuo-Long Yu
IPC分类号： A61K31/404 , C07D209/14
CPC分类号： C07D209/10 , C07D209/12 , C07D209/14 , C07D209/18 , C07D209/24 , C07D401/04 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D409/14 , C07D413/04 , C07D417/04
摘要： Compounds of Formula (I), wherein n is 1 or 2, and R1, R2, R3, R4, R5, R6, R7, and R8 are as defined herein, their preparation, pharmaceutical compositions, and methods of use are disclosed.
摘要翻译：其中n为1或2，R 1，R 2，R 3，R 4，R 5，R 6，R 7和R 8如本文所定义的式（I）化合物，其制备，药物组合物和使用方法公开。

5. 发明申请

US20080214612A1 SELECTIVE ESTROGEN RECEPTOR MODULATORS CONTAINING A PHENYLSULFONYL GROUP 失效
标题翻译：选择性雌激素受体调节剂含有苯磺酰胺类
公开(公告)号：US20080214612A1
公开(公告)日：2008-09-04
申请号：US12100093
申请日：2008-04-09
申请人： Robert Dean Dally , Jeffrey Alan Dodge , Scott Alan Frank , Scott Alan Jones , Timothy Alan Shepherd , Owen Brendan Wallace , Kin Chlu Fong , Conrad Wilson Hummel , George Sal Lewis
发明人： Robert Dean Dally , Jeffrey Alan Dodge , Scott Alan Frank , Scott Alan Jones , Timothy Alan Shepherd , Owen Brendan Wallace , Kin Chlu Fong , Conrad Wilson Hummel , George Sal Lewis
IPC分类号： A61K31/445 , C07D295/08 , A61P35/00 , C07D295/14
CPC分类号： C07D295/088 , C07D295/13 , C07D333/56 , C07D333/64 , C07D333/72 , C07D409/02
摘要： The present invention relates to a selective estrogen receptor modulator of formula I or a pharmaceutical acid addition salt thereof; useful, e.g., for treating endometriosis and/or uterine leiomyoma/leiomyomata.
摘要翻译：本发明涉及式I的选择性雌激素受体调节剂或其药用酸加成盐; 有用的，例如用于治疗子宫内膜异位症和/或子宫平滑肌瘤/平滑肌瘤。

6. 发明授权

US06218425B1 8-substituted B-nor-6-Thiaequilenin compounds having activity as selective estrogen receptor modulators 失效
标题翻译：具有作为选择性雌激素受体调节剂的活性的8-取代的B-nor-6-硫氨嘧啶化合物
公开(公告)号：US06218425B1
公开(公告)日：2001-04-17
申请号：US08902485
申请日：1997-07-29
申请人： Jeffrey Alan Dodge , Charles Willis Lugar, III
发明人： Jeffrey Alan Dodge , Charles Willis Lugar, III
IPC分类号： A61K3138
CPC分类号： C07J73/006
摘要： Certain B-nor-6-thiaequilenin compounds substituted at the 3-position with hydroxy and at the 8-position with hydroxy or alkoxy of from one to four carbon atoms are selective estrogen receptor modulators and are useful in the treatment of estrogen-related disorders including such conditions as osteoporosis, hyperlipidemia, estrogen-dependent breast cancer, uterine fibrosis, endometriosis, and restenosis.
摘要翻译：某些在3-羟基位置被羟基取代的8-去甲基间苯二酚化合物的化合物是8-羟基或1-4个碳原子的烷氧基的选择性雌激素受体调节剂，可用于治疗雌激素相关疾病包括骨质疏松症，高脂血症，雌激素依赖性乳腺癌，子宫纤维化，子宫内膜异位症和再狭窄等病症。

7. 发明授权

US08217032B2 Selective estrogen receptor modulators for the treatment of vasomotor symptoms 有权
标题翻译：选择性雌激素受体调节剂用于治疗血管舒缩症状
公开(公告)号：US08217032B2
公开(公告)日：2012-07-10
申请号：US13167343
申请日：2011-06-23
申请人： Robert Dean Dally , Jeffrey Alan Dodge , Scott Alan Frank , Ronald Jay Hinklin , Timothy Alan Shepherd , Owen Brendan Wallace
发明人： Robert Dean Dally , Jeffrey Alan Dodge , Scott Alan Frank , Ronald Jay Hinklin , Timothy Alan Shepherd , Owen Brendan Wallace
IPC分类号： A61P15/12 , A61K31/4453 , A61K31/4523 , A61K31/55 , C07D295/08 , C07D311/78 , C07D335/04 , C07D221/18
CPC分类号： C07D295/088 , C07D221/18 , C07D311/78 , C07D335/04
摘要： The present invention relates to a selective estrogen receptor modulator of formula I or Ia: (I) (Ia); or a pharmaceutical acid addition salt thereof; useful for treating vasomotor symptoms, in particular hot flashes, night sweats and other symptoms that affect women around menopause.
摘要翻译：本发明涉及式I或Ia的选择性雌激素受体调节剂：（I）（Ia）; 或其药用酸加成盐; 可用于治疗血管舒缩症状，特别是潮热，盗汗等影响更年期周围妇女的症状。

8. 发明授权

US06828331B1 Growth hormone secretagogues 失效
标题翻译：生长激素促分泌素
公开(公告)号：US06828331B1
公开(公告)日：2004-12-07
申请号：US09890163
申请日：2001-07-25
申请人： Jeffrey Alan Dodge , Charles Willis Lugar, III
发明人： Jeffrey Alan Dodge , Charles Willis Lugar, III
IPC分类号： A61K41445
CPC分类号： C07K5/0207 , C07K5/06191
摘要： What is disclosed are growth hormone secretagogues, and their uses, of the formula wherein R1 is C6H5CH2OCH2—, C6H5 (CH2)3— or indol-3-ylmethyl; Y is pyrrolidin-1-yl, 4-C1-C6 alkylpiperidin-1-yl or NR2R2; R2 are each independently a C1 to C6 alkyl; R3 is 2-napthyl or phenyl para-substituted by W; W is H, F, CF3, C1-C6 alkoxy or phenyl; and R4 is H or CH3, or a pharmaceutically acceptable salt or solvate thereof.
摘要翻译：公开的是生长激素促分泌素及其用途，其中R 1是C 6 H 5 CH 2 OCH 2 - ，C 6 H 5（CH 2）3 - 或吲哚-3-基甲基; Y是吡咯烷-1-基，4-C 1 -C 6烷基哌啶-1-基或NR 2 R 2; R2各自独立地为C1至C6烷基; R3是2-萘基或被W取代的苯基; W是H，F，CF 3，C 1 -C 6烷氧基或苯基; 且R 4为H或CH 3，或其药学上可接受的盐或溶剂化物。

9. 发明授权

US06509356B1 1-(4-(Substituted alkoxy)benzyl)naphthalene compounds having estrogen inhibitory activity 失效
标题翻译：具有雌激素抑制活性的1-（4-（取代烷氧基）苄基）萘化合物
公开(公告)号：US06509356B1
公开(公告)日：2003-01-21
申请号：US09129119
申请日：1998-08-04
申请人： Jeffrey Alan Dodge , Andrew Lawrence Glasebrook , Charles Willis Lugar, III
发明人： Jeffrey Alan Dodge , Andrew Lawrence Glasebrook , Charles Willis Lugar, III
IPC分类号： A61K31445
CPC分类号： C07D207/08 , C07C217/20 , C07C275/28 , C07C275/30 , C07C275/34 , C07D207/27 , C07D211/22 , C07D221/20 , C07D295/088 , C07D295/112 , C07D473/08
摘要： A class of substituted benzylnaphthylene compounds of the structure where R1 and R2 are independently hydrogen, alkyl of one to six carbon atoms, acyl of two to six carbon atoms, or phenacyl; X is —(CH2)1-6; Y is absent or is selected from 1,4-piperazinylene; ureido; N-(lower alkyl)ureido; N′-(lower alkyl)ureido; or N, N′-(di-lower alkyl ureido; and Z is 1-, 2- or 3-pyrrolidinyl; 1-, 2-, or 3-[1-(lower alkyl) pyrrolidinyl]; 1- 2-, 3- or 4-piperidinyl; 1-, 2-, 3- or 4-[1-lower alkyl)piperidinyl]; N,N-dialkyl; 1-azepinyl; 1- or 2-naphthylamino, 4-morpholinyl, dimethyl-4-morpholinyl, 3-azaspiro[5.5]undecan-3-yl; pyrrolidinon-1-yl; unsubstituted phenyl; or phenyl substituted with acyl of two to four carbon atoms, alkyl of one to four carbon atoms, halo, or alkoxy of one to four carbon atoms; with the proviso that n is not 2 or 3 when Z is 1-pyrrolidinyl, 1-piperidinyl, 1-azepinyl, 4-morpholinyl, N,N-dimethylamino or N,N-diethylamino; are selective estrogen receptor modulators useful in the prophylaxis or treatment of breast cancer.
摘要翻译：一类取代的苄基萘酚化合物，其中R 1和R 2独立地是氢，1至6个碳原子的烷基，2至6个碳原子的酰基或苯甲酰甲基; X是 - （CH 2）1-6; Y不存在或选自1,4-哌嗪基; 脲基 N-（低级烷基）脲基; N' - （低级烷基）脲基; 或N，N' - （二 - 低级烷基脲基; Z是1-，2-或3-吡咯烷基; 1-，2-或3- [1-（低级烷基）吡咯烷基] 3-或4-哌啶基; 1-，2-，3-或4- [1-低级烷基）哌啶基]; N，N-二烷基; 1-氮杂基; 1-或2-萘基氨基，4-吗啉基，二甲基-4-吗啉基，3-氮杂螺[5.5]十一烷-3-基; 吡咯烷酮-1-基; 未取代的苯基; 或被2-4个碳原子的酰基取代的苯基，1-4个碳原子的烷基，卤素或1-4个碳原子的烷氧基; 条件是当Z是1-吡咯烷基，1-哌啶基，1-氮杂基，4-吗啉基，N，N-二甲基氨基或N，N-二乙基氨基时，n不是2或3。是可用于预防或治疗乳腺癌的选择性雌激素受体调节剂。

10. 发明授权

US06403614B1 Benzothiophenes 失效
标题翻译：苯并噻吩
公开(公告)号：US06403614B1
公开(公告)日：2002-06-11
申请号：US09164024
申请日：1998-09-30
申请人： Jeffrey Alan Dodge , Mark Gregory Stocksdale
发明人： Jeffrey Alan Dodge , Mark Gregory Stocksdale
IPC分类号： A61K31445
CPC分类号： C07D333/56
摘要： This invention provides novel benzothiophene compounds of formula I: which are useful for the inhibition of the various medical conditions associated with postmenopausal syndrome, as well as estrogen dependent diseases including cancer of the breast, uterus, and cervix. The present invention further. relates to pharmaceutical formulations of compounds of formula I.
摘要翻译：本发明提供了新颖的式I的苯并噻吩化合物：其可用于抑制与绝经后综合征相关的各种医学病症，以及雌激素依赖性疾病，包括乳腺癌，子宫癌和子宫颈癌。本发明进一步。涉及式I化合物的药物制剂。

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