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1. 发明授权

US07902343B2 Detection of microsatellite instability and its use in diagnosis of tumors 有权
标题翻译：微卫星不稳定性的检测及其在肿瘤诊断中的应用
公开(公告)号：US07902343B2
公开(公告)日：2011-03-08
申请号：US12109775
申请日：2008-04-25
申请人： Jeffery W. Bacher , Laura Flanagan , Nadine Nassif
发明人： Jeffery W. Bacher , Laura Flanagan , Nadine Nassif
IPC分类号： C07H21/02 , C07H21/04 , C12Q1/68
CPC分类号： C12Q1/6858 , C12Q1/6886 , C12Q2600/16
摘要： Methods and kits are disclosed for use in the analysis of microsatellite instability in genomic DNA. Methods and kits are also disclosed which can be used to detect microsatellite instability DNA present in biological materials, such as tumors. The methods and kits of the present invention can be used to detect or diagnose diseases associated with microsatellite instability, such as certain types of cancer.
摘要翻译：公开了用于分析基因组DNA中的微卫星不稳定性的方法和试剂盒。还公开了可用于检测存在于生物材料如肿瘤中的微卫星不稳定性DNA的方法和试剂盒。本发明的方法和试剂盒可用于检测或诊断与微卫星不稳定性相关的疾病，例如某些类型的癌症。

2. 发明授权

US07364853B2 Detection of microsatellite instability and its use in diagnosis of tumors 有权
标题翻译：微卫星不稳定性的检测及其在肿瘤诊断中的应用
公开(公告)号：US07364853B2
公开(公告)日：2008-04-29
申请号：US11037321
申请日：2005-01-18
申请人： Jeffery W. Bacher , Laura Flanagan , Nadine Nassif
发明人： Jeffery W. Bacher , Laura Flanagan , Nadine Nassif
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/04
CPC分类号： C12Q1/6858 , C12Q1/6886 , C12Q2600/16
摘要： Methods and kits are disclosed for use in the analysis of microsatellite instability in genomic DNA. Methods and kits are also disclosed which can be used to detect microsatellite instability DNA present in biological materials, such as tumors. The methods and kits of the present invention can be used to detect or diagnose diseases associated with microsatellite instability, such as certain types of cancer.
摘要翻译：公开了用于分析基因组DNA中的微卫星不稳定性的方法和试剂盒。还公开了可用于检测存在于生物材料如肿瘤中的微卫星不稳定性DNA的方法和试剂盒。本发明的方法和试剂盒可用于检测或诊断与微卫星不稳定性相关的疾病，例如某些类型的癌症。

3. 发明授权

US06844152B1 Detection of microsatellite instability and its use in diagnosis of tumors 有权
标题翻译：微卫星不稳定性的检测及其在肿瘤诊断中的应用
公开(公告)号：US06844152B1
公开(公告)日：2005-01-18
申请号：US09663020
申请日：2000-09-15
申请人： Jeffery W. Bacher , Laura Flanagan , Nadine Nassif
发明人： Jeffery W. Bacher , Laura Flanagan , Nadine Nassif
IPC分类号： C12N15/09 , C12Q1/68 , C07H21/04 , C12P19/34
CPC分类号： C12Q1/6858 , C12Q1/6886 , C12Q2600/16
摘要： Methods and kits are disclosed for use in the analysis of microsatellite instability in genomic DNA. Methods and kits are also disclosed which can be used to detect microsatellite instability DNA present in biological materials, such as tumors. The methods and kits of the present invention can be used to detect or diagnose diseases associated with microsatellite instability, such as certain types of cancer.
摘要翻译：公开了用于分析基因组DNA中的微卫星不稳定性的方法和试剂盒。还公开了可用于检测存在于生物材料如肿瘤中的微卫星不稳定性DNA的方法和试剂盒。本发明的方法和试剂盒可用于检测或诊断与微卫星不稳定性相关的疾病，例如某些类型的癌症。

4. 发明申请

US20090061438A1 DETECTION OF MICROSATELLITE INSTABILITY AND ITS USE IN DIAGNOSIS OF TUMORS 有权
标题翻译：检测微血管密度不稳定性及其在肿瘤诊断中的应用
公开(公告)号：US20090061438A1
公开(公告)日：2009-03-05
申请号：US12109775
申请日：2008-04-25
申请人： Jeffery W. Bacher , Laura Flanagan , Nadine Nassif
发明人： Jeffery W. Bacher , Laura Flanagan , Nadine Nassif
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6858 , C12Q1/6886 , C12Q2600/16
摘要： Methods and kits are disclosed for use in the analysis of microsatellite instability in genomic DNA. Methods and kits are also disclosed which can be used to detect microsatellite instability DNA present in biological materials, such as tumors. The methods and kits of the present invention can be used to detect or diagnose diseases associated with microsatellite instability, such as certain types of cancer.
摘要翻译：公开了用于分析基因组DNA中的微卫星不稳定性的方法和试剂盒。还公开了可用于检测存在于生物材料如肿瘤中的微卫星不稳定性DNA的方法和试剂盒。本发明的方法和试剂盒可用于检测或诊断与微卫星不稳定性相关的疾病，例如某些类型的癌症。

5. 发明授权

US07202031B2 Detection of microsatellite instability and its use in diagnosis of tumors 有权
标题翻译：微卫星不稳定性的检测及其在肿瘤诊断中的应用
公开(公告)号：US07202031B2
公开(公告)日：2007-04-10
申请号：US10314810
申请日：2002-12-09
申请人： Jeffery W. Bacher , Laura Flanagan , Nadine Nassif
发明人： Jeffery W. Bacher , Laura Flanagan , Nadine Nassif
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/04
CPC分类号： C12Q1/6858 , C12Q1/6827 , C12Q1/6886 , C12Q2600/16 , C12Q2537/143 , C12Q2525/151
摘要： Methods and kits are disclosed for use in the analysis of microsatellite instability in genomic DNA. Methods and kits are also disclosed which can be used to detect microsatellite instability DNA present in biological materials, such as tumors. The methods and kits of the present invention can be used to detect or diagnose diseases associated with microsatellite instability, such as certain types of cancer.
摘要翻译：公开了用于分析基因组DNA中的微卫星不稳定性的方法和试剂盒。还公开了可用于检测存在于生物材料如肿瘤中的微卫星不稳定性DNA的方法和试剂盒。本发明的方法和试剂盒可用于检测或诊断与微卫星不稳定性相关的疾病，例如某些类型的癌症。

6. 发明申请

US20050202473A1 Detection of microsatellite instability and its use in diagnosis of tumors 有权
公开(公告)号：US20050202473A1
公开(公告)日：2005-09-15
申请号：US11037321
申请日：2005-01-18
申请人： Jeffery Bacher , Laura Flanagan , Nadine Nassif
发明人： Jeffery Bacher , Laura Flanagan , Nadine Nassif
IPC分类号： C12N15/09 , C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6858 , C12Q1/6886 , C12Q2600/16
摘要： Methods and kits are disclosed for use in the analysis of microsatellite instability in genomic DNA. Methods and kits are also disclosed which can be used to detect microsatellite instability DNA present in biological materials, such as tumors. The methods and kits of the present invention can be used to detect or diagnose diseases associated with microsatellite instability, such as certain types of cancer.

7. 发明授权

US07749706B2 Detection of microsatellite instability and its use in diagnosis of tumors 有权
标题翻译：微卫星不稳定性的检测及其在肿瘤诊断中的应用
公开(公告)号：US07749706B2
公开(公告)日：2010-07-06
申请号：US11612567
申请日：2006-12-19
申请人： Jeffrey W. Bacher , Laura Flanagan , Nadine Nassif
发明人： Jeffrey W. Bacher , Laura Flanagan , Nadine Nassif
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/04
CPC分类号： C12Q1/6858 , C12Q1/6827 , C12Q1/6886 , C12Q2600/16 , C12Q2537/143 , C12Q2525/151
摘要： Methods and kits are disclosed for use in the analysis of microsatellite instability in genomic DNA. Methods and kits are also disclosed which can be used to detect microsatellite instability DNA present in biological materials, such as tumors. The methods and kits of the present invention can be used to detect or diagnose diseases associated with microsatellite instability, such as certain types of cancer.
摘要翻译：公开了用于分析基因组DNA中的微卫星不稳定性的方法和试剂盒。还公开了可用于检测存在于生物材料如肿瘤中的微卫星不稳定性DNA的方法和试剂盒。本发明的方法和试剂盒可用于检测或诊断与微卫星不稳定性相关的疾病，例如某些类型的癌症。

8. 发明申请

US20070117136A1 DETECTION OF MICROSATELLITE INSTABILITY AND ITS USE IN DIAGNOSIS OF TUMORS 有权
标题翻译：检测微血管密度不稳定性及其在肿瘤诊断中的应用
公开(公告)号：US20070117136A1
公开(公告)日：2007-05-24
申请号：US11612567
申请日：2006-12-19
申请人： Jeffery Bacher , Laura Flanagan , Nadine Nassif
发明人： Jeffery Bacher , Laura Flanagan , Nadine Nassif
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6858 , C12Q1/6827 , C12Q1/6886 , C12Q2600/16 , C12Q2537/143 , C12Q2525/151
摘要： Methods and kits are disclosed for use in the analysis of microsatellite instability in genomic DNA. Methods and kits are also disclosed which can be used to detect microsatellite instability DNA present in biological materials, such as tumors. The methods and kits of the present invention can be used to detect or diagnose diseases associated with microsatellite instability, such as certain types of cancer.
摘要翻译：公开了用于分析基因组DNA中的微卫星不稳定性的方法和试剂盒。还公开了可用于检测存在于生物材料如肿瘤中的微卫星不稳定性DNA的方法和试剂盒。本发明的方法和试剂盒可用于检测或诊断与微卫星不稳定性相关的疾病，例如某些类型的癌症。

9. 发明申请

US20120076870A9 BONE SUBSTITUTE AND METHOD FOR THE PREPARATION THEREOF 有权
标题翻译：骨髓取代物及其制备方法
公开(公告)号：US20120076870A9
公开(公告)日：2012-03-29
申请号：US12999507
申请日：2009-06-26
申请人： Nadine Nassif , Frédéric Gobeaux , Marie-Madeleine Giraud Guille , Gervaise Mosser
发明人： Nadine Nassif , Frédéric Gobeaux , Marie-Madeleine Giraud Guille , Gervaise Mosser
IPC分类号： A61K33/42 , A61P19/08
CPC分类号： A61L27/46 , C08L89/06
摘要： The invention relates to a material that can be used as a bone substitute and to a method for the preparation thereof. The material comprises an organic phase (I) comprising striated collagen fibrils constituted of collagen I triple helices, said fibrils being organized over a large distance according to a 3D geometry associating aligned domains and cholesteric domains, and also isotropic domains where they are not organized; and a mineral phase (II) comprising apatite crystals having a hexagonal crystalline structure, space group 6/m, comprising at least calcium ions and phosphate ions; the axis c of said apatite crystals of the mineral phase is coaligned with the longitudinal axis of the striated collagen fibrils of the organic phase and the collagen content in the material is at least 75 mg/cm3. The method for preparing the material comprises preparing an initial acidic aqueous solution of collagen which is a precursor for the organic phase (I), and at least one aqueous solution of precursors for the mineral phase (II) and precipitating the collagen by increasing the pH to a value of at least 7. According to this method: the concentration of collagen in the acidic aqueous solution is at least 75 mg/ml and remains constant during said increase in pH; the mineral phase precursors comprise at least one calcium salt and at least one phosphate salt; the precipitation of the mineral phase (II) is carried out by bringing the mineral phase precursor solution into contact with the organic phase (I), said bringing into contact being carried out before or after the precipitation of said organic phase (I).
摘要翻译：本发明涉及可用作骨替代物的材料及其制备方法。该材料包括由胶原I三重螺旋构成的条纹胶原原纤维的有机相（I），所述原纤维根据关联对齐的结构域和胆甾醇结构域的3D几何形状，以及它们不组织的各向同性结构域组织在很大的距离上; 和包含六方晶结构的磷灰石晶体的矿物相（II），空间群6 / m，至少包含钙离子和磷酸根离子; 矿物相的所述磷灰石晶体的轴线c与有机相的条纹胶原原纤维的纵向轴线相配合，并且材料中的胶原含量为至少75mg / cm 3。制备该材料的方法包括制备作为有机相（I）的前体的初始酸性水溶液和至少一种矿物相（II）的前体水溶液，并通过增加pH来沉淀胶原蛋白至少为7.根据该方法：酸性水溶液中胶原蛋白的浓度至少为75mg / ml，并且在所述增加的pH期间保持恒定; 矿物相前体包含至少一种钙盐和至少一种磷酸盐; 通过使矿物相前体溶液与有机相（I）接触进行矿化相（II）的沉淀，所述接触在所述有机相（I）的沉淀之前或之后进行。

10. 发明申请

US20130142840A1 DENSE FIBRILLAR COLLAGEN MATRICES FOR TISSUE REPAIR AND THE PREPARATION METHOD THEREOF 有权
标题翻译：用于组织修复的DENSE FIBRILLAR COLLAGEN MATRICES及其制备方法
公开(公告)号：US20130142840A1
公开(公告)日：2013-06-06
申请号：US13701071
申请日：2011-05-30
申请人： Marie-Madeleine Giraud-Guille , Nadine Nassif , Yan Wang , Christophe Helary , Anne Pelle
发明人： Marie-Madeleine Giraud-Guille , Nadine Nassif , Yan Wang , Christophe Helary , Anne Pelle
IPC分类号： A61L27/24
CPC分类号： A61L27/24 , A61L27/18 , A61L2430/40 , C08L71/02
摘要： Method for preparing a homogeneous collagen-based material by concentration of a collagen solution, includes bringing a collagen solution into contact by way of continuous injection and use of the material for tissue repair.
摘要翻译：通过浓缩胶原溶液制备均匀的胶原基材料的方法包括使胶原溶液通过连续注射和使用该组织修复材料进行接触。

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