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1. 发明申请

US20070148661A1 LSAMP Gene Associated With Cardiovascular Disease 审中-公开
标题翻译： LSAMP基因与心血管疾病有关
公开(公告)号：US20070148661A1
公开(公告)日：2007-06-28
申请号：US11458228
申请日：2006-07-18
申请人： Jeffery Vance , Pascal Goldschmidt , Elizabeth Hauser , William Kraus , Margaret Pericak-Vance
发明人： Jeffery Vance , Pascal Goldschmidt , Elizabeth Hauser , William Kraus , Margaret Pericak-Vance
IPC分类号： C12Q1/68 , G06F19/00
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要： The LSAMP gene can be used for cardiovascular disease risk assessment, in particular Left Main Disease. The genetic risk attributable to LSAMP adds to known cardiovascular disease risk factors. Assessment of risk attributable to LSAMP permits early initiation of preventive and therapeutic strategies. Given the pronounced clinical risk associated with Left Main Disease, such risk assessment should significantly reduce morbidity and mortality.
摘要翻译： LSAMP基因可用于心血管疾病风险评估，特别是左主干疾病。归因于LSAMP的遗传风险增加了已知的心血管疾病危险因素。评估LSAMP的风险可以早日开始预防和治疗策略。鉴于与左主干病相关的明显临床风险，这种风险评估应显着降低发病率和死亡率。

2. 发明申请

US20090226420A1 Methods of Determining the Risk of Developing Coronary Artery Disease 审中-公开
标题翻译：确定发生冠状动脉疾病风险的方法
公开(公告)号：US20090226420A1
公开(公告)日：2009-09-10
申请号：US12084759
申请日：2006-11-10
申请人： Elizabeth Hauser , Pascal Goldschmidt , Simon Gregory , William Kraus , Jeffery Vance
发明人： Elizabeth Hauser , Pascal Goldschmidt , Simon Gregory , William Kraus , Jeffery Vance
IPC分类号： C12Q1/68 , A61K39/395 , A61P9/00
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： The invention relates to predicting, or aiding in predicting, which individuals are at risk of developing coronary artery disease. The invention provides a method for identifying an individual who has an altered risk for developing CAD. The invention further relates to methods of reducing the likelihood that a subject will develop CAD. The invention further provides reagents, nucleic acids and kits comprising nucleic acids containing a polymorphism in a CAD-determinative gene.
摘要翻译：本发明涉及预测或协助预测哪些个体处于发展冠状动脉疾病的风险中。本发明提供了一种用于识别具有改变发展CAD风险的个体的方法。本发明还涉及减少受试者发展CAD的可能性的方法。本发明还提供了试剂，核酸和试剂盒，其包含在CAD-决定基因中含有多态性的核酸。

3. 发明申请

US20060115845A1 Methods and compositions for correlating genetic markers with cardiovascular disease 有权
标题翻译：将遗传标记与心血管疾病相关联的方法和组合物
公开(公告)号：US20060115845A1
公开(公告)日：2006-06-01
申请号：US11260842
申请日：2005-10-27
申请人： Jeffery Vance , Pascal Goldschmidt , Simon Gregory , William Kraus
发明人： Jeffery Vance , Pascal Goldschmidt , Simon Gregory , William Kraus
IPC分类号： C12Q1/68 , G06F19/00
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/118 , C12Q2600/156 , C12Q2600/172 , G06F19/18
摘要： The present invention provides methods of identifying a subject having an increased or decreased risk of developing cardiovascular disease, comprising: a) correlating the presence of one or more genetic markers in chromosome 3q13.31 with an increased or decreased risk of developing cardiovascular disease; and b) detecting the one or more genetic markers of step (a) in the subject, thereby identifying the subject as having an increased or decreased risk of developing cardiovascular disease. Also provided are methods of identifying subjects with cardiovascular disease as having a good or poor prognosis, as well as methods of identifying effective treatment regimens for cardiovascular disease, based on correlation with genetic markers in chromosome 3q13.31.
摘要翻译：本发明提供鉴定发生心血管疾病风险增加或降低的受试者的方法，其包括：a）将染色体3q13.31中的一种或多种遗传标记的存在与发生心血管疾病的风险增加或降低相关联; 和b）检测受试者中步骤（a）的一种或多种遗传标记，从而将受试者鉴定为发生心血管疾病的风险增加或降低。还提供了基于与染色体3q13.31中的遗传标记的相关性来鉴定具有心血管疾病的受试者具有良好或不良预后的方法，以及鉴定心血管疾病的有效治疗方案的方法。

4. 发明申请

US20110070583A1 Lsamp gene associated with cardiovascular disease 审中-公开
标题翻译：与心血管疾病相关的Lsamp基因
公开(公告)号：US20110070583A1
公开(公告)日：2011-03-24
申请号：US12806690
申请日：2010-08-19
申请人： Jeffery M. Vance , Pascal Goldschmidt , Elizabeth Hauser , William Kraus , Margaret A. Pericak-Vance
发明人： Jeffery M. Vance , Pascal Goldschmidt , Elizabeth Hauser , William Kraus , Margaret A. Pericak-Vance
IPC分类号： C12Q1/68 , C12Q1/02 , C12Q1/60
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要： The LSAMP gene can be used for cardiovascular disease risk assessment, in particular Left Main Disease. The genetic risk attributable to LSAMP adds to known cardiovascular disease risk factors. Assessment of risk attributable to LSAMP permits early initiation of preventive and therapeutic strategies. Given the pronounced clinical risk associated with Left Main Disease, such risk assessment should significantly reduce morbidity and mortality.
摘要翻译： LSAMP基因可用于心血管疾病风险评估，特别是左主干疾病。归因于LSAMP的遗传风险增加了已知的心血管疾病危险因素。评估LSAMP的风险可以早日开始预防和治疗策略。鉴于与左主干病相关的明显临床风险，这种风险评估应显着降低发病率和死亡率。

5. 发明授权

US06442576B1 Searching for documents with multiple element types 失效
标题翻译：搜索具有多种元素类型的文档
公开(公告)号：US06442576B1
公开(公告)日：2002-08-27
申请号：US08906811
申请日：1997-08-06
申请人： Bradley A. Edelman , William Kraus
发明人： Bradley A. Edelman , William Kraus
IPC分类号： G06F1500
CPC分类号： G06F17/24
摘要： An apparatus and a method perform search operations on a document having nested elements of varying types. The apparatus finds in the document an element which is capable of containing nested elements of one or more varying types. The apparatus can also replace the found element with a substitute element, which is also capable of containing nested elements of one or more varying types. The types of elements include texts, images, animation, and sound clips. For each element, a matching function and a find function are provided. The matching function associated with one element determines if a target element matches itself based on predetermined search criteria. The find function associated with one element searches for a match of a target element within itself. The find function of one element can in turn invoke find functions associated with elements embedded within itself in carrying out the search on the target element.
摘要翻译：一种装置和方法对具有不同类型的嵌套元素的文档进行搜索操作。该装置在文档中发现能够包含一个或多个变化类型的嵌套元素的元素。该装置还可以用替代元素替换发现的元素，替代元素还能够包含一个或多个变化类型的嵌套元素。元素的类型包括文本，图像，动画和声音剪辑。对于每个元素，提供匹配函数和查找函数。与一个元素相关联的匹配功能基于预定的搜索标准来确定目标元素是否匹配其自身。与一个元素相关联的查找函数搜索其内部的目标元素的匹配。一个元素的查找功能可以依次调用与嵌入在其中的元素相关联的查找功能，从而对目标元素进行搜索。

6. 发明申请

US20050122765A1 Reference cell configuration for a 1T/1C ferroelectric memory 审中-公开
标题翻译： 1T / 1C铁电存储器的参考单元配置
公开(公告)号：US20050122765A1
公开(公告)日：2005-06-09
申请号：US10993202
申请日：2004-11-18
申请人： Judith Allen , Dennis Wilson , William Kraus , Lark Lehman
发明人： Judith Allen , Dennis Wilson , William Kraus , Lark Lehman
IPC分类号： G11C11/22
CPC分类号： G11C11/22
摘要： A reference cell layout for use in a 1T/1C ferroelectric memory array includes a transistor of a first polarity type having a gate coupled to a reference word line and a current path coupled between a bit line and an internal cell node, a transistor of a second polarity type having a gate coupled to a pre-charge line and a current path coupled between a source of power supply voltage and the internal cell node, a shunt reference word line extending across the reference cell that is electrically isolated from the reference word line, the pre-charge line and the transistors within the physical boundary of the memory cell, and a ferroelectric capacitor coupled between the internal cell node and a reference plate line.
摘要翻译：用于1T / 1C铁电存储器阵列的参考单元布局包括具有耦合到参考字线的栅极和耦合在位线和内部单元节点之间的电流通路的第一极性类型的晶体管，具有耦合到预充电线的栅极和耦合在电源电压源和内部单元节点之间的电流路径的第二极性类型，跨越参考电池延伸的分流参考字线，其与参考字线电隔离，预充电线和存储单元的物理边界内的晶体管，以及耦合在内部单元节点和参考板线之间的铁电电容器。

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