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1. 发明授权

US08158810B2 ALDH-2 inhibitors in the treatment of addiction 有权
标题翻译： ALDH-2抑制剂治疗成瘾
公开(公告)号：US08158810B2
公开(公告)日：2012-04-17
申请号：US12371398
申请日：2009-02-13
申请人： Jeff Zablocki , Matthew Abelman , Michael Organ , Yaroslav Bilokin , Elfatih Elzein , Tetsuya Kobayashi , Rao Kalla , Thao Perry , Xiaofen Li , Robert Jiang , Ivan Diamond , Lina Yao , Peidong Fan , Maria Pia Arolfo , Zhan Jiang , Wing Ming Keung , Guoxin Tao
发明人： Jeff Zablocki , Matthew Abelman , Michael Organ , Yaroslav Bilokin , Elfatih Elzein , Tetsuya Kobayashi , Rao Kalla , Thao Perry , Xiaofen Li , Robert Jiang , Ivan Diamond , Lina Yao , Peidong Fan , Maria Pia Arolfo , Zhan Jiang , Wing Ming Keung , Guoxin Tao
IPC分类号： A61K31/35 , C07D307/77
CPC分类号： C07D311/36 , C07D413/12 , C07D413/14 , C07F9/65586
摘要： Disclosed are novel isoflavone derivatives having the structure of Formula I which are useful as ALDH-2 inhibitors for treating mammals for dependence upon drugs of addiction, for example addiction to dopamine-producing agent such as cocaine, morphine, amphetamines, nicotine, and alcohol.
摘要翻译：公开了具有式I结构的新型异黄酮衍生物，其可用作用于治疗哺乳动物依赖于成瘾药物的ALDH-2抑制剂，例如对多巴胺产生剂如可卡因，吗啡，苯丙胺，尼古丁和酒精的成瘾。

2. 发明申请

US20090209533A1 ALDH-2 INHIBITORS IN THE TREATMENT OF ADDICTION 有权
标题翻译： ALDH-2抑制剂在治疗中的应用
公开(公告)号：US20090209533A1
公开(公告)日：2009-08-20
申请号：US12371398
申请日：2009-02-13
申请人： Jeff Zablocki , Matthew Abelman , Michael Organ , Yaroslav Bilokin , Elfatih Elzein , Tetsuya Kobayashi , Rao Kalla , Thao Perry , Xiaofen Li , Robert Jiang , Ivan Diamond , Lina Yao , Peidong Fan , Maria Pia Arolfo , Zhan Jiang , Wing Ming Keung , Guoxin Tao
发明人： Jeff Zablocki , Matthew Abelman , Michael Organ , Yaroslav Bilokin , Elfatih Elzein , Tetsuya Kobayashi , Rao Kalla , Thao Perry , Xiaofen Li , Robert Jiang , Ivan Diamond , Lina Yao , Peidong Fan , Maria Pia Arolfo , Zhan Jiang , Wing Ming Keung , Guoxin Tao
IPC分类号： A61K31/352 , C07D417/12 , C07D413/12 , C07D311/22 , A61K31/427 , A61K31/4245 , A61K31/5377 , A61P25/30
CPC分类号： C07D311/36 , C07D413/12 , C07D413/14 , C07F9/65586
摘要： Disclosed are novel isoflavone derivatives having the structure of Formula I which are useful as ALDH-2 inhibitors for treating mammals for dependence upon drugs of addiction, for example addiction to dopamine-producing agent such as cocaine, morphine, amphetamines, nicotine, and alcohol.
摘要翻译：公开了具有式I结构的新型异黄酮衍生物，其可用作用于治疗哺乳动物依赖于成瘾药物的ALDH-2抑制剂，例如对多巴胺产生剂如可卡因，吗啡，苯丙胺，尼古丁和酒精的成瘾。

3. 发明申请

US20080207610A1 ALDH-2 INHIBITORS IN THE TREATMENT OF ADDICTION 审中-公开
标题翻译： ALDH-2抑制剂在治疗中的应用
公开(公告)号：US20080207610A1
公开(公告)日：2008-08-28
申请号：US12019034
申请日：2008-01-24
申请人： Jeff Zablocki , Matthew Abelman , Michael Organ , Yaroslav Bilokin , Robert Jiang , Elfatih Elzein , Tetsuya Kobayashi , Rao Kalla , Thao Perry , Xiaofen Li , Ivan Diamond , Lina Yao , Peidong Fan , Maria Pia Arolfo , Zhan Jiang
发明人： Jeff Zablocki , Matthew Abelman , Michael Organ , Yaroslav Bilokin , Robert Jiang , Elfatih Elzein , Tetsuya Kobayashi , Rao Kalla , Thao Perry , Xiaofen Li , Ivan Diamond , Lina Yao , Peidong Fan , Maria Pia Arolfo , Zhan Jiang
IPC分类号： A61K31/5377 , C07D311/22 , A61K31/352 , A61P25/30 , C07D413/12 , A61K31/4245
CPC分类号： C07D311/36 , C07D413/12 , C07D413/14 , C07F9/65586
摘要： Disclosed are novel isoflavone derivatives having the structure of Formula I which are useful as ALDH-2 inhibitors for treating mammals for dependence upon drugs of addiction, for example addiction to dopamine-producing agent such as cocaine, morphine, amphetamines, nicotine, and alcohol.
摘要翻译：公开了具有式I结构的新型异黄酮衍生物，其可用作用于治疗哺乳动物依赖于成瘾药物的ALDH-2抑制剂，例如对多巴胺产生剂如可卡因，吗啡，苯丙胺，尼古丁和酒精的成瘾。

4. 发明申请

US20080032995A1 ALDH-2 INHIBITORS IN THE TREATMENT OF DRUG ADDICTION 审中-公开
标题翻译： ALDH-2抑制剂治疗药物滥用
公开(公告)号：US20080032995A1
公开(公告)日：2008-02-07
申请号：US11829836
申请日：2007-07-27
申请人： Jeff Zablocki , Matthew Abelman , Michael Organ , Yaroslav Bilokin , Ivan Diamond , Maria Arolfo , Lina Yao , Peidong Fan , Elfatih Elzein , Rao Kalla , Thao Perry , Tetsuya Kobayshi , Xiaofen Lee , Robert Jiang
发明人： Jeff Zablocki , Matthew Abelman , Michael Organ , Yaroslav Bilokin , Ivan Diamond , Maria Arolfo , Lina Yao , Peidong Fan , Elfatih Elzein , Rao Kalla , Thao Perry , Tetsuya Kobayshi , Xiaofen Lee , Robert Jiang
IPC分类号： A61K31/352 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/496 , A61P25/30 , C07D311/04 , C07D405/02 , C07D413/02 , C07D417/02
CPC分类号： C07D413/12 , C07D311/36 , C07D413/14 , C07F9/65586
摘要： Disclosed are novel isoflavone derivatives having the structure of Formula I which are useful as ALDH-2 inhibitors for treating mammals for dependence upon drugs of addiction, for example addiction to dopamine-producing agent such as cocaine, morphine, amphetamines, nicotine, and alcohol.
摘要翻译：公开了具有式I结构的新型异黄酮衍生物，其可用作用于治疗哺乳动物依赖于成瘾药物的ALDH-2抑制剂，例如对多巴胺产生剂如可卡因，吗啡，苯丙胺，尼古丁和酒精的成瘾。

5. 发明申请

US20090124672A1 ALDH-2 INHIBITORS IN THE TREATMENT OF PSYCHIATRIC DISORDERS 审中-公开
标题翻译： ALDH-2抑制剂治疗心理障碍
公开(公告)号：US20090124672A1
公开(公告)日：2009-05-14
申请号：US12266288
申请日：2008-11-06
申请人： Ivan Diamond , David Overstreet
发明人： Ivan Diamond , David Overstreet
IPC分类号： A61K31/4245 , A61P25/24
CPC分类号： A61K31/352 , A61K31/4245
摘要： Disclosed are isoflavone derivatives having the structure of Formula I which are useful as ALDH-2 inhibitors for use treating in mammals suffering from psychiatric disorders such as, for example, depression, generalized anxiety, social phobia, panic disorder, and sleep disorders.
摘要翻译：公开了具有式I结构的异黄酮衍生物，其可用作用于治疗患有精神病障碍（例如抑郁症，广泛性焦虑症，社交恐惧症，惊恐障碍和睡眠障碍）的哺乳动物的ALDH-2抑制剂。

6. 发明授权

US06255057B1 Detection of cellular exposure to ethanol 失效
标题翻译：检测细胞暴露于乙醇
公开(公告)号：US06255057B1
公开(公告)日：2001-07-03
申请号：US08686796
申请日：1996-07-26
申请人： Adrienne Sue Gordon , Ivan Diamond , Doug Paul Dohrman
发明人： Adrienne Sue Gordon , Ivan Diamond , Doug Paul Dohrman
IPC分类号： G01N3353
CPC分类号： G01N33/573 , G01N33/98 , G01N2800/307
摘要： The present invention relates to determinable effects of ethanol exposure on the cellular localization and abundance of specific proteins, referred to herein as ethanol indicative proteins. More specifically, the present invention is based, in part, on the discovery that the catalytic C&agr; subunit of cAMP dependent protein kinase (PKA), which is normally localized in the Golgi apparatus area, appears to translocate to the nucleus upon exposure of a cell to ethanol. The present invention is further based on the observation that the &dgr;-subunit of PKC translocates from the Golgi area to the perinucleus and the nucleus in response to ethanol exposure, while the &egr;-subunit of PKC migrates from the perinucleus into the cytoplasm. The present invention further relates to the discovery that the detectable amount of the regulatory subunit RI of PKA decreases, while the detectable amount of &agr;PKC, &dgr;PKC and &egr;PKC increases upon exposure of a cell to ethanol. These discoveries provide the basis for assays that may be used to detect the exposure of cells to ethanol and assays that may be used for the screening of drugs or the development of treatments to modulate the effects of ethanol consumption. The invention further relates to kits for detecting the exposure of cells to ethanol. Kits of the invention may include antibodies, which preferably are labeled, capable of specifically binding to C&agr; or RI of the cAMP-dependent protein kinase, or, capable of specifically binding to &agr;PKC, &dgr;PKC or &egr;PKC.
摘要翻译：本发明涉及乙醇暴露对细胞定位和特异性蛋白质丰度的可确定的影响，本文称为乙醇指示蛋白。更具体地，本发明部分地基于以下发现：通常位于高尔基体区域中的cAMP依赖性蛋白激酶（PKA）的催化Calpha亚基似乎在细胞暴露时易位于细胞核到乙醇。本发明进一步基于以下观察：PKC的δ-亚基从高尔基域转移到响应于乙醇暴露的周核和核，而PKC的ε亚单位从周核迁移到细胞质中。本发明还涉及PKA的调节亚基RI的可检测量减少的发现，而当细胞暴露于乙醇时，可检测量的αPKC，δPKC和epsiPKC增加。这些发现提供了可用于检测细胞暴露于乙醇的测定的基础，以及可用于筛选药物或开发用于调节乙醇消耗的影响的处理的测定。本发明还涉及用于检测细胞暴露于乙醇的试剂盒。本发明的试剂盒可以包括优选被标记的能够特异性结合cAMP依赖性蛋白激酶的Calpha或RI的抗体，或能够特异性结合αPKC，δPKC或epsiPKC的抗体。

7. 发明申请

US20090203707A1 METHODS FOR TREATING PAIN 审中-公开
标题翻译：治疗疼痛的方法
公开(公告)号：US20090203707A1
公开(公告)日：2009-08-13
申请号：US12367403
申请日：2009-02-06
申请人： Sridharan Rajamani , John Shryock , Ivan Diamond , Luiz Belardinelli
发明人： Sridharan Rajamani , John Shryock , Ivan Diamond , Luiz Belardinelli
IPC分类号： A61K31/495 , A61P25/00
CPC分类号： A61K31/495
摘要： This invention relates to methods for treating a patient suffering from neuropathic or nociceptive pain which may be mechanical, visceral, and/or inflammatory in nature, comprising administering a therapeutically effective amount of Ranolazine to a patient in need thereof.
摘要翻译：本发明涉及用于治疗患有神经性或伤害性疼痛的患者的方法，所述疼痛本质上是机械的，内脏的和/或炎性的，其包括向有需要的患者施用治疗有效量的拉诺嗪。

8. 发明申请

US20060128708A1 Antagonizing an adenosine A2A receptor to ameliorate one or more components of addictive behavior 审中-公开
标题翻译：拮抗腺苷A2A受体以改善成瘾行为的一种或多种成分
公开(公告)号：US20060128708A1
公开(公告)日：2006-06-15
申请号：US11153725
申请日：2005-06-14
申请人： Ivan Diamond , Adrienne Gordon
发明人： Ivan Diamond , Adrienne Gordon
IPC分类号： A61K31/53 , A61K31/519 , A61K31/522
CPC分类号： A61K31/522 , A61K31/519 , A61K31/53
摘要： This invention provides a method of mitigating/ameliorating one or more components of addictive behavior associated with chronic consumption of a substance of abuse, or withdrawal therefrom. The method typically involves administering to a subject in need thereof an adenosine A2A receptor antagonist in an amount sufficient to ameliorate said one or more components of addictive behavior.
摘要翻译：本发明提供了减轻/改善与慢性消耗滥用物质或从其中提取相关的成瘾行为的一种或多种成分的方法。该方法通常涉及向有需要的受试者施用足以改善所述一种或多种成瘾行为成分的量的腺苷A2A受体拮抗剂。

9. 发明授权

US5112671A Tile product having multiple levels of height, multiple levels of gloss and mortar-line surround 失效
标题翻译：瓷砖产品具有多个高度，多层次的光泽和迫击炮环绕
公开(公告)号：US5112671A
公开(公告)日：1992-05-12
申请号：US532915
申请日：1990-06-04
申请人： Ivan Diamond , James J. Lawson , Walter J. Lewicki, Jr. , Stavros C. Stavrinou
发明人： Ivan Diamond , James J. Lawson , Walter J. Lewicki, Jr. , Stavros C. Stavrinou
IPC分类号： B29C35/12 , B29C59/02 , B32B27/30 , E04F15/10
CPC分类号： E04F15/10 , B29C59/026 , B32B27/30 , B32B37/06 , B32B37/1018 , B29C2791/001 , B29C35/12 , B29K2027/06 , B29L2031/104 , Y10T428/16 , Y10T428/162 , Y10T428/24479 , Y10T428/24488 , Y10T428/24504 , Y10T428/2457 , Y10T428/24612 , Y10T428/24777 , Y10T428/24802 , Y10T428/24868 , Y10T428/24876 , Y10T428/24901 , Y10T428/24942 , Y10T428/2495 , Y10T428/24967 , Y10T428/31935
摘要： A tile product having a substantially non-porous vinyl composition base and a multilevel embossing and gloss which has a mechanically embossed mortar-line surround and which is free of gloss defects formed by pockets of air trapped between the wear layer and embossing mold during embossing is produced by applying a vacuum to the press during embossing. Preferably, the tile is laminated in a hot press heated by RF energy and cooled in a cold press to reduce the temperature of the wear layer to below its glass transition temperature.
摘要翻译：具有基本上无孔的乙烯基组合物基材和多层压花和光泽的瓦片产品，其具有机械压花砂浆线环绕，并且在压花期间不存在被困在耐磨层和压花模具之间的空气袋形成的光泽缺陷，通过在压花时向压机施加真空而产生。优选地，将瓦片层压在通过RF能量加热的热压机中并在冷压机中冷却，以将耐磨层的温度降低到其玻璃化转变温度以下。

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