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    • 7. 发明申请
    • Therapeutic Agents Useful for Treating Pain
    • 用于治疗疼痛的治疗剂
    • US20100331369A1
    • 2010-12-30
    • US12817773
    • 2010-06-17
    • Qun SunXin Wen
    • Qun SunXin Wen
    • A61K31/444A61P29/00
    • A61K31/444C07D401/04C07D401/14C07D413/14C07D417/04C07D417/14
    • A compound of formula: where Ar1, Ar2, X, R3, and m are as disclosed herein or a pharmaceutically acceptable salt thereof (a “Cycloheteroalkenyl Compound”); compositions comprising an effective amount of a Cycloheteroalkenyl Compound; and methods for treating or preventing pain, UI, an ulcer, IBD, IBS, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia, or depression in an animal comprising administering to an animal in need thereof an effective amount of a Cycloheteroalkenyl Compound are disclosed herein.
    • 式中的化合物:其中Ar1,Ar2,X,R3和m如本文所公开或其药学上可接受的盐(“环烯基烯基化合物”); 包含有效量的环烯基烯基化合物的组合物; 以及用于治疗或预防疼痛,UI,溃疡,IBD,IBS,成瘾性障碍,帕金森病,帕金森综合征,焦虑,癫痫,中风,癫痫发作,瘙痒症状,精神病,认知障碍,记忆缺陷,受限制 脑功能,亨廷顿舞蹈病,肌萎缩性侧索硬化,痴呆,视网膜病变,肌肉痉挛,偏头痛,呕吐,运动障碍或抑郁症,包括向有需要的动物施用有效量的环烯基烯基化合物。