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1. 发明申请

US20110003850A1 DERIVATIVES OF 4-(N-AZACYCLOALKYL) ANILIDES AS POTASSIUM CHANNEL MODULATORS 有权
标题翻译：作为钾通道调节剂的4-（N-氮杂环丙基）酰胺的衍生物
公开(公告)号：US20110003850A1
公开(公告)日：2011-01-06
申请号：US12698070
申请日：2010-02-01
申请人： Jean-Michel Vernier , Martha Alicia De La Rosa , Huanming Chen , Jim Zhen Wu , Gary Lee Larson , Ian Wayne Cheney
发明人： Jean-Michel Vernier , Martha Alicia De La Rosa , Huanming Chen , Jim Zhen Wu , Gary Lee Larson , Ian Wayne Cheney
IPC分类号： A61K31/472 , C07D217/04 , A61P43/00
CPC分类号： C07D217/04
摘要： This invention provides a compound of formula IA where X=0 or S; Y is 0 or S; q=1 or 0; and other substituents are defined herein. Such compounds can affect the opening of, or otherwise modulate, voltage-gated potassium channels. Such compounds useful for the treatment and prevention of diseases and disorders which are affected by activation or modulation of potassium ion channels. One such condition is seizure disorders.
摘要翻译：本发明提供式IA化合物，其中X = 0或S; Y为0或S; q = 1或0; 和其它取代基在本文中定义。这种化合物可影响电压门控钾通道的开启或以其他方式调节。这些化合物可用于治疗和预防受到钾离子通道活化或调节影响的疾病和病症。一种这样的病症是癫痫发作。

2. 发明授权

US08293911B2 Derivatives of 4-(n-azacycloalkyl) anilides as potassium channel modulators 有权
标题翻译： 4-（正 - 氮杂环烷基）苯胺的衍生物作为钾通道调节剂
公开(公告)号：US08293911B2
公开(公告)日：2012-10-23
申请号：US11894877
申请日：2007-08-22
申请人： Jean-Michel Vernier , Martha Alicia De La Rosa , Huanming Chen , Jim Zhen Wu , Gary Lee Larson , Ian Wayne Cheney
发明人： Jean-Michel Vernier , Martha Alicia De La Rosa , Huanming Chen , Jim Zhen Wu , Gary Lee Larson , Ian Wayne Cheney
IPC分类号： C07D217/02 , C07D217/22 , A61K31/472
CPC分类号： C07D217/14 , C07D217/16
摘要： This invention provides a compound of formula IA where X═O or S; Y is O or S; q=1 or 0; and other substituents are defined herein. Such compounds can affect the opening of, or otherwise modulate, voltage-gated potassium channels. They are potentially useful for the treatment and prevention of diseases and disorders which are affected by activation or modulation of potassium ion channels. One such condition is seizure disorders.
摘要翻译：本发明提供式IA化合物，其中X = O或S; Y为O或S; q = 1或0; 和其它取代基在本文中定义。这种化合物可影响电压门控钾通道的开启或以其他方式调节。它们可用于治疗和预防受到钾离子通道活化或调节影响的疾病和病症。一种这样的病症是癫痫发作。

3. 发明授权

US08993593B2 N-(4-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-2,6-dimethylphenyl)-3,3-dimethylbutanamide as potassium channel modulators 有权
标题翻译： N-（4-（6-氟-3,4-二氢异喹啉-2（1H） - 基）-2,6-二甲基苯基）-3,3-二甲基丁酰胺，为钾通道调节剂
公开(公告)号：US08993593B2
公开(公告)日：2015-03-31
申请号：US12698070
申请日：2010-02-01
申请人： Jean-Michel Vernier , Martha Alicia De La Rosa , Huanming Chen , Jim Zhen Wu , Gary Lee Larson , Ian Wayne Cheney
发明人： Jean-Michel Vernier , Martha Alicia De La Rosa , Huanming Chen , Jim Zhen Wu , Gary Lee Larson , Ian Wayne Cheney
IPC分类号： A61K31/47 , C07D217/00
CPC分类号： C07D217/04
摘要： This invention provides a compound of formula A The compound provided herein can affect the opening of, or otherwise modulate, voltage-gated potassium channels. The compound provided herein is useful for the treatment and prevention of diseases and disorders which are affected by activation or modulation of potassium ion channels. One such condition is seizure disorders.
摘要翻译：本发明提供式A的化合物本文提供的化合物可影响电压门控钾通道的开启或以其他方式调节。本文提供的化合物可用于治疗和预防受到钾离子通道活化或调节影响的疾病和病症。一种这样的病症是癫痫发作。

4. 发明申请

US20080139610A1 Derivatives of 4-(n-azacycloalkyl) anilides as potassium channel modulators 有权
标题翻译： 4-（正 - 氮杂环烷基）苯胺的衍生物作为钾通道调节剂
公开(公告)号：US20080139610A1
公开(公告)日：2008-06-12
申请号：US11894877
申请日：2007-08-22
申请人： Jean-Michel Vernier , Martha Alicia De La Rosa , Huanming Chen , Jim Zhen Wu , Gary Lee Larson , Ian Wayne Cheney
发明人： Jean-Michel Vernier , Martha Alicia De La Rosa , Huanming Chen , Jim Zhen Wu , Gary Lee Larson , Ian Wayne Cheney
IPC分类号： A61K31/472 , A61P25/00 , C07D217/12
CPC分类号： C07D217/14 , C07D217/16
摘要： This invention provides a compound of formula IA where X═O or S; Y is O or S; q=1 or 0; and other substituents are defined herein. Such compounds can affect the opening of, or otherwise modulate, voltage-gated potassium channels. They are potentially useful for the treatment and prevention of diseases and disorders which are affected by activation or modulation of potassium ion channels. One such condition is seizure disorders.
摘要翻译：本发明提供式IA化合物，其中X-O或S; Y为O或S; q = 1或0 和其它取代基在本文中定义。这种化合物可影响电压门控钾通道的开启或以其他方式调节。它们可用于治疗和预防受到钾离子通道活化或调节影响的疾病和病症。一种这样的病症是癫痫发作。

5. 发明授权

US08492588B2 Benzyloxy anilide derivatives useful as potassium channel modulators 有权
标题翻译：可用作钾通道调节剂的苄氧基苯胺衍生物
公开(公告)号：US08492588B2
公开(公告)日：2013-07-23
申请号：US13483018
申请日：2012-05-29
申请人： Jim Zhen Wu , Jean-Michel Vernier , Huanming Chen , Jianlan Song
发明人： Jim Zhen Wu , Jean-Michel Vernier , Huanming Chen , Jianlan Song
IPC分类号： C07C233/00
CPC分类号： C07C233/25 , C07C233/26 , C07C271/28
摘要： The present invention relates to benzyloxyanilide derivatives having the following structural formula: The compounds of the present invention are useful for the treatment and prevention of diseases and disorders which are affected by activation or modulation of potassium ion channels. One such condition is seizure disorders.
摘要翻译：本发明涉及具有以下结构式的苄氧基苯胺衍生物：本发明化合物可用于治疗和预防受钾离子通道活化或调节影响的疾病和病症。一种这样的病症是癫痫发作。

6. 发明申请

US20090326059A1 BENZYLOXY ANILIDE DERIVATIVES USEFUL AS POTASSIUM CHANNEL MODULATORS 有权
标题翻译：可用作钾离子通道调节剂的苯并二恶嗪衍生物
公开(公告)号：US20090326059A1
公开(公告)日：2009-12-31
申请号：US12491055
申请日：2009-06-24
申请人： Jim Zhen Wu , Jean-Michel Vernier , Huanming Chen , Jianlan Song
发明人： Jim Zhen Wu , Jean-Michel Vernier , Huanming Chen , Jianlan Song
IPC分类号： A61K31/27 , C07C271/28 , C07C237/02 , A61K31/165 , A61P25/08
CPC分类号： C07C233/25 , C07C233/26 , C07C271/28
摘要： The present invention relates to benzyloxyanilide derivatives having the following structural formula: The compounds of the present invention are useful for the treatment and prevention of diseases and disorders which are affected by activation or modulation of potassium ion channels. One such condition is seizure disorders.
摘要翻译：本发明涉及具有以下结构式的苄氧基苯胺衍生物：本发明化合物可用于治疗和预防受钾离子通道活化或调节影响的疾病和病症。一种这样的病症是癫痫发作。

7. 发明授权

US08188314B2 Benzyloxy anilide derivatives useful as potassium channel modulators 有权
标题翻译：可用作钾通道调节剂的苄氧基苯胺衍生物
公开(公告)号：US08188314B2
公开(公告)日：2012-05-29
申请号：US12491055
申请日：2009-06-24
申请人： Jim Zhen Wu , Jean-Michel Vernier , Huanming Chen , Jianlan Song
发明人： Jim Zhen Wu , Jean-Michel Vernier , Huanming Chen , Jianlan Song
IPC分类号： C07C233/00
CPC分类号： C07C233/25 , C07C233/26 , C07C271/28
摘要： The present invention relates to benzyloxyanilide derivatives having the following structural formula: The compounds of the present invention are useful for the treatment and prevention of diseases and disorders which are affected by activation or modulation of potassium ion channels. One such condition is seizure disorders.
摘要翻译：本发明涉及具有以下结构式的苄氧基苯胺衍生物：本发明化合物可用于治疗和预防受钾离子通道活化或调节影响的疾病和病症。一种这样的病症是癫痫发作。

8. 发明授权

US08030518B2 1,4 diamino bicyclic retigabine analogues as potassium channel modulators 有权
标题翻译： 1,4-二氨基双环瑞替加滨类似物作为钾通道调节剂
公开(公告)号：US08030518B2
公开(公告)日：2011-10-04
申请号：US11946822
申请日：2007-11-28
申请人： Huanming Chen , Jianlan Song , Jean-Michel Vernier , Jim Zhen Wu
发明人： Huanming Chen , Jianlan Song , Jean-Michel Vernier , Jim Zhen Wu
IPC分类号： C07C233/05 , A61K31/165
CPC分类号： C07C233/41 , C07C2602/08 , C07C2602/10 , C07D213/74
摘要： This invention is directed to compounds of formula I, where G is —O—, —S—, —C(g1)(g2)-, or —NH—, and n=1, 2, or 3. Such compounds modulate potassium channels. The compounds are useful for the treatment and prevention of diseases and disorders which are affected by modulation of potassium ion channels. One such condition is seizure disorders.
摘要翻译：本发明涉及式I化合物，其中G是-O - ， - S-，-C（g1）（g2） - 或-NH-，n = 1,2或3.这样的化合物调节钾频道该化合物可用于治疗和预防受钾离子通道调节影响的疾病和病症。一种这样的病症是癫痫发作。

9. 发明申请

US20120329869A1 BENZYLOXY ANILIDE DERIVATIVES USEFUL AS POTASSIUM CHANNEL MODULATORS 有权
标题翻译：可用作钾离子通道调节剂的苯并二恶嗪衍生物
公开(公告)号：US20120329869A1
公开(公告)日：2012-12-27
申请号：US13483018
申请日：2012-05-29
申请人： Jim Zhen Wu , Jean-Michel Vemier , Huanming Chen , Jianlan Song
发明人： Jim Zhen Wu , Jean-Michel Vemier , Huanming Chen , Jianlan Song
IPC分类号： A61K31/27 , A61P25/08 , A61K31/167
CPC分类号： C07C233/25 , C07C233/26 , C07C271/28
摘要： The present invention relates to benzyloxyanilide derivatives having the following structural formula: The compounds of the present invention are useful for the treatment and prevention of diseases and disorders which are affected by activation or modulation of potassium ion channels. One such condition is seizure disorders.
摘要翻译：本发明涉及具有以下结构式的苄氧基苯胺衍生物：本发明化合物可用于治疗和预防受钾离子通道活化或调节影响的疾病和病症。一种这样的病症是癫痫发作。

10. 发明授权

US08067452B2 3-hydroxyisothiazole-4-carboxamidine derivatives as CHK2 inhibitors 有权
标题翻译： 3-羟基异噻唑-4-甲脒衍生物作为CHK2抑制剂
公开(公告)号：US08067452B2
公开(公告)日：2011-11-29
申请号：US12143672
申请日：2008-06-20
申请人： Jim Zhen Wu , Huanming Chen
发明人： Jim Zhen Wu , Huanming Chen
IPC分类号： A61K31/425 , C07D275/03
CPC分类号： C07D275/03
摘要： This invention provides compounds of Formula I which are inhibitors of Chk2 and are useful as a radiation protection agents in anticancer radiotherapy. A method of modulating Chk2 in vitro includes treating a substrate with Chk2 in the presence of compounds of formula I. A method of making a compound of formula I includes: a) forming a biaryl amine having an amino (NH2) group; b) converting the amino group to an isothiocyanate group; c) adding a cyanoacetamide to the isothiocyanate group to form a thioamide adduct; d) cyclizing the thioamide adduct to form an isothiazole having a cyano group; and e) adding an amine to the cyano group to form a carboxamidine group.
摘要翻译：本发明提供了作为Chk2抑制剂的式I化合物，可用作抗癌放射治疗中的放射防护剂。在体外调节Chk2的方法包括在式I化合物存在下用Chk2处理底物。制备式I化合物的方法包括：a）形成具有氨基（NH 2）基团的联芳基胺; b）将氨基转化为异硫氰酸酯基团; c）将氰基乙酰胺加入到异硫氰酸酯基中以形成硫代酰胺加合物; d）使硫代酰胺加合物环化以形成具有氰基的异噻唑; 和e）向氰基中加入胺形成甲脒基团。

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