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1. 发明申请

US20110044899A1 LABELLED ANALOGUES OF HALOBENZAMIDES AS MULTIMODAL RADIOPHARMACEUTICALS AND THEIR PRECURSORS 审中-公开
标题翻译：作为多模式放射治疗剂及其前体的哈芬碱的标记类似物
公开(公告)号：US20110044899A1
公开(公告)日：2011-02-24
申请号：US12865059
申请日：2009-01-28
申请人： Jean-Michel Chezal , Frederic Dolle , Jean-Claude Madelmont , Aurelie Maisonial , Elisabeth Miot-Noirault , Nicole Moins , Janine Papon , Bertrand Kuhnast , Bertrand Tavitian , Raphael Boisgard
发明人： Jean-Michel Chezal , Frederic Dolle , Jean-Claude Madelmont , Aurelie Maisonial , Elisabeth Miot-Noirault , Nicole Moins , Janine Papon , Bertrand Kuhnast , Bertrand Tavitian , Raphael Boisgard
IPC分类号： A61K51/00 , C07D401/12 , A61K31/498 , C07D241/44 , A61K31/4709 , C07D213/65 , A61K31/44 , C07D471/04 , A61K31/4375 , A61K31/437 , A61K31/473 , C07F7/22 , A61K31/555 , A61P43/00 , A61P35/00
CPC分类号： A61K49/0002 , C07D213/65 , C07D213/76 , C07D215/54 , C07D241/44 , C07D401/12 , C07D487/04
摘要： A compound of formula (I): in which R1 represents a hydrogen atom, an optionally labelled halogen, a radionuclide or a Sn[(C1-C4)alkyl]3 group, Ar represents an aryl group or a heteroaryl group, R9 represents a hydrogen atom, a (C1-C4) alkyl group or forms together with the group R1—Ar a ring fused with the Ar group, A represents a group of formula (β) or (δ): R3 and R4 independently represent a hydrogen atom, a (C1-C6)alkyl group, a (C1-C6) alkenyl group or a group of formula (y): wherein R11 represents an optionally labelled halogen, a radionuclide, an aryl or heteroaryl group optionally substituted by an optionally labelled halogen, a radionuclide, a —NO2 group, a —NR5R6 group, a N+R5R6R7X− group, or a —OSO2R12 group, and their addition salts with pharmaceutically acceptable acids.
摘要翻译：式（I）化合物：其中R 1表示氢原子，任选标记的卤素，放射性核素或Sn [（C 1 -C 4）烷基] 3基团，Ar表示芳基或杂芳基，R 9表示氢原子，（C1-C4）烷基或与基团R1-Ar一起形成与Ar基团稠合的环，A表示式（bgr）或（δ）的基团：R 3和R 4独立地表示氢原子，（C1-C6）烷基，（C1-C6）烯基或式（y）的基团：其中R11表示任选标记的卤素，放射性核素，芳基或杂芳基，卤素，放射性核素，-NO 2基，-NR 5 R 6基，N + R 5 R 6 R 7 X基或-OSO 2 R 12基，以及它们与药学上可接受的酸的加成盐。

2. 发明授权

US08615117B2 Method for estimating the concentration of a tracer in a tissue structure assembly, and corresponding storage medium and device 有权
标题翻译：用于估计组织结构组件中的示踪剂的浓度的方法，以及相应的存储介质和装置
公开(公告)号：US08615117B2
公开(公告)日：2013-12-24
申请号：US13125915
申请日：2009-09-18
申请人： Renaud Maroy , Bertrand Tavitian
发明人： Renaud Maroy , Bertrand Tavitian
IPC分类号： G06K9/00
CPC分类号： G06T11/006 , G06T2211/424
摘要： A method provides for estimating the concentration of a tracer in a tissue structure assembly including at least one tissue structure, from a measurement image of the tracer concentration in said tissue structure assembly, which is obtained by an imaging apparatus, wherein said image includes at least one space domain inside which the tracer concentration is homogenous and at least one region of interest in which the tracer concentration is measured. The method includes: determining a geometric transfer matrix having coefficients representative of the contribution of the space domains in the measurement of the tracer concentration in the regions of interest; optimizing the coefficient of the geometric transfer matrix by defining the best regions of interest in terms of errors in order to measure the tracer concentration, the definition of the regions of interest being carried out according to an iterative loop that includes the following steps upon each iteration: modifying the regions of interest, and calculating the coefficients of the geometric transfer matrix from the modified regions of interest; selecting an optimized geometric transfer matrix among the calculated geometric transfer matrices; and estimating the tracer concentration from the optimized geometric transfer matrix.
摘要翻译：一种方法提供从由成像设备获得的所述组织结构组件中的示踪剂浓度的测量图像中估计包括至少一个组织结构的组织结构组件中的示踪剂的浓度，其中所述图像至少包括一个空间域，其中示踪剂浓度是均匀的，以及至少一个其中测量示踪剂浓度的感兴趣区域。该方法包括：确定具有代表在感兴趣区域中示踪剂浓度的测量中空间域的贡献的系数的几何传递矩阵; 通过根据误差定义感兴趣的最佳区域来优化几何传递矩阵的系数，以便测量示踪剂浓度，根据迭代循环进行感兴趣区域的定义，该迭代循环在每次迭代时包括以下步骤：修改感兴趣区域，以及从感兴趣的修改区域计算几何传递矩阵的系数; 在计算的几何传递矩阵中选择优化的几何传递矩阵; 并从优化的几何传递矩阵估计示踪剂浓度。

3. 发明申请

US20130230467A1 POLYMERIZED MICELLES FOR DIAGNOSIS 有权
标题翻译：聚合物用于诊断
公开(公告)号：US20130230467A1
公开(公告)日：2013-09-05
申请号：US13816414
申请日：2011-07-07
申请人： Eric Doris , Frédéric Duconge , Edmond Gravel , Nicolas MacKiewicz , Bertrand Tavitian
发明人： Eric Doris , Frédéric Duconge , Edmond Gravel , Nicolas MacKiewicz , Bertrand Tavitian
IPC分类号： A61K49/00
CPC分类号： A61K49/0082 , A61K9/1075 , A61K49/0032 , A61K49/0054
摘要： The invention relates to polymerized micelles of size inferior to 100 nm for in vivo diagnosis, in particular of cancer. The polymerized micelles of the invention comprise a diagnostic agent and an amphiphilic polymer obtainable by the polymerization of an amphiphilic monomer, said monomer comprising: a lipophilic chain comprising a polymerizable vinylic or diacetylenic group, and a hydrophilic head comprising a polyoxyethylene or polyoxypropylene chain. The invention finds application in the pharmaceutical field, in particular.
摘要翻译：本发明涉及体积小于100nm的聚合胶束，用于体内诊断，特别是癌症。本发明的聚合胶束包含诊断剂和可通过两亲性单体聚合而获得的两亲性聚合物，所述单体包括：包含可聚合乙烯基或二乙炔基的亲油链和包含聚氧乙烯或聚氧丙烯链的亲水头。本发明特别适用于制药领域。

4. 发明申请

US20060228296A1 Method of screening groups of radioactive molecules and applications thereof 失效
标题翻译：筛选放射性分子组的方法及其应用
公开(公告)号：US20060228296A1
公开(公告)日：2006-10-12
申请号：US10514562
申请日：2003-05-28
申请人： Vincent Dive , Andre Menez , Reto Stocklin , Bertrand Tavitian , Fabrice Beau , Bertrand Czarny , Joel Cotton
发明人： Vincent Dive , Andre Menez , Reto Stocklin , Bertrand Tavitian , Fabrice Beau , Bertrand Czarny , Joel Cotton
IPC分类号： A61K51/00 , C40B30/06
CPC分类号： C07K5/1027 , G01N33/5082
摘要： The invention relates to an amplification-free method of screening groups of radioactive molecules, the products from the molecule groups obtained and the application thereof in order to identify molecules that are capable of binding selectively to a tissue or a particular organ. The inventive method can be used for the development of novel therapeutic compounds and contrast agents for medical imaging and for the screening of medicaments. Said method of screening a group of molecules is characterised in that it comprises at least the following steps: (1) the group of molecules is administered to at least one animal, each molecule being marked first by a suitable radioactive isotope; (2) at least one of the animals is slaughtered and the tissue distribution of the radioactivity of the molecules administered is analysed from sections of tissue or organs taken using suitable imaging devices; (3) sections of tissue or organs in which a radioactivity signal is detected are selected; (4) radioactive fractions from the aforementioned sections of tissue or organs selected during step 3 are isolated using suitable techniques such as chromatography and/or extraction techniques; and (5) the molecule(s) from the radioactive fractions obtained in step 4 are characterised using suitable analysis techniques such as chromatography and/or mass spectrometry. According to one variation of the method, in step 2, where possible, the tissue distribution of the radioactivity of the molecules administered is analysed in vivo using suitable imaging devices from a biological sample which is pre-extracted and selected from the group containing cells and sections of tissue or organs. As a result, said variation does not require the animal to be slaughtered.
摘要翻译：本发明涉及一种无扩增方法，用于筛选放射性分子组，所获得的分子组的产物及其应用，以鉴定能够选择性结合组织或特定器官的分子。本发明的方法可用于开发用于医学成像和药物筛选的新型治疗化合物和造影剂。筛选一组分子的所述方法的特征在于其至少包括以下步骤：（1）向至少一种动物施用分子组，每个分子首先由合适的放射性同位素标记; （2）屠宰至少一只动物，并从使用合适的成像装置取出的组织或器官的部分分析施用的分子的放射性的组织分布; （3）选择检测放射性信号的组织或器官的部分; （4）使用合适的技术如色谱和/或提取技术分离来自步骤3中选择的组织或器官的前述部分的放射性级分; 和（5）来自步骤4中获得的放射性级分的分子使用合适的分析技术如色谱和/或质谱鉴定。根据该方法的一个变体，在步骤2中，在可能的情况下，使用来自生物样品的合适的成像装置在体内分析施用的分子的放射性的组织分布，所述生物样品被预先提取并选自含有细胞的组和组织或器官的部分。因此，所述变体不需要屠宰动物。

5. 发明授权

US09839700B2 Polymerized micelles for diagnosis 有权
公开(公告)号：US09839700B2
公开(公告)日：2017-12-12
申请号：US13816414
申请日：2011-07-07
申请人： Eric Doris , Frédéric Duconge , Edmond Gravel , Nicolas Mackiewicz , Bertrand Tavitian
发明人： Eric Doris , Frédéric Duconge , Edmond Gravel , Nicolas Mackiewicz , Bertrand Tavitian
IPC分类号： A61K9/00 , A61K49/00 , A61K9/107
CPC分类号： A61K49/0082 , A61K9/1075 , A61K49/0032 , A61K49/0054
摘要： The invention relates to polymerized micelles of size inferior to 100 nm for in vivo diagnosis, in particular of cancer. The polymerized micelles of the invention comprise a diagnostic agent and an amphiphilic polymer obtainable by the polymerization of an amphiphilic monomer, said monomer comprising: a lipophilic chain comprising a polymerizable vinylic or diacetylenic group, and a hydrophilic head comprising a polyoxyethylene or polyoxypropylene chain. The invention finds application in the pharmaceutical field, in particular.

6. 发明申请

US20120039816A1 USE OF 7-CHLORO-N,N,5-TRIMETHYL-4-OXO-3-PHENYL-3,5-DIHYDRO-4H-PYRIDAZINO[4,5-B] INDOLE-1-ACETAMIDE AS A BIOMARKER OF PERIPHERAL BENZODIAZEPINE RECEPTOR LEVELS 审中-公开
标题翻译：使用7-氯代-N，N，5-三甲基-4-氧代-3-苯基-3,5-二氢-4H-吡啶并[4,5-B]吲哚-1-乙酰胺作为外周苯并二氮杂受体的生物标志物水平
公开(公告)号：US20120039816A1
公开(公告)日：2012-02-16
申请号：US13126648
申请日：2009-10-27
申请人： Jesus Benavides , Hérve Boutin , Marie-Noëlle Castel , Annelaure Damont , Frédéric Dolle , Philippe Hantraye , Frank Marguet , Thomas Rooney , Luc Rivron , Bertrand Tavitian , Cyrille Thominiaux
发明人： Jesus Benavides , Hérve Boutin , Marie-Noëlle Castel , Annelaure Damont , Frédéric Dolle , Philippe Hantraye , Frank Marguet , Thomas Rooney , Luc Rivron , Bertrand Tavitian , Cyrille Thominiaux
IPC分类号： A61K49/04 , C07D487/04
CPC分类号： G01N33/6872 , A61K51/0459 , G01N33/58 , G01N2333/705
摘要： Use of a radiolabelled form of 7-chloro-Λ/,Λ/,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4/-/-pyridazino[4,5-b]indole-1-acetamide as a biomarker for the detection, in an individual, of PBR levels associated with normal and pathological conditions. Method for the detection of PBR levels associated with normal and pathological conditions. Diagnostic kit.
摘要翻译：使用放射性标记形式的7-氯代Λ/，Λ/，5-三甲基-4-氧代-3-苯基-3,5-二氢-4H-哒嗪并[4,5-b]吲哚-1 - 乙酰胺作为用于在个体中检测与正常和病理状况相关的PBR水平的生物标志物。检测与正常和病理状况相关的PBR水平的方法。诊断套件

7. 发明申请

US20060269130A1 Method of segmentation of a sequence of three-dimensional images, in particular in pharmaco-imagerie 有权
标题翻译：分割三维图像序列的方法，特别是在药物成像中
公开(公告)号：US20060269130A1
公开(公告)日：2006-11-30
申请号：US11335712
申请日：2006-01-20
申请人： Renaud Maroy , Bertrand Tavitian , Vincent Frouin
发明人： Renaud Maroy , Bertrand Tavitian , Vincent Frouin
IPC分类号： G06K9/34 , G06K9/00
CPC分类号： A61B6/508 , A61B6/037 , G06T7/11 , G06T7/143 , G06T7/187 , G06T7/215 , G06T2207/10076 , G06T2207/10104 , G06T2207/30004
摘要： The present invention relates to a method of segmenting a starting image or sequence of tridimensional images for obtaining a tridimensional segmentation image comprising a partition into regions of interest, said image or sequence of images comprising measurements, for each voxel and in the course of n time intervals (n≧1), of the real evolution of a signal representative of at least one variable of said image or sequence, which comprises essentially: a) a modeling (10) of the signal comprising the definition of a parametric model of spatio-temporal evolution of said signal, this model comprising sets of homogeneous parameters respectively specific to structures corresponding to said regions of interest; b) an extraction (30) of samples of voxels respectively included in said structures; then c) a merging (50b) of the samples grouping together those whose evolution model is specific to the same structure, said merging following, preceding or including a classification of all the voxels of said image or sequence of images or of a zone of interest of the latter by aggregation with a group of samples.
摘要翻译：本发明涉及一种分割三维图像的起始图像或序列的方法，用于获得三维分割图像，该三维分割图像包括分割成感兴趣的区域，所述图像或图像序列包括针对每个体素的测量，并且在n个时间段代表所述图像或序列的至少一个变量的信号的实际演变的间隔（n> = 1），其基本上包括：a）信号的建模（10），其包括空间的参数模型的定义所述信号的时间演化，该模型包括分别特定于对应于所述感兴趣区域的结构的均匀参数集合; b）分别包括在所述结构中的体素样本的提取（30）; 然后c）合并（50b）的样本将进化模型特定于相同结构的那些分组在一起，在所述图像或图像序列的所有体素的分类之前或之后合并，后者通过与一组样本的聚合的兴趣。

8. 发明授权

US07630550B2 Method of segmentation of a sequence of three-dimensional images, in particular in pharmaco-imagerie 有权
标题翻译：分割三维图像序列的方法，特别是在药物成像中
公开(公告)号：US07630550B2
公开(公告)日：2009-12-08
申请号：US11335712
申请日：2006-01-20
申请人： Renaud Maroy , Bertrand Tavitian , Vincent Frouin
发明人： Renaud Maroy , Bertrand Tavitian , Vincent Frouin
IPC分类号： G06K9/34
CPC分类号： A61B6/508 , A61B6/037 , G06T7/11 , G06T7/143 , G06T7/187 , G06T7/215 , G06T2207/10076 , G06T2207/10104 , G06T2207/30004
摘要： The present invention relates to a method of segmenting a starting image or sequence of tridimensional images for obtaining a tridimensional segmentation image comprising a partition into regions of interest, said image or sequence of images comprising measurements, for each voxel and in the course of n time intervals (n≧1), of the real evolution of a signal representative of at least one variable of said image or sequence, which comprises essentially: a) a modeling (10) of the signal comprising the definition of a parametric model of spatio-temporal evolution of said signal, this model comprising sets of homogeneous parameters respectively specific to structures corresponding to said regions of interest; b) an extraction (30) of samples of voxels respectively included in said structures; then c) a merging (50b) of the samples grouping together those whose evolution model is specific to the same structure, said merging following, preceding or including a classification of all the voxels of said image or sequence of images or of a zone of interest of the latter by aggregation with a group of samples.
摘要翻译：本发明涉及一种分割三维图像的起始图像或序列的方法，用于获得三维分割图像，该三维分割图像包括分割成感兴趣的区域，所述图像或图像序列包括针对每个体素的测量，并且在n个时间段代表所述图像或序列的至少一个变量的信号的实际演变的间隔（n> = 1），其基本上包括：a）信号的建模（10），其包括空间的参数模型的定义所述信号的时间演化，该模型包括分别特定于对应于所述感兴趣区域的结构的均匀参数集合; b）分别包括在所述结构中的体素样本的提取（30）; 然后c）合并（50b）的样本将进化模型特定于相同结构的那些进行分组，所述合并，在所述图像或图像序列或感兴趣区域的所有体素的分类之前，通过与一组样本的聚合。

9. 发明申请

US20080227735A1 Aptamers Selected From Live Tumor Cells and the Use Thereof 审中-公开
标题翻译：选自活肿瘤细胞的选择及其用途
公开(公告)号：US20080227735A1
公开(公告)日：2008-09-18
申请号：US10593256
申请日：2005-03-17
申请人： Bertrand Tavitian , Frederic Duconge , Domenico Libri , Vittorio De Franciscis , Laura Cerchia
发明人： Bertrand Tavitian , Frederic Duconge , Domenico Libri , Vittorio De Franciscis , Laura Cerchia
IPC分类号： A61K31/7052 , C40B30/04 , C12Q1/68 , A61P35/00 , C07H21/00
CPC分类号： C12Q1/68
摘要： The invention relates to aptamers selected from live tumor cells and to the use thereof for diagnosis and treatment of certain cancers and other pathologies.
摘要翻译：本发明涉及选自活肿瘤细胞的适体及其用于诊断和治疗某些癌症及其他病理学的用途。

10. 发明申请

US20110317889A1 METHOD FOR ESTIMATING THE CONCENTRATION OF A TRACER IN A TISSUE STRUCTURE ASSEMBLY, AND CORRESPONDING STORAGE MEDIUM AND DEVICE 有权
标题翻译：用于估计组织结构组件中的跟踪器的浓度的方法以及相应的存储介质和设备
公开(公告)号：US20110317889A1
公开(公告)日：2011-12-29
申请号：US13125915
申请日：2009-09-18
申请人： Renaud Maroy , Bertrand Tavitian
发明人： Renaud Maroy , Bertrand Tavitian
IPC分类号： G06K9/00
CPC分类号： G06T11/006 , G06T2211/424
摘要： A method provides for estimating the concentration of a tracer in a tissue structure assembly including at least one tissue structure, from a measurement image of the tracer concentration in said tissue structure assembly, which is obtained by an imaging apparatus, wherein said image includes at least one space domain inside which the tracer concentration is homogenous and at least one region of interest in which the tracer concentration is measured. The method includes: determining a geometric transfer matrix having coefficients representative of the contribution of the space domains in the measurement of the tracer concentration in the regions of interest; optimizing the coefficient of the geometric transfer matrix by defining the best regions of interest in terms of errors in order to measure the tracer concentration, the definition of the regions of interest being carried out according to an iterative loop that includes the following steps upon each iteration: modifying the regions of interest, and calculating the coefficients of the geometric transfer matrix from the modified regions of interest; selecting an optimized geometric transfer matrix among the calculated geometric transfer matrices; and estimating the tracer concentration from the optimized geometric transfer matrix.
摘要翻译：一种方法提供从由成像设备获得的所述组织结构组件中的示踪剂浓度的测量图像中估计包括至少一个组织结构的组织结构组件中的示踪剂的浓度，其中所述图像至少包括一个空间域，其中示踪剂浓度是均匀的，以及至少一个其中测量示踪剂浓度的感兴趣区域。该方法包括：确定具有代表在感兴趣区域中示踪剂浓度的测量中空间域的贡献的系数的几何传递矩阵; 通过根据误差定义感兴趣的最佳区域来优化几何传递矩阵的系数，以便测量示踪剂浓度，根据迭代循环进行感兴趣区域的定义，该循环包括在每次迭代时包括以下步骤：修改感兴趣区域，以及从感兴趣的修改区域计算几何传递矩阵的系数; 在计算的几何传递矩阵中选择优化的几何传递矩阵; 并从优化的几何传递矩阵估计示踪剂浓度。

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