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1. 发明授权

US5124930A Method for analyzing a signal by wavelets 失效
标题翻译：通过小波分析信号的方法
公开(公告)号：US5124930A
公开(公告)日：1992-06-23
申请号：US481336
申请日：1990-02-20
申请人： Jean-Marie Nicolas , Alain Lemer
发明人： Jean-Marie Nicolas , Alain Lemer
IPC分类号： G01R23/16
CPC分类号： G01R23/16
摘要： To analyze short-duration signals by means of an analysis using MARRAT's algorithm with the wavelets of DAUBECHIES, at each step the correlation is done both on the signals coming from the correlation at the previous step by the scale .PHI..sub.O signal and on the signals coming from the correlation at the preceding step by the signal .PHI..sub.O. Thus, at the stage p, there is obtained a homogeneous signal consisting of 2.sup.p .times.N.sup.p points of analysis. This makes it possible, in the method of analysis by wavelets, to obtain a depiction of the results having a homogeneous form making it easier to interpret them.
摘要翻译：为了通过使用具有DAUBECHIES小波的MARRAT算法的分析来分析短持续时间信号，在每个步骤中，对来自前一步骤的相关信号由标度PHI O信号和信号来的相关性进行相关从前面步骤的相关信号PHI O.因此，在阶段p，获得由2pxNp分析点组成的均匀信号。这使得在通过小波分析的方法中可以获得具有均匀形式的结果的描绘，使得它们更容易解释。

2. 发明授权

US4750366A Method of and device for measuring an ultrasound scatter function 失效
标题翻译：用于测量超声散射函数的方法和装置
公开(公告)号：US4750366A
公开(公告)日：1988-06-14
申请号：US843894
申请日：1986-03-25
申请人： Jean-Marie Nicolas
发明人： Jean-Marie Nicolas
IPC分类号： G01N29/04 , A61B8/00 , G01N29/44 , G01S7/52 , G01S15/89 , G01N29/00 , A61B10/00
CPC分类号： G01S7/52036 , G01S15/8954 , G01S7/52025
摘要： A biological or other material is scanned along a line or plurality of lines by at least one transducer, and the signals received are separated into n substantially equal, consecutive frequency bands after which the envelope of the signals in each frequency band is determined. Each of the signal envelopes, being proportional to the power spectrum of the echographic signal, is divided by a dividing signal which is proportional to the power spectrum of a phantom which has the same attenuation as the object being examined, the logarithm being determined of the signal resulting from this division, after which the following operations are performed in the channels a, b, . . . , i, . . . n on the basis of the signals thus obtained: (a) calculating the logarithm of a frequency which is representative of the passband of each channel; (b) storing in a memory and/or displaying a function of the ratio of the scatter function of the object scanned and the scatter function of the phantom as a function of the frequency mentioned sub (a); as a representation of the object's scatter function.
摘要翻译：通过至少一个换能器沿线或多条线扫描生物或其他材料，并且接收到的信号被分离成n个基本相等的连续频带，之后确定每个频带中的信号的包络。与回波信号的功率谱成比例的每个信号包络被除以与被检测物体具有相同衰减的体模的功率谱成比例的分频信号，对数被确定为由此划分得到的信号，之后在通道a，b，...中执行以下操作。。。，一世，。。。根据如此获得的信号，n：计算表示每个通道的通带的频率的对数; （b）存储在存储器中和/或显示作为所述sub（a）的频率的函数的扫描对象的散射函数与体模的散射函数的比率的函数的函数; 作为对象散点函数的表示。

3. 发明授权

US4688428A Method of and device for scanning objects by means of ultrasound echography 失效
标题翻译：通过超声波回波检测对物体进行扫描的方法和装置
公开(公告)号：US4688428A
公开(公告)日：1987-08-25
申请号：US843906
申请日：1986-03-25
申请人： Jean-Marie Nicolas
发明人： Jean-Marie Nicolas
IPC分类号： G01N29/44 , A61B8/00 , A61B8/14 , G01N29/04 , G01N29/26 , G01S7/52
CPC分类号： G01S7/52036 , G01S7/52025 , G01S7/52058
摘要： A method of scanning objects by means of ultrasound echography, including the repeated transmission of ultrasound signals by means of at least one ultrasound transducer and the reception of the ultrasound echoes which correspond to the principal obstacles encountered by the transmitted signals in their propagation direction, characterized in that the method includes the following operations:(a) storing an echographic line in a memory;(b) determining the power spectrum for a given observation depth, including the correction for the effects of diffraction and attenuation;(c) storing in a memory and/or displaying the scatter function of the object examined as a function of frequency;(d) repeating the operations (b), (c) for every desired depth on a given echographic line, and the operations (a), (b), (c) for other echographic lines.
摘要翻译：一种通过超声波回波成像扫描物体的方法，包括通过至少一个超声换能器重复传输超声波信号，以及接收对应于传播信号在其传播方向上遇到的主要障碍的超声回波，其特征在于因为该方法包括以下操作：（a）将回波线存储在存储器中; （b）确定给定观测深度的功率谱，包括对衍射和衰减效应的校正; （c）存储在存储器中和/或显示被检查对象的散射函数作为频率的函数; （d）针对给定回波线上的每个所需深度重复操作（b），（c），以及其他回波线的操作（a），（b），（c））。

4. 发明授权

US09504449B2 Ultrasonic imaging device with image acquisition rate optimization 有权
标题翻译：超声波成像装置采用图像采集率优化
公开(公告)号：US09504449B2
公开(公告)日：2016-11-29
申请号：US13984011
申请日：2012-02-03
申请人： Jean-Marie Nicolas , Laurent Kopp , Frédéric Mosca , Claude Cohen-Bacrie , Christophe Fraschini
发明人： Jean-Marie Nicolas , Laurent Kopp , Frédéric Mosca , Claude Cohen-Bacrie , Christophe Fraschini
IPC分类号： A61B8/08 , G01S15/89 , A61B8/14 , A61B8/00
CPC分类号： A61B8/5207 , A61B8/145 , A61B8/4483 , A61B8/469 , A61B8/485 , A61B8/54 , G01S15/8959 , G01S15/8977 , G01S15/8997
摘要： The disclosure includes a method of acquiring high-resolution ultrasound images using an array of transducers using successive transmission matrices. Implementations include operations for determining inter-transducer correlation matrices of an area of interest and an unwanted area; determining a characteristic matrix of the area of interest from the product of the inverse of the inter-transducer correlation matrix of the unwanted area and the inter-transducer correlation matrix of the area of interest; calculating eigenvectors and values of the characteristic matrix to define a transmission matrix; adjusting the image acquisition rate and image quality in order to define eigenvectors for firing; multiplying a reception matrix comprising the acquired signals completed by data set to zero corresponding to the firings not effected by the inverse of the transmission matrix to obtain a complete data set; reconstructing a high-resolution image of the area of interest as in synthetic aperture echographic imaging methods.
摘要翻译：本公开包括使用连续传输矩阵使用换能器阵列来获取高分辨率超声图像的方法。实现包括用于确定感兴趣区域和不需要区域的换能器间相关矩阵的操作; 从所述不需要区域的换能器间相关矩阵的逆的乘积和所述感兴趣区域的换能器间相关矩阵的乘积确定所述感兴趣区域的特征矩阵; 计算特征矩阵的特征向量和值以定义传输矩阵; 调整图像采集率和图像质量，以定义特征向量进行点火; 将包含由数据集合完成的所获取的信号的接收矩阵与对应于不受发送矩阵的逆的影响的发出相乘以获得完整的数据集; 如合成孔径回波成像方法重建感兴趣区域的高分辨率图像。

5. 发明授权

US5100591A Process for preparing lipid microparticles 失效
标题翻译：制备脂质微球的方法
公开(公告)号：US5100591A
公开(公告)日：1992-03-31
申请号：US582053
申请日：1990-09-14
申请人： Brigitte Leclef , Patrick Cerfontaine , Jean-Marie Nicolas , Henri Wantier , Andre Trouet
发明人： Brigitte Leclef , Patrick Cerfontaine , Jean-Marie Nicolas , Henri Wantier , Andre Trouet
IPC分类号： A61K9/14 , A61K9/107 , A61K9/127 , A61K9/16 , A61K9/51 , A61K9/52 , A61K31/70
CPC分类号： A61K9/5123 , A61K31/7048 , A61K9/1617
摘要： The present invention relates to a process for preparing lipid microparticles of microcrystalline appearance, of a water-insoluble substance possessing an affinity for phospholipids and of at least one phospholipid, the microparticles being stable in suspension in an aqueous solution, characterized in that:a) the said substance and the said phospholipid or phospholipids are dissolved in a common organic solvent for the said substance and for the said phospholipid or phospholipids,b) the solution of said substance and of the said phospholipid or phospholipids is mixed with an aqueous solution in an amount such that an insolubilization takes place in the form of a precipitate, andc) the organic solution is removed to recover an aqueous solution containing the microparticles in the form of microsuspensions.
摘要翻译：本发明涉及一种制备微晶外观的脂质微粒的方法，其具有对磷脂和至少一种磷脂具有亲和性的水不溶性物质，所述微粒在水溶液中悬浮稳定，其特征在于：a）所述物质和所述磷脂或磷脂溶解在用于所述物质和所述磷脂或磷脂的普通有机溶剂中，b）将所述物质和所述磷脂或磷脂的溶液与水溶液混合在一起使得不溶解以沉淀物的形式发生，和c）除去有机溶液以回收含微量悬浮液形式的微粒的水溶液。

6. 发明授权

US4702258A Device for combined B-scan and B/A imaging 失效
标题翻译：用于组合B扫描和B / A成像的装置
公开(公告)号：US4702258A
公开(公告)日：1987-10-27
申请号：US825844
申请日：1986-02-04
申请人： Jean-Marie Nicolas , Patrick Pesque
发明人： Jean-Marie Nicolas , Patrick Pesque
IPC分类号： G01S15/89 , A61B8/08 , G01N29/06 , G01N29/44 , G01S7/52 , A61B10/00
CPC分类号： G01S7/52071 , G01N29/0609 , G01S7/52025 , G01S7/52036 , G01S7/52058 , G01N2291/02491
摘要： The combined modality device comprises an ultrasound transducer (10) which is suitable for transmission as well as reception and which is connected to a transmitter stage (20) as well as to a receiver stage (30). The transducer (10) has a bandwidth which at least equals approximately one octave. The transmitter stage (20) comprises a generator for generating activation signals for the transducer (10) with a frequency f.sub.o near the lower limit of said bandwidth, the spectrum of these activation signals excluding the frequency f.sub.1 =2f.sub.o. The receiver stage (30) comprises a B-scan channel and also a B/A processing channel (200) which itself includes a bandpass filter (210) which is centered around said frequency f.sub.1, an envelope detector (220, 230), a comparison circuit (240), a differentiation circuit (250) and a display device (260) whereby measured results in both modalities may be displayed.
摘要翻译：组合的模式装置包括适于传输和接收的超声换能器（10），并且其连接到发射台（20）以及接收器级（30）。换能器（10）具有至少等于大约一个八度的带宽。发射机级（20）包括发生器，用于以接近所述带宽下限的频率fo产生用于换能器（10）的激活信号，这些激活信号的频谱不包括频率f1 = 2fo。接收机级（30）包括B扫描通道和B / A处理通道（200），B / A处理通道本身包括以所述频率f1为中心的带通滤波器（210），包络检测器（220,230），比较电路（240），微分电路（250）和显示装置（260），由此可以显示两种模式的测量结果。

7. 发明申请

US20140024943A1 IMAGING DEVICE WITH IMAGE ACQUISITION RATE OPTIMIZATION 有权
标题翻译：具有图像获取速率优化的成像设备
公开(公告)号：US20140024943A1
公开(公告)日：2014-01-23
申请号：US13984011
申请日：2012-02-03
申请人： Jean-Marie Nicolas , Laurent Kopp , Frederic Mosca , Claude Cohen-Bacrie , Christophe Fraschini
发明人： Jean-Marie Nicolas , Laurent Kopp , Frederic Mosca , Claude Cohen-Bacrie , Christophe Fraschini
IPC分类号： A61B8/08 , A61B8/00 , A61B8/14
CPC分类号： A61B8/5207 , A61B8/145 , A61B8/4483 , A61B8/469 , A61B8/485 , A61B8/54 , G01S15/8959 , G01S15/8977 , G01S15/8997
摘要： The disclosure includes a method of acquiring high-resolution ultrasound images using an array of transducers using successive transmission matrices. Implementations include operations for determining inter-transducer correlation matrices of an area of interest and an unwanted area; determining a characteristic matrix of the area of interest from the product of the inverse of the inter-transducer correlation matrix of the unwanted area and the inter-transducer correlation matrix of the area of interest; calculating eigenvectors and values of the characteristic matrix to define a transmission matrix; adjusting the image acquisition rate and image quality in order to define eigenvectors for firing; multiplying a reception matrix comprising the acquired signals completed by data set to zero corresponding to the firings not effected by the inverse of the transmission matrix to obtain a complete data set; reconstructing a high-resolution image of the area of interest as in synthetic aperture echographic imaging methods.
摘要翻译：本公开包括使用连续传输矩阵使用换能器阵列获取高分辨率超声图像的方法。实现包括用于确定感兴趣区域和不需要区域的换能器间相关矩阵的操作; 从所述不需要区域的换能器间相关矩阵的逆的乘积和所述感兴趣区域的换能器间相关矩阵的乘积确定所述感兴趣区域的特征矩阵; 计算特征矩阵的特征向量和值以定义传输矩阵; 调整图像采集率和图像质量，以定义特征向量进行点火; 将包含由数据集合完成的所获取的信号的接收矩阵与对应于不受发送矩阵的逆的影响的发出相乘以获得完整的数据集; 如合成孔径回波成像方法重建感兴趣区域的高分辨率图像。

8. 发明授权

US4794546A Method of and apparatus for scanning objects by means of ultrasound echography 失效
标题翻译：通过超声波回波检查对物体进行扫描的方法和装置
公开(公告)号：US4794546A
公开(公告)日：1988-12-27
申请号：US843905
申请日：1986-03-25
申请人： Jean-Marie Nicolas
发明人： Jean-Marie Nicolas
IPC分类号： G01N29/44 , A61B8/00 , A61B8/14 , G01N29/04 , G01N29/26 , G01S7/52 , G01N9/24
CPC分类号： G01S7/52036 , G01S7/52025 , G01S7/52058
摘要： A method and device of scanning objects by means of ultrasound echography by repeated transmission of ultrasound signals and the reception of the ultrasound echoes includes the following operations:(a) storing an echographic line in a memory;(b) determining the ratio of the power spectra for two distinct observation depths, including correction for the effects of the diffraction;(c) storing in a memory and/or displaying the frequency-dependency of the scatter function of the object examined;(d) repeating the proceding operations for two other observation depths which correspond to resepctive boundaries of homogeneous zones, and for other echographic lines.
摘要翻译：通过超声波信号的重复发送和超声波回波的接收，通过超声回波造影来扫描物体的方法和装置包括以下操作：（a）将回波线存储在存储器中; （b）确定两个不同观察深度的功率谱的比率，包括对衍射影响的校正; （c）存储在存储器中和/或显示检查对象的散射函数的频率依赖性; （d）重复对应于同质区域的重叠边界和其他回波线的两个其他观测深度的程序操作。

9. 发明授权

US4762132A Device for scanning objects by means of ultrasound echography 失效
标题翻译：用于通过超声波回波扫描来扫描物体的装置
公开(公告)号：US4762132A
公开(公告)日：1988-08-09
申请号：US851837
申请日：1986-04-14
申请人： Jean-Marie Nicolas , Jean-Luc Bernatets
发明人： Jean-Marie Nicolas , Jean-Luc Bernatets
IPC分类号： G01S7/523 , A61B8/00 , A61B8/14 , G01S7/52 , G01S7/526 , G01S15/89 , A61B10/00
CPC分类号： A61B8/00 , G01S15/8977
摘要： A device for scanning objects, notably biological tissues, by means of ultrasound echography, which device includes at least one ultrasound transducer (10) which is connected to a transmitter stage (20) for the repeated transmission of ultrasound waves to the object to be examined, and to a receiver stage for receiving the echoes reflected in the direction of the transducer. The device in accordance with the invention is characterized mainly in that the receiver stage includes:(A) a transformation device (110) for transforming the echographic signal by calculation of the Mellin transform of this signal;(B) an arithmetic device (120) for calculating a correction function by transformation of the attenuation function;(C) a processing device (130) which consists of a series connection of a multiplier circuit (131) for multiplying the respective output signals of the transformation devices (110) and (120) and a circuit (132) for calculating the inverse Mellin transform of the signal thus obtained.(D) a processing device (140) for processing the output signal of the arithmetic circuit (132) for calculating the inverse Mellin transform for the display of images of the region scanned and/or data which are representative of the region scanned.
摘要翻译：一种用于通过超声波回波造影来扫描物体（特别是生物组织）的装置，该装置包括至少一个超声波换能器（10），该超声波换能器连接到发射台（20），用于将超声波重复传输到被检查物体以及接收器级，用于接收在换能器的方向上反射的回波。根据本发明的装置的特征主要在于接收机级包括：（A）通过计算该信号的Mellin变换来变换回波信号的变换装置（110）（B）用于通过衰减函数的变换来计算校正函数的算术装置（120）（C）处理装置（130），其由用于乘以变换装置（110）和（120）的各个输出信号的乘法器电路（131）和用于计算反Mellin的电路（132）的串联连接构成由此获得的信号的变换。（D）处理装置（140），用于处理运算电路（132）的输出信号，用于计算用于显示所扫描区域和/或表示扫描区域的数据的图像的反Mellin变换。

10. 发明授权

US4680966A Apparatus for examining an object by ultrasonic echography 失效
标题翻译：用于通过超声波回波检查来检查物体的装置
公开(公告)号：US4680966A
公开(公告)日：1987-07-21
申请号：US743222
申请日：1985-06-10
申请人： Jean-Marie Nicolas
发明人： Jean-Marie Nicolas
IPC分类号： A61B8/14 , A61B8/00 , G01H5/00 , G01N29/44 , G01S7/52 , G01S15/89 , G01N29/00
CPC分类号： G01H5/00 , G01S15/8913 , G01S15/8977 , G01S7/52046 , G01S15/8915
摘要： An apparatus for examining objects by ultrasonic echography comprising an ultrasonic transmitting transducer (10) and an ultrasonic receiving transducer (20), with which are associated a transmitter stage (30), a receiver stage (40) constituted by a channel (100) for processing the echo signals reflected to the receiving transducer by the obstacles they meet in the said region and a storage and/or visualization stage (60), characterized in that the transmitting transducer (10) is at the same time a receiver and in that the receiver stage (40) also comprises a channel (200) for processing the output signals of the said transmitting/receiving transducer (10) thus formed and a subtraction device (500), whose output is connected to a first input (560) of the storage and/or visualization stage and whose two inputs receive the output signals of the said channels (100) and (200) representative of the real and theoretical travelling times, respectively, between the transducers.
摘要翻译：一种用于通过超声波回波检查检查物体的装置，包括超声波发射换能器（10）和超声波接收换能器（20），与发射器级（30），由通道（100）构成的接收器级（40）通过其在所述区域中遇到的障碍物以及存储和/或可视化阶段（60）处理反射到接收换能器的回波信号，其特征在于，发射换能器（10）同时是接收器，接收机级（40）还包括用于处理由此形成的所述发送/接收换能器（10）的输出信号的通道（200）和减法装置（500），其输出端连接到存储和/或可视化阶段，其两个输入分别接收代表换能器之间的实际和理论行进时间的所述通道（100）和（200）的输出信号。

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