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1. 发明授权

US4060613A 3-Aryloxy-2(4-loweralkyl-1-piperazinyl)propanols, their alkylethers, and use thereof 失效
标题翻译： 3-芳氧基-2（4-低级烷基-1-哌嗪基）丙醇，其烷基醚及其用途
公开(公告)号：US4060613A
公开(公告)日：1977-11-29
申请号：US687851
申请日：1976-05-19
申请人： Jean-Marie Ferland , Real Laliberte , Wilbur Lippmann , Thomas A. Pugsley
发明人： Jean-Marie Ferland , Real Laliberte , Wilbur Lippmann , Thomas A. Pugsley
IPC分类号： C07D295/092 , C07D295/13 , A61K31/495 , C07D241/04
CPC分类号： C07D295/088 , C07D295/13
摘要： Disclosed herein are compounds of the formula ##STR1## in which Ar is phenyl or 1-naphthyl; R.sup.1 is hydrogen or lower alkyl; and R.sup.2 and R.sup.3 together with the nitrogen atom to which they are joined form a hyterocyclic amine radical selected from the group consisting of 1-pyrrolidinyl, piperidino, morpholino and 4-(lower alkyl)-1-piperazinyl. The compounds are antidepressant agents and methods for their preparation and use also are disclosed.
摘要翻译：本文公开的是式“IMAGE”的化合物，其中Ar是苯基或1-萘基; R1是氢或低级烷基; 和R2和R3与它们所连接的氮原子一起形成选自1-吡咯烷基，哌啶子基，吗啉代和4-（低级烷基）-1-哌嗪基的杂环胺基。这些化合物是抗抑郁剂，并且也公开了它们的制备和使用方法。

2. 发明授权

US4170653A Antidepressant naphthyloxy piperidino and pyrrolidino propanol ethers 失效
标题翻译：抗抑郁萘环氧基哌啶子基和吡咯烷子基丙醇醚
公开(公告)号：US4170653A
公开(公告)日：1979-10-09
申请号：US829769
申请日：1977-09-01
申请人： Jean-Marie Ferland , Real Laliberte , Wilbur Lippmann , Thomas A. Pugsley
发明人： Jean-Marie Ferland , Real Laliberte , Wilbur Lippmann , Thomas A. Pugsley
IPC分类号： C07D295/092 , C07D295/13 , A61K31/445 , C07D211/14
CPC分类号： C07D295/088 , C07D295/13
摘要： Disclosed herein are compounds of the formula ##STR1## in which Ar is phenyl or 1-naphthyl; R.sup.1 is hydrogen or lower alkyl; and R.sup.2 and R.sup.3 together with the nitrogen atom to which they are joined form a heterocyclic amine radical selected from the group consisting of 1-pyrrolidinyl, piperidino, morpholino and 4-(lower alkyl)-1-piperazinyl. The compounds are antidepressant agents and methods for their preparation and use also are disclosed.
摘要翻译：本文公开的是式“IMAGE”的化合物，其中Ar是苯基或1-萘基; R1是氢或低级烷基; 和R2和R3与它们所连接的氮原子一起形成选自1-吡咯烷基，哌啶子基，吗啉代和4-（低级烷基）-1-哌嗪基的杂环胺基。这些化合物是抗抑郁剂，并且也公开了它们的制备和使用方法。

3. 发明授权

US4071552A Aryloxy aminobutanols, their preparation and use thereof 失效
标题翻译：芳氧基氨基丁醇，其制备和用途
公开(公告)号：US4071552A
公开(公告)日：1978-01-31
申请号：US687852
申请日：1976-05-19
申请人： Jean-Marie Ferland , Real Laliberte , Wilbur Lippmann , Thomas A. Pugsley
发明人： Jean-Marie Ferland , Real Laliberte , Wilbur Lippmann , Thomas A. Pugsley
IPC分类号： A61K31/135 , C07C233/16 , C07C91/16 , C07C93/18
CPC分类号： A61K31/135 , C07C233/16
摘要： Disclosed herein are compounds of the formula ##STR1## in which Ar is phenyl or 1-naphthyl; R.sup.1 is hydrogen or lower alkyl; and R.sup.2 and R.sup.3 are either the same or different selected from the group consisting of hydrogen or lower alkyl; with the proviso that when R.sup.1 is lower alkyl then R.sup.2 is the same lower alkyl. The compounds are antidepressant agents and methods for their preparation and use also are disclosed.
摘要翻译：本文公开的是式“IMAGE”的化合物，其中Ar是苯基或1-萘基; R1是氢或低级烷基; 并且R 2和R 3可以相同或不同，选自氢或低级烷基; 条件是当R 1为低级烷基时，则R 2为相同的低级烷基。这些化合物是抗抑郁剂，并且也公开了它们的制备和使用方法。

4. 发明授权

US4118511A Aryloxy aminobutanols for alleviating symptoms of depression 失效
标题翻译：用于缓解抑郁症状的芳氧基氨基丁醇
公开(公告)号：US4118511A
公开(公告)日：1978-10-03
申请号：US852657
申请日：1977-11-18
申请人： Jean-Marie Ferland , Real Laliberte , Wilbur Lippmann , Thomas A. Pugsley
发明人： Jean-Marie Ferland , Real Laliberte , Wilbur Lippmann , Thomas A. Pugsley
IPC分类号： A61K31/135 , C07C233/16
CPC分类号： A61K31/135 , C07C233/16
摘要： Disclosed herein are compounds of the formula ##STR1## in which Ar is phenyl or 1-naphthyl; R.sup.1 is hydrogen or lower alkyl; and R.sup.2 and R.sup.3 are either the same or different selected from the group consisting of hydrogen or lower alkyl; with the proviso that when R.sup.1 is lower alkyl then R.sup.2 is the same lower alkyl. The compounds are antidepressant agents and methods for their preparation and use also are disclosed.
摘要翻译：本文公开的是式“IMAGE”的化合物，其中Ar是苯基或1-萘基; R1是氢或低级烷基; 并且R 2和R 3可以相同或不同，选自氢或低级烷基; 条件是当R 1为低级烷基时，则R 2为相同的低级烷基。这些化合物是抗抑郁剂，并且也公开了它们的制备和使用方法。

5. 发明授权

US4140779A Aryloxy propyldiamines 失效
标题翻译：丙烯酰氧基丙基二胺
公开(公告)号：US4140779A
公开(公告)日：1979-02-20
申请号：US687850
申请日：1976-05-19
申请人： Jean-Marie Ferland , Real R. Laliberte , Wilbur Lippmann , Thomas A. Pugsley
发明人： Jean-Marie Ferland , Real R. Laliberte , Wilbur Lippmann , Thomas A. Pugsley
IPC分类号： C07D295/092 , C07D295/13 , C07D295/12 , A61K31/455
CPC分类号： C07D295/088 , C07D295/13
摘要： Disclosed herein are compounds of the formula ##STR1## in which Ar is l-naphthyl; R.sup.1 and R.sup.2 are either the same or different selected from the group consisting of hydrogen or lower alkyl, or R.sup.1 and R.sup.2 together with the nitrogen atom to which they are joined form a heterocyclic amine radical selected from the group consisting of 1-pyrrolidinyl, piperidine, morpholine and 4-(lower alkyl)-1-piperazinyl; and R.sup.3 and R.sup.4 are either the same or different selected from the group consisting of hydrogen or lower alkyl, or R.sup.3 and R.sup.4 together with the nitrogen to which they are joined represent a heterocyclic amine radical selected from the group consisting of 1-pyrrolidinyl, piperidino, morpholino and 4-(lower alkyl)-1-piperazinyl; or a therapeutically acceptable acid addition salt thereof. The compounds are antidepressant agents and methods for their preparation and use also are disclosed.
摘要翻译：本文公开的是其中Ar是1-萘基的式“IMAGE”1的化合物; R 1和R 2可以相同或不同，选自氢或低级烷基，或者R 1和R 2与它们所连接的氮原子一起形成杂环胺基，其选自1-吡咯烷基，哌啶，吗啉和4-（低级烷基）-1-哌嗪基; 并且R 3和R 4可以相同或不同，选自氢或低级烷基，或者R 3和R 4与它们所连接的氮一起代表杂环胺基，其选自1-吡咯烷基，哌啶子基，吗啉代和4-（低级烷基）-1-哌嗪基; 或其治疗上可接受的酸加成盐。这些化合物是抗抑郁剂，并且也公开了它们的制备和使用方法。

6. 发明授权

US4118495A Method of treating hyperglucagonemia with 1,3-dioxo-1H-benz[de]-isoquinoline-2(3H)-acetic acid 失效
标题翻译：用1,3-二氧代-1H-苯并[{[{{（异喹啉-2（3H）） - 乙酸处理高胰高血糖素血症的方法
公开(公告)号：US4118495A
公开(公告)日：1978-10-03
申请号：US818379
申请日：1977-07-25
申请人： Wilbur Lippmann
发明人： Wilbur Lippmann
IPC分类号： C07D221/14 , A61K31/47 , A61K31/473 , A61P3/08 , A61P3/10
CPC分类号： A61K31/47
摘要： A method is disclosed for preventing or decreasing the secretion or availability of excessive amounts of glucagon in a human having abnormally increased levels of glucagon by administering an effective amount of 1,3-dioxo-1H-benz[de]isoquinoline-2(3H)-acetic acid.
摘要翻译：公开了一种通过施用有效量的1,3-二氧代-1H-苯并[d]异喹啉-2（3H） - 酮来防止或降低过量量的胰高血糖素在人胰岛素异常升高的人群中的分泌或可用性的方法， -醋酸。

7. 发明授权

US4405625A Method of treating hyperglycemia with 1,3-dioxo-1H-benz[de]isoquinoline-2(3H)-acetic acid 失效
标题翻译：用1,3-二氧代-1H-苯并[de]异喹啉-2（3H） - 乙酸处理高血糖症的方法
公开(公告)号：US4405625A
公开(公告)日：1983-09-20
申请号：US45376
申请日：1979-06-04
申请人： Wilbur Lippmann
发明人： Wilbur Lippmann
IPC分类号： A61K31/47
CPC分类号： A61K31/47 , Y10S514/866
摘要： A method is disclosed for lowering blood glucose levels in a diabetic mammal by administering an effective amount of 1,3-dioxo-1H-benz[de]isoquinoline-2(3H)-acetic acid.
摘要翻译：公开了一种通过施用有效量的1,3-二氧代-1H-苯并[de]异喹啉-2（3H） - 乙酸来降低糖尿病哺乳动物血糖水平的方法。

8. 发明授权

US3937801A Reducing the incidence of gastrointestinal side effects during the treatment of inflammatory conditions with antiinflammatory drugs 失效
标题翻译：在治疗炎性反应性药物的治疗条件期间减少胃肠道副作用的发生率
公开(公告)号：US3937801A
公开(公告)日：1976-02-10
申请号：US378112
申请日：1973-07-10
申请人： Wilbur Lippmann
发明人： Wilbur Lippmann
IPC分类号： A61K31/405 , A61K31/415 , C07C405/00 , C07D309/12 , C07F9/40 , A61K31/19 , A61K31/40 , A61K31/61
CPC分类号： C07C405/00 , A61K31/405 , A61K31/415 , C07D309/12 , C07F9/4018 , Y10S514/922
摘要： A method is disclosed for inhibiting and alleviating gastrointestinal side effects often encountered during therapy with antiinflammatory agents such as indomethacin, phenylbutazone, oxyphenylbutazone and the like. The method comprises the administration to a mammal receiving such therapy of a prostaglandin derivative of formula 1, ##SPC1##In whichA. W is C = O, X and Y each are single bonds, Z is either C = O, CHOH or C(CH.sub.3)OH, R.sup.1 and R.sup.2 each are hydrogen, R.sup.3 is (CH.sub.2).sub.3 CH.sub.3 and R.sup.4 is hydrogen or lower alkyl;B. W is CHOH, X and Y each are single bonds, Z is either CHOH or C(CH.sub.3)OH, R.sup.1 and R.sup.2 each are hydrogen, R.sup.3 is (CH.sub.2).sub.3 CH.sub.3 and R.sup.4 is hydrogen or lower alkyl;C. W is C = O, X is a single bond, Y is a trans double bond, Z is CH.sub.2, CHOH or C(CH.sub.3)OH, R.sup.1 and R.sup.2 each are hydrogen and R.sup.3 is (CH.sub.2).sub.3 CH.sub.3 and R.sup.4 is hydrogen or lower alkyl;D. W is C = O, X is a single bond, Y is a trans double bond, Z is CHOH, R.sup.1 and R.sup.2 each are hydrogen, R.sup.3 is cyclohexyl and R.sup.4 is hydrogen or lower alkyl;E. W is C = O, X is a cis double bond, Y is a trans double bond, Z is CHOH, or C(CH.sub.3)OH, R.sup.1 is hydrogen and R.sup.2 is hydrogen or methyl, R.sup.3 is (CH.sub.2).sub.3 CH.sub.3 and R.sup.4 is hydrogen or lower alkyl; orF. W is C = O, X is a cis double bond, Y is a trans double bond, Z is CHOH, R.sup.1 and R.sup.2 each are methyl, R.sup.3 is (CH.sub.2).sub.3 CH.sub.3 and R.sup.4 is hydrogen or lower alkyl.Also disclosed are useful pharmaceutical compositions for treating inflammatory conditions comprising a combination of a gastrointestinal side effect-inhibiting dose of the above prostaglandin derivative of formula 1 and a therapeutic dose of an antiinflammatory agent.

9. 发明授权

US4267189A Method of use and composition for 1,3-dihydro-3-(2-hydroxy-2-methylpropyl)-2H-isoindol-1-one 失效
标题翻译： 1,3-二氢-3-（2-羟基-2-甲基丙基）-2H-异吲哚-1-酮的使用方法和组合物
公开(公告)号：US4267189A
公开(公告)日：1981-05-12
申请号：US78548
申请日：1979-09-24
申请人： Wilbur Lippmann
发明人： Wilbur Lippmann
IPC分类号： A61K31/40 , C07D209/46
CPC分类号： A61K31/40 , C07D209/46 , Y10S514/925
摘要： Disclosed is pharmaceutical compositions and methods of using 1,3-dihydro-3-(2-hydroxy-2-methylpropyl)-2H-isoindol-1-one for treating ulcers in a mammal and for preventing or decreasing the secretion or availability of excessive amounts of gastric acid in a mammal suffering from hyperchlorhydria and/or associated conditions.
摘要翻译：公开了使用1,3-二氢-3-（2-羟基-2-甲基丙基）-2H-异吲哚-1-酮治疗哺乳动物溃疡的药物组合物和方法，以及用于预防或减少过量的分泌或可用性患有高氯酸盐和/或相关病症的哺乳动物中胃酸的量。

10. 发明授权

US4118493A Method of treating hyperchlorhydria and/or associated conditions with 1,3-dioxo-1H-benz(de)isoquinoline-2-(3H)-acetic acid 失效
标题翻译：用1,3-二氧代-1H-苯并（de）异喹啉-2-（3H） - 乙酸处理高氯酸盐和/或相关条件的方法
公开(公告)号：US4118493A
公开(公告)日：1978-10-03
申请号：US818378
申请日：1977-07-25
申请人： Wilbur Lippmann
发明人： Wilbur Lippmann
IPC分类号： C07D221/14 , A61K31/47 , A61K31/473 , A61P1/04
CPC分类号： A61K31/47
摘要： A method is disclosed for preventing the secretion of excessive amounts of hydrochloric acid in the stomach of humans suffering from hyperchlorhydria and/or associated conditions by administering an effective amount of 1,3-dioxo-1H-benz[de]isoquinoline-2(3H)-acetic acid.
摘要翻译：公开了一种通过施用有效量的1,3-二氧代-1H-苯并[de]异喹啉-2（3H）的方法，防止过量盐酸在患有高氯酸盐和/或相关病症的人的胃中的分泌）-醋酸。

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