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1. 发明申请

US20050118650A1 Fourier transform mass spectrometry of complex biological samples 失效
标题翻译：复杂生物样品的傅立叶变换质谱
公开(公告)号：US20050118650A1
公开(公告)日：2005-06-02
申请号：US10657810
申请日：2003-09-08
申请人： Jean-Louis Dasseux , Roger Newton , Thomas Rea , Charles Bisgaier , Michael Pape
发明人： Jean-Louis Dasseux , Roger Newton , Thomas Rea , Charles Bisgaier , Michael Pape
IPC分类号： G01N27/62 , C12Q1/08 , G01N33/00 , G01N33/15 , G01N33/483 , G01N33/50 , G01N33/68 , G01N33/53 , G01N33/567 , G06F19/00 , G01N33/48
CPC分类号： G01N33/5011 , G01N33/5008 , G01N33/502 , G01N33/5038 , G01N33/5091 , Y02A90/26 , Y10T436/24
摘要： The present invention relates to methods for high information content (HIC) analysis or screening of complex biological systems using Fourier transform mass spectrometry (FTMS). The present methods are useful for analyzing complex biological mixtures containing both high molecular weight molecules (e.g., polynucleotides, proteins, polysaccharides) and low molecular weight molecules (e.g., oligonucleotides, peptides, lipids, oligosaccharides, steroid hormones, catabolic and metabolic intermediates) permit the elucidation of molecular differences between complex biological samples, and permit the identification of biologically active molecules (e.g. therapeutically active drugs, etc.).
摘要翻译：本发明涉及使用傅里叶变换质谱（FTMS）的复杂生物系统的高信息含量（HIC）分析或筛选方法。本方法可用于分析含有高分子量分子（例如多核苷酸，蛋白质，多糖）和低分子量分子（例如寡核苷酸，肽，脂质，寡糖，类固醇激素，分解代谢和代谢中间体）的复杂生物混合物澄清复杂生物样品之间的分子差异，并允许鉴定生物活性分子（例如治疗活性药物等）。

2. 发明申请

US20050148654A1 Statin-carboxyalkylether combinations 审中-公开
标题翻译：他汀类 - 羧基烷基醚组合
公开(公告)号：US20050148654A1
公开(公告)日：2005-07-07
申请号：US11067847
申请日：2005-02-28
申请人： Charles Bisgaier , Roger Newton , Howard Ando , Donald Butler , Gary Dozeman
发明人： Charles Bisgaier , Roger Newton , Howard Ando , Donald Butler , Gary Dozeman
IPC分类号： A61K31/22 , A61K31/225 , A61K31/365 , A61K31/366 , A61K31/40 , A61K31/401 , A61K31/405 , A61K31/44 , C07C59/305 , A61K31/25
CPC分类号： A61K31/194 , A61B5/7275 , A61K31/22 , A61K31/225 , A61K31/365 , A61K31/366 , A61K31/40 , A61K31/401 , A61K31/405 , A61K31/44 , C07C59/305 , A61K2300/00
摘要： The invention is a pharmaceutical composition comprising a carboxyalkylether which lowers triglycerides and elevated HDL, and a statin which inhibits HMG-CoA reductase, thereby reducing LDL, said composition being useful for treating vascular diseases.
摘要翻译：本发明是一种药物组合物，其包含降低甘油三酯和升高的HDL的羧基烷基醚，以及抑制HMG-CoA还原酶的他汀类，从而降低LDL，所述组合物可用于治疗血管疾病。

3. 发明申请

US20060142293A1 Phthalazinone derivatives 有权
公开(公告)号：US20060142293A1
公开(公告)日：2006-06-29
申请号：US11352178
申请日：2006-02-10
申请人： Niall Martin , Graeme Smith , Charles White , Roger Newton , Diane Douglas , Penny Eversley , Julia Vile
发明人： Niall Martin , Graeme Smith , Charles White , Roger Newton , Diane Douglas , Penny Eversley , Julia Vile
IPC分类号： A61K31/502
CPC分类号： C07D401/12 , A61K31/50 , A61K31/502 , C07D237/32 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： A method of treatment of a disease of the human or animal body mediated by PARP comprising administering to such a subject a therapeutically effective amount of a compound of formula: or an isomer, salt, solvate, chemically protected form, and prodrug thereof, wherein: A and B together represent an optionally substituted, fused aromatic ring; RC is represented by -L-RL, where L is of formula: —(CH2)n1-Qn2-(CH2)n3— wherein n1, n2 and n3 are each selected from 0, 1, 2 and 3, the sum of n1, n2 and n3 is 1, 2 or 3 and Q is selected from O, S, NH, C(═O) or —CR1R2—, where R1 and R2 are independently selected from hydrogen, halogen or optionally substituted C1-7 alkyl, or may together with the carbon atom to which they are attached form a C3-7 cyclic alkyl group, which may be saturated (a C3-7 cycloalkyl group) or unsaturated (a C3-7 cycloalkenyl group), or one of R1 and R2 may be attached to an atom in RL to form an unsaturated C3-7 cycloalkenyl group which comprises the carbon atoms to which R1 and R2 are attached in Q, —(CH2)n3— (if present) and part of RL; and RL is optionally substituted C5-20 aryl; and RN is selected from hydrogen, optionally substituted C1-7 alkyl, C3-20 heterocyclyl, and C5-20 aryl, hydroxy, ether, nitro, amino, amido, thiol, thioether, sulfoxide and sulfone.

4. 发明申请

US20130262503A1 METHODS, APPARATUSES AND COMPUTER PROGRAM PRODUCTS FOR AUDITING PROTECTED HEALTH INFORMATION 有权
标题翻译：用于审查受保护的健康信息的方法，装置和计算机程序产品
公开(公告)号：US20130262503A1
公开(公告)日：2013-10-03
申请号：US13436134
申请日：2012-03-30
申请人： Roger Newton , Barbara Brank , Robert Kells , Jason K. Martin
发明人： Roger Newton , Barbara Brank , Robert Kells , Jason K. Martin
IPC分类号： G06F17/30
CPC分类号： G06F21/552 , G06F19/00 , G06F21/6227 , G06F21/6245 , G06F2221/2101 , G16H10/60
摘要： An apparatus is provided for auditing protected health information of one or more patients. The apparatus includes at least one memory and at least one processor configured to detect a query to access information stored in a database including patient-related information. The processor is further configured to save the query in an event file. The processor is further configured to capture query-related information associated with the query and save the query-related information in the event file. The processor is further configured to determine that the query involves protected health information. The processor is further configured to transmit, in response to determining that the query involves protected health information, the query-related information to be used in a reporting table. Corresponding computer program products and methods are also provided.
摘要翻译：提供了一种用于审核一个或多个患者的受保护的健康信息的装置。该装置包括至少一个存储器和至少一个处理器，其被配置为检测查询以访问存储在包括患者相关信息的数据库中的信息。处理器还被配置为将查询保存在事件文件中。处理器还被配置为捕获与查询相关联的查询相关信息，并将查询相关信息保存在事件文件中。处理器还被配置为确定查询涉及受保护的健康信息。所述处理器还被配置为响应于确定所述查询涉及受保护的健康信息，发送要在报告表中使用的查询相关信息。还提供了相应的计算机程序产品和方法。

5. 发明授权

US09158917B2 Methods, apparatuses and computer program products for auditing protected health information 有权
标题翻译：用于审核受保护的健康信息的方法，设备和计算机程序产品
公开(公告)号：US09158917B2
公开(公告)日：2015-10-13
申请号：US13436134
申请日：2012-03-30
申请人： Roger Newton , Barbara Brank , Robert Kells , Jason K. Martin
发明人： Roger Newton , Barbara Brank , Robert Kells , Jason K. Martin
IPC分类号： G06F21/55 , G06F19/00 , G06F21/62
CPC分类号： G06F21/552 , G06F19/00 , G06F21/6227 , G06F21/6245 , G06F2221/2101 , G16H10/60
摘要： An apparatus is provided for auditing protected health information of one or more patients. The apparatus includes at least one memory and at least one processor configured to detect a query to access information stored in a database including patient-related information. The processor is further configured to save the query in an event file. The processor is further configured to capture query-related information associated with the query and save the query-related information in the event file. The processor is further configured to determine that the query involves protected health information. The processor is further configured to transmit, in response to determining that the query involves protected health information, the query-related information to be used in a reporting table. Corresponding computer program products and methods are also provided.
摘要翻译：提供了一种用于审核一个或多个患者的受保护的健康信息的装置。该装置包括至少一个存储器和至少一个处理器，其被配置为检测查询以访问存储在包括患者相关信息的数据库中的信息。处理器还被配置为将查询保存在事件文件中。处理器还被配置为捕获与查询相关联的查询相关信息，并将查询相关信息保存在事件文件中。处理器还被配置为确定查询涉及受保护的健康信息。所述处理器还被配置为响应于确定所述查询涉及受保护的健康信息，发送要在报告表中使用的查询相关信息。还提供了相应的计算机程序产品和方法。

6. 发明申请

US20050020607A1 Statin-MMP inhibitor combinations 审中-公开
标题翻译：他汀类MMP抑制剂组合
公开(公告)号：US20050020607A1
公开(公告)日：2005-01-27
申请号：US10925553
申请日：2004-08-24
申请人： Roger Newton , Bruce Roth
发明人： Roger Newton , Bruce Roth
IPC分类号： A61K31/225 , A61K31/401 , A61K31/445 , A61K31/495 , A61K45/06
CPC分类号： A61K45/06 , A61K31/225 , A61K31/401 , A61K31/445 , A61K31/495 , A61K2300/00
摘要： The invention is a pharmaceutical composition comprising an MMP inhibitor and a statin, said composition being useful for treating vascular diseases.
摘要翻译：本发明是包含MMP抑制剂和他汀类的药物组合物，所述组合物可用于治疗血管疾病。

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