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1. 发明申请

US20050004082A1 Ether compounds 失效
标题翻译：醚化合物
公开(公告)号：US20050004082A1
公开(公告)日：2005-01-06
申请号：US10893791
申请日：2004-07-16
申请人： Jean-Louis Dasseux , Carmen Oniciu
发明人： Jean-Louis Dasseux , Carmen Oniciu
IPC分类号： C07D233/74 , A61K31/08 , A61K31/6615 , A61P1/18 , A61P3/00 , A61P3/04 , A61P3/06 , A61P3/08 , A61P7/00 , A61P7/02 , A61P9/00 , A61P9/12 , A61P13/12 , A61P15/10 , A61P25/28 , A61P29/00 , A61P35/00 , A61P43/00 , C07C31/20 , C07C31/36 , C07C41/01 , C07C41/18 , C07C43/13 , C07C59/125 , C07C311/04 , C07C311/24 , C07D233/72 , C07F9/09 , A61K31/66 , A61K31/185 , A61K31/19
CPC分类号： C07D233/72 , C07C43/132 , C07C59/125 , C07C311/04 , C07F9/091 , Y10S514/866 , Y10S514/909
摘要： The present invention relates to novel ether compounds, compositions comprising ether compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a composition comprising an ether compound. The compounds, compositions, and methods of the invention are also useful for treating and preventing Alzheimer's Disease, Syndrome X, peroxisome proliferator activated receptor-related disorders, septicemia, thrombotic disorders, obesity, pancreatitis, hypertension, renal disease, cancer, inflammation, and impotence. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.
摘要翻译：本发明涉及新型醚化合物，包含醚化合物的组合物和用于治疗和预防心血管疾病，血脂异常，dysproteinemias和葡萄糖代谢紊乱的方法，包括施用包含醚化合物的组合物。本发明的化合物，组合物和方法还可用于治疗和预防阿尔茨海默病，综合征X，过氧化物酶体增殖物激活受体相关病症，败血症，血栓形成障碍，肥胖症，胰腺炎，高血压，肾脏疾病，癌症，炎症和阳。在某些实施方案中，本发明的化合物，组合物和方法可用于与其它治疗剂如降胆固醇和降血糖药物组合治疗。

2. 发明申请

US20080064661A1 DIHYDROXYL COMPOUNDS AND COMPOSITIONS FOR CHOLESTEROL MANAGEMENT AND RELATED USES 有权
标题翻译：二羟基化合物和组合物用于胆固醇管理和相关用途
公开(公告)号：US20080064661A1
公开(公告)日：2008-03-13
申请号：US11928045
申请日：2007-10-30
申请人： Jean-Louis Dasseux , Carmen Oniciu
发明人： Jean-Louis Dasseux , Carmen Oniciu
IPC分类号： A61K31/192 , A61K31/351 , A61K31/4365 , A61K31/6615 , A61P25/00 , A61P3/00 , A61P35/00 , A61P9/00
CPC分类号： C07C31/27 , A61K31/191 , A61K31/194 , A61K31/20 , A61K31/23 , C07C31/20 , C07C31/22 , C07C31/24 , C07C33/26 , C07C47/19 , C07C47/34 , C07C59/01 , C07C59/105 , C07C59/11 , C07C59/245 , C07C59/285 , C07C59/29 , C07C59/46 , C07C59/48 , C07C59/54 , C07C61/12 , C07C62/02 , C07C62/06 , C07C65/17 , C07C69/003 , C07C69/017 , C07C69/675 , C07C69/757 , C07C255/00 , C07C309/08 , C07C309/24 , C07C309/25 , C07C2101/02 , C07C2101/04 , C07C2101/08 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07D213/80 , C07D257/04 , C07D261/08 , C07D261/12 , C07D305/12 , C07D307/33 , C07D309/10 , C07D309/12 , C07D309/30 , C07D405/12 , C07D495/04 , C07F9/093 , C07F9/094 , C07F9/11 , C07F9/117 , C07F9/12 , C07F9/2408 , C07F9/2416 , C07F9/242 , C07F9/2425 , C07F9/4423
摘要： The present invention relates to novel dihydroxyl compounds, compositions comprising hydroxyl compounds, and methods useful for treating and preventing a variety of diseases and conditions such as, but not limited to aging, Alzheimer's Disease, cancer, cardiovascular disease, diabetic nephropathy, diabetic retinopathy, a disorder of glucose metabolism, dyslipidemia, dyslipoproteinemia, hypertension, impotence, inflammation, insulin resistance, lipid elimination in bile, obesity, oxysterol elimination in bile, pancreatitis, Parkinson's disease, a peroxisome proliferator activated receptor-associated disorder, phospholipid elimination in bile, renal disease, septicemia, metabolic syndrome disorders (e.g., Syndrome X), thrombotic disorder. Compounds and methods of the invention can also be used to modulate C reactive protein or enhance bile production in a patient. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.
摘要翻译：本发明涉及新的二羟基化合物，包含羟基化合物的组合物和可用于治疗和预防各种疾病和病症例如但不限于老化，阿尔茨海默氏病，癌症，心血管疾病，糖尿病性肾病，糖尿病性视网膜病变，胆汁中的葡萄糖代谢障碍，血脂异常，血脂异常，高血压，阳ence，炎症，胰岛素抵抗，脂质消除，肥胖，胆汁中的氧固醇消除，胰腺炎，帕金森病，过氧化物酶体增殖物激活受体相关病症，胆汁中的磷脂消除，肾脏疾病，败血症，代谢综合症（如X综合症），血栓形成障碍。本发明的化合物和方法也可用于调节C反应蛋白或增强患者的胆汁产生。在某些实施方案中，本发明的化合物，组合物和方法可用于与其它治疗剂如降胆固醇和降血糖药物组合治疗。

3. 发明申请

US20070179120A1 HYDROXYL COMPOUNDS AND COMPOSITIONS FOR CHOLESTEROL MANAGEMENT AND RELATED USES 有权
标题翻译：羟丙基化合物和组合物用于胆固醇管理和相关用途
公开(公告)号：US20070179120A1
公开(公告)日：2007-08-02
申请号：US11680105
申请日：2007-02-28
申请人： Jean-Louis Dasseux , Carmen Oniciu
发明人： Jean-Louis Dasseux , Carmen Oniciu
IPC分类号： A61K31/66 , A61K31/4743 , A61K31/4166 , A61K31/42 , A61K31/41
CPC分类号： C07C31/27 , A61K31/191 , A61K31/194 , A61K31/20 , A61K31/23 , C07C31/20 , C07C31/22 , C07C31/24 , C07C33/26 , C07C47/19 , C07C47/34 , C07C59/01 , C07C59/105 , C07C59/11 , C07C59/245 , C07C59/285 , C07C59/29 , C07C59/46 , C07C59/48 , C07C59/54 , C07C61/12 , C07C62/02 , C07C62/06 , C07C65/17 , C07C69/003 , C07C69/017 , C07C69/675 , C07C69/757 , C07C255/00 , C07C309/08 , C07C309/24 , C07C309/25 , C07C2101/02 , C07C2101/04 , C07C2101/08 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07D213/80 , C07D257/04 , C07D261/08 , C07D261/12 , C07D305/12 , C07D307/33 , C07D309/10 , C07D309/12 , C07D309/30 , C07D405/12 , C07D495/04 , C07F9/093 , C07F9/094 , C07F9/11 , C07F9/117 , C07F9/12 , C07F9/2408 , C07F9/2416 , C07F9/242 , C07F9/2425 , C07F9/4423
摘要： The present invention relates to novel hydroxyl compounds, compositions comprising hydroxyl compounds, and methods useful for treating and preventing a variety of diseases and conditions such as, but not limited to aging, Alzheimer's Disease, cancer, cardiovascular disease, diabetic nephropathy, diabetic retinopathy, a disorder of glucose metabolism, dyslipidemia, dyslipoproteinemia, hypertension, impotence, inflammation, insulin resistance, lipid elimination in bile, obesity, oxysterol elimination in bile, pancreatitis, pancreatitius, Parkinson's disease, a peroxisome proliferator activated receptor-associated disorder, phospholipid elimination in bile, renal disease, septicemia, metabolic syndrome disorders (e.g., Syndrome X), thrombotic disorder. Compounds and methods of the invention can also be used to modulate C reactive protein or enhance bile production in a patient. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.
摘要翻译：本发明涉及新的羟基化合物，包含羟基化合物的组合物和可用于治疗和预防各种疾病和病症例如但不限于老化，阿尔茨海默氏病，癌症，心血管疾病，糖尿病性肾病，糖尿病性视网膜病变，葡萄糖代谢异常，血脂异常，脂蛋白血症，高血压，阳ence，炎症，胰岛素抵抗，胆汁中的脂质清除，肥胖，胆汁中的氧固醇消除，胰腺炎，胰腺炎，帕金森病，过氧化物酶体增殖物激活受体相关病症，磷脂消除胆汁，肾脏疾病，败血症，代谢综合症（如X综合症），血栓形成障碍。本发明的化合物和方法也可用于调节C反应蛋白或增强患者的胆汁产生。在某些实施方案中，本发明的化合物，组合物和方法可用于与其它治疗剂如降胆固醇和降血糖药物组合治疗。

4. 发明申请

US20120232005A1 LIPOPROTEIN COMPLEXES AND MANUFACTURING AND USES THEREOF 审中-公开
标题翻译：利培酮复合物及其制备及其用途
公开(公告)号：US20120232005A1
公开(公告)日：2012-09-13
申请号：US13367237
申请日：2012-02-06
申请人： Jean-Louis Dasseux , Daniela Carmen Oniciu , Rose Ackermann
发明人： Jean-Louis Dasseux , Daniela Carmen Oniciu , Rose Ackermann
IPC分类号： A61K38/17 , C07K1/113 , C12N5/10 , C12P21/00 , C07K14/775 , A61P3/06 , B82Y5/00 , B82B1/00
CPC分类号： A61K38/1709 , A61K38/17 , A61K38/18 , A61K45/00 , A61K47/50 , C07K1/04 , C07K1/042 , C07K14/775 , Y10T428/2982
摘要： The present disclosure relates to lipoprotein complexes and lipoprotein populations and their use in the treatment and/or prevention of dyslipidemic diseases, disorders, and/or conditions. The disclosure further relates to recombinant expression of apolipoproteins, purification of apolipoproteins, and production of lipoprotein complexes using thermal cycling-based methods.
摘要翻译：本公开涉及脂蛋白复合物和脂蛋白种群及其在治疗和/或预防血脂异常疾病，病症和/或病症中的用途。本公开还涉及载脂蛋白的重组表达，载脂蛋白的纯化，以及使用基于热循环的方法产生脂蛋白复合物。

5. 发明申请

US20050043278A1 Hydroxyl compounds and compositions for cholesterol management and related uses 有权
标题翻译：用于胆固醇管理和相关用途的羟基化合物和组合物
公开(公告)号：US20050043278A1
公开(公告)日：2005-02-24
申请号：US10743470
申请日：2003-12-23
申请人： Jean-Louis Dasseux , Carmen Oniciu
发明人： Jean-Louis Dasseux , Carmen Oniciu
IPC分类号： A61P3/10 , C07C31/20 , C07C31/22 , C07C31/24 , C07C59/11 , C07C59/245 , C07C59/285 , C07C59/29 , C07C59/46 , C07C59/48 , C07C59/54 , C07C62/02 , C07C62/06 , C07C65/17 , C07C69/757 , C07D213/80 , C07D309/10 , C07D309/12 , C07D405/12 , C07F9/09 , C07F9/117 , C07F9/24 , C07F9/44 , A61K31/66 , C07D305/12 , C07F9/02 , A61K31/366 , A61K31/365 , A61K31/19 , A61K31/185
CPC分类号： C07C31/27 , A61K31/191 , A61K31/194 , A61K31/20 , A61K31/23 , C07C31/20 , C07C31/22 , C07C31/24 , C07C33/26 , C07C47/19 , C07C47/34 , C07C59/01 , C07C59/105 , C07C59/11 , C07C59/245 , C07C59/285 , C07C59/29 , C07C59/46 , C07C59/48 , C07C59/54 , C07C61/12 , C07C62/02 , C07C62/06 , C07C65/17 , C07C69/003 , C07C69/017 , C07C69/675 , C07C69/757 , C07C255/00 , C07C309/08 , C07C309/24 , C07C309/25 , C07C2101/02 , C07C2101/04 , C07C2101/08 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07D213/80 , C07D257/04 , C07D261/08 , C07D261/12 , C07D305/12 , C07D307/33 , C07D309/10 , C07D309/12 , C07D309/30 , C07D405/12 , C07D495/04 , C07F9/093 , C07F9/094 , C07F9/11 , C07F9/117 , C07F9/12 , C07F9/2408 , C07F9/2416 , C07F9/242 , C07F9/2425 , C07F9/4423
摘要： The present invention relates to novel hydroxyl compounds, compositions comprising hydroxyl compounds, and methods useful for treating and preventing a variety of diseases and conditions such as, but not limited to aging, Alzheimer's Disease, cancer, cardiovascular disease, diabetic nephropathy, diabetic retinopathy, a disorder of glucose metabolism, dyslipidemia, dyslipoproteinemia, hypertension, impotence, inflammation, insulin resistance, lipid elimination in bile, obesity, oxysterol elimination in bile, pancreatitis, pancreatitius, Parkinson's disease, a peroxisome proliferator activated receptor-associated disorder, phospholipid elimination in bile, renal disease, septicemia, metabolic syndrome disorders (e.g., Syndrome X), thrombotic disorder. Compounds and methods of the invention can also be used to modulate C reactive protein or enhance bile production in a patient. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.
摘要翻译：本发明涉及新的羟基化合物，包含羟基化合物的组合物和可用于治疗和预防各种疾病和病症例如但不限于老化，阿尔茨海默氏病，癌症，心血管疾病，糖尿病性肾病，糖尿病性视网膜病变，葡萄糖代谢异常，血脂异常，脂蛋白血症，高血压，阳ence，炎症，胰岛素抵抗，胆汁中的脂质清除，肥胖，胆汁中的氧固醇消除，胰腺炎，胰腺炎，帕金森病，过氧化物酶体增殖物激活受体相关病症，磷脂消除胆汁，肾脏疾病，败血症，代谢综合症（如X综合症），血栓形成障碍。本发明的化合物和方法也可用于调节C反应蛋白或增强患者的胆汁产生。在某些实施方案中，本发明的化合物，组合物和方法可用于与其它治疗剂如降胆固醇和降血糖药物组合治疗。

6. 发明申请

US20060229281A1 Cycloalkyl-Hydroxyl Compounds and Compositions for Cholesterol Management and Related Uses 有权
标题翻译：环烷基 - 羟基化合物和组合物用于胆固醇管理和相关用途
公开(公告)号：US20060229281A1
公开(公告)日：2006-10-12
申请号：US11426380
申请日：2006-06-26
申请人： Jean-Louis Dasseux , Carmen Oniciu
发明人： Jean-Louis Dasseux , Carmen Oniciu
IPC分类号： C07D498/02 , A61K31/4743 , A61K31/42 , A61K31/365 , A61K31/366
CPC分类号： C07C31/27 , A61K31/191 , A61K31/194 , A61K31/20 , A61K31/23 , C07C31/20 , C07C31/22 , C07C31/24 , C07C33/26 , C07C47/19 , C07C47/34 , C07C59/01 , C07C59/105 , C07C59/11 , C07C59/245 , C07C59/285 , C07C59/29 , C07C59/46 , C07C59/48 , C07C59/54 , C07C61/12 , C07C62/02 , C07C62/06 , C07C65/17 , C07C69/003 , C07C69/017 , C07C69/675 , C07C69/757 , C07C255/00 , C07C309/08 , C07C309/24 , C07C309/25 , C07C2101/02 , C07C2101/04 , C07C2101/08 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07D213/80 , C07D257/04 , C07D261/08 , C07D261/12 , C07D305/12 , C07D307/33 , C07D309/10 , C07D309/12 , C07D309/30 , C07D405/12 , C07D495/04 , C07F9/093 , C07F9/094 , C07F9/11 , C07F9/117 , C07F9/12 , C07F9/2408 , C07F9/2416 , C07F9/242 , C07F9/2425 , C07F9/4423
摘要： The present invention relates to novel cycloalkyl-hydroxyl compounds, compositions comprising hydroxyl compounds, and methods useful for treating and preventing a variety of diseases and conditions such as, but not limited to aging, Alzheimer's Disease, cancer, cardiovascular disease, diabetic nephropathy, diabetic retinopathy, a disorder of glucose metabolism, dyslipidemia, dyslipoproteinemia, hypertension, impotence, inflammation, insulin resistance, lipid elimination in bile, obesity, oxysterol elimination in bile, pancreatitis, Parkinson's disease, a peroxisome proliferator activated receptor-associated disorder, phospholipid elimination in bile, renal disease, septicemia, Syndrome X, thrombotic disorder. Compounds and methods of the invention can also be used to modulate C reactive protein or enhance bile production in a patient. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.
摘要翻译：本发明涉及新的环烷基 - 羟基化合物，包含羟基化合物的组合物和可用于治疗和预防各种疾病和病症例如但不限于老化，阿尔茨海默氏病，癌症，心血管疾病，糖尿病性肾病，糖尿病视网膜病变，葡萄糖代谢紊乱，血脂异常，脂蛋白血症，高血压，阳ence，炎症，胰岛素抵抗，胆汁中的脂质消除，肥胖，胆汁中的氧固醇消除，胰腺炎，帕金森病，过氧化物酶体增殖物激活受体相关病症，磷脂消除胆汁，肾脏疾病，败血症，X综合征，血栓形成障碍。本发明的化合物和方法也可用于调节C反应蛋白或增强患者的胆汁产生。在某些实施方案中，本发明的化合物，组合物和方法可用于与其它治疗剂如降胆固醇和降血糖药物组合治疗。

7. 发明授权

US07304093B2 Ketone compounds and compositions for cholesterol management and related uses 有权
标题翻译：酮类化合物和胆固醇管理及相关用途的组合物
公开(公告)号：US07304093B2
公开(公告)日：2007-12-04
申请号：US10743952
申请日：2003-12-24
申请人： Jean-Louis Dasseux , Daniela Carmen Oniciu
发明人： Jean-Louis Dasseux , Daniela Carmen Oniciu
IPC分类号： A61K31/194 , C07C55/02
CPC分类号： C07C49/17 , C07C49/185 , C07C49/215 , C07C49/245 , C07C49/258 , C07C49/507 , C07C49/723 , C07C49/743 , C07C49/747 , C07C49/782 , C07C49/82 , C07C49/86 , C07C50/30 , C07C59/347 , C07C59/353 , C07C59/84 , C07C69/716 , C07C69/738 , C07C261/04 , C07C309/07 , C07C309/24 , C07D233/72 , C07D233/84 , C07D233/86 , C07D257/04 , C07D261/12 , C07D305/12 , C07D307/33 , C07D309/12 , C07D309/30 , C07D309/40 , C07D495/04 , C07F9/093 , C07F9/2425 , C07F9/4423
摘要： The present invention relates to novel ketone compounds, compositions comprising ketone compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a composition comprising a ketone compound. The compounds, compositions, and methods of the invention are also useful for treating and preventing Alzheimer's Disease, Syndrome X, peroxisome proliferator activated receptor-related disorders, septicemia, thrombotic disorders, obesity, pancreatitis, hypertension, renal disease, cancer, inflammation, and impotence. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.
摘要翻译：本发明涉及新颖的酮化合物，包含酮化合物的组合物，以及可用于治疗和预防心血管疾病，血脂异常，dysproteinemias和葡萄糖代谢紊乱的方法，包括施用包含酮化合物的组合物。本发明的化合物，组合物和方法还可用于治疗和预防阿尔茨海默病，综合征X，过氧化物酶体增殖物激活受体相关病症，败血症，血栓形成障碍，肥胖症，胰腺炎，高血压，肾脏疾病，癌症，炎症和阳。在某些实施方案中，本发明的化合物，组合物和方法可用于与其它治疗剂如降胆固醇和降血糖药物组合治疗。

8. 发明申请

US20050192347A1 Urea and thiourea compounds and compositions for cholesterol management and related uses 审中-公开
标题翻译：尿素和硫脲化合物和胆固醇管理和相关用途的组合物
公开(公告)号：US20050192347A1
公开(公告)日：2005-09-01
申请号：US11021777
申请日：2004-12-23
申请人： Jean-Louis Dasseux , Carmen Oniciu
发明人： Jean-Louis Dasseux , Carmen Oniciu
IPC分类号： C07C275/10 , C07C275/16 , C07C275/24 , C07C335/08 , C07C335/12 , C07D233/72 , C07D233/86 , C07D257/04 , C07D261/12 , C07D307/33 , C07D309/12 , C07D309/30 , C07D309/40 , C07D519/00 , C07F9/09 , C07F9/24 , A61K31/277 , A61K31/17 , C07C275/30 , C07C335/20
CPC分类号： C07D257/04 , C07C275/10 , C07C275/16 , C07C275/24 , C07C335/08 , C07C335/12 , C07D233/72 , C07D233/86 , C07D261/12 , C07D307/33 , C07D309/12 , C07D309/30 , C07D309/40 , C07F9/091 , C07F9/2408 , C07F9/2429
摘要： The present invention relates to novel urea and thiourea compounds, compositions comprising urea or thiourea compounds, and methods useful for treating and preventing aging, Alzheimer's Disease, cancer, cardiovascular disease, diabetic nephropathy, diabetic retinopathy, a disorder of glucose metabolism, dyslipidemia, dyslipoproteinemia, enhancing bile production, enhancing reverse lipid transport, hypertension, impotence, inflammation, insulin resistance, lipid elimination in bile, modulating C reactive protein, obesity, oxysterol elimination in bile, pancreatitis, Parkinson's disease, a peroxisome proliferator activated receptor-associated disorder, phospholipid elimination in bile, renal disease, septicemia, metabolic syndrome disorders (e.g., Syndrome X), a thrombotic disorder, gastrointestinal disease, irritable bowel syndrome (IBS), inflammatory bowel disease (e.g., Crohn's Disease, ulcerative colitis), arthritis (e.g., rheumatoid arthritis, osteoarthritis), autoimmune disease (e.g., systemic lupus erythematosus), scleroderma, ankylosing spondylitis, gout and pseudogout, muscle pain: polymyositis/polymyalgia rheumatica/fibrositis; infection and arthritis, juvenile rheumatoid arthritis, tendonitis, bursitis and other soft tissue rheumatism. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.
摘要翻译：本发明涉及新型尿素和硫脲化合物，包含尿素或硫脲化合物的组合物，以及用于治疗和预防衰老，阿尔茨海默病，癌症，心血管疾病，糖尿病性肾病，糖尿病性视网膜病变，葡萄糖代谢障碍，血脂异常，血脂异常增加胆汁产生，增强胆汁产生，增加逆转脂质运输，高血压，阳ence，炎症，胰岛素抵抗，胆汁中的脂质消除，调节C反应蛋白，肥胖，胆汁中的氧固醇消除，胰腺炎，帕金森病，过氧化物酶体增殖物激活受体相关疾病，胆汁中的磷脂消除，肾脏疾病，败血症，代谢综合症（例如，X综合症），血栓形成障碍，胃肠道疾病，肠易激综合征（IBS），炎性肠病（例如克罗恩病，溃疡性结肠炎），关节炎，类风湿性关节炎，骨关节炎），自身免疫性疾病（例如，强直性脊柱炎，痛风和假阴性，肌肉疼痛：多发性肌炎/风湿性多发性肌痛/纤维器炎; 感染和关节炎，青少年类风湿关节炎，腱炎，滑囊炎等软组织风湿病。在某些实施方案中，本发明的化合物，组合物和方法可用于与其它治疗剂如降胆固醇和降血糖药物组合治疗。

9. 发明申请

US20080058270A1 Apolipoprotein A-I agonists and their use to treat dyslipidemic disorders 审中-公开
标题翻译：载脂蛋白A-1激动剂及其用于治疗血脂异常的疾病
公开(公告)号：US20080058270A1
公开(公告)日：2008-03-06
申请号：US11704871
申请日：2007-02-09
申请人： Jean-Louis Dasseux , Renate Sekul , Klaus Buttner , Isabelle Cornut , Gunther Metz
发明人： Jean-Louis Dasseux , Renate Sekul , Klaus Buttner , Isabelle Cornut , Gunther Metz
IPC分类号： A61K38/10 , A61K38/16 , A61P3/00 , A61P9/00 , C07K14/00 , C07K7/00
CPC分类号： A61K38/10 , A61K38/16 , C07K14/775
摘要： The present invention provides peptides and peptide analogues that mimic the structural and pharmacological properties of human ApoA-I. The peptides and peptide analogues are useful to treat a variety of disorders associated with dyslipidemia.
摘要翻译：本发明提供模拟人ApoA-I的结构和药理学性质的肽和肽类似物。肽和肽类似物可用于治疗与血脂异常相关的各种障碍。

10. 发明授权

US07307058B2 Multimeric Apo A-I agonist compounds 失效
标题翻译：多聚体Apo A-1激动剂化合物
公开(公告)号：US07307058B2
公开(公告)日：2007-12-11
申请号：US10715895
申请日：2003-11-17
申请人： Jean-Louis Dasseux , Renate Sekul , Klaus Büttner , Isabelle Cornut , Günther Metz , Jean Dufourcq
发明人： Jean-Louis Dasseux , Renate Sekul , Klaus Büttner , Isabelle Cornut , Günther Metz , Jean Dufourcq
IPC分类号： A01N37/18 , A61K38/10 , A61K38/16 , A61K9/127
CPC分类号： C07K14/775 , A61K38/1709 , C07K7/08
摘要： The present invention provides peptides and peptide analogues that mimic the structural and pharmacological properties of human ApoA-I. The peptides and peptide analogues are useful to treat a variety of disorders associated with dyslipidemia.
摘要翻译：本发明提供模拟人ApoA-I的结构和药理学性质的肽和肽类似物。肽和肽类似物可用于治疗与血脂异常相关的各种障碍。

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