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1. 发明申请

US20100092426A1 2-SUBSTITUTED BENZIMIDAZOLES 有权
公开(公告)号：US20100092426A1
公开(公告)日：2010-04-15
申请号：US11993136
申请日：2006-06-20
申请人： Jean-Francois Bonfanti , Philippe Muller , Jérôme Michel Claude Fortin , Frédéric Marc Maurice Doublet
发明人： Jean-Francois Bonfanti , Philippe Muller , Jérôme Michel Claude Fortin , Frédéric Marc Maurice Doublet
IPC分类号： C07D401/06 , C07D413/14 , A61K31/5377 , A61K31/4439 , A61P31/12 , A61K38/21 , A61K38/19
CPC分类号： C07D401/06 , C07D235/30
摘要： Inhibitors of RSV replication of formula (I) the addition salts and stereochemically isomeric forms thereof, wherein Q is hydrogen, C1-6alkyl optionally substituted with a heterocycle or Q is C1-6alkyl substituted with both —OR4 and a heterocycle; wherein said heterocycle is oxazolidine, thiazolidine, 1-oxo-thiazolidine, 1,1-dioxothiazolidine, morpholinyl, thiomorpholinyl, 1-oxo-thiomorpholinyl, 1,1-dioxothiomorpholinyl, hexahydrooxazepine, hexahydro-thiazepine, 1-oxo-hexahydrothiazepine, 1,1-dioxo-hexahydrothiazepine, pyrrolidine, piperidine, homopiperidine, piperazine; which heterocyle may be substituted with 1-2 substituents; each Alk is C1-6alkanediyl; R1 is Ar2 or optionally substituted piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, pyridyl, pyrazinyl, pyridazinyl, pyrimidinyl, furanyl, tetrahydro-furanyl, thienyl, pyrrolyl, thiazolyl, oxazolyl, imidazolyl, isothiazolyl, pyrazolyl, isoxazolyl, oxadiazolyl, quinolinyl, quinoxalinyl, benzofuranyl, benzothienyl, benzimidazolyl, benzoxazolyl, benzthiazolyl, pyridopyridyl, naphthiridinyl, 1H-imidazo[4,5-b]pyridinyl, 3H-imidazo[4,5-b]pyridinyl, imidazo[1,2-a]pyridinyl or 2,3-dihydro-1,4-dioxino[2,3-b]pyridyl; R3 is hydroxyC1-6alkyl, C1-6alkoxyC1-6alkyl, cyanoC1-6alkyl, aminocarbonyl-C1-6-alkyl, mono- or di(C1-6alkyl)aminocarbonyl-C1-6-alkyl, carboxyl-C1-6-alkyl, C1-6alkoxycarbonyl-C1-6alkyl; R2 is hydrogen or C1-6alkyl; R3 and R4 are hydrogen, C1-6alkyl, Ar2, Ar2C1-6alkyl, C1-6alkylcarbonyl, Ar2carbonyl, Ar2C1-6alkylcarbonyl, C1-6alkylsulfonyl, aminosulfonyl, Ar1sulfonyl, Ar1C1-6alkylsulfonyl, C1-6alkyloxyC1-6alkyl, aminoC1-6alkyl, mono- or di(C1-6alkyl)-aminoC1-6alkyl, hydroxyC1-6alkyl, aminocarbonylC1-6alkyl, C1-4alkyloxycarbonyl-C1-6alkyl, hydroxycarbonylC1-6alkyl, aminosulfonylC1-6alkyl, Het, Het-C1-6alkyl, Het-carbonyl, Het-sulfonyl, HetC1-6alkylsulfonyl, Het-C1-6alkylcarbonyl; Het is an optionally substituted heterocycle; pharmaceutical compositions containing compounds (I) and processes for preparing compounds (I).

2. 发明授权

US08883837B2 Morpholinyl containing benzimidazoles as inhibitors of respiratory syncytial virus replication 有权
标题翻译：含有吗啉基的苯并咪唑作为呼吸道合胞病毒复制的抑制剂
公开(公告)号：US08883837B2
公开(公告)日：2014-11-11
申请号：US12140686
申请日：2008-06-17
申请人： Jean-Francois Bonfanti , Koenraad Jozef Lodewijk Andries , Jérôme Michel Claude Fortin , Philippe Muller , Frédéric Marc Maurice Doublet , Christophe Meyer , Rudy Edmond Willebrords , Tom Valerius Josepha Gevers , Philip Maria Martha Bern Timmerman
发明人： Jean-Francois Bonfanti , Koenraad Jozef Lodewijk Andries , Jérôme Michel Claude Fortin , Philippe Muller , Frédéric Marc Maurice Doublet , Christophe Meyer , Rudy Edmond Willebrords , Tom Valerius Josepha Gevers , Philip Maria Martha Bern Timmerman
IPC分类号： A01N43/52 , A61K31/415 , C07D233/00 , C07D235/02 , C07D487/04 , C07D487/06 , C07D413/12
CPC分类号： C07D413/12 , C07D401/06 , C07D401/14 , C07D413/14
摘要： The present invention concerns morpholinyl containing benzimidazoles having inhibitory activity on the replication of the respiratory syncytial virus and having the formula a prodrug, N-oxide, addition salt, quaternary amine, metal complex or stereochemically isomeric form thereof. It further concerns the preparation thereof and compositions comprising these compounds, as well as the use thereof as a medicine.
摘要翻译：本发明涉及对具有对呼吸道合胞病毒复制具有抑制活性的含有吗啉基的苯并咪唑，其具有前药，N-氧化物，加成盐，季胺，金属络合物或其立体化学异构形式。还涉及其制备方法和包含这些化合物的组合物，以及作为药物的用途。

3. 发明申请

US20090062278A1 5- OR 6-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AS INHIBITORS OF RESPIRATORY SYNCYTIAL VIRUS REPLICATION 有权
标题翻译： 5-或6-取代的苯并咪唑衍生物作为呼吸道同种病毒复制的抑制剂
公开(公告)号：US20090062278A1
公开(公告)日：2009-03-05
申请号：US12253450
申请日：2008-10-17
申请人： Jean-Francois Bonfanti , Koenraad Jozef Lodewijk Andries , Jerome Michel Claude Fortin , Philippe Muller , Frederic Marc Maurice Doublet , Christophe Meyer , Rudy Edmond Willebrords , Tom Valerius Josepha Gevers , Philip Maria Martha Bern Timmerman
发明人： Jean-Francois Bonfanti , Koenraad Jozef Lodewijk Andries , Jerome Michel Claude Fortin , Philippe Muller , Frederic Marc Maurice Doublet , Christophe Meyer , Rudy Edmond Willebrords , Tom Valerius Josepha Gevers , Philip Maria Martha Bern Timmerman
IPC分类号： A61K31/5377 , A61K31/4545 , C07D211/06 , C07D413/14 , A61P31/12 , A61K31/496 , C07D403/14
CPC分类号： C07D401/06 , C07D401/14 , C07D405/14
摘要： The present invention concerns 5- or 6-substituted-benzimidazole derivatives having inhibitory activity on the replication of the respiratory syncytial virus and having the formula a prodrug, N-oxide, addition salt, quaternary amine, metal complex or stereochemically isomeric form thereof wherein Q is Ar2, R6, pyrrolidinyl substituted with R6, piperidinyl substituted with R6 or homopiperidinyl substituted with R6, G is a direct bond or optionally substituted C1-10alkanediyl; R1 is Ar1 or a monocyclic or bicyclic heterocycle; one of R2a and R2b is cyanoC1-6alkyl, cyanoC2-6alkenyl, Ar3C1-6alkyl, Het1C1-6alkyl, N(R8aR8b)C1-6alkyl, Ar3C2-6alkenyl, Het1C2-6alkenyl, Ar3aminoC1-6alkyl, Het1aminoC1-6alkyl, Ar3thioC1-6alkyl, Het1thioC1-6alkyl, Ar3sulfonylC1-6alkyl, Het1sulfonylC1-6alkyl, Ar3aminocarbonyl, Het1aminocarbonyl, Ar3(CH2)naminocarbonyl, Het1(CH2)naminocarbonyl, Ar3carbonylamino, Het1carbonylamino, Ar3(CH2)ncarbonylamino, Het1(CH2)ncarbonylamino, and the other one of R2a and R2b is hydrogen; in case R2a is hydrogen, then R3 is hydrogen; in case R2b is hydrogen, the R3 is hydrogen or C1-6alkyl. It further concerns their preparation and compositions comprising them, as well as their use as a medicine.
摘要翻译：本发明涉及对呼吸道合胞病毒复制具有抑制活性的5-或6-取代苯并咪唑衍生物，其具有前药，N-氧化物，加成盐，季胺，金属络合物或其立体化学异构形式，其中Q 是Ar 2，R 6，被R 6取代的吡咯烷基，被R 6取代的哌啶基或被R 6取代的高哌啶基，G是直接键或任意取代的C 1-10烷二基; R1是Ar1或单环或双环杂环; R2a和R2b之一是氰基C 1-6烷基，氰基C 2-6烯基，Ar 3 C 1-6烷基，Het 1 C 1-6烷基，N（R 8 a R 8 b）C 1-6烷基，Ar 3 C 2-6烯基，Het 1 C 2-6烯基，Ar 3氨基C 1-6烷基，Het 1氨基C 1-6烷基，Ar 3硫代C 1-6烷基， Het 1硫基C 1-6烷基，Ar 3磺酰基C 1-6烷基，Het 1磺酰基C 1-6烷基，Ar 3氨基羰基，Het 1氨基羰基，Ar 3（CH 2）n氨基羰基，Het 1（CH 2）n氨基羰基，Ar 3羰基氨基，Het 1羰基氨基，Ar 3（CH 2）n - 羰基氨基，Het 1（CH 2）n羰基氨基，和R2b是氢; 在R2a为氢的情况下，R3为氢; 在R2b为氢的情况下，R3为氢或C1-6烷基。它还涉及它们的制备方法和包含它们的组合物，以及它们作为药物的用途。

4. 发明申请

US20080280881A1 MORPHOLINYL CONTAINING BENZIMIDAZOLES AS INHIBITORS OF RESPIRATORY SYNCYTIAL VIRUS REPLICATION 有权
公开(公告)号：US20080280881A1
公开(公告)日：2008-11-13
申请号：US12140686
申请日：2008-06-17
申请人： Jean-Francois Bonfanti , Koenraad Josef Lodewijk Andries , Jerome Michel Claude Fortin , Philippe Muller , Frederic Marc Maurice Doublet , Christophe Meyer , Rudy Edmond Willebrords , Tom Valerius Josepha Gevers , Philip Maria Martha Born Timmerman
发明人： Jean-Francois Bonfanti , Koenraad Josef Lodewijk Andries , Jerome Michel Claude Fortin , Philippe Muller , Frederic Marc Maurice Doublet , Christophe Meyer , Rudy Edmond Willebrords , Tom Valerius Josepha Gevers , Philip Maria Martha Born Timmerman
IPC分类号： A61K31/553 , C07D413/14 , A61K31/5377 , A61P31/12 , C07D267/02
CPC分类号： C07D413/12 , C07D401/06 , C07D401/14 , C07D413/14
摘要： The present invention concerns morpholinyl containing benzimidazoles having inhibitory activity on the replication of the respiratory syncytial virus and having the formula a prodrug, N-oxide, addition salt, quaternary amine, metal complex or stereochemically isomeric form thereof wherein G is a direct bond or optionally substituted C1-10alkanediyl; R1 is Ar1 or a monocyclic or bicyclic heterocycle Q is R7, pyrrolidinyl substituted with R7, piperidinyl substituted with R7 or homopiperidinyl substituted with R7; one of R2a and R3a is selected from halo, optionally mono- or polysubstituted C1-6alkyl, optionally mono- or polysubstituted C2-6alkenyl, nitro, hydroxy, Ar2, N(R4aR4b), N(R4aR4b)sulfonyl, N(R4aR4b)carbonyl, C1-6alkyloxy, Ar2oxy, Ar2C1-6alkyloxy, carboxyl, C1-6alkyloxycarbonyl, or —C(=Z)Ar2; and the other one of R2a and R3a is hydrogen; in case R2a is different from hydrogen then R2b is hydrogen, C1-6alkyl or halogen and R3b is hydrogen; in case R3a is different from hydrogen then R3b is hydrogen, C1-6alkyl or halogen and R2b is hydrogen. It further concerns the preparation thereof and compositions comprising these compounds, as well as the use thereof as a medicine.

5. 发明申请

US20070099924A1 Aminobenzimidazoles and benzimidazoles as inhibitors of respiratory syncytial virus replication 有权
公开(公告)号：US20070099924A1
公开(公告)日：2007-05-03
申请号：US10596514
申请日：2004-12-20
申请人： Jean-Francois Bonfanti , Koenraad Jozef Lodewijk Andries , Jerome Michel Claude Fortin , Philippe Muller , Frederic Marc Maurice Doublet , Chirstophe Meyer , Rudy Edmond Willebrods , Tom Valerius Josepha Gevers , Philip Maria Martha Bern Timmerman
发明人： Jean-Francois Bonfanti , Koenraad Jozef Lodewijk Andries , Jerome Michel Claude Fortin , Philippe Muller , Frederic Marc Maurice Doublet , Chirstophe Meyer , Rudy Edmond Willebrods , Tom Valerius Josepha Gevers , Philip Maria Martha Bern Timmerman
IPC分类号： A61K31/498 , A61K31/497 , A61K31/4709 , A61K31/4439 , A61K31/4184 , C07D403/02
CPC分类号： C07D401/06 , C07D235/20 , C07D235/30 , C07D401/12 , C07D401/14 , C07D403/02 , C07D405/14 , C07D471/04 , C07F9/65583
摘要： Aminobenzimidazoles and benzimidazoles having inhibitory activity on RSV replication and having the formula the prodrugs, N-oxides, addition salts, quaternary amines, metal complexes and stereochemically isomeric forms thereof, wherein G is a direct bond or C1-10alkanediyl optionally substituted with one or more hydroxy, C1-6alkyloxy, Ar1C1-6alkyloxy, C1-6alkylthio, Ar1C1-6alkylthio, HO(—CH2—CH2—O)n—, C1-6alkyloxy(—CH2—CH2—O)n— or Ar1C1-6alkyloxy(—CH2—CH2—O)n—; R1 is Ar1 or a monocyclic or bicyclic heterocycle; Q is hydrogen, amino or mono- or di(C1-4alkyl)amino; one of R2a and R3a is selected from halo, optionally mono- or polysubstituted C1-6alkyl, optionally mono- or polysubstituted C2-6alkenyl, nitro, hydroxy, Ar2, N(R4aR4b), N(R4aR4b)sulfonyl, N(R4aR4b)carbonyl, C1-6alkyloxy, Ar2oxy, Ar2C1-6alkyloxy, carboxyl, C1-6alkyloxycarbonyl, or —C(═Z)Ar2; and the other one of R2a and R3a is hydrogen; in case R2a is different from hydrogen then R2b is hydrogen, C1-6alkyl or halogen and R3b is hydrogen; in case R3a is different from hydrogen then R3b is hydrogen, C1-6alkyl or halogen and R2b is hydrogen. Compositions containg these compounds as active ingredient and processes for preparing these compounds and compositions.

6. 发明申请

US20070093502A1 5- Or 6-substituted benzimidazole derivatives as inhibitors of respiratory syncytial virus replication 审中-公开
公开(公告)号：US20070093502A1
公开(公告)日：2007-04-26
申请号：US10596521
申请日：2004-12-20
申请人： Jean-Francois Bonfanti , Koenraad Andries , Jerome Fortin , Philippe Muller , Frederic Doublet , Christophe Meyer , Rudy Willebrords , Tom Gevers , Philip Timmerman
发明人： Jean-Francois Bonfanti , Koenraad Andries , Jerome Fortin , Philippe Muller , Frederic Doublet , Christophe Meyer , Rudy Willebrords , Tom Gevers , Philip Timmerman
IPC分类号： A61K31/496 , A61K31/454 , A61K31/4184 , C07D403/02
CPC分类号： C07D401/06 , C07D401/14 , C07D405/14
摘要： The present invention concerns 5- or 6-substituted-benzimidazole derivatives having inhibitory activity on the replication of the respiratory syncytial virus and having the formula a prodrug, N-oxide, addition salt, quaternary amine, metal complex or stereochemically isomeric form thereof wherein Q is Ar2, R6, pyrrolidinyl substituted with R6, piperidinyl substituted with R6 or homopiperidinyl substituted with R6, G is a direct bond or optionally substituted C1-10-alkanediyl; R1 is Ar1 or a monocyclic or bicyclic heterocycle; one of R2a and R2b is cyanoC1-6alkyl, cyanoC2-6alkenyl, Ar3C1-6alkyl, Het-C1-6alkyl, N(R8aR8b)C1-6alkyl, Ar3C2-6alkenyl, Het-C2-6alkenyl, Ar3aminoC1-6alkyl, Het-aminoC1-6alkyl, Ar3thioC1-6alkyl, Het-thioC1-6alkyl, Ar3sulfonylC1-6alkyl, Het-sulfonylC1-6alkyl, Ar3aminocarbonyl, Het-aminocarbonyl, Ar3(CH2)naminocarbonyl, Het-(CH2)naminocarbonyl, Ar3carbonylamino, Het-carbonylamino, Ar3(CH2)ncarbonylamino, Het-(CH2)ncarbonylamino, and the other one of R2a and R2b is hydrogen; in case R2a is hydrogen, then R3 is hydrogen; in case R2b is hydrogen, the R3 is hydrogen or C1-6alkyl. It further concerns their preparation and compositions comprising them, as well as their use as a medicine.

7. 发明申请

US20100272683A1 HETEROCYCLYLAMINOALKYL SUBSTITUTED BENZIMIDAZOLES 有权
公开(公告)号：US20100272683A1
公开(公告)日：2010-10-28
申请号：US11993126
申请日：2006-06-20
申请人： Jean-Francois Bonfanti
发明人： Jean-Francois Bonfanti
IPC分类号： A61K31/5377 , C07D413/14 , A61K38/21 , A61K38/19 , A61P31/12 , A61P31/14
CPC分类号： C07D401/06 , C07D401/14
摘要： Heterocyclylaminoalkyl Substituted Benzimidazoles Inhibitors of RSV replication of formula (I): The salts and stereochemically isomeric forms thereof, wherein Q is hydrogen, C1-6alkyl optionally substituted with a heterocycle or Q is C1-6alkyl substituted with both —OR4 and a heterocycle; wherein said heterocycle is oxazolidine, thiazolidine, 1-oxo-thiazolidine, 1,1-dioxothiazolidine, morpholinyl, thiomorpholinyl, 1-oxo-thiomorpholinyl, 1,1-dioxothiomorpholinyl, hexahydrooxazepine, hexahydrothiazepine, 1-oxo-hexahydrothiazepine, 1,1-dioxo-hexahydrothiazepine, pyrrolidine, piperidine, homopiperidine, piperazine; which heterocyle may be substituted with 1-2 substituents; each Alk is C1-6alkanediyl; R1 is Ar or optionally substituted piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, pyridyl, pyrazinyl, pyridazinyl, pyrimidinyl, furanyl, tetrahydrofuranyl, thienyl, pyrrolyl, thiazolyl, oxazolyl, imidazolyl, isothiazolyl, pyrazolyl, isoxazolyl, oxadiazolyl, quinolinyl, quinoxalinyl, benzofuranyl, benzothienyl, benzimidazolyl, benzoxazolyl, benzthiazolyl, pyridopyridyl, naphthiridinyl, 1H-imidazo[4,5-b]pyridinyl, 3H-imidazo[4,5-b]pyridinyl, imidazo[1,2-a]pyridinyl or 2,3-dihydro-1,4-dioxino[2,3-b]pyridyl; R3 is hydroxyC1-6alkyl, C1-6alkoxyC1-6alkyl, cyanoC1-6alkyl, aminocarbonyl-C1-6-alkyl, mono- or di(C1-6alkyl)aminocarbonyl-C1-6-alkyl, carboxyl-C1-6-alkyl, C1-6alkoxycarbonyl-C1-6 alkyl; R2, R4 and R5 are hydrogen or C1-6alkyl; Het is pyridyl, pyrazinyl, pyridazinyl, pyrimidinyl, furanyl, tetrahydrofuranyl, thienyl, pyrrolyl, thiazolyl, oxazolyl, imidazolyl, isothiazolyl, pyrazolyl, isoxazolyl, oxadiazolyl, quinolinyl, quinoxalinyl, benzofuranyl, benzothienyl, benzimidazolyl, benzoxazolyl, benzthiazolyl, pyridopyridyl, naphthiridinyl, 1H-imidazo[4,5-b]-pyridinyl, 3H-imidazo[4,5-b]pyridinyl, imidazo[1,2-a]pyridinyl and 2,3-dihydro-1,4-dioxino[2,3-b]pyridyl; Ar is optionally substituted phenyl; pharmaceutical compositions containing compounds (I) and processes for preparing compounds (I).

8. 发明申请

US20070093659A1 Piperdine-amino-benzimidazole derivatives as inhibitors of respiratory syncytial virus replication 有权
公开(公告)号：US20070093659A1
公开(公告)日：2007-04-26
申请号：US10596519
申请日：2004-12-20
申请人： Jean-Francois Bonfanti , Koenraad Andries , Frans Janssens , Francois Sommen , Jerome Guillemont , Jean Lacrampe
发明人： Jean-Francois Bonfanti , Koenraad Andries , Frans Janssens , Francois Sommen , Jerome Guillemont , Jean Lacrampe
IPC分类号： C07D473/00
CPC分类号： C07D401/14 , C07D417/14
摘要： The present invention concerns piperidine-amino-benzimidazoles having inhibitory activity on the replication of the respiratory syncytial virus and having the formula their prodrugs, N-oxides, addition salts, quaternary amines, metal complexes and stereochemically isomeric forms wherein Q is C1-6alkyl optionally substituted with trifluoromethyl, C3-7cycloalkyl, Ar2, hydroxy, C1-4alkoxy, C1-4alkylthio, Ar2-oxy-, Ar2-thio-, Ar2(CH2)noxy, Ar2(CH2)nthio, hydroxycarbonyl, aminocarbonyl, C1-4alkylcarbonyl, Ar2carbonyl, C1-4alkoxycarbonyl, Ar2(CH2)ncarbonyl, aminocarbonyloxy, C1-4alkylcarbonyloxy, Ar2carbonyloxy, Ar2(CH2)ncarbonyloxy, C1-4alkoxy-carbonyl(CH2)noxy, mono- or di(C1-4alkyl)aminocarbonyl, mono- or di(C1-4alkyl)-aminocarbonyloxy, aminosulfonyl, mono- or di(C1-4alkyl)aminosulfonyl or a heterocycles selected from the group consisting of pyrrolidinyl, pyrrolyl, dihydropyrrolyl, imidazolyl, triazolyl, piperidinyl, homopiperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, 1-oxo-thiomorpholinyl, 1,1-dioxothiomorpholinyl, pyridyl and tetrahydropyridyl, wherein each of said heterocycle may optionally be substituted with oxo or C1-6alkyl; G is a direct bond or optionally substituted C1-10alkanediyl; R1 is Ar1 or a monocyclic or bicyclic heterocycle; one of R2a and R3a is C1-6alkyl and the other one of R2a and R3a is hydrogen; in case R2a is different from hydrogen then R2b is hydrogen or C1-6alkyl, and R3b is hydrogen; in case R3a is different from hydrogen then R3b is hydrogen or C1-6alkyl, and R2b is hydrogen; t is 1, 2 or 3; Ar1 is phenyl or substituted phenyl; and Ar2 is phenyl or substituted phenyl. It further concerns their preparation and compositions comprising them, as well as their use as a medicine.

9. 发明申请

US20120172367A1 MACROCYCLIC INTEGRASE INHIBITORS 有权
标题翻译：大环集成抑制剂
公开(公告)号：US20120172367A1
公开(公告)日：2012-07-05
申请号：US13395891
申请日：2010-10-13
申请人： Johannes Wilhelmus J Thuring , Jean-Francois Bonfanti , Jerome Michel Claude Fortin
发明人： Johannes Wilhelmus J Thuring , Jean-Francois Bonfanti , Jerome Michel Claude Fortin
IPC分类号： A61K31/4375 , C07D471/22 , A61P31/18 , C07D515/18 , C07D513/18 , A61K31/4985 , C07D471/18 , C07D498/22
CPC分类号： C07D513/18 , C07D471/18 , C07D498/18 , C07D498/22 , C07D515/18
摘要： Compound having formula (I), wherein —W is NH—, —N(CH3)— or piperazine, —X is a bond, —C(═O)— or S(═O)2—, —Y is C3-7alkylene, and —Z is NH—C(═O)— or —O—, and pharmaceutically acceptable salts thereof, their pharmaceutical formulations and use as HIV inhibitors.
摘要翻译：具有式（I）的化合物，其中-W是NH-，-N（CH 3） - 或哌嗪，-X是键，-C（= O） - 或S（= O）2 - ， - 7亚烷基和-Z是NH-C（= O） - 或-O-，及其药学上可接受的盐，它们的药物制剂和用作HIV抑制剂。

10. 发明申请

US20090221559A1 BENZODIAZEPINES AS HCV INHIBITORS 审中-公开
标题翻译：苯丙嗪作为HCV抑制剂
公开(公告)号：US20090221559A1
公开(公告)日：2009-09-03
申请号：US12065345
申请日：2006-09-01
申请人： Jean-Francois Bonfanti , Frederic Marc Maurice Doublet , Origene Nyanguile , Pierre Jean-Marie Bernard Raboisson , Anne-Sophie Helene Marie Rebstock , Carlo Willy Maurice Boutton
发明人： Jean-Francois Bonfanti , Frederic Marc Maurice Doublet , Origene Nyanguile , Pierre Jean-Marie Bernard Raboisson , Anne-Sophie Helene Marie Rebstock , Carlo Willy Maurice Boutton
IPC分类号： A61K31/5513 , C07D243/14 , A61P31/12
CPC分类号： A61K31/5513 , Y02A50/387
摘要： The present invention relates to the use of benzodiazepines as inhibitors of HCV replication as well as their use in pharmaceutical compositions aimed to treat or combat HCV infections. In addition, the present invention relates to benzodiazepine compounds per se and their use as medicines. The present invention also concerns processes for the preparation of such compounds, pharmaceutical compositions comprising them, and combinations of said compounds with other anti-HCV agents.
摘要翻译：本发明涉及苯并二氮杂卓作为HCV复制的抑制剂的用途，以及它们在旨在治疗或抗击HCV感染的药物组合物中的用途。此外，本发明涉及苯并二氮杂类化合物本身及其作为药物的用途。本发明还涉及制备这些化合物的方法，包含它们的药物组合物以及所述化合物与其它抗HCV药剂的组合。

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