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1. 发明授权

US4727084A Novel 4H-1,2,4-triazole derivatives 失效
标题翻译：新型4H-1,2,4-三唑衍生物
公开(公告)号：US4727084A
公开(公告)日：1988-02-23
申请号：US896858
申请日：1986-08-14
申请人： Jean Meier , Francois Clemence
发明人： Jean Meier , Francois Clemence
IPC分类号： A61K31/41 , A61P25/04 , C07C243/38 , C07D249/08 , C07D317/46 , C07D405/04
CPC分类号： C07D249/08 , C07C243/38 , C07D317/46 , Y10S514/886
摘要： Compounds selected from the group consisting of 4H-1,2,4-triazoles of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 may be in different positions of the benzene ring, R.sub.1, R.sub.3 and R.sub.4 are individually selected from the group consisting of hydrogen, --OH, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, halogen, --CH.sub.3, --NO.sub.2, --NH.sub.2 and NH--AlK and ##STR2## R.sub.2 is selected from the group consisting of hydrogen, --OH, alkyl of 1 to 4 carbon atoms, halogen, --CF.sub.3, --NO.sub.2, --NH.sub.2, --NH--AlK and ##STR3## and AlK, AlK.sub.1 and AlK.sub.2 are alkyl of 1 to 4 carbon atoms or R.sub.1 and R.sub.2 together and/or R.sub.3 and R.sub.4 together are methylenedioxy, R is selected from the group consisting of ethyl, --CH.sub.2 --COOH and CH.sub.2 --COOAlK.sub.3 and AlK.sub.3 is alkyl of 1 to 4 carbon atoms and their non-toxic, pharmaceutically acceptable acid addition salts, with the proviso that R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are not all hydrogen having a remarkable analgesic activity and a novel method for their preparation.
摘要翻译：选自下列化合物的化合物的化合物其中R 1，R 2，R 3和R 4可以位于苯环，R 1，R 3和R 4的不同位置的式Ia，由氢，-OH，1至4个碳原子的烷基，1至4个碳原子的烷氧基，卤素，-CH 3，-NO 2，-NH 2和NH-AlK和R 2选自下组：的氢，-OH，1至4个碳原子的烷基，卤素，-CF 3，-NO 2，-NH 2，-NH-AlK和AlGaN，AlK，AlK1和AlK2是1至4个碳原子的烷基或R1和 R 2一起和/或R 3和R 4一起是亚甲二氧基，R选自乙基，-CH 2 -COOH和CH 2 -COOAlK 3，AlK 3是1至4个碳原子的烷基及其无毒的药学上可接受的酸加成盐，条件是R1，R2，R3和R4不都是具有显着镇痛活性的氢和它们制备的新方法。

2. 发明授权

US4512997A 4,5-Bis(aryl)-4H-1,2,4-triazole derivatives and analgesic use 失效
标题翻译： 4,5-双（芳基）-4H-1,2,4-三唑衍生物和止痛用途
公开(公告)号：US4512997A
公开(公告)日：1985-04-23
申请号：US552747
申请日：1983-11-17
申请人： Jean Meier , Francois Clemence
发明人： Jean Meier , Francois Clemence
IPC分类号： A61K31/41 , A61P25/04 , C07C243/38 , C07D249/08 , C07D317/46 , C07D405/04 , A61K31/395
CPC分类号： C07D249/08 , C07C243/38 , C07D317/46 , Y10S514/886
摘要： Novel 4H-1,2,4-triazoles of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 may be in different positions of the benzene rings and are individually selected from the group consisting of hydrogen, --OH, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, halogen, --CF.sub.3, --NO.sub.2, --NH.sub.2 and --NH--AlK and ##STR2## and AlK, AlK.sub.1 and AlK.sub.2 are alkyl of 1 to 4 carbon atoms or R.sub.1 and R.sub.2 together and/or R.sub.3 and R.sub.4 together are methylenedioxy, R is selected from the group consisting hydrogen, alkyl of 1 to 4 carbon atoms, --CH.sub.2 --COOH and --CH.sub.2 --COOAlK.sub.3 and AlK.sub.3 is alkyl of 1 to 4 carbon atoms and their non-toxic, pharmaceutically acceptable acid addition salts having a remarkable analgesic activity and a novel method for their preparation.
摘要翻译：式（Ⅰ）的新型4H-1,2,4-三唑其中R 1，R 2，R 3和R 4可以在苯环的不同位置，并且分别选自氢，-OH， 1至4个碳原子的烷氧基，1至4个碳原子的烷氧基，卤素，-CF 3，-NO 2，-NH 2和-NH-AlK，和AlK，AlK1和AlK2是1至4个碳原子的烷基， R 2一起和/或R 3和R 4一起是亚甲二氧基，R选自氢，1至4个碳原子的烷基，-CH 2 -COOH和-CH 2 -COOAlK 3，AlK 3是1至4个碳原子的烷基，无毒，药学上可接受的具有显着镇痛活性的酸加成盐及其制备方法。

3. 发明授权

US4659729A Novel 4H-1,2,4-triazole derivatives 失效
标题翻译：新型4H-1,2,4-三唑衍生物
公开(公告)号：US4659729A
公开(公告)日：1987-04-21
申请号：US582051
申请日：1984-02-21
申请人： Jean Meier , Francois Clemence
发明人： Jean Meier , Francois Clemence
IPC分类号： A61K31/41 , A61P25/04 , C07C243/38 , C07D249/08 , C07D317/46 , C07D405/04 , A61K31/395
CPC分类号： C07D249/08 , C07C243/38 , C07D317/46 , Y10S514/886
摘要： Compounds selected from the group consisting of 4H-1,2,4-triazoles of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 may be in different positions of the benzene ring, R.sub.1, R.sub.3 and R.sub.4 are individually selected from the group consisting of hydrogen, --OH, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, halogen, --CF.sub.3, --NO.sub.2, --NH.sub.2 and NH--AlK and ##STR2## R.sub.2 is selected from the group consisting of hydrogen, --OH, alkyl of 1 to 4 carbon atoms, halogen, --CF.sub.3, --NO.sub.2, --NH.sub.2, --NH--AlK and ##STR3## and AlK, AlK.sub.1 and AlK.sub.2 are alkyl of 1 to 4 carbon atoms or R.sub.1 and R.sub.2 together and/or R.sub.3 and R.sub.4 together are methylenedioxy, R is selected from the group consisting of ethyl, --CH.sub.2 --COOH and CH.sub.2 --COOAlK.sub.3 and AlK.sub.3 is alkyl of 1 to 4 carbon atoms and their non-toxic, pharmaceutically acceptable acid addition salts, with the proviso that R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are not all hydrogen having a remarkable analgesic activity and a novel method for their preparation.
摘要翻译：选自下列化合物的化合物的化合物其中R 1，R 2，R 3和R 4可以位于苯环，R 1，R 3和R 4的不同位置的式Ia，由氢，-OH，1至4个碳原子的烷基，1至4个碳原子的烷氧基，卤素，-CF 3，-NO 2，-NH 2和NH-AlK和R 2选自下组：的氢，-OH，1至4个碳原子的烷基，卤素，-CF 3，-NO 2，-NH 2，-NH-AlK和AlGaN，AlK，AlK1和AlK2是1至4个碳原子的烷基或R1和 R 2一起和/或R 3和R 4一起是亚甲二氧基，R选自乙基，-CH 2 -COOH和CH 2 -COOAlK 3，AlK 3是1至4个碳原子的烷基及其无毒的药学上可接受的酸加成盐，条件是R1，R2，R3和R4不都是具有显着镇痛活性的氢和它们制备的新方法。

4. 发明授权

US4337353A Novel carboxylic acids, benzoyl phenyl alkanoic acids and use thereof 失效
标题翻译：新型羧酸，苯甲酰基苯基链烷酸及其应用
公开(公告)号：US4337353A
公开(公告)日：1982-06-29
申请号：US875323
申请日：1978-02-06
申请人： Andre Allais , Francois Clemence , Jean Meier , Roger Deraedt
发明人： Andre Allais , Francois Clemence , Jean Meier , Roger Deraedt
IPC分类号： C07C59/76 , C07C45/41 , C07C51/00 , C07C51/08 , C07C51/09 , C07C59/84 , C07C59/88 , C07C59/90 , C07C67/00
CPC分类号： C07C59/90 , C07C45/41 , C07C59/84 , C07C59/88
摘要： Novel carboxylic acids of the formula ##STR1## wherein Z is an aliphatic hydrocarbon chain selected from the group consisting of --(CH.sub.2).sub.n -- and --CH.dbd.CH--(CH.sub.2).sub.n-2 -- where the double bond may be at any point in the chain, n is an integer from 5 to 10 and X, X.sub.1, X.sub.2 and X.sub.3 are individually selected from the group consisting of hydrogen, halogen, alkyl of 1 to 5 carbon atoms, alkoxy of 1 to 5 carbon atoms, alkylthio of 1 to 5 carbon atoms, CF.sub.3 --, CF.sub.3 O-- and CF.sub.3 S-- and their non-toxic, pharmaceutically acceptable organic and inorganic salts and esters having analgesic and anti-inflammatory activity and their preparation.
摘要翻译：式（Ⅰ）的新型羧酸，其中Z是选自 - （CH 2）n - 和-CH = CH-（CH 2）n-2-的脂族烃链，其中双键可以是任何 n为5至10的整数，X，X 1，X 2和X 3分别选自氢，卤素，1至5个碳原子的烷基，1至5个碳原子的烷氧基，烷硫基 1至5个碳原子，CF 3 - ，CF 3 O-和CF 3 S-及其无毒的药学上可接受的有镇痛和抗炎活性的有机和无机盐和酯及其制备。

5. 发明授权

US5380722A Indole carboxamides 失效
标题翻译：吲哚甲酰胺
公开(公告)号：US5380722A
公开(公告)日：1995-01-10
申请号：US66565
申请日：1993-05-25
申请人： Francois Clemence , Jacques Guillaume , Gilles Hamon
发明人： Francois Clemence , Jacques Guillaume , Gilles Hamon
IPC分类号： C07D209/08 , C07D209/34 , A61K31/535 , A61K31/495 , C07D403/00 , C07D413/00
CPC分类号： C07D209/08 , C07D209/34
摘要： Novel indole-carboxamides of the formula ##STR1## and their non-toxic pharmaceutically acceptable acid addition salts having remarkable anti-arrhytmic properties.
摘要翻译：新颖的式I的吲哚 - 甲酰胺及其无毒的药学上可接受的酸加成盐具有显着的抗arrhyty性质。

6. 发明授权

US5130329A Benzocyclohexanes and benzocycloheptanes useful as analgesics 失效
标题翻译：苯并噻唑和苄唑醇作为分析物有用
公开(公告)号：US5130329A
公开(公告)日：1992-07-14
申请号：US591283
申请日：1990-10-01
申请人： Anne-Marie Moura , Francois Clemence , Daniel Frechet , Michel Fortin
发明人： Anne-Marie Moura , Francois Clemence , Daniel Frechet , Michel Fortin
IPC分类号： A61K31/165 , A61K31/33 , A61K31/38 , A61K31/381 , A61K31/40 , A61P7/10 , A61P9/06 , A61P9/12 , A61P25/04 , A61P25/28 , C07C67/00 , C07C209/00 , C07C209/16 , C07C209/60 , C07C211/42 , C07C215/44 , C07C215/70 , C07C217/74 , C07C233/79 , C07C235/14 , C07C271/52 , C07D295/12 , C07D295/135 , C07D333/54 , C07D333/60 , C07D521/00
CPC分类号： C07D295/135 , C07D333/60
摘要： Novel all possible enantiomeric and diastereoisomeric forms of compounds of the formula ##STR1## wherein R.sub.1 is selected from the group consisting of hydrogen, halogen, alkyl and alkoxy of 1 to 5 carbon atoms, --No.sub.2, --NH.sub.2 and mono and dialkylamino of 1 to 5 alkyl carbon atoms, A and B have the trans configuration, one of A and B being ##STR2## R.sub.2 is hydrogen or alkyl of 1 to 5 carbon atoms, Z is --(CH.sub.2).sub.n2, n.sub.2 being an integer from 0 to 5 or branched alkylene of 2 to 8 carbon atoms or --CH.sub.2 --O--, Y is selected from the group consisting of phenyl, naphthyl, indenyl, heteromonocycle of 5 to 6 ring atoms and heterobicycle, all optionally having at least one substituent and the other of A and B is ##STR3## R.sub.4 and R.sub.5 individually being selected from the group consisting of hydrogen and alkyl of 1 to 5 carbon atoms or taken together with the nitrogen to which they are attached form a 5 to 6 ring heterocycle optionally containing a heteroatom selected from the group consisting of --O--, --S-- and --NH-- and their non-toxic, pharmaceutically acceptable acid addition salts having central analgesic properties and a strong affinity for opiate receptors.

7. 发明授权

US5093337A Substituted derivatives of 20,21-dinoreburnamenine, their use as medicaments and the pharmaceutical compositions containing them 失效
标题翻译：其作为药物和含有它们的药物组合物的二十二碳三烯酸的取代衍生物
公开(公告)号：US5093337A
公开(公告)日：1992-03-03
申请号：US391511
申请日：1989-07-18
申请人： Nurgun Aktogu , Francois Clemence , Claude Oberlander
发明人： Nurgun Aktogu , Francois Clemence , Claude Oberlander
IPC分类号： C07D461/00 , A61K20060101 , A61K31/435 , A61K31/445 , A61K31/475 , A61K31/495 , A61P9/08 , A61P9/10 , A61P25/00 , A61P25/24 , A61P25/26 , C07D20060101
CPC分类号： C07D461/00
摘要： The invention concerns compounds of formula (I); ##STR1## in which R.sub.1, R.sub.2 and R.sub.3, identical or different, stand for hydrogen, halogen, alkyl or alkoxy (C.sub.1-5), hydroxy, trifluoromethyl, nitro, amino, alkylamino, dialkylamino, acylamino, R.sub.1, R.sub.2 and R.sub.3 being unable to stand for hydrogen simultaneously and in which (a) stands for (b), (c), or (d), all possible isomeric forms of said products of formula (I) being racemic or optically active, as well as their additional salts with acids, their preparation and the new intermediate products obtained, their application as drugs in particular nootropes, antidepressants, neuronal protectors, anti-anoxics, anti-ischemics, and the compositions containing them.
摘要翻译： PCT No.PCT / FR88 / 00562 Sec。 371日期：1989年7月18日 102（e）日期1989年7月18日PCT提交1988年11月16日PCT公布。出版物WO89 / 04830 日期：1989年6月1日。本发明涉及式（I）化合物。其中R1，R2和R3相同或不同，代表氢，卤素，烷基或烷氧基（C1-5），羟基，三氟甲基，硝基，氨基，烷基氨基，二烷基氨基，酰基氨基， R1，R2和R3不能同时代表氢，其中（a）代表（b），（c）或（d），所有式（I）产物的所有可能的异构形式是外消旋或光学活性的以及它们与酸的附加盐，它们的制备和获得的新的中间产物，它们作为药物特别是助推剂，抗抑郁药，神经元保护剂，抗缺氧剂，抗缺血剂以及含有它们的组合物的应用。

8. 发明授权

US4877796A Decahydroquinolines and central analgesic method of use thereof 失效
标题翻译：十氢喹啉和中枢镇痛药的使用方法
公开(公告)号：US4877796A
公开(公告)日：1989-10-31
申请号：US084456
申请日：1987-08-12
申请人： Francois Clemence , Odile Le Martret , Francoise Delevallee , Michel Fortin
发明人： Francois Clemence , Odile Le Martret , Francoise Delevallee , Michel Fortin
IPC分类号： A61K31/47 , A61P7/06 , A61P7/10 , A61P9/06 , A61P9/12 , A61P25/04 , C07D215/40 , C07D401/12 , C07D409/12
CPC分类号： C07D215/40
摘要： A compound selected from the group consisting of all enantiomeric and diastereoisomeric forms of a decahydroquinoline of the formula ##STR1## wherein R.sub.1 is alkyl of 1 to 5 carbon atoms, R.sub.2 is selected from the group consisting of hydrogen and akyl of 1 to 5 carbon atoms, A is selected from the group consisting of --(CH.sub.2).sub.n --, --CH.sub.2 O-- and alkylene substituted with alkyl having a total of 2 to 8 carbon atoms, n is an integer from 0 to 5, Z is selected from the group consisting of optionally substituted phenyl, optionally substituted naphthyl, optionally substituted indenyl, optionally substituted heteromonocycle of 5 to 6 members and optionally substituted heterobicycle with the proviso that when Z is o-alkoxy-phenyl, A is not --(CH.sub.2).sub.n -- in which n is O, and their non-toxic, pharmaceutically acceptable acid addition salts and their quaternary ammonium salts and intermediates having analgesic, diuretic, hypotensive, anti-arrithmic and anti-cerebral-ischaemic properties.
摘要翻译：选自下式的化合物：其中R 1为1至5个碳原子的烷基，R 2选自氢和1至5个碳原子的烷基的所有对映异构体和非对映异构体形式的十氢喹啉的化合物原子，A选自 - （CH 2）n - ， - CH 2 O-和被具有总共2至8个碳原子的烷基取代的亚烷基，n是0至5的整数，Z选自由任选取代的苯基，任选取代的萘基，任选取代的茚基，任选取代的5至6个成员的异单环和任选取代的杂双环，条件是当Z是邻 - 烷氧基 - 苯基时，A不是 - （CH2）n-，其中 n是O，它们的无毒的药学上可接受的酸加成盐及其季铵盐和具有止痛，利尿，降压，抗对数和抗脑缺血性质的中间体。

9. 发明授权

US4650811A Ethenylphenol-indoles having antiarythmic utility 失效
标题翻译：具有抗血浆效用的乙烯基苯酚吲哚
公开(公告)号：US4650811A
公开(公告)日：1987-03-17
申请号：US691163
申请日：1985-01-14
申请人： Jacques Guillaume , Francois Clemence , Neil L. Brown
发明人： Jacques Guillaume , Francois Clemence , Neil L. Brown
IPC分类号： A61K31/40 , A61K31/403 , A61K31/404 , A61P3/00 , A61P3/04 , A61P3/08 , A61P3/10 , A61P7/00 , A61P9/06 , A61P9/12 , A61P13/02 , A61P15/00 , A61P25/02 , A61P43/00 , C07D209/08 , C07D209/30 , C07D209/34 , C07D407/12 , C07D209/12
CPC分类号： C07D407/12 , C07D209/08 , C07D209/30 , C07D209/34
摘要： Novel ethenylphenol indoles of the formula ##STR1## wherein R and R.sub.1 are individually selected from the group consisting of hydrogen, alkyl of 1 to 5 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, cycloalkylalkyl of 4 to 7 carbon atoms and aralkyl of 7 to 12 carbon atoms optionally substituted with 1 to 3 members of the group consisting of halogen, methyl, ethyl, methoxy, ethoxy, methylthio, --CF.sub.3, --NH.sub.2 and --NO.sub.2 or R and R.sub.1 together with the nitrogen atom form an optionally unsaturated heterocycle optionally containing a second heteroatom selected from the group consisting of --O--, --S-- and ##STR2## R' is hydrogen or alkyl of 1 to 5 carbon atoms, a together with X is .dbd.0 and b is hydrogen or a together with b is a carbon-carbon bond and X is hydrogen, the dotted line indicates the possibility of a double bond with the compounds having the trans configuration if a double bond, A is selected from the group consisting of ##STR3## and --(CH.sub.2).sub.n --, n is 2,3,4 or 5, R.sub.2 is selected from the group consisting of hydrogen and alkyl of 1 to 5 carbon atoms with the proviso that R and R.sub.1 are not both hydrogen when A is ##STR4## and their non-toxic, pharmaceutically acceptable acid addition salts having anti-arrhythmic and anti hypertensive properties and the property of blocking slow calcium-sodium channels and novel intermediates.
摘要翻译：式Ⅰ的新型乙烯基苯酚吲哚，其中R和R 1分别选自氢，1至5个碳原子的烷基，3至7个碳原子的环烷基，4至7个碳原子的环烷基烷基和芳烷基任选被1至3个由卤素，甲基，乙基，甲氧基，乙氧基，甲硫基，-CF 3，-NH 2和-NO 2组成的组中任意取代的7至12个碳原子，或者R和R 1与氮原子一起形成任选不饱和的任选地含有选自-O - ， - S-和R'的第二杂原子的杂环是氢或1至5个碳原子的烷基，以及X是= 0，b是氢或一起其中b是碳 - 碳键，X是氢，虚线表示与具有反式构型的化合物具有双键的可能性，如果双键，A选自和 - （CH2 ）n-，n为2,3,4或5，R2选自c 存在氢和1至5个碳原子的烷基，条件是当A为A时，R和R1不同时为氢，并且它们具有抗心律失常和抗高血压性质的无毒的药学上可接受的酸加成盐和其特性阻断缓慢的钙钠通道和新型中间体。

10. 发明授权

US4281012A [4H]-1,3-Benzodioxin-2-carboxylic acids 失效
标题翻译： [4H] -1,3-苯并二恶英-2-羧酸
公开(公告)号：US4281012A
公开(公告)日：1981-07-28
申请号：US034432
申请日：1979-04-30
申请人： Daniel Humbert , Francois Clemence , Michele Dagnaux
发明人： Daniel Humbert , Francois Clemence , Michele Dagnaux
IPC分类号： A61K31/335 , A61K31/357 , A61P3/04 , A61P9/00 , C07C39/17 , C07C39/28 , C07C39/367 , C07C39/373 , C07C39/42 , C07C41/30 , C07C43/23 , C07C45/46 , C07C49/83 , C07C49/84 , C07D319/08
CPC分类号： C07D319/08 , C07C39/17 , C07C39/28 , C07C39/367 , C07C39/373 , C07C39/42 , C07C41/30 , C07C45/46 , C07C49/83 , C07C49/84 , C07C2101/14
摘要： Novel racemates and optically active isomers and mixtures of isomers of [4H]-1,3-benzodioxin-2-carboxylic acid compounds of the formula ##STR1## wherein R.sub.1 is selected from the group consisting of hydrogen, alkyl of 1 to 5 carbon atoms, dialkylamino alkyl with alkyls of 1 to 5 carbon atoms, alkali metal, alkaline earth metal, aluminum, --NH.sub.4, non-toxic pharmaceutically acceptable amines, 2,3-dihydroxypropanyl and (2,2-dimethyl-1,3-dioxolan-4-yl)-methyl, R.sub.2 is selected from the group consisting of hydrogen and alkyl of 1 to 5 carbon atoms, R.sub.3 and R.sub.6 are individually selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms, ethenyl and cyclohexyl and taken together with the carbon atom to which they are attached form cyclohexyl, R.sub.5 is selected from the group consisting of hydrogen and halogen or R.sub.1 and R.sub.2 have the above definitions, R.sub.6 is ##STR2## R.sub.4 and R.sub.5 are individually selected from the group consisting of hydrogen, halogen, --CF.sub.3, cyclohexyl, alkoxy of 1 to 3 carbon atoms, alkyl of 1 to 3 carbon atoms and p-chlorophenoxy and R.sub.3 is selected from the group consisting of 2-propenyl, ethenyl, cyclohexyl, benzyl, hydrogen and alkyl of 1 to 5 carbon atoms with the proviso that when R.sub.3 is alkyl, at least one of R.sub.4 and R.sub.5 is no hydrogen or halogen and when R.sub.3 is hydrogen, at least one of R.sub.4 and R.sub.5 is not hydrogen, halogen or --CF.sub.3 and the non-toxic, pharmaceutically acceptable acid addition salts thereof when R.sub.1 is dialkylaminoalkyl which have a marked hypolipemiant activity and reduces the plasmatic level of lipids, triglycerides and cholestrol and their preparation.
摘要翻译：新颖的外消旋物和光学活性异构体以及式[IMAGE] I的[4H] -1,3-苯并二恶英-2-羧酸化合物的异构体的混合物，其中R 1选自氢，1至5个碳的烷基原子，具有1至5个碳原子的烷基的二烷基氨基烷基，碱金属，碱土金属，铝，-NH 4，无毒的药学上可接受的胺，2,3-二羟基丙酰基和（2,2-二甲基-1,3-二氧戊环） -4-基） - 甲基，R 2选自氢和1至5个碳原子的烷基，R 3和R 6分别选自氢，1至6个碳原子的烷基，乙烯基和环己基并且与它们所连接的碳原子一起形成环己基，R 5选自氢和卤素，或者R 1和R 2具有上述定义，R 6和R 5各自独立地选自的氢，卤素，-CF 3，环己基，1〜3个碳原子的烷氧基在原子上具有1至3个碳原子的烷基和对氯苯氧基，R3选自2-丙烯基，乙烯基，环己基，苄基，氢和1至5个碳原子的烷基，条件是当R3为烷基，R 4和R 5中的至少一个不是氢或卤素，并且当R 3是氢时，当R 1是二烷基氨基烷基时，R 4和R 5中的至少一个不是氢，卤素或-CF 3及其无毒的药学上可接受的酸加成盐其具有显着的降胆固醇活性并降低脂质，甘油三酯和胆甾醇的血浆水平及其制备。

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