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1. 发明申请

US20060247320A1 Compounds for inhibiting KSP kinesin activity 审中-公开
标题翻译：抑制KSP驱动蛋白活性的化合物
公开(公告)号：US20060247320A1
公开(公告)日：2006-11-02
申请号：US11369643
申请日：2006-03-07
申请人： Jayaram Tagat , Timothy Guzi , Marc Labroli , Cory Poker , Yushi Xiao , Angela Kerekes , Tao Yu , Sunil Paliwal , Hon-Chung Tsui , Neng-Yang Shih , Stuart McCombie , Vincent Madison , Charles Lesburg , Jose Duca
发明人： Jayaram Tagat , Timothy Guzi , Marc Labroli , Cory Poker , Yushi Xiao , Angela Kerekes , Tao Yu , Sunil Paliwal , Hon-Chung Tsui , Neng-Yang Shih , Stuart McCombie , Vincent Madison , Charles Lesburg , Jose Duca
IPC分类号： A61K31/12
CPC分类号： C07D519/00 , C07D493/10 , C07D495/04 , C07D495/06 , C07D495/14 , C07D495/20 , C07D513/04
摘要： The present invention provides compounds of Formula I (wherein R1, R3, X, W, Z and ring Y are as defined herein). The present invention also provides compositions comprising these compounds that are useful for treating cellular proliferative diseases or disorders associated with KSP kinesin activity and for inhibiting KSP kinesin activity.
摘要翻译：本发明提供式I化合物（其中R 1，R 3，X，W，Z和环Y如本文所定义）。本发明还提供了包含这些化合物的组合物，其可用于治疗与KSP驱动蛋白活性相关的细胞增殖性疾病或病症并抑制KSP驱动蛋白活性。

2. 发明申请

US20060281778A1 Compounds for inhibiting KSP Kinesin activity 审中-公开
标题翻译：用于抑制KSP驱动蛋白活性的化合物
公开(公告)号：US20060281778A1
公开(公告)日：2006-12-14
申请号：US11369625
申请日：2006-03-07
申请人： Jayaram Tagat , Timothy Guzi , Marc Labroli , Cory Poker , Angela Kerekes , Tao Yu , Hon-Chung Tsui , Neng-Yang Shih , Yushi Xiao , Sunil Paliwal
发明人： Jayaram Tagat , Timothy Guzi , Marc Labroli , Cory Poker , Angela Kerekes , Tao Yu , Hon-Chung Tsui , Neng-Yang Shih , Yushi Xiao , Sunil Paliwal
IPC分类号： A61K31/4745 , C07D498/02
CPC分类号： C07D495/04
摘要： The present invention provides compounds of Formula I (wherein R1, R3, X, W, Z and ring Y are as defined herein). The present invention also provides compositions comprising these compounds that are useful for treating cellular proliferative diseases or disorders associated with KSP kinesin activity and for inhibiting KSP kinesin activity.
摘要翻译：本发明提供式I化合物（其中R 1，R 3，X，W，Z和环Y如本文所定义）。本发明还提供了包含这些化合物的组合物，其可用于治疗与KSP驱动蛋白活性相关的细胞增殖性疾病或病症并抑制KSP驱动蛋白活性。

3. 发明申请

US20160194330A1 PIPERAZINE-SUBSTITUTED [1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-5-AMINE COMPOUNDS WITH A2A ANTAGONIST PROPERTIES 有权
标题翻译：哌嗪取代[1,2,4]三唑[1,5-C]喹唑啉-5-胺化合物，具有A2A拮抗剂性质
公开(公告)号：US20160194330A1
公开(公告)日：2016-07-07
申请号：US14655572
申请日：2013-12-20
申请人： Amjad ALI , Michael Man-Chu LO , Yeon-Hee LIM , Andrew STAMFORD , Rongze KUANG , Paul TEMPEST , Younong YU , Michael BERLIN , Pauline TING , Gang ZHOU , Tao YU , Christopher BOYCE , Joseph Michael KELLY , Jayaram TAGAT , Junying ZHENG , Xianhai HUANG , Wei ZHOU , Jae-Hun KIM , Nicolas ZORN , Dong XIAO , Gioconda V. GALLO , Walter WON , Heping WU , Rajan ANAND , MERCK SHARP & DOHME CORP.
发明人： Amjad Ali , Michael Man-Chu Lo , Yeon-Hee Lim , Andrew Stamford , Rongze Kuang , Paul Tempest , Younong Yu , Michael Berlin , Pauline Ting , Gang Zhou , Tao Yu , Christopher Boyce , Joseph Michael Kelly , Jayaram R. Tagat , Junying Zheng , Xianhai Huang , Wei Zhou , Jae-Hun Kim , Nicolas Zorn , Dong Xiao , Gioconda V. Gallo , Walter Won , Heping Wu , Rajan Anand , Qiaolin Deng
IPC分类号： C07D487/04 , C07D487/18 , C07D487/08 , C07D513/04
CPC分类号： C07D487/04 , C07D487/08 , C07D487/18 , C07D513/04
摘要： Disclosed are compounds of Formula A: (structurally represented) where “RG1”, “RG2a”, “RG4”, “RG5”, “MG1”, “n” and “m” are defined herein which compounds are antagonists of A2A receptor. Disclosed herein also are uses of the compounds described herein as antagonists of the A2a receptor in the potential treatment or prevention of neurological disorders and diseases in which A2A receptors are involved. Disclosed herein also are pharmaceutical compositions comprising these compounds and uses of these pharmaceutical compositions.
摘要翻译：公开了式A化合物（结构表示），其中“RG1”，“RG2a”，“RG4”，“RG5”，“MG1”，“n”和“m”在本文中定义为哪些化合物是A2A受体的拮抗剂。本文还公开了本文所述的化合物作为A2a受体的拮抗剂的潜在治疗或预防涉及A2A受体的神经障碍和疾病的用途。本文还公开了包含这些化合物的药物组合物和这些药物组合物的用途。

4. 发明授权

US09676780B2 Piperazine-substituted [1,2,4]triazolo[1,5-C]quinazolin-5-amine compounds with A2A antagonist properties 有权
公开(公告)号：US09676780B2
公开(公告)日：2017-06-13
申请号：US14655572
申请日：2013-12-20
申请人： MERCK SHARP & DOHME CORP. , Amjad Ali , Michael Man-Chu Lo , Yeon-Hee Lim , Andrew Stamford , Rongze Kuang , Paul Tempest , Younong Yu , Michael Berlin , Pauline Ting , Gang Zhou , Tao Yu , Christopher Boyce , Joseph Michael Kelly , Jayaram R. Tagat , Junying Zheng , Xianhai Huang , Wei Zhou , Jae-Hun Kim , Nicolas Zorn , Dong Xiao , Gioconda V. Gallo , Walter Won , Heping Wu , Rajan Anand , Qiaolin Deng
发明人： Amjad Ali , Michael Man-Chu Lo , Yeon-Hee Lim , Andrew Stamford , Rongze Kuang , Paul Tempest , Younong Yu , Michael Berlin , Pauline Ting , Gang Zhou , Tao Yu , Christopher Boyce , Joseph Michael Kelly , Jayaram R. Tagat , Junying Zheng , Xianhai Huang , Wei Zhou , Jae-Hun Kim , Nicolas Zorn , Dong Xiao , Gioconda V. Gallo , Walter Won , Heping Wu , Rajan Anand , Qiaolin Deng
IPC分类号： C07D487/04 , A61K31/519 , C07D487/08 , C07D487/18 , C07D513/04
CPC分类号： C07D487/04 , C07D487/08 , C07D487/18 , C07D513/04
摘要： Disclosed are compounds of Formula A: (structurally represented) where “RG1”, “RG2a”, “RG4”, “RG5”, “MG1”, “n” and “m” are defined herein which compounds are antagonists of A2A receptor. Disclosed herein also are uses of the compounds described herein as antagonists of the A2a receptor in the potential treatment or prevention of neurological disorders and diseases in which A2A receptors are involved. Disclosed herein also are pharmaceutical compositions comprising these compounds and uses of these pharmaceutical compositions.

5. 发明授权

US08977908B2 Method and apparatus for detecting a suspect memory leak 有权
标题翻译：用于检测可疑内存泄漏的方法和装置
公开(公告)号：US08977908B2
公开(公告)日：2015-03-10
申请号：US13596095
申请日：2012-08-28
申请人： Jie Qiu , Hai Shan Wu , Jie Yang , Tao Yu
发明人： Jie Qiu , Hai Shan Wu , Jie Yang , Tao Yu
IPC分类号： G06F11/00 , G06F11/07 , G06F11/34
CPC分类号： G06F11/073 , G06F11/076 , G06F11/3452 , G06F11/3466
摘要： A method for determining a suspect memory leak, including: sampling the throughput and memory usage of an application server; based on the sampled throughput, monitoring whether the throughput decrease continually, and based on the sampled memory usage, monitoring whether the memory usage remains stable within a predefined range; in response to a continual decrease of the throughput and the memory usage remaining stable within the predetermined range, determining that the application server is suspected of having a memory leak. Using the solution of the present invention can free an administrator of the burden of artificially identifying suspect servers, can identify a suspect server during runtime and further determine whether it actually has a memory leak.
摘要翻译：一种用于确定可疑内存泄漏的方法，包括：对应用服务器的吞吐量和内存使用进行采样; 基于采样的吞吐量，监测吞吐量是否持续下降，并且基于采样的存储器使用情况，监视存储器使用是否在预定范围内保持稳定; 响应于吞吐量的持续降低和在预定范围内的存储器使用量保持稳定，确定应用服务器被怀疑具有存储器泄漏。使用本发明的解决方案可以使管理员免除人为识别可疑服务器的负担，可以在运行时识别可疑服务器，并且进一步确定它是否实际上具有内存泄漏。

6. 发明申请

US20140282082A1 Consistent Interface for Appointment Activity Business Object 有权
标题翻译：用于预约活动业务对象的一致接口
公开(公告)号：US20140282082A1
公开(公告)日：2014-09-18
申请号：US13832561
申请日：2013-03-15
申请人： Adam Stollarski , Uwe Herold , Rainer Heun , Thomas Konstandin , Olaf Schulte , Volkmar Stegmann , Balaji Vummiti , Tao Yu
发明人： Adam Stollarski , Uwe Herold , Rainer Heun , Thomas Konstandin , Olaf Schulte , Volkmar Stegmann , Balaji Vummiti , Tao Yu
IPC分类号： H04L12/58
CPC分类号： H04L51/00 , H04L51/34
摘要： A business object model, which reflects data that is used during a given business transaction, is utilized to generate interfaces. This business object model facilitates commercial transactions by providing consistent interfaces that are suitable for use across industries, across businesses, and across different departments within a business during a business transaction. In some operations, software creates, updates, or otherwise processes information related to an appointment activity business object.
摘要翻译：用于反映在给定业务事务期间使用的数据的业务对象模型被用于生成接口。该业务对象模型通过提供一致的接口来促进商业交易，该接口适合于在业务交易期间跨业务，跨企业以及业务中的不同部门使用。在某些操作中，软件创建，更新或以其他方式处理与预约活动业务对象相关的信息。

7. 发明授权

US08828173B2 Polysiloxanes with amino functionalities having reversible thickening and adhesion properties and systems and methods for crude oil, petroleum product or chemical spill containment and remediation 有权
标题翻译：具有氨基官能团的具有可逆增稠和粘附性能的聚硅氧烷，以及用于原油，石油产品或化学品泄漏物封存和修复的系统和方法
公开(公告)号：US08828173B2
公开(公告)日：2014-09-09
申请号：US13636375
申请日：2011-03-22
申请人： Richard G Weiss , Tao Yu , Koji Wakuda
发明人： Richard G Weiss , Tao Yu , Koji Wakuda
IPC分类号： C08G77/392 , C09J183/08 , B32B38/10 , C08L83/08
CPC分类号： C08G77/26 , C08L83/08
摘要： Reversibly and irreversibly-linking amino-polysiloxanes, methods of making such amino-polysiloxanes, and systems and methods of using such amino-polysiloxanes for the containment and/or remediation of a release and/or spill of a crude oil, a petroleum product and/or a chemical is described. Gels and/or emulsions formed from the combination and/or contacting of such an amino-polysiloxane with these materials can be used to recover these oils or chemicals while allowing the amino-polysiloxane to be recovered and reused to clean up or contain additional materials. Such amino-polysiloxanes can be used as well for the selective uptake of one component of liquid mixtures when such mixtures contain more and less lipophilic components. Methods of making and using adhesive and sealants containing such amino-polysiloxanes are described. The adhesive and sealants can be used in a variety of applications to adhere and/or seal various materials including plastics, metals, glass, ceramics, paper, paper products, wood, and wood products.
摘要翻译：可逆和不可逆地连接的氨基 - 聚硅氧烷，制备这种氨基 - 聚硅氧烷的方法，以及使用这种氨基 - 聚硅氧烷用于容纳和/或修复原油，石油产品的释放和/或溢出的系统和方法，以及 /或化学品被描述。由这种氨基 - 聚硅氧烷与这些材料的组合和/或接触形成的凝胶和/或乳液可以用于回收这些油或化学品，同时允许氨基聚硅氧烷被回收并重复使用以清除或容纳另外的材料。当这种混合物含有越来越少的亲脂性组分时，这种氨基 - 聚硅氧烷也可用于选择性吸收液体混合物的一种组分。描述了制备和使用含有这种氨基 - 聚硅氧烷的粘合剂和密封剂的方法。粘合剂和密封剂可用于各种应用中以粘合和/或密封各种材料，包括塑料，金属，玻璃，陶瓷，纸，纸制品，木材和木制品。

8. 发明申请

US20140120013A1 Reversible Room-Temperature Ionic Liquids 有权
标题翻译：可逆室温离子液体
公开(公告)号：US20140120013A1
公开(公告)日：2014-05-01
申请号：US14072439
申请日：2013-11-05
申请人： Tao Yu , Richard G. Weiss , Taisuke Yamada , Mathew George
发明人： Tao Yu , Richard G. Weiss , Taisuke Yamada , Mathew George
IPC分类号： C07D487/04 , B01D53/62 , C07C271/02
CPC分类号： B01D53/62 , B01D53/1493 , C07C213/08 , C07C257/14 , C07C271/02 , C07C319/20 , C07C323/43 , C07D487/04 , C07C323/25 , C07C215/08 , C07C215/30
摘要： One aspect of the present invention relates to salts that are room-temperature ionic liquids (RTILs), methods of making them, and methods of using them in connection with temporary or permanent gas sequestration. Another aspect of the present invention relates to a class of solvents which can be transformed into RTILs by exposure to a gas, and methods of using them in connection with temporary or permanent gas sequestration.
摘要翻译：本发明的一个方面涉及作为室温离子液体（RTIL）的盐，制备它们的方法以及将它们与临时或永久性气体隔离结合使用的方法。本发明的另一方面涉及一类可通过暴露于气体中而被转化成RTIL的溶剂，以及将它们与临时或永久性气体隔离结合使用的方法。

10. 发明授权

US08606723B2 Consistent set of interfaces derived from a business object model 有权
标题翻译：从业务对象模型派生的一组接口
公开(公告)号：US08606723B2
公开(公告)日：2013-12-10
申请号：US11166065
申请日：2005-06-24
申请人： Michael Seubert , Jochen Rasch , Axel Kuehl , Stefan Adelmann , Gabriel Alvarez , Markus Biehler , Daniel Bock , Andreas Bold , Andreas Brossler , Daniel Buchmann , Renzo Colle , Robert Doerner , Stefan Elfner , Stefan Franke , Werner Gnan , Antonia Gross , Patrick Gross , Toralf Grossmann , Gerhard Gschwender , Joerg Hendricks , Wolf Hengevoss , Stephan Hetzer , Christine Hofmann , Volker Jaeck , Bernhard Kelnberger , Johann Kemmer , Joachim Kenntner , Adam Kiwon , Karsten Koetter , Thilo Kraehmer , Corinne Kuster , Christoph Lehner , Werner Liebold , Thomas Maag , Otto Makris , Andreas Morsch , Wolfgang Nieswand , Thomas Nitschke , Dietmar Nowotny , Markus Peter , Georg Podhajsky , Dominic Poetschke , Uwe Pyka , Ruediger Radcke , Frank Reinemuth , Gregor Rieken , Volker Ripp , Gerd Ritter , Paola Sala , Daniela Schapler , Matthias Schmitt , Andreas Schneider , Armulf Schueler , Dagmar Schultze , Reiner Seyler , Ralf Sievers , Gunther Stuhec , Frank Thome , Andre Wagner , Rudolf Winkel , Tao Yu , Jens Zachmann , Renato Zadro , Theo Zimmerman , Michael Zoeller
发明人： Michael Seubert , Jochen Rasch , Axel Kuehl , Stefan Adelmann , Gabriel Alvarez , Markus Biehler , Daniel Bock , Andreas Bold , Andreas Brossler , Daniel Buchmann , Renzo Colle , Robert Doerner , Stefan Elfner , Stefan Franke , Werner Gnan , Antonia Gross , Patrick Gross , Toralf Grossmann , Gerhard Gschwender , Joerg Hendricks , Wolf Hengevoss , Stephan Hetzer , Christine Hofmann , Volker Jaeck , Bernhard Kelnberger , Johann Kemmer , Joachim Kenntner , Adam Kiwon , Karsten Koetter , Thilo Kraehmer , Corinne Kuster , Christoph Lehner , Werner Liebold , Thomas Maag , Otto Makris , Andreas Morsch , Wolfgang Nieswand , Thomas Nitschke , Dietmar Nowotny , Markus Peter , Georg Podhajsky , Dominic Poetschke , Uwe Pyka , Ruediger Radcke , Frank Reinemuth , Gregor Rieken , Volker Ripp , Gerd Ritter , Paola Sala , Daniela Schapler , Matthias Schmitt , Andreas Schneider , Armulf Schueler , Dagmar Schultze , Reiner Seyler , Ralf Sievers , Gunther Stuhec , Frank Thome , Andre Wagner , Rudolf Winkel , Tao Yu , Jens Zachmann , Renato Zadro , Theo Zimmerman , Michael Zoeller
IPC分类号： G06Q10/06 , G06Q10/10 , G06Q40/00
CPC分类号： G06Q30/04
摘要： Methods and systems consistent with the present invention provide a data processing system having a business object model reflecting the data used during a business transaction. Consistent interfaces are generated from the business object model. These interfaces are suitable for use across industries, across businesses, and across different departments within a business during a business transaction.
摘要翻译：与本发明一致的方法和系统提供了一种数据处理系统，其具有反映业务交易中使用的数据的业务对象模型。从业务对象模型生成一致的接口。这些接口适合在业务交易期间跨行业，跨企业以及业务中的不同部门使用。

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