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1. 发明申请

US20050137538A1 Drug delivery device 审中-公开
标题翻译：给药装置
公开(公告)号：US20050137538A1
公开(公告)日：2005-06-23
申请号：US11006914
申请日：2004-12-08
申请人： Jay Kunzler , Adrian Raiche , Dharmendra Jani
发明人： Jay Kunzler , Adrian Raiche , Dharmendra Jani
IPC分类号： A61F2/00 , A61F9/00 , A61M35/00
CPC分类号： A61F9/0017 , A61F2250/0067
摘要： A drug delivery device for placement in the eye includes a drug core comprising a pharmaceutically active agent, and a holder that holds the drug core. The holder is made of a material impermeable to passage of the active agent and includes an opening for passage of the pharmaceutically agent therethrough to eye tissue. The device includes a layer of material permeable to passage of the active agent. The device further includes a disc of impermeable material disposed between the drug core and the opening in the holder.
摘要翻译：用于放置在眼睛中的药物递送装置包括包含药物活性剂的药物核心和保持药物核心的保持器。保持器由不透过活性剂通过的材料制成，并且包括用于药剂通过其通过眼组织的开口。该装置包括可渗透活性剂通过的材料层。该装置还包括设置在药物核心和保持器中的开口之间的防渗材料盘。

2. 发明申请

US20060252850A1 Radiation-absorbing polymeric materials and ophthalmic devices comprising same 审中-公开
标题翻译：吸收辐射的聚合物材料和包括其的眼科装置
公开(公告)号：US20060252850A1
公开(公告)日：2006-11-09
申请号：US11122180
申请日：2005-05-04
申请人： Dharmendra Jani , Jay Kunzler , Joseph Salamone , Richard Blackwell
发明人： Dharmendra Jani , Jay Kunzler , Joseph Salamone , Richard Blackwell
IPC分类号： C03C17/00
CPC分类号： C08K5/3475 , C07D249/20 , C08F220/14 , C08F220/26 , C08F222/1006 , C08L33/14 , G02B1/043
摘要： A radiation-absorbing polymeric material comprises units of a polymerizable UV-absorbing compound and a monomer, and is capable of absorbing UV radiation, and at least about 50 percent of light having wavelengths in the range from about 400 nm to about 425 nm. The radiation-absorbing polymeric material can further comprise units of a crosslinking agent. Ophthalmic devices, such as contact lenses, corneal rings, corneal inlays, keratoprostheses, and intraocular lenses, are made from such polymeric material.
摘要翻译：辐射吸收聚合物材料包含可聚合的UV吸收化合物和单体的单元，并且能够吸收紫外线辐射，并且至少约50％的波长在约400nm至约425nm的范围内。辐射吸收聚合物材料还可包含交联剂单元。诸如隐形眼镜，角膜环，角膜嵌体，角膜假体和眼内透镜的眼科装置由这种聚合材料制成。

3. 发明申请

US20060078592A1 Drug delivery systems 审中-公开
标题翻译：药物输送系统
公开(公告)号：US20060078592A1
公开(公告)日：2006-04-13
申请号：US11210124
申请日：2005-08-23
申请人： Jay Kunzler , Dharmendra Jani , Joseph Salamone
发明人： Jay Kunzler , Dharmendra Jani , Joseph Salamone
IPC分类号： A61F2/00
CPC分类号： A61K9/0051 , A61F9/0017
摘要： A method for making an ocular drug delivery device involves subjecting the device to a supercritical fluid to remove contaminants from the device. The supercritical fluid includes supercritical carbon dioxide. The contaminants include unreacted monomers or oligomers present in the polymeric material used to form the device.
摘要翻译：用于制造眼药物递送装置的方法包括使装置经受超临界流体以从装置中去除污染物。超临界流体包括超临界二氧化碳。污染物包括存在于用于形成该装置的聚合物材料中的未反应的单体或低聚物。

4. 发明申请

US20050254003A1 Photochromic blue light filtering materials and ophthalmic devices 审中-公开
标题翻译：光致变色蓝光过滤材料和眼科装置
公开(公告)号：US20050254003A1
公开(公告)日：2005-11-17
申请号：US11121960
申请日：2005-05-04
申请人： Dharmendra Jani , Jay Kunzler , Joseph Salamone
发明人： Dharmendra Jani , Jay Kunzler , Joseph Salamone
IPC分类号： G02B1/04 , G02C7/04 , G02C7/10
CPC分类号： G02B5/23 , A61L27/50 , A61L2430/16 , G02B1/043 , G02C7/102 , G03C1/73
摘要： Polymeric compositions have photochromic and blue-light filtering ability and are useful in the manufacture of ophthalmic medical devices. The polymeric compositions comprise a photochromic material incorporated into polymeric host materials and are activatable by blue light having a first wavelength range to become photochromic, and are thereby capable of absorbing blue light in a second wavelength range. Methods of making the compositions comprise incorporating a photochromic material into a polymeric host material.
摘要翻译：聚合物组合物具有光致变色和蓝光过滤能力，并且可用于制造眼科医疗装置。聚合物组合物包含并入聚合物主体材料中的光致变色材料，并且可通过具有第一波长范围的蓝光激发而变为光致变色，从而能够吸收第二波长范围内的蓝光。制备组合物的方法包括将光致变色材料掺入聚合物主体材料中。

5. 发明申请

US20070159594A9 Photochromic blue light filtering materials and ophthalmic devices 审中-公开
标题翻译：光致变色蓝光过滤材料和眼科装置
公开(公告)号：US20070159594A9
公开(公告)日：2007-07-12
申请号：US11121960
申请日：2005-05-04
申请人： Dharmendra Jani , Jay Kunzler , Joseph Salamone
发明人： Dharmendra Jani , Jay Kunzler , Joseph Salamone
IPC分类号： G02C7/04 , G02C7/10
CPC分类号： G02B5/23 , A61L27/50 , A61L2430/16 , G02B1/043 , G02C7/102 , G03C1/73
摘要： Polymeric compositions have photochromic and blue-light filtering ability and are useful in the manufacture of ophthalmic medical devices. The polymeric compositions comprise a photochromic material incorporated into polymeric host materials and are activatable by blue light having a first wavelength range to become photochromic, and are thereby capable of absorbing blue light in a second wavelength range. Methods of making the compositions comprise incorporating a photochromic material into a polymeric host material.
摘要翻译：聚合物组合物具有光致变色和蓝光过滤能力，并且可用于制造眼科医疗装置。聚合物组合物包含并入聚合物主体材料中的光致变色材料，并且可通过具有第一波长范围的蓝光激发而变为光致变色，从而能够吸收第二波长范围内的蓝光。制备组合物的方法包括将光致变色材料掺入聚合物主体材料中。

6. 发明申请

US20050031669A1 Rate controlled release of a pharmaceutical agent in a biodegradable device 审中-公开
标题翻译：在可生物降解的装置中速率控制药剂的释放
公开(公告)号：US20050031669A1
公开(公告)日：2005-02-10
申请号：US10887381
申请日：2004-07-08
申请人： Afshin Shafiee , Joseph Salamone , Dharmendra Jani , Stephen Bartels , Jay Kunzler
发明人： Afshin Shafiee , Joseph Salamone , Dharmendra Jani , Stephen Bartels , Jay Kunzler
IPC分类号： A61K9/00 , A61K9/16 , A61P27/02 , C12N5/02
CPC分类号： A61K9/0051 , A61K9/1647
摘要： Chemical erosion drug delivery systems are provided that allow sustained release of therapeutic agents within a treated area for a prolonged period of time.
摘要翻译：提供化学腐蚀药物递送系统，其允许治疗剂在处理区域内持续释放较长时间。

7. 发明授权

US09060847B2 Optical hydrogel material with photosensitizer and method for modifying the refractive index 有权
$Optical hydrogel material with photosensitizer and method for modifying the refractive index$
公开(公告)号：US09060847B2
公开(公告)日：2015-06-23
申请号：US12380892
申请日：2009-03-04
申请人： Thomas Smith , Wayne H. Knox , Li Ding , Dharmendra Jani , Jeffrey G. Linhardt
发明人： Thomas Smith , Wayne H. Knox , Li Ding , Dharmendra Jani , Jeffrey G. Linhardt
IPC分类号： B05D3/06 , A61L27/50 , A61L27/52 , A61F9/008 , B29D11/00 , A61F2/16
CPC分类号： A61F9/00804 , A61F2/1451 , A61F2/1627 , A61F2/1635 , A61L27/50 , A61L27/52 , A61L2430/16 , B29D11/00009 , G02C2202/14
摘要： A method for modifying the refractive index of an optical, hydrogel polymeric material. The method comprises irradiating predetermined regions of an optical, polymeric material with a laser to form refractive structures. To facilitate the formation of the refractive structures the optical, hydrogel polymeric material comprises a photosensitizer. The presence of the photosensitizer permits one to set a scan rate to a value that is at least fifty times greater than a scan rate without the photosensitizer in the material, yet provides similar refractive structures in terms of the observed change in refractive index. Alternatively, the photosensitizer in the polymeric material permits one to set an average laser power to a value that is at least two times less than an average laser power without the photosensitizer in the material, yet provide similar refractive structures.

8. 发明申请

US20120310340A1 Method for Modifying the Refractive Index of an Optical Material and Resulting Optical Vision Component 有权
$Method for Modifying the Refractive Index of an Optical Material and Resulting Optical Vision Component$
标题翻译：用于修改光学材料和所得光学视觉组件的折射率的方法
公开(公告)号：US20120310340A1
公开(公告)日：2012-12-06
申请号：US13238143
申请日：2011-09-21
申请人： Wayne H. Knox , Thomas Smith , Dharmendra Jani , Li Ding
发明人： Wayne H. Knox , Thomas Smith , Dharmendra Jani , Li Ding
IPC分类号： A61F2/16 , B29D11/00
CPC分类号： G02B3/0087 , A61F2/1618 , A61F2/1627 , A61F9/00834 , A61L27/16 , A61L27/50 , A61L27/52 , A61L2400/18 , A61L2430/16 , G02B2003/0093 , G02C2202/12 , G02C2202/14 , C08L33/10
摘要： A method for modifying the refractive index of an optical polymeric material. The method comprises continuously irradiating predetermined regions of an optical, polymeric material with femtosecond laser pulses to form a gradient index refractive structure within the material. An optical device includes an optical, polymeric lens material having an anterior surface and posterior surface and an optical axis intersecting the surfaces and at least one laser-modified, GRIN layer disposed between the anterior surface and the posterior surface and arranged along a first axis 45° to 90° to the optical axis, and further characterized by a variation in index of refraction across at least one of at least a portion of the adjacent segments and along each segment.
摘要翻译：一种用于改变光学聚合物材料的折射率的方法。该方法包括用飞秒激光脉冲连续照射光学聚合材料的预定区域，以在材料内形成梯度折射率折射结构。光学装置包括具有前表面和后表面的光学聚合物透镜材料和与表面相交的光轴以及设置在前表面和后表面之间并且沿着第一轴线45布置的至少一个激光修饰的GRIN层 °至90°，并且进一步的特征在于，相邻段的至少一部分中的至少一个和沿着每个段的折射率的变化。

9. 发明申请

US20090143858A1 OPTICAL MATERIAL AND METHOD FOR MODIFYING THE REFRACTIVE INDEX 有权
标题翻译：光学材料和修正折射指数的方法
公开(公告)号：US20090143858A1
公开(公告)日：2009-06-04
申请号：US11948298
申请日：2007-11-30
申请人： Wayne H. Knox , Li Ding , Jay F. Kunzler , Dharmendra Jani , Candido D. Pinto
发明人： Wayne H. Knox , Li Ding , Jay F. Kunzler , Dharmendra Jani , Candido D. Pinto
IPC分类号： A61F2/16 , G02B1/12
CPC分类号： A61F2/1613 , A61B18/20 , A61F2/14 , A61F2/16 , A61F2/1627 , A61F2/1635 , B29D11/00461 , B29D11/023 , C08J7/12 , C08J7/123 , G02C2202/14
摘要： A method for modifying the refractive index of an optical, polymeric material. The method comprises irradiating select regions of the optical, polymeric material with a focused, visible or near-IR laser having a pulse energy from 0.05 nJ to 1000 nJ. The irradiation results in the formation of refractive optical structures, characterized by a change in refractive index, exhibit little or no scattering loss, and exhibit no significant differences in the Raman spectrum with respect to the non-irradiated optical, polymeric material. The method can be used to modify the refractive index of an intraocular lens following the surgical implantation of the intraocular lens in a human eye. The invention is also directed to an optical device comprising refractive optical structures, wherein the refractive structures are characterized by a change in refractive index, exhibit little or no scattering loss, and exhibit no significant differences in the Raman spectrum with respect to the non-irradiated optical, polymeric material.
摘要翻译：用于改变光学聚合物材料的折射率的方法。该方法包括用具有0.05nJ至1000nJ的脉冲能量的聚焦，可见或近红外激光照射光学聚合物材料的选择区域。照射导致折射光学结构的形成，其特征在于折射率的变化，显示很少或没有散射损失，并且在拉曼光谱方面相对于未照射的光学聚合物材料没有显着差异。该方法可以用于在人眼中手术植入人工晶状体后修改眼内透镜的折射率。本发明还涉及一种包括折射光学结构的光学器件，其中折射结构的特征在于折射率的变化，表现出很少的或没有散射损耗，并且在拉曼光谱方面相对于未辐照的表现没有显着的差异光学，聚合材料。

10. 发明申请

US20070053948A1 Lens care solution demonstration kit 审中-公开
标题翻译：镜头护理解决方案演示套件
公开(公告)号：US20070053948A1
公开(公告)日：2007-03-08
申请号：US11518023
申请日：2006-11-10
申请人： Daniel Ammon , Suzanne Groemminger , Dharmendra Jani
发明人： Daniel Ammon , Suzanne Groemminger , Dharmendra Jani
IPC分类号： A01N25/00
CPC分类号： A61L12/086 , A45C11/005 , A45C13/02
摘要： A demonstration kit and method for marketing lens care solution. The kit contains two demonstrations. One demonstration is directed to lubricity and the other demonstration is directed to protein stabilization. The protein assay uses a solution of urea.
摘要翻译：用于营销镜片护理解决方案的演示套件和方法。该套件包含两个演示。一个示范是针对润滑性，另一个演示针对蛋白质稳定。蛋白质测定使用尿素溶液。

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