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1. 发明申请

US20080142038A1 SURFACE TREATMENT OF MEDICAL DEVICES 审中-公开
标题翻译：医疗器械的表面处理
公开(公告)号：US20080142038A1
公开(公告)日：2008-06-19
申请号：US11924336
申请日：2007-10-25
申请人： Jay F. Kunzler , Mark Stachowski , Jeffrey G. Linhardt , Joseph C. Salamone
发明人： Jay F. Kunzler , Mark Stachowski , Jeffrey G. Linhardt , Joseph C. Salamone
IPC分类号： B08B7/00
CPC分类号： G02B1/043 , A61L27/34 , A61L27/50 , C08J7/047 , C08J7/14 , C08J2383/04
摘要： A method for improving the wettability of a medical device is provided, the method comprising the steps of (a) providing a medical device formed from a monomer mixture comprising a hydrophilic monomer and a siloxy-containing monomer, (b) subjecting a surface of the medical device to a surface treatment, and (c) contacting the treated surface of the medical device with a wetting agent solution comprising a carboxylic acid-containing polymer or copolymer to form a carboxylic acid-containing polymeric or copolymeric layer on the treated surface of the medical device.
摘要翻译：提供一种改善医疗装置的润湿性的方法，所述方法包括以下步骤：（a）提供由包含亲水性单体和含甲硅烷氧基的单体的单体混合物形成的医疗装置，（b）使医疗装置进行表面处理，以及（c）使处理过的医疗装置的表面与包含含羧酸的聚合物或共聚物的润湿剂溶液接触，以在经处理的表面上形成含羧酸的聚合物或共聚物层医疗装置。

2. 发明授权

US08100528B2 Coating solutions comprising segmented interactive block copolymers 失效
标题翻译：涂层溶液包括分段交互嵌段共聚物
公开(公告)号：US08100528B2
公开(公告)日：2012-01-24
申请号：US12334619
申请日：2008-12-15
申请人： Jeffrey G. Linhardt , Devon A. Shipp , Jay F. Kunzler , David Paul Vanderbilt
发明人： Jeffrey G. Linhardt , Devon A. Shipp , Jay F. Kunzler , David Paul Vanderbilt
IPC分类号： G02C7/04 , C08F130/08 , A61F2/24 , A61F2/16 , A61F2/06 , A61F2/14 , A61F2/12 , A61F2/02
CPC分类号： G02B1/043 , A61L27/34 , A61L31/10 , A61M25/0045 , C08F130/08 , C08F230/00 , C08F293/005 , C08F2438/03 , C08J7/04 , C08J2343/04 , C08J2383/00 , Y10T428/31536 , Y10T428/31663
摘要： This invention is directed toward surface treatment of a device. The surface treatment comprises the attachment of interactive segmented block copolymers to the surface of the substrate by means of interactive functionalities of the segmented block copolymer reacting with complementary surface functionalities in monomeric units along the polymer substrate. The present invention is also directed to a surface modified medical device, examples of which include contact lenses, intraocular lenses, vascular stents, phakic intraocular lenses, aphakic intraocular lenses, corneal implants, catheters, implants, and the like, comprising a surface made by such a method.
摘要翻译：本发明涉及一种装置的表面处理。表面处理包括通过与沿着聚合物基底的单体单元的互补表面官能团反应的分段嵌段共聚物的相互作用官能团将相互作用的嵌段共聚物连接到基材的表面。本发明还涉及一种表面改性医疗装置，其实例包括隐形眼镜，眼内透镜，血管支架，晶状体眼内透镜，无晶状体眼内透镜，角膜植入物，导管，植入物等，其包括由这样一种方法。

3. 发明申请

US20090173044A1 Packaging Solutions 有权
标题翻译：包装解决方案
公开(公告)号：US20090173044A1
公开(公告)日：2009-07-09
申请号：US12258916
申请日：2008-10-27
申请人： Jeffrey G. Linhardt , Jay F. Kunzler
发明人： Jeffrey G. Linhardt , Jay F. Kunzler
IPC分类号： B65B55/02
CPC分类号： C11D3/0078 , A45C11/005 , A61L12/04 , B65B25/008 , B65B55/06 , C11D1/82 , C11D17/041 , Y10S514/84
摘要： Packaging systems for storing ophthalmic devices such as contact lenses and to methods for packaging such ophthalmic devices with solutions to improve the comfort of the lenses during wear are disclosed. A packaging system includes an ophthalmic device stored in an aqueous packaging solution comprising a substantially water-soluble silicone-containing surfactant. Such solutions are retained on the surface of an unused lens for extended periods of time, resulting in surface modification that persists in the eye, which may provide significant improvement in the wetting properties of fresh contact lenses used for the first time and, moreover, even several hours after lens insertion, preventing dryness and improving lubricity.
摘要翻译：公开了用于存储诸如隐形眼镜的眼科装置的包装系统，以及用于包装这些眼科装置的方法以提供穿戴期间镜片的舒适度的解决方案。包装系统包括存储在包含基本上水溶性的含硅氧烷表面活性剂的水性包装溶液中的眼科装置。这种溶液长时间保留在未使用的镜片的表面上，导致眼睛中持续存在的表面改性，这可以显着改善首次使用的新鲜隐形眼镜的润湿性能，此外甚至镜片插入后数小时，防止干燥，提高润滑性。

4. 发明申请

US20090171027A1 SEGMENTED INTERACTIVE BLOCK COPOLYMERS 审中-公开
标题翻译： SEGMENTED交互式嵌段共聚物
公开(公告)号：US20090171027A1
公开(公告)日：2009-07-02
申请号：US12334615
申请日：2008-12-15
申请人： Jeffrey G. Linhardt , Devon A. Shipp , Jay F. Kunzler , David Vanderbilt
发明人： Jeffrey G. Linhardt , Devon A. Shipp , Jay F. Kunzler , David Vanderbilt
IPC分类号： C08F299/00
CPC分类号： G02B1/043 , A61L27/34 , A61L31/10 , A61M25/0045 , C08F130/08 , C08F230/00 , C08F293/005 , C08F2438/03 , C08J7/04 , C08J2343/04 , C08J2383/00 , Y10T428/31536 , Y10T428/31663
摘要： This invention is directed toward interactive segmented block copolymers useful to treat the surface of a substrate by means of interactive functionalities of the interactive segmented block copolymer material binding with complementary surface functionalities of the polymer substrate.
摘要翻译：本发明涉及用于通过与聚合物基质的互补表面官能团结合的相互作用的分段嵌段共聚物材料的相互作用功能来处理基材表面的相互作用的嵌段共聚物。

5. 发明授权

US07942929B2 Coating solutions comprising segmented reactive block copolymers 失效
标题翻译：包含分段反应性嵌段共聚物的涂布溶液
公开(公告)号：US07942929B2
公开(公告)日：2011-05-17
申请号：US12334618
申请日：2008-12-15
申请人： Jeffrey G. Linhardt , Devon A. Shipp , Jay F. Kunzler
发明人： Jeffrey G. Linhardt , Devon A. Shipp , Jay F. Kunzler
IPC分类号： A61F2/16 , G02B1/04 , B32B9/04 , A61L33/00
CPC分类号： G02B1/043 , A61L27/34 , A61L31/10 , A61M25/0045 , C08F130/08 , C08F230/00 , C08F293/005 , C08F2438/03 , C08J7/04 , C08J2343/04 , C08J2383/00 , Y10T428/31536 , Y10T428/31663
摘要： This invention is directed toward surface treatment of a device. The surface treatment comprises the attachment of reactive segmented block copolymers to the surface of the substrate by means of reactive functionalities of the terminal functionalized surfactant material reacting with complementary surface reactive functionalities in monomeric units along the polymer substrate. The present invention is also directed to a surface modified medical device, examples of which include contact lenses, intraocular lenses, vascular stents, phakic intraocular lenses, aphakic intraocular lenses, corneal implants, catheters, implants, and the like, comprising a surface made by such a method.
摘要翻译：本发明涉及一种装置的表面处理。表面处理包括通过末端官能化表面活性剂材料与沿聚合物基质的单体单元的互补表面反应性官能团反应的反应性官能团将反应性嵌段共聚物附着到基材表面。本发明还涉及一种表面改性医疗装置，其实例包括隐形眼镜，眼内透镜，血管支架，晶状体眼内透镜，无晶状体眼内透镜，角膜植入物，导管，植入物等，包括由这样一种方法。

6. 发明授权

US07915323B2 Mono ethylenically unsaturated polycarbosiloxane monomers 有权
标题翻译：单烯属不饱和聚碳硅氧烷单体
公开(公告)号：US07915323B2
公开(公告)日：2011-03-29
申请号：US12499853
申请日：2009-07-09
申请人： Alok Kumar Awasthi , Jason K. Stanbro , Jay F. Kunzler , Jeffrey G. Linhardt
发明人： Alok Kumar Awasthi , Jason K. Stanbro , Jay F. Kunzler , Jeffrey G. Linhardt
IPC分类号： G02B1/04
CPC分类号： C08F30/08 , G02B1/043 , C08L83/06
摘要： The present invention relates to polymeric compositions useful in the manufacture of biocompatible medical devices. More particularly, the present invention relates to certain monoethylenically unsaturated polycarbosiloxane monomers capable of polymerization to form polymeric compositions having desirable physical characteristics useful in the manufacture of ophthalmic devices.
摘要翻译：本发明涉及可用于制造生物相容性医疗器械的聚合物组合物。更具体地说，本发明涉及能够聚合形成具有用于制造眼科装置的理想物理特性的聚合物组合物的某些单烯属不饱和聚碳硅氧烷单体。

7. 发明申请

US20090171459A1 COATING SOLUTIONS COMPRISING SEGMENTED REACTIVE BLOCK COPOLYMERS 失效
标题翻译：包含SEGMENTED反应性嵌段共聚物的涂料溶液
公开(公告)号：US20090171459A1
公开(公告)日：2009-07-02
申请号：US12334618
申请日：2008-12-15
申请人： Jeffrey G. Linhardt , Devon A. Shipp , Jay F. Kunzler
发明人： Jeffrey G. Linhardt , Devon A. Shipp , Jay F. Kunzler
IPC分类号： A61F2/16 , A61F13/84 , G02C7/04
CPC分类号： G02B1/043 , A61L27/34 , A61L31/10 , A61M25/0045 , C08F130/08 , C08F230/00 , C08F293/005 , C08F2438/03 , C08J7/04 , C08J2343/04 , C08J2383/00 , Y10T428/31536 , Y10T428/31663
摘要： This invention is directed toward surface treatment of a device. The surface treatment comprises the attachment of reactive segmented block copolymers to the surface of the substrate by means of reactive functionalities of the terminal functionalized surfactant material reacting with complementary surface reactive functionalities in monomeric units along the polymer substrate. The present invention is also directed to a surface modified medical device, examples of which include contact lenses, intraocular lenses, vascular stents, phakic intraocular lenses, aphakic intraocular lenses, corneal implants, catheters, implants, and the like, comprising a surface made by such a method.
摘要翻译：本发明涉及一种装置的表面处理。表面处理包括通过末端官能化表面活性剂材料与沿聚合物基质的单体单元的互补表面反应性官能团反应的反应性官能团将反应性嵌段共聚物附着到基材表面。本发明还涉及一种表面改性医疗装置，其实例包括隐形眼镜，眼内透镜，血管支架，晶状体眼内透镜，无晶状体眼内透镜，角膜植入物，导管，植入物等，包括由这样一种方法。

8. 发明申请

US20090171049A1 SEGMENTED REACTIVE BLOCK COPOLYMERS 审中-公开
标题翻译： SEGMENTED反应性嵌段共聚物
公开(公告)号：US20090171049A1
公开(公告)日：2009-07-02
申请号：US12333345
申请日：2008-12-12
申请人： Jeffrey G. Linhardt , Devon A. Shipp , Jay F. Kunzler
发明人： Jeffrey G. Linhardt , Devon A. Shipp , Jay F. Kunzler
IPC分类号： C08F26/10 , C08G69/40
CPC分类号： G02B1/043 , A61L27/34 , A61L31/10 , A61M25/0045 , C08F130/08 , C08F230/00 , C08F293/005 , C08F2438/03 , C08J7/04 , C08J2343/04 , C08J2383/00 , Y10T428/31536 , Y10T428/31663
摘要： This invention is directed toward reactive segmented block copolymers useful to treat the surface of a substrate by means of reactive functionalities of the reactive segmented block copolymer material reacting with complementary surface reactive functionalities of the polymer substrate.
摘要翻译：本发明涉及用于通过与聚合物基质的互补表面反应性官能团反应的反应性嵌段共聚物材料的反应性官能团来处理基材表面的反应性分段嵌段共聚物。

9. 发明授权

US08083348B2 Biomedical devices 有权
标题翻译：生物医学装置
公开(公告)号：US08083348B2
公开(公告)日：2011-12-27
申请号：US12456420
申请日：2009-06-16
申请人： Jeffrey G. Linhardt , Jay F. Kunzler , Devon A. Shipp
发明人： Jeffrey G. Linhardt , Jay F. Kunzler , Devon A. Shipp
IPC分类号： G02C7/04 , C08F28/04
CPC分类号： G02B1/043 , C08F20/56 , C08F26/08 , C08F118/02 , C08F226/02 , C08L81/00 , C08L83/10
摘要： Biomedical devices such as contact lenses formed from a polymerization product of a mixture comprising an ethylenically unsaturated-containing non-amphiphilic macromonomer comprising hydrophilic units or hydrophobic units derived from a living radical polymerization of one or more ethylenically unsaturated hydrophilic monomers or one or more ethylenically unsaturated hydrophobic monomers are disclosed.
摘要翻译：生物医学装置，例如由含有烯键式不饱和的非两亲性大分子单体的混合物的聚合产物形成的隐形眼镜，其包含亲水单元或衍生自一种或多种烯属不饱和亲水单体的活性自由基聚合的疏水单元或一种或多种烯属不饱和单体公开疏水单体。

10. 发明授权

US07994356B2 Mono ethylenically unsaturated polycarbosiloxane monomers 有权
公开(公告)号：US07994356B2
公开(公告)日：2011-08-09
申请号：US12499854
申请日：2009-07-09
申请人： Alok Kumar Awasthi , Jason K. Stanbro , Jay F. Kunzler , Jeffrey G. Linhardt
发明人： Alok Kumar Awasthi , Jason K. Stanbro , Jay F. Kunzler , Jeffrey G. Linhardt
IPC分类号： C07F7/02 , C07F7/10
CPC分类号： C08G77/50 , C07F7/0838 , C08G77/20
摘要： The present invention relates to polymeric compositions useful in the manufacture of biocompatible medical devices. More particularly, the present invention relates to certain monoethylenically unsaturated polycarbosiloxane monomers capable of polymerization to form polymeric compositions having desirable physical characteristics useful in the manufacture of ophthalmic devices.

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