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1. 发明申请

US20070070497A1 System and method for enhancing confocal reflectance images of tissue specimens 审中-公开
标题翻译：用于增强组织标本的共焦反射图像的系统和方法
公开(公告)号：US20070070497A1
公开(公告)日：2007-03-29
申请号：US11601203
申请日：2006-11-17
申请人： Jay Eastman , Milind Rajadhyaksha , James Zavislan
发明人： Jay Eastman , Milind Rajadhyaksha , James Zavislan
IPC分类号： G02B21/06
CPC分类号： G02B21/0068 , A61K49/001 , G01N33/5743
摘要： A system using cross polarization effects and an enhancement agent having citric or other similar alpha hydroxy acid to enhance confocal microscope reflectance images and particularly images of the nuclei of BCCs (basal cell carcinomas) and SCCs (squamous cell carcinomas) in the confocal reflectance images of excised tumor slices obtained during Mohs surgery by illuminating the tissue being imaged (a tumor slice) using polarized light. The reflected illumination is passed to a polarization analyzer, which passes the polarization component which is crossed with respect to the polarization of the illuminating light. The light from the analyzer is passed through the confocal aperture and detected. The section of the tissue either at the surface or within the tissue is scanned and the reflectance image is produced with enhanced visualization of the cellular or nuclear structure thereof thereby enabling determination of the extent of the tumor (cancerous cells) in the section. A method is also provided using the system for diagnosing cancerous cells in skin tissue.
摘要翻译：使用交叉极化效应的系统和具有柠檬酸或其它类似α羟基酸的增强剂来增强共聚焦显微镜反射图像，特别是BCC（基底细胞癌）和SCC（鳞状细胞癌）的核的图像在共聚焦反射图像中通过使用偏振光照射被成像的组织（肿瘤切片）在Mohs手术期间获得的切除的肿瘤切片。反射的照明被传递到偏振分析器，偏振分析器使相对于照明光的偏振交叉的偏振分量通过。来自分析仪的光通过共焦孔并检测。扫描在表面或组织内的组织的部分，并且通过细胞或核结构的增强的可视化产生反射图像，从而能够确定该部分中肿瘤（癌细胞）的程度。还提供了一种用于诊断皮肤组织中的癌细胞的系统的方法。

2. 发明申请

US20050101871A1 Microscopic imaging apparatus and method 有权
标题翻译：显微成像设备及方法
公开(公告)号：US20050101871A1
公开(公告)日：2005-05-12
申请号：US11013099
申请日：2004-12-15
申请人： James Zavislan , Jay Eastman
发明人： James Zavislan , Jay Eastman
IPC分类号： A61B5/00 , A61B5/103 , A61B6/00
CPC分类号： A61B5/444 , A61B5/0059 , A61B5/0064 , A61B5/0068 , A61B2562/146
摘要： A handheld confocal imaging system for in vivo observation of dermal and subdermal tissue allows diagnosis of conditions substantially beneath the surface of the skin. A confocal head has optics which scan the tissue so as to provide images of vertical sections of the tissue. Both two and three dimensional imaging may be provided for diagnosis and location of basal cell carcinomas and melanomas, and so as to enable visualization of tumor borders prior to excision.
摘要翻译：用于体内观察皮肤和皮下组织的手持共聚焦成像系统允许诊断基本上在皮肤表面下方的状况。共焦头具有扫描组织以便提供组织的垂直部分的图像的光学元件。可以提供二维和三维成像用于诊断和定位基底细胞癌和黑素瘤，并且可以在切除前使肿瘤边界可视化。

3. 发明申请

US20070206275A1 System for macroscopic and confocal imaging of tissue 有权
标题翻译：用于组织的宏观和共焦成像的系统
公开(公告)号：US20070206275A1
公开(公告)日：2007-09-06
申请号：US11357234
申请日：2006-02-17
申请人： Paul Hemmer , Zachary Eastman , Jay Eastman , William Fox , James Zavislan
发明人： Paul Hemmer , Zachary Eastman , Jay Eastman , William Fox , James Zavislan
IPC分类号： G02B21/06
CPC分类号： G02B21/0012 , G02B21/0024 , G02B21/365
摘要： A system for macroscopic and confocal imaging of tissue having a macroscopic imager for capturing a macroscopic image of the tissue's surface, a confocal imager for capturing one or more optically formed sectional microscopic images on or within tissue, a computer for receiving images from such imagers, and a tissue attachment device in which the macroscopic imager and confocal imager are each individually presented to the tissue utilizing the tissue attachment device in a predefined alignment, such that imaging locations of the confocal imager with respect to the tissue surface spatially correlate with macroscopic image. A user interface is operable on the computer to enable display of the macroscopic image on a display coupled to the computer, and to indicate a region within the macroscopic image associated with the field of view of the tissue imagable by the confocal imager. The user interface enables graphical tracking and targeting of imaging locations of the confocal imager in macroscopic image, and marking on the macroscopic image of the locations of confocal images with respect to the tissue surface.
摘要翻译：一种具有用于捕获组织表面的宏观图像的宏观成像器的组织的宏观和共焦成像系统，用于捕获组织上或组织内的一个或多个光学形成的截面微观图像的共焦成像器，用于从这样的成像器接收图像的计算机，以及组织附着装置，其中宏观成像器和共聚焦成像器各自以预定对准单独地呈现给组织，使得共焦成像器相对于组织表面的成像位置在空间上与宏观图像相关。用户界面在计算机上可操作以使得能够在耦合到计算机的显示器上显示宏观图像，并且指示与由共焦成像器可成像的组织的视场相关联的宏观图像内的区域。用户界面能够在宏观图像中进行图像跟踪和共焦成像器的成像位置的瞄准，并且在相对于组织表面的共聚焦图像的位置的宏观图像上进行标记。

4. 发明申请

US20080067331A1 METHOD AND APPARATUS FOR DETECTING EMBEDDED MATERIAL WITHIN AN INTERACTION REGION OF A STRUCTURE 失效
标题翻译：用于检测结构相互作用区域中的嵌入材料的方法和装置
公开(公告)号：US20080067331A1
公开(公告)日：2008-03-20
申请号：US11861184
申请日：2007-09-25
申请人： Paul Denney , Jay Eastman , Ta-Chieh Huang
发明人： Paul Denney , Jay Eastman , Ta-Chieh Huang
IPC分类号： G01J5/08
CPC分类号： B23K26/032 , B23K26/03 , B23K26/034 , B23K26/043 , B23K26/12 , B23K26/123 , B23K26/128 , B23K26/142 , B23K26/16 , G01J3/02 , G01J3/0218 , G01J3/0291 , G01J3/28
摘要： A system and method processes a structure comprising embedded material. The system includes a laser adapted to generate light and to irradiate an interaction region of the structure. The system further includes an optical system adapted to receive light from the interaction region and to generate a detection signal indicative of the presence of embedded material in the interaction region. The system further includes a controller operatively coupled to the laser and the optical system. The controller is adapted to receive the detection signal and to be responsive to the detection signal by selectively adjusting the laser.
摘要翻译：系统和方法处理包括嵌入材料的结构。该系统包括适于产生光并照射结构的相互作用区域的激光器。该系统还包括适于接收来自相互作用区域的光并且产生指示在相互作用区域中存在嵌入材料的检测信号的光学系统。该系统还包括可操作地耦合到激光器和光学系统的控制器。控制器适于接收检测信号，并通过选择性调节激光来响应检测信号。

5. 发明申请

US20060144834A1 Containment plenum for laser irradiation and removal of material from a surface of a structure 审中-公开
标题翻译：用于激光照射和从结构表面去除材料的容纳气室
公开(公告)号：US20060144834A1
公开(公告)日：2006-07-06
申请号：US11363805
申请日：2006-02-28
申请人： Paul Denney , Jay Eastman , Paul Fallara , Andrew Joseph , John Phillips
发明人： Paul Denney , Jay Eastman , Paul Fallara , Andrew Joseph , John Phillips
IPC分类号： B23K26/14 , B23K26/08
CPC分类号： B23K26/032 , B23K26/035 , B23K26/042 , B23K26/12 , B23K26/123 , B23K26/127 , B23K26/128 , B23K26/16 , B23K26/206
摘要： A containment plenum is adapted to deliver laser light to an interaction region of a structure to remove material from the structure. The containment plenum includes a window substantially transparent to the laser light. The window transmits laser light towards the interaction region and provides a barrier to transport of particulate matter generated by interaction of the laser light and the structure. The containment plenum further includes a nozzle fluidly coupled to a source of compressed gas. The laser light and the compressed gas are transmitted through the nozzle towards the interaction region of the structure. The nozzle is either gas-cooled or liquid-cooled. The containment plenum further includes a resilient interface that resiliently contacts the structure and substantially surrounds the interaction region, thereby confining the material and removing the material from the interaction region.
摘要翻译：容纳气室适于将激光传送到结构的相互作用区域以从结构中去除材料。容纳气室包括对激光大致透明的窗口。该窗口将激光发射到相互作用区域，并且提供了通过激光和结构的相互作用产生的颗粒物质的输送的屏障。容纳气室还包括流体耦合到压缩气体源的喷嘴。激光和压缩气体通过喷嘴传递到结构的相互作用区域。喷嘴是气冷式或液冷式。容纳气室还包括弹性接触，弹性接触结构并且基本上围绕相互作用区域，从而限制材料并从相互作用区域移除材料。

6. 发明授权

US5019698A Bar code reading systems having electrical power conservation and laser radiation power limiting means 失效
标题翻译：具有电功率节省和激光辐射功率限制装置的条形码读取系统
公开(公告)号：US5019698A
公开(公告)日：1991-05-28
申请号：US390020
申请日：1989-08-07
申请人： Jay Eastman
发明人： Jay Eastman
IPC分类号： G06K7/10
CPC分类号： G06K7/10841 , G06K7/10851 , G06K2207/1018
摘要： Bar code readers using laser diodes conserve electrical power and limit output laser radiation to levels required by governmental regulation (1 milliwatt average power) by utilizing a laser diode having a output optical power vs laser current characteristic which has a slope efficiency (the ratio of the change in power to the change in current, .DELTA.P/.DELTA.I, which is less than 1 in the region where stimulated (laser) emission occurs. The laser is operated with current pulses having a duty cycle less than 100%, and preferably in the range from 50% to 20% in the stimulated emission region of its characteristic, such that the average output laser power does not exceed the level required by government regulations (1 mw) while the laser output during the pulses is greater than 1 mw. Upon detection after reflection or scattering (return of light) from the bar code, the optical signal is photodetected to provide an electrical signal which is envelope detected and components of the signal at the repetition rate of the current pulses are removed, as by filtering. The filtered signal is digitized to provide a digital signal from which the bar code may be decoded.
摘要翻译：使用激光二极管的条形码读取器通过利用具有输出光功率与激光电流特性的激光二极管来节省电力并将输出激光辐射限制在政府调节所需的水平（1毫瓦平均功率）上，该激光二极管具有斜率效率在激发（激光）发射的区域中，电流变化的功率变化DELTA P / DELTA I小于1，激光器的工作周期小于100％的电流脉冲，最好在其特征的受激发射区域的范围从50％到20％，使得平均输出激光功率不超过政府规定要求的水平（1mw），而脉冲期间的激光输出大于1mw。在从条形码反射或散射（返回光）之后检测到，光信号被光电检测，以提供被包络检测的电信号和信号的分量以当前脉冲的重复率被除去，如通过滤波。经滤波的信号被数字化以提供可以从其解码条形码的数字信号。

7. 发明申请

US20060278620A1 Method and apparatus for material processing 失效
标题翻译：材料加工方法和装置
公开(公告)号：US20060278620A1
公开(公告)日：2006-12-14
申请号：US11401114
申请日：2006-04-10
申请人： Paul Denney , Jay Eastman , Paul Fallara , Andrew Joseph , John Phillips , Ta-Chieh Huang , Michael Patena , Tim Burnham , Paul Coleman
发明人： Paul Denney , Jay Eastman , Paul Fallara , Andrew Joseph , John Phillips , Ta-Chieh Huang , Michael Patena , Tim Burnham , Paul Coleman
IPC分类号： B23K26/08 , B23K26/14
CPC分类号： B23K26/0884 , B23K26/032 , B23K26/12 , B23K26/123 , B23K26/128 , B23K26/1464
摘要： An apparatus processes a surface of an inhabitable structure. The apparatus includes a base unit adapted to provide energy waves to an interaction region, the energy waves removing material from the structure. The base unit includes an energy wave generator and a head coupled to the energy wave generator. The head is adapted to remove the material from the interaction region, thereby providing reduced disruption to activities within the structure. The apparatus further includes a manipulation system which includes an anchoring mechanism adapted to be releasably coupled to the structure and a positioning mechanism coupled to the anchoring mechanism and coupled to the head. The manipulation system is adapted to controllably adjust the position of the head relative to the structure. The apparatus further includes a controller electrically coupled to the base unit. The controller is adapted to transmit control signals to the base unit in response to user input.
摘要翻译：一种装置处理可居住结构的表面。该装置包括适于向相互作用区域提供能量波的基本单元，该能量波从该结构移除材料。基本单元包括能量波发生器和耦合到能量波发生器的头部。头适于从相互作用区域移除材料，从而减少对结构内的活动的破坏。该装置还包括操纵系统，该操纵系统包括适于可释放地联接到该结构的锚固机构，以及联接到该锚定机构并联接到头部的定位机构。操纵系统适于可控地调节头部相对于结构的位置。该装置还包括电耦合到基座单元的控制器。控制器适于响应于用户输入将控制信号发送到基本单元。

8. 发明申请

US20060196861A1 Manipulation apparatus for system that removes material from a surface of a structure 失效
标题翻译：用于从结构表面去除材料的系统的操纵装置
公开(公告)号：US20060196861A1
公开(公告)日：2006-09-07
申请号：US11401116
申请日：2006-04-10
申请人： Paul Denney , Jay Eastman , Paul Fallara , Andrew Joseph , John Phillips , Michael Patena , Tim Burnham , Paul Coleman
发明人： Paul Denney , Jay Eastman , Paul Fallara , Andrew Joseph , John Phillips , Michael Patena , Tim Burnham , Paul Coleman
IPC分类号： B23K26/08
CPC分类号： B23K26/032 , B23K26/10 , B23K26/12 , B23K26/123 , B23K26/128 , B23K26/16
摘要： A manipulation system controllably moves a head relative to a surface of an inhabitable structure for irradiating the surface with energy waves from the head. The manipulation system includes a positioning mechanism coupled to the head. The positioning mechanism includes a first-axis position system adapted to move the head along a first direction substantially parallel to the surface. The positioning mechanism further includes a second-axis position system coupled to the first-axis position system and adapted to move the head along a second direction substantially parallel to the surface. The manipulation system further includes an anchoring mechanism coupled to the positioning mechanism and releasably coupled to the structure.
摘要翻译：操纵系统可控制地相对于可居住结构的表面移动头部，以用头部的能量波照射表面。该操纵系统包括一个联接到头部的定位机构。定位机构包括适于沿着基本平行于表面的第一方向移动头部的第一轴位置系统。定位机构还包括耦合到第一轴位置系统并适于沿着基本上平行于表面的第二方向移动头部的第二轴位置系统。操纵系统还包括联接到定位机构并且可释放地联接到结构的锚定机构。

9. 发明申请

US20060106304A1 System and method for enhancing microscope images of tissue using citric acid and agents of the like 有权
公开(公告)号：US20060106304A1
公开(公告)日：2006-05-18
申请号：US11297599
申请日：2005-12-08
申请人： Jay Eastman
发明人： Jay Eastman
IPC分类号： A61B6/00
CPC分类号： A61K49/00 , A61B5/0059 , A61B5/0066
摘要： A system and method for enhancing images of ex-vivo or in-vivo tissue produced by confocal microscopy, optical coherence tomography, two-photon microscopy, or ultrasound, is provided by applying to the tissue a solution or gel having an effective concentration of citric or other alpha-hydroxy acid which enhances tissue structures, such as cellular nuclei, in such images. Such concentration may be 3-20% acid, and preferably 5% acid.

10. 发明申请

US20070189347A1 Method and apparatus for material processing 失效
标题翻译：材料加工方法和装置
公开(公告)号：US20070189347A1
公开(公告)日：2007-08-16
申请号：US11653081
申请日：2007-01-12
申请人： Paul Denney , Jay Eastman , Paul Fallara , Andrew Joseph , John Phillips , Ta-Chieh Huang , Michael Patena , Tim Burnham , Paul Coleman
发明人： Paul Denney , Jay Eastman , Paul Fallara , Andrew Joseph , John Phillips , Ta-Chieh Huang , Michael Patena , Tim Burnham , Paul Coleman
IPC分类号： H01S3/00
CPC分类号： B23K26/0884 , B23K26/032 , B23K26/12 , B23K26/123 , B23K26/128 , B23K26/1464
摘要： An apparatus processes a surface of an inhabitable structure. The apparatus includes a laser base unit adapted to provide laser light to an interaction region, the laser light removing material from the structure. The laser base unit includes a laser generator and a laser head coupled to the laser generator. The laser head is adapted to remove the material from the interaction region, thereby providing reduced disruption to activities within the structure. The apparatus further includes an anchoring mechanism adapted to be releasably coupled to the structure and releasably coupled to the laser head. The apparatus further includes a controller electrically coupled to the laser base unit. The controller is adapted to transmit control signals to the laser base unit in response to user input.
摘要翻译：一种装置处理可居住结构的表面。该装置包括适于向相互作用区域提供激光的激光基座单元，该结构的激光去除材料。激光基座单元包括激光发生器和耦合到激光发生器的激光头。激光头适于从相互作用区域去除材料，从而减少对结构内活动的破坏。该装置还包括适于可释放地联接到结构并且可释放地联接到激光头的锚定机构。该装置还包括电耦合到激光基座单元的控制器。控制器适于响应于用户输入将控制信号发送到激光基座单元。

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