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1. 发明申请

US20080317830A1 Compositions and Methods for the Treatment of Wounds and Scar Tissue 审中-公开
标题翻译：伤口和疤痕组织治疗的组成和方法
公开(公告)号：US20080317830A1
公开(公告)日：2008-12-25
申请号：US11768053
申请日：2007-06-25
申请人： Jay A. Goldstein , Bernard Grubstein , Michael Rothman , Whe-Yong Lo , Patrea L. Pabst
发明人： Jay A. Goldstein , Bernard Grubstein , Michael Rothman , Whe-Yong Lo , Patrea L. Pabst
IPC分类号： A61K33/24 , A61K33/08 , A61K33/30 , A61L15/18 , A61K33/12
CPC分类号： A61K33/08 , A61K33/06 , A61K33/24 , A61K33/30 , A61L15/18 , A61L26/0004
摘要： Compositions for the treatment of wounds and/or scars are described herein. The compositions contain between 1 and up to 30% by weight, more preferably between 1 and 20%, most preferably between about 5 and 10% by weight particles, such as titanium dioxide or a similar material in a pharmaceutically acceptable base or carrier, such as petrolatum. The compositions are less greasy than petrolatum alone, and thus are more aesthetically pleasing. The compositions exhibit occlusive properties comparable to petrolatum. The compositions are absorbed into the skin, unlike petrolatum, and exhibit significant wound healing characteristics not observed with petrolatum alone. In one embodiment, the pharmaceutically acceptable base is petrolatum and the particles are titanium dioxide. The compositions can be used to treat complex, hard to heal wounds, such as diabetic ulcers; pressure sores, such as bed sores; lacerations; bite wounds; burns; penetrating wounds; surgical wounds, etc. The composition can also be used to promote normal healing of scar tissue. The compositions can also be used for the topical delivery of one or more active agent. The compositions can be used to reduce fine lines and wrinkles, and to rehydrate skin or to treat dry skin.
摘要翻译：本文描述了用于治疗伤口和/或伤痕的组合物。组合物含有1至高达30重量％，更优选1至20重量％，最优选约5至10重量％的颗粒，例如二氧化钛或药学上可接受的碱或载体中的相似材料，例如作为凡士林。组合物比单独的凡士林油脂少，因此更美观。该组合物表现出与凡士林相当的闭塞性质。组合物被吸收到皮肤中，与凡士林不同，并且表现出明显的伤口愈合特征，单独用凡士林观察不到。在一个实施方案中，药学上可接受的碱是凡士林，并且颗粒是二氧化钛。组合物可用于治疗复杂的难愈合伤口，例如糖尿病性溃疡; 压疮，如褥疮; 撕裂咬伤烧伤穿透伤口; 手术伤口等。组合物也可用于促进瘢痕组织的正常愈合。组合物也可用于局部递送一种或多种活性剂。该组合物可用于减少细纹和皱纹，并使皮肤脱水或治疗干性皮肤。

2. 发明授权

US08232304B2 Antifungal formulations 有权
标题翻译：抗真菌配方
公开(公告)号：US08232304B2
公开(公告)日：2012-07-31
申请号：US10691928
申请日：2003-10-23
申请人： Jay A. Goldstein , Michael Rothman , Whe-Yong Lo
发明人： Jay A. Goldstein , Michael Rothman , Whe-Yong Lo
IPC分类号： A61K31/415 , A61K31/58 , A61K31/56 , A61K9/06 , A61K9/08 , A61K9/12 , A61K9/14
CPC分类号： A61Q17/005 , A61K8/63 , A61K9/0014 , A61K31/00 , A61K31/4174 , A61K31/57 , A61K45/06 , A61K47/02 , A61K47/06 , A61K47/10 , A61K47/14 , A61K47/26 , A61K47/44 , A61Q19/00 , A61K2300/00
摘要： A topical composition and the method using the composition, which contains an antifungal agent and a low potency anti-inflammatory steroid which is safe and effective such as desonide or its derivative. The low potency steroid agent does not cause side effects such as skin atrophy, striae and hypopigmentation. In a representative example, the low potency anti-inflammatory steroid has the following structure: wherein R1, R2, R3, and R4 taken independently can be H, C1-C10 alkyl, C1-C10 alkenyl, C3-C10 cycloalkyl, and phenyl groups; R1 and R2 taken together can be C3-C10 cycloalkyl; and R3, and R4 taken independently can be H, C1-C10 alkyl, C1-C10 alkenyl, C3-C10 cycloalkyl, phenyl, C7-C10 phenylalkyl, carboxylate, sulfonyl, phosphoryl, and phosphonyl groups. The composition can be formulated in a dosage form such as a cream, ointment, gel, lotion, foam, powder, aerosol, spray, shampoo, or liquid solution. The composition can be used to treat a fungal disease such as tinea pedis, tinea capitis, tinea corporis, tinea versicolor, tinea cruris, and candidiasis as well as intertriginous dermatitis complicated by candidiasis.
摘要翻译：一种外用组合物和使用该组合物的方法，其含有抗真菌剂和安全有效的低效抗炎类固醇，例如去氧化物或其衍生物。低效甾类药物不会引起副作用，如皮肤萎缩，皮肤色素沉着和色素沉着不足。在代表性的例子中，低效抗炎类固醇具有以下结构：其中独立地取代的R 1，R 2，R 3和R 4可以是H，C 1 -C 10烷基，C 1 -C 10烯基，C 3 -C 10环烷基和苯基 ; R 1和R 2一起可以是C 3 -C 10环烷基; R 3和R 4独立地可以是H，C 1 -C 10烷基，C 1 -C 10烯基，C 3 -C 10环烷基，苯基，C 7 -C 10苯基烷基，羧酸酯，磺酰基，磷酰基和膦酰基。组合物可以配制成剂型，例如霜剂，软膏剂，凝胶剂，洗剂，泡沫剂，粉剂，气雾剂，喷雾剂，洗发剂或液体溶液。该组合物可用于治疗真菌性疾病，例如足癣，头癣，体癣，花斑斑，斑癣和念珠菌病以及由念珠菌病复杂的间质性皮炎。

3. 发明申请

US20120165302A1 ANTIFUNGAL FORMULATIONS 审中-公开
标题翻译：反制公式
公开(公告)号：US20120165302A1
公开(公告)日：2012-06-28
申请号：US13349929
申请日：2012-01-13
申请人： Jay A. Goldstein , Michael Rothman , Whe-Yong Lo
发明人： Jay A. Goldstein , Michael Rothman , Whe-Yong Lo
IPC分类号： A61K31/56 , A61P29/00 , A61P31/10 , A61K31/58 , A61K31/573
CPC分类号： A61Q17/005 , A61K8/63 , A61K9/0014 , A61K31/00 , A61K31/4174 , A61K31/57 , A61K45/06 , A61K47/02 , A61K47/06 , A61K47/10 , A61K47/14 , A61K47/26 , A61K47/44 , A61Q19/00 , A61K2300/00
摘要： A topical composition and the method using the composition, which contains an antifungal agent and a low potency anti-inflammatory steroid which is safe and effective such as desonide or its derivative. The low potency steroid agent does not cause side effects such as skin atrophy, striae and hypopigmentation. The composition can be formulated in a dosage form such as a cream, ointment, gel, lotion, foam, powder, aerosol, spray, shampoo, or liquid solution. The composition can be used to treat a fungal disease such as tinea pedis, tinea capitis, tinea corporis, tinea versicolor, tinea cruris, and candidiasis as well as intertriginous dermatitis complicated by candidiasis.
摘要翻译：一种外用组合物和使用该组合物的方法，其含有抗真菌剂和安全有效的低效抗炎类固醇，例如去氧化物或其衍生物。低效甾类药物不会引起副作用，如皮肤萎缩，皮肤色素沉着和色素沉着不足。组合物可以配制成剂型，例如霜剂，软膏剂，凝胶剂，洗剂，泡沫剂，粉剂，气雾剂，喷雾剂，洗发剂或液体溶液。该组合物可用于治疗真菌性疾病，例如足癣，头癣，体癣，花斑斑，斑癣和念珠菌病以及由念珠菌病复杂的间质性皮炎。

4. 发明授权

US4981145A Method and apparatus for determining sebum production for selection of cosmetics of complementary formulation 失效
标题翻译：用于确定补体制剂化妆品选择皮脂产生的方法和装置
公开(公告)号：US4981145A
公开(公告)日：1991-01-01
申请号：US426115
申请日：1989-10-24
申请人： Jay A. Goldstein
发明人： Jay A. Goldstein
IPC分类号： A61B5/103 , A61B10/00
CPC分类号： A61B5/441 , A61B10/0064
摘要： A sampling device and method for collection of sebum secreted by a person for determination of the person's skin oil characteristics includes a sampling element having a backing member of liquid impervious material. An absorbent material is disposed upon the backing member for absorbing sebum secreted by a person's skin, the absorbent material defining an absorption surface. A device is provided for disposing the absorption surface in contact with a region of the person's skin during the predetermined sampling period. The element is sealed within a liquid impervious pouch formed at least in part of the backing member during transport of the collected sebum to a site for measurement. A method for collection of sebum for selection of facial cosmetics of complementary formula is also described, including the step of providing a line of facial cosmetics formulated with oil and the like present at stepped levels preselected to complement a range of sebum production.
摘要翻译：用于收集由人分泌的用于确定人的皮肤油特性的皮脂的采样装置和方法包括具有不透液体材料的背衬构件的取样元件。吸收材料设置在背衬构件上，用于吸收由人的皮肤分泌的皮脂，吸收材料限定吸收表面。提供了一种装置，用于在预定的采样周期内将吸收表面布置成与人的皮肤区域接触。在将收集的皮脂运送到测量部位期间，该元件被密封在至少部分背衬部件中形成的不透液体的小袋中。还描述了用于选择补充配方的面部化妆品的皮脂的收集方法，包括提供以预先选定以补充一定范围的皮脂产生的阶梯级别呈现的以油等形式配制的面部化妆品系列的步骤。

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