专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20060286121A1 Adenoviral vector-based vaccines 审中-公开
标题翻译：基于腺病毒载体的疫苗
公开(公告)号：US20060286121A1
公开(公告)日：2006-12-21
申请号：US11337866
申请日：2006-01-23
申请人： Jason Gall , Thomas Wickham , William Enright , Douglas Brough , Mohammed Zuber , C. King , Gary Nabel , Cheng Cheng
发明人： Jason Gall , Thomas Wickham , William Enright , Douglas Brough , Mohammed Zuber , C. King , Gary Nabel , Cheng Cheng
IPC分类号： A61K39/12 , A61K39/395
CPC分类号： C12N15/86 , A61K48/00 , A61K2039/5256 , C07K2319/00 , C12N2710/10343 , C12N2710/10345
摘要： The invention provides a method of inducing an immune response in a mammal. The method comprises administering to the mammal a non-subgroup C adenoviral vector comprising an adenoviral fiber protein having an amino acid sequence comprising about 80% or more identity to an amino acid sequence encoding a subgroup C adenoviral fiber protein. The adenoviral vector further comprises a nucleic acid sequence encoding an antigen which is expressed in the mammal to induce an immune response. The invention further comprises a method of producing an adenoviral vector, and a composition comprising a serotype 41 or a serotype 35 adenoviral vector and a carrier. The invention also provides an adenoviral vector comprising a nucleic acid sequence encoding an adenoviral pIX protein operably linked to a heterologous expression control sequence, as well as a method of enhancing the stability and/or packaging capacity of an adenoviral vector.
摘要翻译：本发明提供在哺乳动物中诱导免疫应答的方法。该方法包括向哺乳动物施用非亚组C腺病毒载体，其包含具有与编码亚组C腺病毒纤维蛋白的氨基酸序列具有约80％或更高同一性的氨基酸序列的腺病毒纤维蛋白。腺病毒载体还包含编码在哺乳动物中表达以诱导免疫应答的抗原的核酸序列。本发明还包括产生腺病毒载体的方法和包含血清型41或血清型35腺病毒载体和载体的组合物。本发明还提供了一种腺病毒载体，其包含编码与异源表达控制序列可操作地连接的腺病毒pIX蛋白的核酸序列，以及增强腺病毒载体的稳定性和/或包装能力的方法。

2. 发明申请

US20080069836A1 METHOD OF USING ADENOVIRAL VECTORS WITH INCREASED IMMUNOGENICITY IN VIVO 审中-公开
标题翻译：使用腺病毒载体在体内具有增加的免疫原性的方法
公开(公告)号：US20080069836A1
公开(公告)日：2008-03-20
申请号：US11678947
申请日：2007-02-26
申请人： Gary Nabel , Cheng Cheng , Jason Gall , Thomas Wickham
发明人： Gary Nabel , Cheng Cheng , Jason Gall , Thomas Wickham
IPC分类号： A61K39/00 , A61P37/04 , C12N15/63
CPC分类号： C12N15/86 , A61K39/00 , C12N2710/10343 , Y02A50/412
摘要： The invention provides a method of inducing an immune response in a mammal. The method comprises administering to the mammal an adenoviral vector comprising (a) a subgroup C fiber protein wherein a native coxsackievirus and adenovirus receptor (CAR)-binding site is disrupted, (b) a subgroup C penton base protein wherein a native integrin-binding site is disrupted, and (c) a nucleic acid sequence encoding at least one antigen derived from an infectious agent other than an adenovirus which is expressed in the mammal to induce an immune response.
摘要翻译：本发明提供在哺乳动物中诱导免疫应答的方法。该方法包括向哺乳动物施用腺病毒载体，其包含（a）亚组C纤维蛋白，其中天然柯萨奇病毒和腺病毒受体（CAR）结合位点被破坏，（b）亚基C戊聚糖碱基蛋白，其中天然整联蛋白结合位点被破坏，和（c）编码至少一种来源于哺乳动物中表达的腺病毒以外的感染因子的抗原以诱导免疫应答的核酸序列。

3. 发明申请

US20080003236A1 ADENOVIRUS FIBER SHAFT COMPOSITION AND METHODS OF USE 审中-公开
标题翻译： ADENOVIRUS纤维轴组合物及其使用方法
公开(公告)号：US20080003236A1
公开(公告)日：2008-01-03
申请号：US11734851
申请日：2007-04-13
申请人： C. King , Jason Gall , Gary Nabel , Cheng Cheng
发明人： C. King , Jason Gall , Gary Nabel , Cheng Cheng
IPC分类号： A61K38/00 , A61K39/00 , A61K39/385 , A61P43/00 , C12N15/00 , C12P21/06
CPC分类号： A61K38/162 , A61K38/164 , C12N15/86 , C12N2710/10322 , C12N2710/10343 , C12N2750/14143 , Y02A50/386 , Y02A50/412
摘要： The invention provides a gene transfer vector and a conjugate comprising at least three contiguous amino acids of a shaft region of a subgroup C adenovirus fiber protein. The invention also provides methods of using the gene transfer vector and the conjugate to induce an immune response in a mammal, and to deliver a protein or a non-proteinaceous molecule to a specific cell type.
摘要翻译：本发明提供了一种基因转移载体和包含亚组C腺病毒纤维蛋白的轴区域的至少三个相邻氨基酸的缀合物。本发明还提供了使用基因转移载体和缀合物在哺乳动物中诱导免疫应答并将蛋白质或非蛋白质分子递送至特定细胞类型的方法。

4. 发明申请

US20070207166A1 Method of Using Adenoviral Vectors to Induce an Immune Response 审中-公开
标题翻译：使用腺病毒载体诱导免疫反应的方法
公开(公告)号：US20070207166A1
公开(公告)日：2007-09-06
申请号：US11578096
申请日：2005-04-12
申请人： Gary Nabel , Cheng Cheng , Wing-Pui Kong , Jason Gall , C. Richter King
发明人： Gary Nabel , Cheng Cheng , Wing-Pui Kong , Jason Gall , C. Richter King
IPC分类号： A61K39/12 , C12N15/861
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K2039/5256 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/57 , C12N7/00 , C12N15/86 , C12N2710/10343 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2740/16234
摘要： The invention provides a method of inducing an immune response against a human immunodeficiency virus (HIV) in a mammal. The method comprises administering to the mammal an adenoviral vector composition comprising one or more adenoviral vectors encoding two or more different HIV antigens, the production of which induces an immune response against HIV in the mammal. The invention also provides an adenoviral vector composition comprising four adenoviral vectors encoding an HIV clade A Env protein, an HIV clade B Env protein, an HIV clade C Env protein, and a fusion protein comprising an HIV clade B Gag protein and Pol protein, respectively.
摘要翻译：本发明提供一种在哺乳动物中诱导针对人类免疫缺陷病毒（HIV）的免疫应答的方法。该方法包括向哺乳动物施用腺病毒载体组合物，其包含编码两种或更多种不同HIV抗原的一种或多种腺病毒载体，其产生在哺乳动物中诱导针对HIV的免疫应答。本发明还提供一种腺病毒载体组合物，其包含分别编码HIV进化枝A Env蛋白，HIV进化枝B Env蛋白，HIV进化枝C Env蛋白和包含HIV进化枝B Gag蛋白和Pol蛋白的融合蛋白的四种腺病毒载体。

5. 发明授权

US09526777B2 Methods for the induction of ebola virus-specific immune responses comprising administering a replication-defective chimpanzee adenovirus vector expressing the ebola virus glycoprotein 有权
标题翻译：用于诱导埃博拉病毒特异性免疫应答的方法，包括给予表达埃博拉病毒糖蛋白的复制缺陷型黑猩猩腺病毒载体
公开(公告)号：US09526777B2
公开(公告)日：2016-12-27
申请号：US13641655
申请日：2011-04-15
申请人： Nancy J. Sullivan , Gary J. Nabel , Clement Asiedu , Cheng Cheng , Alfredo Nicosia , Riccardo Cortese , Virginia Ammendola , Stefano Colloca
发明人： Nancy J. Sullivan , Gary J. Nabel , Clement Asiedu , Cheng Cheng , Alfredo Nicosia , Riccardo Cortese , Virginia Ammendola , Stefano Colloca
IPC分类号： A61K39/295 , A61K39/12 , A61K39/00
CPC分类号： C12N15/86 , A61K39/12 , A61K2039/5254 , A61K2039/5256 , A61K2039/545 , C07K14/005 , C12N7/00 , C12N2710/10343 , C12N2760/14134
摘要： This invention provides vaccines for inducing an immune response and protection against filovirus infection for use as a preventative vaccine in humans. In particular, the invention provides chimpanzee adenoviral vectors expressing filovirus proteins from different strains of Ebola virus (EBOV) or Marburg virus (MARV).
摘要翻译：本发明提供用于诱导免疫应答的疫苗和针对用于人类预防性疫苗的禽流感病毒感染的保护。特别地，本发明提供了表达来自埃博拉病毒（EBOV）或马尔堡病毒（MARV）的不同菌株的病毒蛋白的黑猩猩腺病毒载体。

6. 发明申请

US20140017278A1 ADENOVIRUS SEROTYPE 26 AND SEROTYPE 35 FILOVIRUS VACCINES 有权
标题翻译： ADENOVIRUS SEROTYPE 26和SEROTYPE 35 FILOVIRUS VACCINES
公开(公告)号：US20140017278A1
公开(公告)日：2014-01-16
申请号：US13994532
申请日：2011-12-14
申请人： Nancy J. Sullivan , Gary J. Nabel , Clement Asiedu , Cheng Cheng , Maria Grazia Pau , Jaap Goudsmit
发明人： Nancy J. Sullivan , Gary J. Nabel , Clement Asiedu , Cheng Cheng , Maria Grazia Pau , Jaap Goudsmit
IPC分类号： C07K14/005
CPC分类号： C07K14/005 , A61K39/12 , A61K2039/5254 , A61K2039/5256 , A61K2039/70 , C12N2710/10034 , C12N2710/10043 , C12N2760/14034 , C12N2760/14134
摘要： Provided are recombinant adenovirus vectors (serotype 26 and serotype 35) encoding filovirus antigens. The adenovirus vectors can be used to induce protective immune responses against filovirus infection.
摘要翻译：提供了编码病毒抗原的重组腺病毒载体（血清型26和血清型35）。腺病毒载体可用于诱导针对病毒感染的保护性免疫应答。

7. 发明申请

US20090286860A1 Method of using adenoviral vectors to induce an immune response 审中-公开
标题翻译：使用腺病毒载体诱导免疫应答的方法
公开(公告)号：US20090286860A1
公开(公告)日：2009-11-19
申请号：US12477712
申请日：2009-06-03
申请人： Gary J. Nabel , Cheng Cheng , Wing-Pui Kong , Jason G. D. Gall , C. Richter King
发明人： Gary J. Nabel , Cheng Cheng , Wing-Pui Kong , Jason G. D. Gall , C. Richter King
IPC分类号： A61K31/711 , A61P37/02
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K2039/5256 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/57 , C12N7/00 , C12N15/86 , C12N2710/10343 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2740/16234
摘要： The invention provides a method of inducing an immune response against a human immunodeficiency virus (HIV) in a mammal. The method comprises administering to the mammal an adenoviral vector composition comprising one or more adenoviral vectors encoding two or more different HIV antigens, the production of which induces an immune response against HIV in the mammal. The invention also provides an adenoviral vector composition comprising four adenoviral vectors encoding an HIV clade A Env protein, an HIV clade B Env protein, an V clade C Env protein, and a fusion protein comprising an HIV clade B Gag protein and Pol protein, respectively.
摘要翻译：本发明提供一种在哺乳动物中诱导针对人类免疫缺陷病毒（HIV）的免疫应答的方法。该方法包括向哺乳动物施用腺病毒载体组合物，其包含编码两种或更多种不同HIV抗原的一种或多种腺病毒载体，其产生在哺乳动物中诱导针对HIV的免疫应答。本发明还提供一种腺病毒载体组合物，其包含分别编码HIV进化枝A Env蛋白，HIV进化枝B Env蛋白，V进化枝C Env蛋白和包含HIV进化枝B Gag蛋白和Pol蛋白的融合蛋白的四种腺病毒载体。

8. 发明申请

US20060106685A1 Generating system for automatically generating the bill of materials for electrical products 审中-公开
标题翻译：用于自动生成电气产品材料清单的发电系统
公开(公告)号：US20060106685A1
公开(公告)日：2006-05-18
申请号：US10988516
申请日：2004-11-16
申请人： Cheng Cheng , Hsu Lin , Hsin Lee , Feng Hus
发明人： Cheng Cheng , Hsu Lin , Hsin Lee , Feng Hus
IPC分类号： A01K5/02 , G06F17/50
CPC分类号： G06Q10/087 , G06Q10/0875
摘要： A generating system of automatically generating electrical type product bill of materials of the present invention comprises a stock number grouping database, a stock number ranking database, and a bill of materials automatically generating processing program. The stock number grouping database comprises at least one material group records comprising at least a product group with the same electrical specification and at least one stock number group component supplier/vendor code. The stock number ranking database comprises at least one stock number ranking record, each stock number ranking record corresponds to one of the stock number group records and is used to record an evaluating rate after evaluating with the stock number group records according to a ranking critical factor. The bill of materials automatically generating processing program is used to generate a bill of materials of the corresponding electrical circuit design according to the bill of materials outline of the input electrical circuit design diagram, stock number grouping database, stock number ranking database, and a material choosing critical factor.
摘要翻译：本发明的自动生成电型产品材料清单的生成系统包括库存编号分组数据库，库存编号排序数据库和自动产生处理程序的物料清单。库存编号分组数据库包括至少一个材料组记录，其至少包括具有相同电气规格的产品组和至少一个库存数量组成分供应商/供应商代码。库存数量数据库包括至少一个库存编号排列记录，每个库存数量排序记录对应于一个库存编号组记录，并且用于根据排序关键因素与库存编号组记录进行评估之后记录评估率。物料清单自动生成处理程序用于根据输入电路设计图，库存编号分组数据库，库存编号排序数据库和材料的材料清单生成相应电路设计的材料清单选择关键因素。

9. 发明授权

US08753622B2 Seneca valley virus based compositions and methods for treating disease 有权
标题翻译：基于Seneca谷病毒的组合物和治疗疾病的方法
公开(公告)号：US08753622B2
公开(公告)日：2014-06-17
申请号：US13209124
申请日：2011-08-12
申请人： Paul Hallenbeck , Seshidhar Reddy Police , Laura M. Hales , Carl Hay , Shanthi Ganesh , Ling Xu , Jingping Yang , Cheng Cheng
发明人： Paul Hallenbeck , Seshidhar Reddy Police , Laura M. Hales , Carl Hay , Shanthi Ganesh , Ling Xu , Jingping Yang , Cheng Cheng
IPC分类号： A61K35/76 , C12N7/00 , C07K14/005 , A61K39/00
CPC分类号： A61K35/768 , A61K39/00 , A61K2039/525 , C07K14/005 , C07K16/1009 , C12N7/00 , C12N2770/32021 , C12N2770/32022 , C12N2770/32032 , C12N2770/32033 , C12N2770/32061 , G01N33/5011 , G01N2333/085
摘要： The present invention relates to a novel RNA picornavirus that is called Seneca Valley virus (“SVV”). The invention provides isolated SVV nucleic acids and proteins encoded by these nucleic acids. Further, the invention provides antibodies that are raised against the SVV proteins. Because SVV has the ability to selectively kill some types of tumors, the invention provides methods of using SVV and SVV polypeptides to treat cancer. Because SVV specifically targets certain tumors, the invention provides methods of using SVV nucleic acids and proteins to detect cancer. Additionally, due to the information provided by the tumor-specific mechanisms of SVV, the invention provides methods of making new oncolytic virus derivatives and of altering viruses to have tumor-specific tropisms.
摘要翻译：本发明涉及一种称为塞尼卡谷病毒（“SVV”）的新型小RNA病毒RNA。本发明提供了由这些核酸编码的分离的SVV核酸和蛋白质。此外，本发明提供针对SVV蛋白产生的抗体。由于SVV具有选择性地杀死一些类型的肿瘤的能力，本发明提供了使用SVV和SVV多肽治疗癌症的方法。由于SVV特异性靶向某些肿瘤，本发明提供了使用SVV核酸和蛋白质来检测癌症的方法。另外，由于SVV的肿瘤特异性机制提供的信息，本发明提供了制备新的溶瘤病毒衍生物和改变病毒以具有肿瘤特异性嗜性的方法。

10. 发明授权

US08039606B2 Seneca Valley virus based compositions and methods for treating disease 失效
标题翻译：基于Seneca谷病毒的组合物和治疗疾病的方法
公开(公告)号：US08039606B2
公开(公告)日：2011-10-18
申请号：US12576296
申请日：2009-10-09
申请人： Paul Hallenbeck , Seshidhar Reddy Police , Laura M. Hales , Carl Hay , Shanthi Ganesh , Ling Xu , Jingping Yang , Cheng Cheng
发明人： Paul Hallenbeck , Seshidhar Reddy Police , Laura M. Hales , Carl Hay , Shanthi Ganesh , Ling Xu , Jingping Yang , Cheng Cheng
IPC分类号： C12N15/11 , A61K35/00
CPC分类号： A61K35/768 , A61K39/00 , A61K2039/525 , C07K14/005 , C07K16/1009 , C12N7/00 , C12N2770/32021 , C12N2770/32022 , C12N2770/32032 , C12N2770/32033 , C12N2770/32061 , G01N33/5011 , G01N2333/085
摘要： The present invention relates to a novel RNA picornavirus that is called Seneca Valley virus (“SVV”). The invention provides isolated SVV nucleic acids and proteins encoded by these nucleic acids. Further, the invention provides antibodies that are raised against the SVV proteins. Because SVV has the ability to selectively kill some types of tumors, the invention provides methods of using SVV and SVV polypeptides to treat cancer. Because SVV specifically targets certain tumors, the invention provides methods of using SVV nucleic acids and proteins to detect cancer. Additionally, due to the information provided by the tumor-specific mechanisms of SVV, the invention provides methods of making new oncolytic virus derivatives and of altering viruses to have tumor-specific tropisms.
摘要翻译：本发明涉及一种称为塞尼卡谷病毒（“SVV”）的新型小RNA病毒RNA。本发明提供了由这些核酸编码的分离的SVV核酸和蛋白质。此外，本发明提供针对SVV蛋白产生的抗体。由于SVV具有选择性地杀死一些类型的肿瘤的能力，本发明提供了使用SVV和SVV多肽治疗癌症的方法。由于SVV特异性靶向某些肿瘤，本发明提供了使用SVV核酸和蛋白质来检测癌症的方法。另外，由于SVV的肿瘤特异性机制提供的信息，本发明提供了制备新的溶瘤病毒衍生物和改变病毒以具有肿瘤特异性嗜性的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式