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    • 2. 发明申请
    • Systems and Methods to Assess Clinical Status and Response to Drug Therapy and Exercise
    • 评估药物治疗和运动的临床状态和反应的系统和方法
    • US20140172442A1
    • 2014-06-19
    • US14045763
    • 2013-10-03
    • Jeff BroderickJames Kovach
    • Jeff BroderickJames Kovach
    • G06F19/00
    • G06F19/3481Y02A90/26
    • New methods and machine implemented systems measure patient health symptoms and clinical endpoints, communicate prescribed exercise programs to patients, coach or encourage patients to exert themselves within a predetermined protocol or beyond accustomed levels (in treatment of Parkinson's disease), or below accustomed levels (in treatment of cardiac rehabilitation), track patient compliance to exercise instructions, record and commutate data for physician review and for system optimization wherein databases of exercise programs may be modified to comport with measured patient success. Measurements of patient exercises and health changes are also used to provide refined diagnosis and status of disease. Individual exercise programs may be modified in response to physician input and/or patient progress. The continues loop feedback between a patient and the system optimizes the use of exercise as a treatment for disease.
    • 新的方法和机器实施的系统测量患者健康症状和临床终点,向患者传达规定的运动计划,教导或鼓励患者在预定方案内或超出习惯水平(治疗帕金森病)或低于习惯水平(在 治疗心脏康复),跟踪患者对锻炼指导的遵守情况,记录和整理医师审查和系统优化的数据,其中可以修改运动程序的数据库以与测量的患者成功相匹配。 患者运动和健康变化的测量也用于提供精确的诊断和疾病状态。 可以响应于医师输入和/或患者进展来修改个体运动程序。 患者和系统之间的持续回路反馈优化了运动的使用,作为疾病的治疗。
    • 3. 发明申请
    • Dilution system and method
    • 稀释系统和方法
    • US20070137314A1
    • 2007-06-21
    • US10545820
    • 2004-02-16
    • David WatsonLewis JonesJames Kovach
    • David WatsonLewis JonesJames Kovach
    • G01N1/38G01N35/02G01N15/10
    • G01N15/10G01N1/2035G01N1/38G01N35/085G01N2001/1012G01N2001/383G01N2015/025G01N2015/1087G01N2015/1409G01N2015/1493G01N2035/1032Y10T436/25625
    • A multi-stage dilution device, comprising a first stage dilution apparatus (A), and a second stage dilution apparatus (B), each of the stage dilution device comprising: (i) a housing (1) having a diluent inlet (7); (ii) a sample inlet (2) having a sample introducer within the housing (1) adapted to introduce the sample at an introducer point (4) within the housing (1); and, (iii) a mixing conduit (5) mounted at least partially within the housing (1), the mixing conduit (5) having an inlet section comprising a mouth (10), and a fluid outlet (8), and a throat section (9) capable of producing a pressure drop within the mixing conduit (5), the pressure drop being sufficient to draw sample through the sample inlet (2); the introducer point (4) of the sample inlet (2) being proximate the mixing conduit inlet; and wherein the fluid output (8) of the first stage dilution apparatus (A) is in communication with the sample inlet (2) of the second stage dilution apparatus (B). A method of diluting a sample is also disclosed.
    • 一种多级稀释装置,包括第一级稀释装置(A)和第二级稀释装置(B),每种级稀释装置包括:(i)具有稀释剂入口(7)的壳体(1) ; (ii)样品入口(2),其具有在所述壳体(1)内的样品引入器,适于将所述样品引入所述壳体(1)内的导引点(4); 以及(iii)至少部分地安装在所述壳体(1)内的混合管道(5),所述混合管道(5)具有包括口(10)和流体出口(8)的入口部分,以及喉部 能够在所述混合管道(5)内产生压降的部分(9),所述压降足以将样品通过所述样品入口(2); 样品入口(2)的导引点(4)靠近混合导管入口; 并且其中所述第一级稀释装置(A)的流体输出(8)与所述第二级稀释装置(B)的样品入口(2)连通。 还公开了稀释样品的方法。