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1. 发明授权

US08425418B2 Method of ultrasonic imaging and biopsy of the prostate 有权
标题翻译：前列腺超声成像和活检方法
公开(公告)号：US08425418B2
公开(公告)日：2013-04-23
申请号：US11740807
申请日：2007-04-26
申请人： Jasjit S. Suri , Ramkrishnan Narayanan
发明人： Jasjit S. Suri , Ramkrishnan Narayanan
IPC分类号： A61B8/08
CPC分类号： A61B8/0833
摘要： A system and method (i.e, utility) are disclosed for positioning a needle in three-dimensions based on patient related statistics for extracting tissue during biopsy procedures. Aspects of the utility can be applied independently or serve as an aid to the urologist when regions of interest are hard to discern in an ultrasound image. Regions of interest that correspond to high cancer risk regions (e.g., statistically) are automatically superimposed on an ultrasound image of a patient in real time. Additionally a statistical map based on one or more demographic parameters of a patient and containing cancer probability locations are also automatically mapped on the ultrasound image in real time displaying potential cancer locations. Aspects of the system are also capable of displaying optimal needle placement positions based on statistical priors and will be able to accurately navigate the needle to that position for biopsy extraction and/or treatment.
摘要翻译：公开了一种系统和方法（即效用），用于基于用于在活检程序期间提取组织的患者相关统计信息来三维定位针头。当超声波图像中难以辨别出感兴趣的区域时，可以独立地应用实用方面或作为泌尿科医师的辅助。对应于高癌症风险区域（例如，统计学）的感兴趣区域被实时地自动叠加在患者的超声图像上。此外，基于患者的一个或多个人口统计学参数并且包含癌症概率位置的统计图也被实时地自动映射在超声图像上，显示潜在的癌症位置。该系统的方面还能够基于统计学先验显示最佳的针位置，并且能够精确地将针导向该位置用于活组织检查提取和/或治疗。

2. 发明申请

US20080039723A1 SYSTEM AND METHOD FOR 3-D BIOPSY 有权
标题翻译： 3-D BIOPSY的系统和方法
公开(公告)号：US20080039723A1
公开(公告)日：2008-02-14
申请号：US11740807
申请日：2007-04-26
申请人： Jasjit S. Suri , Ramkrishnan Narayanan
发明人： Jasjit S. Suri , Ramkrishnan Narayanan
IPC分类号： A61B8/00
CPC分类号： A61B8/0833
摘要： A system and method (i.e, utility) are disclosed for positioning a needle in three-dimensions based on patient related statistics for extracting tissue during biopsy procedures. Aspects of the utility can be applied independently or serve as an aid to the urologist when regions of interest are hard to discern in an ultrasound image. Regions of interest that correspond to high cancer risk regions (e.g., statistically) are automatically superimposed on an ultrasound image of a patient in real time. Additionally a statistical map based on one or more demographic parameters of a patient and containing cancer probability locations are also automatically mapped on the ultrasound image in real time displaying potential cancer locations. Aspects of the system are also capable of displaying optimal needle placement positions based on statistical priors and will be able to accurately navigate the needle to that position for biopsy extraction and/or treatment.
摘要翻译：公开了一种系统和方法（即效用），用于基于用于在活检程序期间提取组织的患者相关统计信息来三维定位针头。当超声波图像中难以辨别出感兴趣的区域时，可以独立地应用实用方面或作为泌尿科医师的辅助。对应于高癌症风险区域（例如，统计学）的感兴趣区域被实时地自动叠加在患者的超声图像上。此外，基于患者的一个或多个人口统计学参数并且包含癌症概率位置的统计图也被实时地自动映射在超声图像上，显示潜在的癌症位置。该系统的方面还能够基于统计学先验显示最佳的针位置，并且能够精确地将针导向该位置用于活组织检查提取和/或治疗。

3. 发明申请

US20090326363A1 FUSED IMAGE MODALITIES GUIDANCE 审中-公开
标题翻译：融合图像模式指导
公开(公告)号：US20090326363A1
公开(公告)日：2009-12-31
申请号：US12434990
申请日：2009-05-04
申请人： Lu Li , Ramkrishnan Narayanan , Jasjit S. Suri
发明人： Lu Li , Ramkrishnan Narayanan , Jasjit S. Suri
IPC分类号： A61B5/055 , A61B8/00 , G06K9/00
CPC分类号： A61B8/4461 , A61B8/12 , A61B8/483 , A61B8/5238 , G06T7/12 , G06T7/174 , G06T7/33 , G06T2207/10088 , G06T2207/10136 , G06T2207/30081
摘要： An improved system and method (i.e. utility) for registration of medical images is provided. The utility registers a previously obtained volume onto an ultrasound volume during an ultrasound procedure to produce a multimodal image. The multimodal image may be used to guide a medical procedure, In one arrangement, the multimodal image includes MRI and/or MRSI information presented in the framework of a TRUS image during a TRUS procedure.
摘要翻译：提供了用于医学图像的注册的改进的系统和方法（即实用程序）。该实用程序在超声程序期间将先前获得的体积记录到超声波体积上以产生多峰图像。多模态图像可以用于指导医疗过程。在一种布置中，多模式图像包括在TRUS过程期间在TRUS图像的框架中呈现的MRI和/或MRSI信息。

4. 发明申请

US20090048515A1 BIOPSY PLANNING SYSTEM 审中-公开
标题翻译：生物计划系统
公开(公告)号：US20090048515A1
公开(公告)日：2009-02-19
申请号：US11838518
申请日：2007-08-14
申请人： Jasjit S. Suri , Dinesh Kumar , Yujun Guo , Ramkrishnan Narayanan
发明人： Jasjit S. Suri , Dinesh Kumar , Yujun Guo , Ramkrishnan Narayanan
IPC分类号： A61B10/02 , A61B8/13
CPC分类号： A61B8/12 , A61B10/02 , A61B2017/00274 , A61B2018/00547 , A61B2090/367
摘要： Guided biopsy is a commonly used method to remove suspicious tissues from an internal organ for pathological tests so that malignancy can be established. Provided herein are systems and methods (i.e., utilities) that allow for automated application of one or more predefined biopsy target plans to an acquired medical image including without limitation, an ultrasound prostate image. Due to different shapes and sizes of prostates as well as orientation of prostate with respect to an ultrasound probe during image, acquisition a simple prostate model (e.g., ellipse) with a fixed plan may not be sufficient. Accordingly, it has been determined that a deformable shape model with integrated biopsy target locations/sites may be fit to a prostate image to provide improved automated biopsy targeting.
摘要翻译：引导活检是一种常用的方法，用于从内部器官中清除可疑组织进行病理检查，以确定恶性。本文提供了允许将一个或多个预定义的活检目标计划自动应用于所获取的医学图像的系统和方法（即实用程序），包括但不限于超声前列腺图像。由于在图像期间由于前列腺的不同形状和尺寸以及相对于超声探头的前列腺的取向，所以采集具有固定计划的简单前列腺模型（例如椭圆）可能不足够。因此，已经确定具有集成活检目标位置/位点的可变形形状模型可以适合于前列腺图像以提供改进的自动活检靶向。

5. 发明授权

US08708914B2 Validation embedded segmentation method for vascular ultrasound images 失效
标题翻译：验证嵌入式分割方法用于血管超声图像
公开(公告)号：US08708914B2
公开(公告)日：2014-04-29
申请号：US12960491
申请日：2010-12-04
申请人： Jasjit S. Suri
发明人： Jasjit S. Suri
IPC分类号： A61B8/00 , G06K9/00 , A61B8/08 , G06T7/00 , A61B5/02 , A61B8/14
CPC分类号： A61B8/085 , A61B5/02007 , A61B8/0858 , A61B8/0891 , A61B8/14 , A61B8/145 , A61B8/5207 , A61B8/5223 , A61B8/585 , G06F19/00 , G06T7/0012 , G06T7/13 , G06T2207/10132 , G06T2207/20016 , G06T2207/30101
摘要： A computer-implemented system and method for intima-media thickness (IMT) measurements using a validation embedded segmentation method. Various embodiments include receiving biomedical imaging data and patient demographic data corresponding to a current scan of a patient; checking the biomedical imaging data in real-time to determine if an artery of the patient has a calcium deposit in a proximal wall of the artery; acquiring arterial data of the patient as a combination of longitudinal B-mode and transverse B-mode data; using a data processor to automatically recognize the artery by embedding anatomic information; using the data processor to calibrate a region of interest around the automatically recognized artery; automatically computing the weak or missing edges of intima-media and media-adventitia walls using edge flow, labeling and connectivity; and determining the intima-media thickness (IMT) of an arterial wall of the automatically recognized artery.
摘要翻译：一种使用验证嵌入式分割方法的计算机实现的内膜中厚度（IMT）测量系统和方法。各种实施例包括接收对应于患者的当前扫描的生物医学成像数据和患者人口统计数据; 实时检查生物医学成像数据，以确定患者的动脉是否在动脉近端壁具有钙沉积物; 获取患者的动脉数据作为纵向B模式和横向B模式数据的组合; 使用数据处理器通过嵌入解剖信息自动识别动脉; 使用数据处理器校准在自动识别的动脉周围的感兴趣区域; 使用边缘流，标签和连接自动计算内膜和媒体 - 外膜壁的弱或缺失边缘; 并确定自动识别的动脉的动脉壁的内膜 - 中膜厚度（IMT）。

6. 发明申请

US20120220875A1 Mobile Architecture Using Cloud for Hashimoto's Thyroiditis Disease Classification 审中-公开
标题翻译：使用云的桥梁甲状腺炎疾病分类的移动架构
公开(公告)号：US20120220875A1
公开(公告)日：2012-08-30
申请号：US13465091
申请日：2012-05-07
申请人： Jasjit S. Suri
发明人： Jasjit S. Suri
IPC分类号： A61B6/00 , A61B8/13
CPC分类号： G06F19/321 , G06F19/3418 , G16H50/20 , G16H50/70
摘要： Hashimoto's Thyroiditis (HT) is the most common type of inflammation of the thyroid gland and accurate diagnosis of HT would be advantageous in predicting thyroid failure. The application presents three tier architecture for image-based diagnosis and monitoring application using Cloud is described. The presentation layer is run on the tablet (mobile device), while the business and persistence layer runs on a single cloud or distributed on different Clouds in a multi-tenancy and multi-user application. Such architecture is used for automated data mining application for diagnosis of Hashimoto's Thyroiditis (HT) Disease using ultrasound.
摘要翻译：桥本甲状腺炎（HT）是甲状腺最常见的炎症类型，HT的准确诊断将有利于预测甲状腺功能衰竭。该应用程序介绍了使用云的基于图像的诊断和监视应用程序的三层架构。表现层在平板电脑（移动设备）上运行，而业务和持久层在多租户和多用户应用程序中运行在单个云上或分布在不同的云上。这种架构用于使用超声波诊断桥本甲状腺炎（HT）疾病的自动化数据挖掘应用。

7. 发明申请

US20120059261A1 Dual Constrained Methodology for IMT Measurement 审中-公开
标题翻译：用于IMT测量的双重约束方法
公开(公告)号：US20120059261A1
公开(公告)日：2012-03-08
申请号：US13219695
申请日：2011-08-28
申请人： Jasjit S. Suri
发明人： Jasjit S. Suri
IPC分类号： A61B8/00 , A61B8/14
CPC分类号： A61B8/0891 , A61B8/0858 , A61B8/469 , A61B8/5223 , A61B8/585 , G06T2207/10132 , G06T2207/20021 , G06T2207/20064 , G06T2207/30101 , G16H50/20
摘要： A computer-implemented system and method for intima-media thickness (IMT) measurements using a validation embedded segmentation method. Various embodiments include receiving biomedical imaging data and patient demographic data corresponding to a current scan of a patient; checking the biomedical imaging data in real-time to determine if an artery of the patient has a atherosclerosis deposit in a proximal wall of the artery; acquiring arterial data of the patient as a combination of longitudinal B-mode or M-mode and transverse B-mode or M-mode data; using a data processor to automatically recognize the artery by embedding anatomic information; using the data processor to calibrate a region of interest around the automatically recognized artery; automatically computing the lumen intima and media-adventita borders by evolving the initial lumen intima and initial media-adventita borders constrained by distances based on polyline method or centerline method; and determining the intima-media thickness (IMT) of an arterial wall of the automatically recognized artery.
摘要翻译：一种使用验证嵌入式分割方法的计算机实现的内膜中厚度（IMT）测量系统和方法。各种实施例包括接收对应于患者的当前扫描的生物医学成像数据和患者人口统计数据; 实时检查生物医学成像数据，以确定患者的动脉是否在动脉近端壁具有动脉粥样硬化沉积物; 获取患者的动脉数据作为纵向B模式或M模式和横向B模式或M模式数据的组合; 使用数据处理器通过嵌入解剖信息自动识别动脉; 使用数据处理器校准在自动识别的动脉周围的感兴趣区域; 通过基于折线方法或中心线方法演变最初的内腔和初始媒体 - 异体边界受距离限制，自动计算流明内膜和媒体 - 异体边界; 并确定自动识别的动脉的动脉壁的内膜 - 中膜厚度（IMT）。

8. 发明申请

US20110257545A1 IMAGING BASED SYMPTOMATIC CLASSIFICATION AND CARDIOVASCULAR STROKE RISK SCORE ESTIMATION 审中-公开
公开(公告)号：US20110257545A1
公开(公告)日：2011-10-20
申请号：US13053971
申请日：2011-03-22
申请人： Jasjit S. Suri
发明人： Jasjit S. Suri
IPC分类号： A61B5/02
CPC分类号： A61B6/5217 , A61B5/02007 , A61B5/726 , A61B5/7267 , A61B6/03 , A61B6/504 , A61B8/0891 , A61B8/5223 , G06T7/0012 , G06T7/13 , G06T2207/10081 , G06T2207/10088 , G06T2207/10136 , G06T2207/20064 , G06T2207/30101 , G06T2207/30172
摘要： Characterization of carotid atherosclerosis and classification of plaque into symptomatic or asymptomatic along with the risk score estimation are key steps necessary for allowing the vascular surgeons to decide if the patient has to definitely undergo risky treatment procedures that are needed to unblock the stenosis. This application describes a statistical (a) Computer Aided Diagnostic (CAD) technique for symptomatic versus asymptomatic plaque automated classification of carotid ultrasound images and (b) presents a cardiovascular stroke risk score computation. We demonstrate this for longitudinal Ultrasound, CT, MR modalities and extendable to 3D carotid Ultrasound. The on-line system consists of Atherosclerotic Wall Region estimation using AtheroEdge™ for longitudinal Ultrasound or Athero-CTView™ for CT or Athero-MRView from MR. This greyscale Wall Region is then fed to a feature extraction processor which computes: (a) Higher Order Spectra; (b) Discrete Wavelet Transform (DWT); (c) Texture and (d) Wall Variability. The output of the Feature Processor is fed to the Classifier which is trained off-line from the Database of similar Atherosclerotic Wall Region images. The off-line Classifier is trained from the significant features from (a) Higher Order Spectra; (b) Discrete Wavelet Transform (DWT); (c) Texture and (d) Wall Variability, selected using t-test. Symptomatic ground truth information about the training patients is drawn from cross modality imaging such as CT or MR or 3D ultrasound in the form of 0 or 1. Support Vector Machine (SVM) supervised classifier of varying kernel functions is used off-line for training. The Atheromatic™ system is also demonstrated for Radial Basis Probabilistic Neural Network (RBPNN), or Nearest Neighbor (KNN) classifier or Decision Trees (DT) Classifier for symptomatic versus asymptomatic plaque automated classification. The obtained training parameters are then used to evaluate the test set. The system also yields the cardiovascular stroke risk score value on the basis of the four set of wall features.

9. 发明授权

US07942829B2 Biopsy planning and display apparatus 有权
标题翻译：活检规划和显示装置
公开(公告)号：US07942829B2
公开(公告)日：2011-05-17
申请号：US12014214
申请日：2008-01-15
申请人： Steven Dean Miller , Jasjit S. Suri
发明人： Steven Dean Miller , Jasjit S. Suri
IPC分类号： A61B10/00 , A61B5/103 , A61B5/117
CPC分类号： A61B90/36 , A61B10/0241 , A61B90/37 , A61B2017/00274 , A61B2018/00547 , A61B2034/107 , A61B2034/256
摘要： Systems are provided for managing, planning and displaying the location of biopsy core sites across multiple same-patient visits or other stored biopsy plans to increase the confidence and accuracy of biopsy results. The systems may allow the operator to fuse multiple predefined and/or automatically generated biopsy core site plans in addition to previous biopsy sites with a current prostate image to assist in creating a final new biopsy core site plan. Further, the system may allow the operator to selectively view singular parts of the final plan to simplify the planning process. Further, the systems may assist the operator during the navigation phase of the biopsy by hiding biopsy core sites from the final plan that are not of immediate interest during the biopsy phase and thereby reducing clutter and distraction during biopsy sample acquisition.
摘要翻译：提供系统用于管理，规划和显示活检核心部位在多个同一病人访问或其他存活的活检计划中的位置，以增加活检结果的置信度和准确性。该系统可以允许操作员除了先前的活检部位与目前的前列腺图像之外，还可以将多个预定义和/或自动生成的活检核心部位计划融合，以帮助创建最终的新活检核心部位计划。此外，系统可以允许操作者选择性地查看最终计划的单个部分以简化规划过程。此外，系统可以在活检的导航阶段期间通过在活检期间隐藏来自最终计划的活检核心部位而不是立即感兴趣的活动，从而减少活检样本采集期间的杂乱和分散，从而辅助操作者。

10. 发明授权

US07916918B2 Diagnostic system for multimodality mammography 有权
标题翻译：多模态乳房X线摄影诊断系统
公开(公告)号：US07916918B2
公开(公告)日：2011-03-29
申请号：US11632082
申请日：2005-07-07
申请人： Jasjit S. Suri , Roman Janer , Yujun Guo , Idris A. Elbakri
发明人： Jasjit S. Suri , Roman Janer , Yujun Guo , Idris A. Elbakri
IPC分类号： G06K9/00 , A61B6/00 , A61B5/05
CPC分类号： G06T7/38 , G06T2207/30068
摘要： A method includes acquiring first imaging information of a region of interest, said first imaging information providing data correlated to three spatial dimensions of a reference frame including said region of interest; acquiring second projection imaging information of said region of interest, said second imaging information providing data correlated to said reference frame but is lacking information concerning at least one spatial dimension; and processing said first and second imaging information such that said first imaging information is registered with said second imaging information. An apparatus includes a first imaging system for acquiring imaging information of a region of interest, said first imaging information providing data correlated to three spatial dimensions of a reference frame including said region of interest; a second imaging system for acquiring second imaging information of said region of interest, said second imaging information providing data correlated to said reference frame but is lacking information concerning at least one spatial dimension; and a processor for processing said first and second imaging information such that said first imaging information is registered with said second imaging information.
摘要翻译：一种方法包括获取感兴趣区域的第一成像信息，所述第一成像信息提供与包括所述感兴趣区域的参考帧的三个空间维度相关的数据; 获取所述感兴趣区域的第二投影成像信息，所述第二成像信息提供与所述参考帧相关的数据，但缺少关于至少一个空间维度的信息; 以及处理所述第一和第二成像信息，使得所述第一成像信息与所述第二成像信息一起登记。一种装置包括用于获取感兴趣区域的成像信息的第一成像系统，所述第一成像信息提供与包括所述感兴趣区域的参考帧的三个空间维度相关的数据; 第二成像系统，用于获取所述感兴趣区域的第二成像信息，所述第二成像信息提供与所述参考帧相关的数据，但缺少关于至少一个空间维度的信息; 以及处理器，用于处理所述第一和第二成像信息，使得所述第一成像信息与所述第二成像信息一起登记。

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