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1. 发明授权

US08588933B2 Medical lead termination sleeve for implantable medical devices 有权
标题翻译：用于可植入医疗器械的医用引线端接套管
公开(公告)号：US08588933B2
公开(公告)日：2013-11-19
申请号：US12685543
申请日：2010-01-11
申请人： Jared Floyd , Christopher Genau , Kent W. Leyde
发明人： Jared Floyd , Christopher Genau , Kent W. Leyde
IPC分类号： A61N1/00
CPC分类号： A61N1/05 , A61B5/04 , A61B5/4094 , H01R4/20 , H01R2201/12 , Y10T29/49218
摘要： A wire and electrode combination suitable for use with implanted medical devices, and a method for coupling the wire and electrode to achieve a robust electrical connection suitable for use with such medical devices are disclosed. The apparatus employs a wire that is optimized for strength, an electrode optimized for biocompatibility, and a termination sleeve with a closed distal end for coupling the wire to the electrode, while eliminating the potential for galvanic corrosion, enhancing weld quality, and facilitating manufacture of the apparatus. The method involves compressing the sleeve to engage the wire at two locations, where contact between the sleeve and wire at the first location seals the interior of the sleeve, and contact between the sleeve and wire at the second location electrically couples the wire to the sleeve. The sleeve, which is easier to manipulate than the wire, is then spot welded to the electrode.
摘要翻译：公开了适用于植入的医疗装置的线和电极组合，以及用于耦合线和电极以实现适合于与这种医疗装置一起使用的坚固的电连接的方法。该设备使用针对强度优化的电线，针对生物相容性优化的电极，以及具有闭合远端的终端套管，用于将电线耦合到电极，同时消除电偶腐蚀的可能性，提高焊接质量，并促进制造该装置。该方法包括压缩套筒以在两个位置处接合线，其中在第一位置处的套筒和线之间的接触密封套筒的内部，并且在第二位置处的套筒和线之间的接触将电线耦合到套筒。然后将比线更容易操作的套管点焊到电极上。

2. 发明申请

US20100179627A1 Medical Lead Termination Sleeve for Implantable Medical Devices 有权
标题翻译：可植入医疗器械的医用铅封端口套管
公开(公告)号：US20100179627A1
公开(公告)日：2010-07-15
申请号：US12685543
申请日：2010-01-11
申请人： Jared Floyd , Christopher Genau , Kent W. Leyde
发明人： Jared Floyd , Christopher Genau , Kent W. Leyde
IPC分类号： A61N1/05 , A61B5/04
CPC分类号： A61N1/05 , A61B5/04 , A61B5/4094 , H01R4/20 , H01R2201/12 , Y10T29/49218
摘要： A wire and electrode combination suitable for use with implanted medical devices, and a method for coupling the wire and electrode to achieve a robust electrical connection suitable for use with such medical devices are disclosed. The apparatus employs a wire that is optimized for strength, an electrode optimized for biocompatibility, and a termination sleeve with a closed distal end for coupling the wire to the electrode, while eliminating the potential for galvanic corrosion, enhancing weld quality, and facilitating manufacture of the apparatus. The method involves compressing the sleeve to engage the wire at two locations, where contact between the sleeve and wire at the first location seals the interior of the sleeve, and contact between the sleeve and wire at the second location electrically couples the wire to the sleeve. The sleeve, which is easier to manipulate than the wire, is then spot welded to the electrode.
摘要翻译：公开了适用于植入的医疗装置的线和电极组合，以及用于耦合线和电极以实现适合于与这种医疗装置一起使用的坚固的电连接的方法。该设备使用针对强度优化的电线，针对生物相容性优化的电极，以及具有闭合远端的终端套管，用于将电线耦合到电极，同时消除电偶腐蚀的可能性，提高焊接质量，并促进制造该装置。该方法包括压缩套筒以在两个位置处接合线，其中在第一位置处的套筒和线之间的接触密封套筒的内部，并且在第二位置处的套筒和线之间的接触将电线耦合到套筒。然后将比线更容易操作的套管点焊到电极上。

3. 发明申请

US20090171420A1 Housing for an Implantable Medical Device 有权
标题翻译：可植入医疗器械的住房
公开(公告)号：US20090171420A1
公开(公告)日：2009-07-02
申请号：US12343386
申请日：2008-12-23
申请人： David Brown , Christopher Genau , Kent W. Leyde , Shan Gaw , Jeffrey Stewart
发明人： David Brown , Christopher Genau , Kent W. Leyde , Shan Gaw , Jeffrey Stewart
IPC分类号： A61N1/05 , A61N1/08
CPC分类号： A61N1/3787 , A61N1/37223 , A61N1/375 , A61N1/3758
摘要： An implantable medical device having a concave ceramic housing component; a concave metal housing component attached to the ceramic housing component to form a hermetically sealed enclosure; and an electronic trans-housing magnetic flux component disposed within the enclosure. Another aspect of the invention provides an implantable medical device having a ceramic housing component; a metal housing component; a circumferential sealing member attached to a periphery of the ceramic housing component and to a periphery of the metal housing component to form a hermetically sealed enclosure; and an electronic trans-housing magnetic flux component disposed within the enclosure. Still another aspect of the invention provides an implantable medical device with a first metal housing component; a second metal housing component, the second metal housing component forming an opening; a ceramic housing component disposed in the opening, the first metal housing component, the second metal housing component and the ceramic housing component cooperating to form a hermetically sealed enclosure; and an electronic trans-housing magnetic flux component disposed within the enclosure.
摘要翻译：一种具有凹形陶瓷壳体部件的可植入医疗装置; 连接到陶瓷壳体部件的凹入金属壳体部件以形成密封的外壳; 以及设置在所述外壳内的电子跨壳体磁通部件。本发明的另一方面提供一种具有陶瓷壳体部件的可植入医疗装置; 金属外壳部件; 周向密封构件，其附接到陶瓷壳体部件的周边和金属壳体部件的周边，以形成密封的外壳; 以及设置在所述外壳内的电子跨壳体磁通部件。本发明的另一方面提供一种具有第一金属壳体部件的可植入医疗装置; 第二金属壳体部件，所述第二金属壳体部件形成开口; 设置在所述开口中的陶瓷壳体部件，所述第一金属壳体部件，所述第二金属壳体部件和所述陶瓷壳体部件协作以形成气密密封的壳体; 以及设置在所述外壳内的电子跨壳体磁通部件。

4. 发明授权

US09259591B2 Housing for an implantable medical device 有权
标题翻译：可植入医疗器械的外壳
公开(公告)号：US09259591B2
公开(公告)日：2016-02-16
申请号：US12343386
申请日：2008-12-23
申请人： David Brown , Christopher Genau , Kent W. Leyde , Shan Gaw , Jeffrey Stewart
发明人： David Brown , Christopher Genau , Kent W. Leyde , Shan Gaw , Jeffrey Stewart
IPC分类号： A61N1/378 , A61N1/375 , A61N1/372
CPC分类号： A61N1/3787 , A61N1/37223 , A61N1/375 , A61N1/3758
摘要： An implantable medical device having a concave ceramic housing component; a concave metal housing component attached to the ceramic housing component to form a hermetically sealed enclosure; and an electronic trans-housing magnetic flux component disposed within the enclosure. Another aspect of the invention provides an implantable medical device having a ceramic housing component; a metal housing component; a circumferential sealing member attached to a periphery of the ceramic housing component and to a periphery of the metal housing component to form a hermetically sealed enclosure; and an electronic trans-housing magnetic flux component disposed within the enclosure. Still another aspect of the invention provides an implantable medical device with a first metal housing component; a second metal housing component, the second metal housing component forming an opening; a ceramic housing component disposed in the opening, the first metal housing component, the second metal housing component and the ceramic housing component cooperating to form a hermetically sealed enclosure; and an electronic trans-housing magnetic flux component disposed within the enclosure.
摘要翻译：一种具有凹形陶瓷壳体部件的可植入医疗装置; 连接到陶瓷壳体部件的凹入金属壳体部件以形成密封的外壳; 以及设置在所述外壳内的电子跨壳体磁通部件。本发明的另一方面提供一种具有陶瓷壳体部件的可植入医疗装置; 金属外壳部件; 周向密封构件，其附接到陶瓷壳体部件的周边和金属壳体部件的周边，以形成密封的外壳; 以及设置在所述外壳内的电子跨壳体磁通部件。本发明的另一方面提供一种具有第一金属壳体部件的可植入医疗装置; 第二金属壳体部件，所述第二金属壳体部件形成开口; 设置在所述开口中的陶瓷壳体部件，所述第一金属壳体部件，所述第二金属壳体部件和所述陶瓷壳体部件协作以形成气密密封的壳体; 以及设置在所述外壳内的电子跨壳体磁通部件。

5. 发明授权

US09643019B2 Neurological monitoring and alerts 有权
公开(公告)号：US09643019B2
公开(公告)日：2017-05-09
申请号：US13026961
申请日：2011-02-14
申请人： Jason A. Higgins , Michael Bland , Kent W. Leyde , W. Douglas Sheffield , John F. Harris , David M. Himes
发明人： Jason A. Higgins , Michael Bland , Kent W. Leyde , W. Douglas Sheffield , John F. Harris , David M. Himes
IPC分类号： A61B5/04 , A61N1/372 , A61B5/00 , A61N1/00 , A61N1/05
CPC分类号： A61N1/37258 , A61B5/4094 , A61N1/00 , A61N1/0529 , G16H40/67
摘要： A system for providing alerts of neurological events occurring in a human subject is provided. The system includes: a monitoring module adapted to detect and sample a neurological signal; an event detection module coupled to the monitoring module for detecting one or more types of predetermined reportable events based on the detected neurological signal; and an alert module coupled to the event detection module, wherein upon the detection of a reportable event by the event detection module, said alert module selects a first alert contact from a plurality of contacts contained in a contact list, and generates a first alert communication to the first alert contact.

6. 发明授权

US08849390B2 Processing for multi-channel signals 有权
公开(公告)号：US08849390B2
公开(公告)日：2014-09-30
申请号：US12649098
申请日：2009-12-29
申请人： Javier Ramón Echauz , David E. Snyder , Kent W. Leyde
发明人： Javier Ramón Echauz , David E. Snyder , Kent W. Leyde
IPC分类号： A61B5/04 , A61B5/0476 , A61B5/00
CPC分类号： A61B5/0476 , A61B5/4094
摘要： Method and apparatus for improved processing for multi-channel signals. In an exemplary embodiment, an anomaly metric is computed for a multi-channel signal over a time window. The magnitude of the anomaly metric may be used to determine whether an anomaly is present in the multi-channel signal over the time window. In an exemplary embodiment, the anomaly metric may be a condition number associated with the singular values of the multi-channel signal over the time window, as further adjusted by the number of channels to produce a data condition number. Applications of the anomaly metric computation include the scrubbing of signal archives for epileptic seizure detection/prediction/counter-prediction algorithm training, pre-processing of multi-channel signals for real-time monitoring of bio-systems, and boot-up and/or adaptive self-checking of such systems during normal operation.

7. 发明授权

US08786624B2 Processing for multi-channel signals 有权
标题翻译：多通道信号处理
公开(公告)号：US08786624B2
公开(公告)日：2014-07-22
申请号：US12792582
申请日：2010-06-02
申请人： Javier Ramón Echauz , David E. Snyder , Kent W. Leyde
发明人： Javier Ramón Echauz , David E. Snyder , Kent W. Leyde
IPC分类号： G06T11/20 , G09G5/02 , G06F19/00 , G06F17/18
CPC分类号： A61B5/0476 , A61B5/076 , A61B5/4094 , A61B2560/0271 , G06K9/00536 , G06T11/206
摘要： Method and apparatus for improved processing for multi-channel signals. In an exemplary embodiment, an anomaly metric is computed for a multi-channel signal over a time window. The magnitude of the anomaly metric may be used to determine whether an anomaly is present in the multi-channel signal over the time window. In an exemplary embodiment, the anomaly metric may be a condition number associated with the singular values of the multi-channel signal over the time window, as further adjusted by the number of channels to produce a data condition number. Applications of the anomaly metric computation include the scrubbing of signal archives for epileptic seizure detection/prediction/counter-prediction algorithm training, pre-processing of multi-channel signals for real-time monitoring of bio-systems, and boot-up and/or adaptive self-checking of such systems during normal operation.
摘要翻译：用于改善多通道信号处理的方法和装置。在示例性实施例中，针对时间窗口上的多信道信号计算异常度量。可以使用异常度量的大小来确定在时间窗口上的多通道信号中是否存在异常。在示例性实施例中，异常度量可以是与时间窗口上的多信道信号的奇异值相关联的条件数，如通过产生数据条件数的信道数进一步调整的。异常度量计算的应用包括擦除用于癫痫发作检测/预测/反预测算法训练的信号档案，用于实时监测生物系统的多通道信号的预处理，以及启动和/或这种系统在正常运行期间的自适应自检。

8. 发明申请

US20110213222A1 Communication Error Alerting in an Epilepsy Monitoring System 有权
标题翻译：癫痫监测系统通信错误警报
公开(公告)号：US20110213222A1
公开(公告)日：2011-09-01
申请号：US13070333
申请日：2011-03-23
申请人： Kent W. Leyde , John F. Harris
发明人： Kent W. Leyde , John F. Harris
IPC分类号： A61B5/00 , A61B5/04
CPC分类号： A61B5/0476 , A61B5/0006 , A61B5/0031 , A61B5/4094 , A61B2560/0271 , A61M5/14276 , A61N1/36082 , A61N1/37247 , A61N1/37258 , A61N1/37282 , G06F19/3418
摘要： Systems and methods for monitoring neurological signals in a patient are provided. The system includes: an implantable sensor adapted to collect neurological signals; an implantable assembly configured to sample the neurological signals collected by the sensor; and a rechargeable communication device external to the patient's body, said communication device configured to wirelessly communicate with the implantable assembly and to transmit a communication error alert to a caregiver advisory device in the event of a communication error between the implantable assembly and the communication device.
摘要翻译：提供了用于监测患者神经信号的系统和方法。该系统包括：适于收集神经信号的可植入传感器; 植入式组件，被配置为对由所述传感器收集的神经信号进行采样; 以及在患者身体外部的可充电通信设备，所述通信设备被配置为与可植入组件进行无线通信，并且在可植入组件和通信设备之间发生通信错误的情况下向通知设备发送通信错误警报。

9. 发明申请

US20110172554A1 Patient Entry Recording in an Epilepsy Monitoring System 审中-公开
标题翻译：癫痫监测系统中的患者进入记录
公开(公告)号：US20110172554A1
公开(公告)日：2011-07-14
申请号：US13070357
申请日：2011-03-23
申请人： Kent W. Leyde , John F. Harris
发明人： Kent W. Leyde , John F. Harris
IPC分类号： A61B5/048
CPC分类号： A61B5/0476 , A61B5/0006 , A61B5/0031 , A61B5/4094 , A61B2560/0271 , A61M5/14276 , A61N1/36082 , A61N1/37247 , A61N1/37258 , A61N1/37282 , G06F19/3418
摘要： Systems and methods for monitoring a patient are provided. The system includes: an implantable sensor adapted to collect neurological signals; an implantable assembly configured to sample the neurological signals collected by the sensor; and a rechargeable external assembly configured to wirelessly receive the sampled neurological signals from the implantable assembly, said external assembly being further configured to record a patient entry in response to receiving an input from the patient. The method includes: collecting neurological signals with a sensor implanted in the patient; sampling the neurological signals collected by the sensor with an implantable assembly implanted in the patient; and transmitting the sampled neurological signals from the implantable assembly to a rechargeable external assembly external to the patient; and recording a patient entry in response to receiving an input from the patient.
摘要翻译：提供了用于监测患者的系统和方法。该系统包括：适于收集神经信号的可植入传感器; 植入式组件，被配置为对由所述传感器收集的神经信号进行采样; 以及可充电外部组件，其被配置为从所述可植入组件无线地接收所述取样的神经信号，所述外部组件还被配置为响应于接收到来自所述患者的输入而记录患者入口。该方法包括：用植入患者的传感器收集神经信号; 用植入患者的可植入组件对由传感器收集的神经信号进行采样; 以及将所述取样的神经信号从所述可植入组件传输到患者外部的可再充电外部组件; 以及响应于从患者接收到输入而记录患者入口。

10. 发明申请

US20100302270A1 Processing for Multi-Channel Signals 有权
标题翻译：多通道信号处理
公开(公告)号：US20100302270A1
公开(公告)日：2010-12-02
申请号：US12792582
申请日：2010-06-02
申请人： Javier Ramón Echauz , David E. Snyder , Kent W. Leyde
发明人： Javier Ramón Echauz , David E. Snyder , Kent W. Leyde
IPC分类号： G06T11/20 , G09G5/02 , G06F19/00 , G06F17/18
CPC分类号： A61B5/0476 , A61B5/076 , A61B5/4094 , A61B2560/0271 , G06K9/00536 , G06T11/206
摘要： Method and apparatus for improved processing for multi-channel signals. In an exemplary embodiment, an anomaly metric is computed for a multi-channel signal over a time window. The magnitude of the anomaly metric may be used to determine whether an anomaly is present in the multi-channel signal over the time window. In an exemplary embodiment, the anomaly metric may be a condition number associated with the singular values of the multi-channel signal over the time window, as further adjusted by the number of channels to produce a data condition number. Applications of the anomaly metric computation include the scrubbing of signal archives for epileptic seizure detection/prediction/counter-prediction algorithm training, pre-processing of multi-channel signals for real-time monitoring of bio-systems, and boot-up and/or adaptive self-checking of such systems during normal operation.
摘要翻译：用于改善多通道信号处理的方法和装置。在示例性实施例中，针对时间窗口上的多信道信号计算异常度量。可以使用异常度量的大小来确定在时间窗口上的多通道信号中是否存在异常。在示例性实施例中，异常度量可以是与时间窗口上的多信道信号的奇异值相关联的条件数，如通过产生数据条件数的信道数进一步调整的。异常度量计算的应用包括擦除用于癫痫发作检测/预测/反预测算法训练的信号档案，用于实时监测生物系统的多通道信号的预处理，以及启动和/或这种系统在正常运行期间的自适应自检。

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