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1. 发明申请

US20090149866A1 IMPLANTABLE ELECTRODES AND INSERTION METHODS AND TOOLS 失效
标题翻译：可植入电极和插入方法和工具
公开(公告)号：US20090149866A1
公开(公告)日：2009-06-11
申请号：US12371276
申请日：2009-02-13
申请人： Janusz A. Kuzma , Todd K. Whitehurst , Lani A. Smith , Chuladatta Thenuwara
发明人： Janusz A. Kuzma , Todd K. Whitehurst , Lani A. Smith , Chuladatta Thenuwara
IPC分类号： A61N1/05 , A61B17/00
CPC分类号： A61N1/0551 , A61N1/0529 , A61N1/0553
摘要： An insertion kit for implanting an electrode in a patient can include a handle; an insertion member coupled to the handle at a proximal end of the insertion member and configured and arranged to be inserted into a patient; an alignment member coupled to the handle and disposed over the distal end of the insertion member; and an electrode configured and arranged to be inserted into the patient using the insertion member. In some instances, the insertion kit may also include one or more of a marker that cooperates with the alignment member to mark a position of the electrode on the skin of the patient; a pointer that cooperates with the alignment member to find the marked position on the skin of the patient; and a second electrode and a second insertion member configured and arranged for detachably coupling to the handle in place of the insertion member.
摘要翻译：用于将电极植入患者体内的插入套件可以包括手柄; 插入构件，其在所述插入构件的近端处联接到所述手柄并且被配置和布置成插入到患者体内; 对准构件，其联接到所述手柄并设置在所述插入构件的远端上方; 以及电极，其构造和布置成使用插入构件插入到患者体内。在一些情况下，插入套件还可以包括与对准构件配合以标记电极在患者皮肤上的位置的标记物中的一个或多个; 与对准构件协作以在患者皮肤上找到标记位置的指针; 以及第二电极和第二插入构件，其构造和布置成可替代所述插入构件可拆卸地联接到所述手柄。

2. 发明授权

US08204604B2 Implantable electrodes and insertion methods and tools 失效
标题翻译：可植入电极和插入方法和工具
公开(公告)号：US08204604B2
公开(公告)日：2012-06-19
申请号：US12371276
申请日：2009-02-13
申请人： Janusz A. Kuzma , Todd K. Whitehurst , Lani A. Smith , Chuladatta Thenuwara
发明人： Janusz A. Kuzma , Todd K. Whitehurst , Lani A. Smith , Chuladatta Thenuwara
IPC分类号： A61N1/02
CPC分类号： A61N1/0551 , A61N1/0529 , A61N1/0553
摘要： An insertion kit for implanting an electrode in a patient can include a handle; an insertion member coupled to the handle at a proximal end of the insertion member and configured and arranged to be inserted into a patient; an alignment member coupled to the handle and disposed over the distal end of the insertion member; and an electrode configured and arranged to be inserted into the patient using the insertion member. In some instances, the insertion kit may also include one or more of a marker that cooperates with the alignment member to mark a position of the electrode on the skin of the patient; a pointer that cooperates with the alignment member to find the marked position on the skin of the patient; and a second electrode and a second insertion member configured and arranged for detachably coupling to the handle in place of the insertion member.
摘要翻译：用于将电极植入患者体内的插入套件可以包括手柄; 插入构件，其在所述插入构件的近端处联接到所述手柄并且被配置和布置成插入到患者体内; 对准构件，其联接到所述手柄并设置在所述插入构件的远端上方; 以及电极，其构造和布置成使用插入构件插入到患者体内。在一些情况下，插入套件还可以包括与对准构件配合以标记电极在患者皮肤上的位置的标记物中的一个或多个; 与对准构件协作以在患者皮肤上找到标记位置的指针; 以及第二电极和第二插入构件，其构造和布置成可替代所述插入构件可拆卸地联接到所述手柄。

3. 发明授权

US06901296B1 Methods and systems for direct electrical current stimulation as a therapy for cancer and other neoplastic diseases 有权
标题翻译：直接电流刺激作为癌症和其他肿瘤疾病治疗的方法和系统
公开(公告)号：US06901296B1
公开(公告)日：2005-05-31
申请号：US10133768
申请日：2002-04-26
申请人： Todd K. Whitehurst , James P. McGivern , Janusz A. Kuzma
发明人： Todd K. Whitehurst , James P. McGivern , Janusz A. Kuzma
IPC分类号： A61N1/08 , A61N1/10 , A61N1/20 , A61N1/372
CPC分类号： A61N1/205 , A61N1/08 , A61N1/37205
摘要： A small implantable stimulator(s) includes at least two electrodes for delivering electrical stimulation to surrounding tissue. The small stimulator provides means of stimulating a neoplasm with direct electrical current, such as relatively low-level direct current, without the need for external appliances during the stimulation session. The stimulator may be configured to be small enough to be implanted entirely within a neoplasm. Open- and closed-loop systems are disclosed.
摘要翻译：一个小的植入式刺激器包括至少两个用于向周围组织传递电刺激的电极。小的刺激器提供了用直接电流刺激肿瘤的手段，例如相对低的直流电流，而不需要在刺激期间的外部器具。刺激器可以被配置为足够小以完全植入肿瘤内。公开了开环和闭环系统。

4. 发明授权

US08548604B2 Implantable microstimulators and methods for unidirectional propagation of action potentials 失效
标题翻译：可植入的微型激励器和动作电位单向传播的方法
公开(公告)号：US08548604B2
公开(公告)日：2013-10-01
申请号：US12960722
申请日：2010-12-06
申请人： Todd K. Whitehurst , Rafael Carbunaru , James P. McGivern , Matthew I. Haller , Tom Xiaohai He , Kerry Bradley , Janusz A. Kuzma
发明人： Todd K. Whitehurst , Rafael Carbunaru , James P. McGivern , Matthew I. Haller , Tom Xiaohai He , Kerry Bradley , Janusz A. Kuzma
IPC分类号： A61N1/05
CPC分类号： A61N1/37252 , A61N1/05 , A61N1/0556 , A61N1/36071 , A61N1/37205 , A61N1/37217 , A61N1/37288
摘要： Miniature implantable stimulators (i.e., microstimulators) are capable of producing unidirectionally propagating action potentials (UPAPs). The methods and configurations described may, for instance, arrest action potentials traveling in one direction, arrest action potentials of small diameters nerve fibers, arrest action potentials of large diameter nerve fibers. These methods and systems may limit side effects of bidirectional and/or less targeted stimulation.
摘要翻译：微型植入式刺激器（即微型刺激器）能够产生单向传播动作电位（UPAP）。所描述的方法和结构可以例如阻止在一个方向上行进的动作电位，阻止小直径神经纤维的动作电位，阻止大直径神经纤维的动作电位。这些方法和系统可以限制双向和/或较少靶向刺激的副作用。

5. 发明授权

US06788975B1 Fully implantable miniature neurostimulator for stimulation as a therapy for epilepsy 有权
标题翻译：用于刺激作为癫痫治疗的完全可植入的微型神经刺激器
公开(公告)号：US06788975B1
公开(公告)日：2004-09-07
申请号：US10057115
申请日：2002-01-24
申请人： Todd K. Whitehurst , James P. McGivern , Janusz A. Kuzma
发明人： Todd K. Whitehurst , James P. McGivern , Janusz A. Kuzma
IPC分类号： A61N118
CPC分类号： A61N1/37205 , A61N1/0529 , A61N1/36064
摘要： A small implantable stimulator(s) with at least two electrodes is small enough to have the electrodes located adjacent to a nerve structure at least partially responsible for epileptic seizures. The small stimulator provides a means of stimulating a nerve structure(s) when desired, and may be implanted via a minimal surgical procedure.
摘要翻译：具有至少两个电极的小型可植入刺激器足够小以使得电极位于与神经结构相邻的位置，至少部分地负责癫痫发作。小刺激器提供了在需要时刺激神经结构的手段，并且可以通过最小的外科手术植入。

6. 发明授权

US06735475B1 Fully implantable miniature neurostimulator for stimulation as a therapy for headache and/or facial pain 有权
标题翻译：用于刺激作为头痛和/或面部疼痛的治疗的完全可植入的微型神经刺激器
公开(公告)号：US06735475B1
公开(公告)日：2004-05-11
申请号：US10057088
申请日：2002-01-24
申请人： Todd K. Whitehurst , James P. McGivern , Carla Mann Woods , Paul M. Meadows , Janusz A. Kuzma
发明人： Todd K. Whitehurst , James P. McGivern , Carla Mann Woods , Paul M. Meadows , Janusz A. Kuzma
IPC分类号： A61N130
CPC分类号： A61N1/36071 , A61N1/08 , A61N1/37205
摘要： A small implantable stimulator(s) with at least two electrodes is small enough to have the electrodes located adjacent to a nerve structure at least partially responsible for headache and/or facial pain. The small stimulator provides a means of stimulating a nerve structure(s) when desired, and may be implanted via a minimal surgical procedure.
摘要翻译：具有至少两个电极的小型可植入刺激器足够小以使电极位于与神经结构相邻的位置，至少部分地负责头痛和/或面部疼痛。小刺激器提供了在需要时刺激神经结构的手段，并且可以通过最小的外科手术植入。

7. 发明授权

US06871099B1 Fully implantable microstimulator for spinal cord stimulation as a therapy for chronic pain 有权
标题翻译：用于脊髓刺激的完全可植入的微刺激作为慢性疼痛的治疗
公开(公告)号：US06871099B1
公开(公告)日：2005-03-22
申请号：US09929597
申请日：2001-08-13
申请人： Todd K. Whitehurst , James P. McGivern , Carla M. Mann , Janusz A. Kuzma
发明人： Todd K. Whitehurst , James P. McGivern , Carla M. Mann , Janusz A. Kuzma
IPC分类号： A61N1/34 , A61N1/18
CPC分类号： A61N1/36071
摘要： An implantable stimulator(s), small enough to be located near or within an area of the spine responsible for sensations in a region experiencing chronic pain uses a power source/storage device, such as a rechargeable battery. Periodic recharging of such a power source/storage device is accomplished, for example, by inductive coupling with an external appliance. The small stimulator provides a means of stimulating a nerve(s) or other tissue when desired, without the need for external appliances during the stimulation session. When necessary, external appliances are used for the transmission of data to and/or from the stimulator(s) and for the transmission of power, it necessary. In a preferred embodiment, the system is capable of open- and closed-loop operation. In closed-loop operation, at least one implant includes at least one sensor, and the sensed condition is used to adjust stimulation parameters.
摘要翻译：小到足以位于脊柱区域内的负责在慢性疼痛区域感觉的植入式刺激器使用诸如可再充电电池的电源/存储装置。这样的电源/存储装置的定期再充电例如通过与外部电器的感应耦合来实现。小刺激器提供了在需要时刺激神经或其他组织的手段，而不需要在刺激期间的外部器具。必要时，必须使用外部设备将数据传送到和/或从激励器传输，并传输电力。在优选实施例中，系统能够进行开环和闭环操作。在闭环操作中，至少一个植入物包括至少一个传感器，并且所感测到的条件用于调整刺激参数。

8. 发明授权

US06733485B1 Microstimulator-based electrochemotherapy methods and systems 失效
标题翻译：基于微刺激剂的电化疗方法和系统
公开(公告)号：US06733485B1
公开(公告)日：2004-05-11
申请号：US10133770
申请日：2002-04-26
申请人： Todd K. Whitehurst , James P. McGivern , Matthew I. Haller , Janusz A. Kuzma
发明人： Todd K. Whitehurst , James P. McGivern , Matthew I. Haller , Janusz A. Kuzma
IPC分类号： A61M3100
CPC分类号： A61M31/002 , A61M5/14276 , A61M2205/3523 , A61N1/205 , A61N1/326
摘要： A small implantable stimulator(s) includes at least two electrodes for delivering electrical stimulation to surrounding tissue and/or a pump and at least one outlet for delivering a drug or drugs to surrounding tissue. One electrochemotherapy method disclosed includes delivery of electrical stimulation in the form of a direct electric current and/or a periodic waveform that locally potentiates the cytotoxic effects of a systemically and/or locally administered chemotherapy agent(s). Open- and closed-loop systems are disclosed.
摘要翻译：小型可植入刺激器包括至少两个用于将电刺激递送至周围组织和/或泵的电极以及用于将药物或药物递送至周围组织的至少一个出口。所公开的一种电化疗方法包括以局部增强全身和/或局部施用的化疗剂的细胞毒性作用的直接电流和/或周期性波形的形式递送电刺激。公开了开环和闭环系统。

9. 发明申请

US20120316622A1 IMPLANTABLE MICROSTIMULATORS WITH PROGRAMMABLE MULTIELECTRODE CONFIGURATION AND USES THEREOF 审中-公开
标题翻译：可编程微控制器，具有可编程多电路配置及其用途
公开(公告)号：US20120316622A1
公开(公告)日：2012-12-13
申请号：US13546873
申请日：2012-07-11
申请人： Todd K. Whitehurst , Rafael Carbunaru , Kerry Bradley , James P. McGivern , Matthew I. Haller , Tom Xiaohai He , Janusz A. Kuzma
发明人： Todd K. Whitehurst , Rafael Carbunaru , Kerry Bradley , James P. McGivern , Matthew I. Haller , Tom Xiaohai He , Janusz A. Kuzma
IPC分类号： A61N1/36
CPC分类号： A61N1/37217 , A61N1/0556 , A61N1/36071 , A61N1/37205 , A61N1/37288
摘要： Miniature implantable stimulators (i.e., microstimulators) with programmably configurable electrodes allow, among other things, steering of the electric fields created. In addition, the microstimulators are capable of producing unidirectionally propagating action potentials (UPAPs).
摘要翻译：具有可编程可配置电极的微型可植入刺激器（即，微型激励器）除了别的以外还允许所产生的电场的转向。此外，微型激励器能够产生单向传播动作电位（UPAP）。

10. 发明授权

US06901294B1 Methods and systems for direct electrical current stimulation as a therapy for prostatic hypertrophy 失效
标题翻译：直接电流刺激作为前列腺肥大治疗的方法和系统
公开(公告)号：US06901294B1
公开(公告)日：2005-05-31
申请号：US10133771
申请日：2002-04-26
申请人： Todd K. Whitehurst , James P. McGivern , Janusz A. Kuzma
发明人： Todd K. Whitehurst , James P. McGivern , Janusz A. Kuzma
IPC分类号： A61N1/08 , A61N1/20 , A61N1/32 , A61N1/36 , A61N1/372
CPC分类号： A61N1/36007 , A61N1/37205
摘要： A small implantable stimulator(s) includes at least two electrodes for delivering electrical stimulation to surrounding tissue. The small stimulator provides means of stimulating the prostate with direct electrical current, such as relatively low-level direct current, without the need for external appliances during the stimulation session. The stimulator may be configured to be small enough to be implanted entirely within the prostate. Open- and closed-loop systems are disclosed.
摘要翻译：一个小的植入式刺激器包括至少两个用于向周围组织传递电刺激的电极。小型刺激器提供了在直接电流（例如相对低水平的直流）刺激前列腺的手段，而在刺激期间不需要外部装置。刺激器可以被配置为足够小以完全植入前列腺。公开了开环和闭环系统。

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