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    • 8. 发明授权
    • Saccharopeptides and derivatives thereof
    • 糖肽及其衍生物
    • US5849709A
    • 1998-12-15
    • US438669
    • 1995-05-10
    • Peter FugediCsaba Peto
    • Peter FugediCsaba Peto
    • A61K31/70A61K31/7028A61P9/00A61P25/28A61P27/02A61P29/00A61P31/00A61P35/00A61P37/00A61P43/00C07H3/06C07H13/04C07H15/04C07H15/18A61K38/04
    • A61K31/7008A61K31/7016A61K31/702C07H13/04C07H15/04C07H15/18C07H3/06
    • Saccharopeptides and methods of using the novel saccharopeptides are described having the following structural formula I: W--�--Y--W--!.sub.m (I) wherein W is independently one or more saccharide(s); Y is independently --CO--NH-- or --NH--CO--; and m is an integer greater than or equal to one; or structural formula II: W--Y--�W--X--W--Y!.sub.n --W (II) wherein W is independently one or more saccharide(s); S is a difunctional or polyfunctional alkyl, aryl or aralkyl group, lipid, amino acid or peptide capable of covalently joining together said saccharides; Y is independently --CO--NH-- or --NH--CO--; and n is an integer greater than or equal to zero; or formula III: W--Y.sup.1 --X.sup.1 --Y.sup.2 --W (III) wherein W is independently one or more saccharide(s); X.sup.1 is a difunctional or polyfunctional alkyl, aryl or aralkyl group capable of covalently joining together said saccharides; Y.sup.1 is --NH--CO--; and Y.sup.2 is --CO--NH--.
    • 描述了使用这种新型糖肽的糖肽和具有以下结构式I的W - [ - Y-W-] m(I),其中W独立地为一种或多种糖类; Y独立地是-CO-NH-或-NH-CO-; m是大于或等于1的整数; 或结构式II:W-Y- [W-X-W-Y] n -W(II)其中W独立地为一种或多种糖类; S是能够将所述糖共价连接在一起的二官能或多官能的烷基,芳基或芳烷基,脂质,氨基酸或肽; Y独立地是-CO-NH-或-NH-CO-; 并且n是大于或等于零的整数; 或式III:W-Y1-X1-Y2-W(III)其中W独立地为一个或多个糖; X1是能够将所述糖共价连接在一起的二官能或多官能的烷基,芳基或芳烷基; Y1是-NH-CO-; 而Y2是-CO-NH-。