专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20130045960A1 Abuse-Deterrent Pharmaceutical Compositions of Opiods and Other Drugs 有权
标题翻译：鸦片和其他药物的滥用威慑药物组合物
公开(公告)号：US20130045960A1
公开(公告)日：2013-02-21
申请号：US13551455
申请日：2012-07-17
申请人： Jane Hirsh , Alexander M. Klibanov , Timothy M. Swager , Stephen L. Buchwald , Whe Yong Lo , Alison Fleming , Roman V. Rariy
发明人： Jane Hirsh , Alexander M. Klibanov , Timothy M. Swager , Stephen L. Buchwald , Whe Yong Lo , Alison Fleming , Roman V. Rariy
IPC分类号： A61K31/555 , A61K31/485 , C07D489/08 , A61P25/36 , C07F3/06
CPC分类号： A61K31/485 , A61K9/145 , A61K9/1617 , A61K9/1682 , A61K9/1694 , A61K9/4858 , A61K9/50 , A61K9/5052 , A61K9/5084 , A61K31/20 , A61K47/12
摘要： An abuse-deterrent pharmaceutical composition has been developed to reduce the likelihood of improper administration of drugs, especially drugs such as opiods. In the preferred embodiment, a drug is modified to increase its lipophilicity. In preferred embodiments the modified drug is homogeneously dispersed within microparticles composed of a material that is either slowly soluble or not soluble in water. The abuse-deterrent composition retards the release of drug, even if the physical integrity of the formulation is compromised (for example, by chopping with a blade or crushing) and the resulting material is placed in water, snorted, or swallowed. However, when administered as directed, the drug is slowly released from the composition as the composition is broken down or dissolved gradually within the GI tract by a combination of enzymatic degradation, surfactant action of bile acids, and mechanical erosion.
摘要翻译：已经开发了一种滥用威慑药物组合物，以减少药物不当管理的可能性，特别是诸如阿片类药物。在优选的实施方案中，修饰药物以增加其亲油性。在优选实施方案中，改性药物均匀地分散在由缓慢溶解或不溶于水的材料组成的微粒内。即使制剂的物理完整性受到损害（例如通过用刀片切碎或破碎）并且将所得材料置于水中，嗅到或吞咽，滥用威慑组合物也会延缓释放药物。然而，当按照指导施用时，通过酶降解，胆汁酸的表面活性作用和机械侵蚀的组合，组合物被分解或逐渐溶解在胃肠道内，药物从组合物中缓慢释放。

2. 发明授权

US09044398B2 Abuse-deterrent pharmaceutical compositions of opiods and other drugs 有权
标题翻译：鸦片和其他药物的滥用威慑药物组合物
公开(公告)号：US09044398B2
公开(公告)日：2015-06-02
申请号：US13551455
申请日：2012-07-17
申请人： Jane Hirsh , Alexander M. Klibanov , Timothy M. Swager , Stephen L. Buchwald , Whe Yong Lo , Alison Fleming , Roman V. Rariy
发明人： Jane Hirsh , Alexander M. Klibanov , Timothy M. Swager , Stephen L. Buchwald , Whe Yong Lo , Alison Fleming , Roman V. Rariy
IPC分类号： A61K9/14 , A61K9/42 , A61K31/20 , A61K31/485 , A61K9/16 , A61K47/12 , A61K9/48 , A61K9/50
CPC分类号： A61K31/485 , A61K9/145 , A61K9/1617 , A61K9/1682 , A61K9/1694 , A61K9/4858 , A61K9/50 , A61K9/5052 , A61K9/5084 , A61K31/20 , A61K47/12
摘要： An abuse-deterrent pharmaceutical composition has been developed to reduce the likelihood of improper administration of drugs, especially drugs such as opiods. In the preferred embodiment, a drug is modified to increase its lipophilicity. In preferred embodiments the modified drug is homogeneously dispersed within microparticles composed of a material that is either slowly soluble or not soluble in water. The abuse-deterrent composition retards the release of drug, even if the physical integrity of the formulation is compromised (for example, by chopping with a blade or crushing) and the resulting material is placed in water, snorted, or swallowed. However, when administered as directed, the drug is slowly released from the composition as the composition is broken down or dissolved gradually within the GI tract by a combination of enzymatic degradation, surfactant action of bile acids, and mechanical erosion.
摘要翻译：已经开发了一种滥用威慑药物组合物，以减少药物不当管理的可能性，特别是诸如阿片类药物。在优选的实施方案中，修饰药物以增加其亲油性。在优选实施方案中，改性药物均匀地分散在由缓慢溶解或不溶于水的材料组成的微粒内。即使制剂的物理完整性受到损害（例如通过用刀片切碎或破碎）并且将所得材料置于水中，嗅到或吞咽，滥用威慑组合物也会延缓释放药物。然而，当按照指导给药时，由于组合物通过酶降解，胆汁酸的表面活性作用和机械侵蚀的组合被分解或逐渐溶解在胃肠道内，药物从组合物中缓慢释放。

3. 发明授权

US07399488B2 Abuse-deterrent pharmaceutical compositions of opiods and other drugs 有权
标题翻译：阿片类药物和其他药物的滥用药物组合物
公开(公告)号：US07399488B2
公开(公告)日：2008-07-15
申请号：US10614866
申请日：2003-07-07
申请人： Jane Hirsh , Alexander M. Kibanov , Timothy M. Swager , Stephen L. Buchwald , Whe Yong Lo , Alison B. Fleming , Roman V. Rariy
发明人： Jane Hirsh , Alexander M. Kibanov , Timothy M. Swager , Stephen L. Buchwald , Whe Yong Lo , Alison B. Fleming , Roman V. Rariy
IPC分类号： A61K9/14 , A61K9/50
CPC分类号： A61K31/485 , A61K9/145 , A61K9/1617 , A61K9/1682 , A61K9/1694 , A61K9/4858 , A61K9/50 , A61K9/5052 , A61K9/5084 , A61K31/20 , A61K47/12
摘要： An abuse-deterrent pharmaceutical composition has been developed to reduce the likelihood of improper administration of drugs, especially drugs such as opiods. In the preferred embodiment, a drug is modified to increase its lipophilicity. In preferred embodiments the modified drug is homogeneously dispersed within microparticles composed of a material that is either slowly soluble or not soluble in water. In some embodiments the drug containing microparticles or drug particles are coated with one or more coating layers, where at least one coating is water insoluble and preferably organic solvent insoluble, but enzymatically degradable by enzymes present in the human gastrointestinal tract. The abuse-deterrent composition retards the release of drug, even if the physical integrity of the formulation is compromised (for example, by chopping with a blade or crushing) and the resulting material is placed in water, snorted, or swallowed. However, when administered as directed, the drug is slowly released from the composition as the composition is broken down or dissolved gradually within the GI tract by a combination of enzymatic degradation, surfactant action of bile acids, and mechanical erosion.
摘要翻译：已经开发了一种滥用威慑药物组合物，以减少药物不当管理的可能性，特别是诸如阿片类药物。在优选的实施方案中，修饰药物以增加其亲油性。在优选实施方案中，改性药物均匀地分散在由缓慢溶解或不溶于水的材料组成的微粒内。在一些实施方案中，含有微粒或药物颗粒的药物涂覆有一个或多个涂层，其中至少一个涂层是水不溶性的，优选有机溶剂不溶，但是通过存在于人胃肠道中的酶可酶促降解。即使制剂的物理完整性受到损害（例如通过用刀片切碎或破碎）并且将所得材料置于水中，嗅到或吞咽，滥用威慑组合物也会延缓释放药物。然而，当按照指导给药时，由于组合物通过酶降解，胆汁酸的表面活性作用和机械侵蚀的组合被分解或逐渐溶解在胃肠道内，药物从组合物中缓慢释放。

4. 发明授权

US08557291B2 Abuse-deterrent pharmaceutical compositions of opioids and other drugs 有权
标题翻译：阿片类药物和其他药物的滥用药物组合物
公开(公告)号：US08557291B2
公开(公告)日：2013-10-15
申请号：US12473073
申请日：2009-05-27
申请人： Roman V. Rariy , Alison B. Fleming , Jane Hirsh , Alexander M. Klibanov
发明人： Roman V. Rariy , Alison B. Fleming , Jane Hirsh , Alexander M. Klibanov
IPC分类号： A61K9/14 , A61K9/20 , A61K9/48
CPC分类号： A61K47/46 , A61K9/1617 , A61K9/5026 , A61K31/485 , A61K45/06 , A61K47/12
摘要： An abuse-deterrent pharmaceutical composition has been developed to reduce the likelihood of improper administration of drugs, especially drugs such as opioids. In a preferred embodiment, a drug is modified to increase its lipophilicity. In some embodiments the modified drug is homogeneously dispersed within spherical microparticles composed of a material that is either slowly soluble or not soluble in water. In some embodiments the drug containing microparticles or drug particles are coated with one or more coating layers, where at least one coating is water insoluble and/or organic solvent insoluble. The abuse-deterrent composition retards the release of drug, even if the physical integrity of the formulation is compromised (for example, by chopping with a blade or crushing) and the resulting material is placed in water, snorted, or swallowed. However, when administered as directed, the drug is slowly released from the composition as the composition is passes through the GI tract.
摘要翻译：已经开发了一种滥用威慑药物组合物，以减少药物不当管理的可能性，特别是阿片样物质等药物。在优选的实施方案中，修饰药物以增加其亲油性。在一些实施方案中，改性药物均匀地分散在由缓慢溶解或不溶于水的材料组成的球形微粒内。在一些实施方案中，含有微粒或药物颗粒的药物涂覆有一个或多个涂层，其中至少一种涂层是不溶于水的和/或有机溶剂不溶的。即使制剂的物理完整性受到损害（例如通过用刀片切碎或破碎）并且将所得材料置于水中，嗅到或吞咽，滥用威慑组合物也会延缓释放药物。然而，当按照指导给药时，当组合物通过胃肠道时，药物从组合物缓慢释放。

5. 发明申请

US20090297617A1 ABUSE-DETERRENT PHARMACEUTICAL COMPOSITIONS OF OPIOIDS AND OTHER DRUGS 有权
标题翻译：阿片类药物和其他药物的滥用药物组合物
公开(公告)号：US20090297617A1
公开(公告)日：2009-12-03
申请号：US12473073
申请日：2009-05-27
申请人： Roman V. Rariy , Alison B. Fleming , Jane Hirsh , Alexander M. Klibanov
发明人： Roman V. Rariy , Alison B. Fleming , Jane Hirsh , Alexander M. Klibanov
IPC分类号： A61K9/50 , A61K31/485
CPC分类号： A61K47/46 , A61K9/1617 , A61K9/5026 , A61K31/485 , A61K45/06 , A61K47/12
摘要： An abuse-deterrent pharmaceutical composition has been developed to reduce the likelihood of improper administration of drugs, especially drugs such as opioids. In a preferred embodiment, a drug is modified to increase its lipophilicity. In some embodiments the modified drug is homogeneously dispersed within spherical microparticles composed of a material that is either slowly soluble or not soluble in water. In some embodiments the drug containing microparticles or drug particles are coated with one or more coating layers, where at least one coating is water insoluble and/or organic solvent insoluble. The abuse-deterrent composition retards the release of drug, even if the physical integrity of the formulation is compromised (for example, by chopping with a blade or crushing) and the resulting material is placed in water, snorted, or swallowed. However, when administered as directed, the drug is slowly released from the composition as the composition is passes through the GI tract.
摘要翻译：已经开发了一种滥用威慑药物组合物，以减少药物不当管理的可能性，特别是阿片样物质等药物。在优选的实施方案中，修饰药物以增加其亲油性。在一些实施方案中，改性药物均匀地分散在由缓慢溶解或不溶于水的材料组成的球形微粒内。在一些实施方案中，含有微粒或药物颗粒的药物涂覆有一个或多个涂层，其中至少一种涂层是不溶于水的和/或有机溶剂不溶的。即使制剂的物理完整性受损（例如通过用刀片切碎或破碎），所述滥用威慑组合物也会延缓药物的释放，并将所得物质置于水中，嗅到或吞咽。然而，当按照指导给药时，当组合物通过胃肠道时，药物从组合物缓慢释放。

6. 发明申请

US20080260819A1 SUSTAINED RELEASE COMPOSITIONS OF DRUGS 审中-公开
标题翻译：持续发布药物组合物
公开(公告)号：US20080260819A1
公开(公告)日：2008-10-23
申请号：US12112937
申请日：2008-04-30
申请人： Alison B. Fleming , Roman V. Rariy , Jane Hirsh , Alexander M. Klibanov
发明人： Alison B. Fleming , Roman V. Rariy , Jane Hirsh , Alexander M. Klibanov
IPC分类号： A61K9/52 , A61K9/00 , A61K9/26
CPC分类号： A61K31/485 , A61K9/145 , A61K9/1617 , A61K9/1682 , A61K9/1694 , A61K9/4858 , A61K9/50 , A61K9/5052 , A61K9/5084 , A61K31/20 , A61K47/12
摘要： A sustained release pharmaceutical composition has been developed. The composition resists dose dumping when broken, crushed or chewed, which enhances the safety of the dosage form should it be accidentally or intentionally physically compromised. In the preferred embodiment, a drug is modified to increase its lipophilicity. In preferred embodiments the modified drug is homogeneously dispersed within microparticles composed of a material that is either slowly soluble or not soluble in water. In some embodiments the drug containing microparticles coated with one or more coating layers. The sustained release composition retards the release of drug, even if the physical integrity of the formulation is compromised (for example, by chewing or crushing) and the resulting material is placed in 0.1N HCl. However, when administered as directed, the drug is slowly released from the composition as the composition is broken down or dissolved gradually within the GI tract by a combination of diffusion, surfactant action of bile acids, mechanical erosion, and in some embodiments, enzymatic degradation.
摘要翻译：持续释放的药物组合物已被开发出来。当破碎，粉碎或咀嚼时，组合物抵抗剂量倾倒，如果意外或故意身体受损，则可提高剂型的安全性。在优选的实施方案中，修饰药物以增加其亲油性。在优选实施方案中，改性药物均匀地分散在由缓慢溶解或不溶于水的材料组成的微粒内。在一些实施方案中，含有涂覆有一个或多个涂层的微粒的药物。即使制剂的物理完整性受损（例如通过咀嚼或破碎），并将所得材料置于0.1N HCl中，持续释放组合物延缓了药物的释放。然而，当按照指导施用时，当组合物通过扩散，胆汁酸的表面活性作用，机械侵蚀，以及在一些实施方案中的酶降解的组合被分解或逐渐溶解在胃肠道内时，药物缓慢地从组合物中释放。

7. 发明申请

US20080199530A1 ABUSE-DETERRENT PHARMACEUTICAL COMPOSITIONS OF OPIOIDS AND OTHER DRUGS 审中-公开
标题翻译：阿片类药物和其他药物的滥用药物组合物
公开(公告)号：US20080199530A1
公开(公告)日：2008-08-21
申请号：US12112993
申请日：2008-04-30
申请人： Jane Hirsh , Alison Fleming , Roman V. Rariy
发明人： Jane Hirsh , Alison Fleming , Roman V. Rariy
IPC分类号： A61K9/16
CPC分类号： A61K31/485 , A61K9/145 , A61K9/1617 , A61K9/1682 , A61K9/1694 , A61K9/4858 , A61K9/50 , A61K9/5052 , A61K9/5084 , A61K31/20 , A61K47/12
摘要： An abuse-deterrent pharmaceutical composition has been developed to reduce the likelihood of improper administration of drugs, especially drugs such as opiods. In the preferred embodiment, a drug is modified to increase its lipophilicity. In preferred embodiments the modified drug is homogeneously dispersed within microparticles composed of a material that is either slowly soluble or not soluble in water. In some embodiments the drug containing microparticles or drug particles are coated with one or more coating layers, where at least one coating is water insoluble and preferably organic solvent insoluble, but enzymatically degradable by enzymes present in the human gastrointestinal tract. The abuse-deterrent composition retards the release of drug, even if the physical integrity of the formulation is compromised (for example, by chopping with a blade or crushing) and the resulting material is placed in water, snorted, or swallowed. However, when administered as directed, the drug is slowly released from the composition as the composition is broken down or dissolved gradually within the GI tract by a combination of enzymatic degradation, surfactant action of bile acids, and mechanical erosion.
摘要翻译：已经开发了一种滥用威慑药物组合物，以减少药物不当管理的可能性，特别是诸如阿片类药物。在优选的实施方案中，修饰药物以增加其亲油性。在优选实施方案中，改性药物均匀地分散在由缓慢溶解或不溶于水的材料组成的微粒内。在一些实施方案中，含有微粒或药物颗粒的药物涂覆有一个或多个涂层，其中至少一个涂层是水不溶性的，优选有机溶剂不溶，但是通过存在于人胃肠道中的酶可酶促降解。即使制剂的物理完整性受到损害（例如通过用刀片切碎或破碎）并且将所得材料置于水中，嗅到或吞咽，滥用威慑组合物也会延缓释放药物。然而，当按照指导给药时，由于组合物通过酶降解，胆汁酸的表面活性作用和机械侵蚀的组合被分解或逐渐溶解在胃肠道内，药物从组合物中缓慢释放。

8. 发明授权

US06863901B2 Pharmaceutical composition for compressed annular tablet with molded triturate tablet for both intraoral and oral administration 有权
标题翻译：用于口内和口服给药的具有模制的triturate片剂的压缩环形片剂的药物组合物
公开(公告)号：US06863901B2
公开(公告)日：2005-03-08
申请号：US10015930
申请日：2001-11-30
申请人： Jane Hirsh , Kamal Midha , Mark Hirsh , Whe-Yong Lo
发明人： Jane Hirsh , Kamal Midha , Mark Hirsh , Whe-Yong Lo
IPC分类号： A61J3/10 , A61K9/00 , A61K9/22 , A61K9/24 , A61K9/26 , A61K9/30 , A61K9/36 , A61K9/42 , A61K45/00 , A61K47/12 , A61K47/14 , A61K47/16 , A61K47/32 , A61K47/36 , A61K47/38 , A61K47/44 , A61P9/00 , A61P19/00 , A61P25/00 , A61P37/00 , A61K9/20 , A61K9/46
CPC分类号： A61K9/209 , A61K9/0056
摘要： New pharmaceutical compositions in unit dosage form are disclosed for both intraoral and oral administration to a patient, said unit dosage form configured to be placed intraorally of said patient, which comprises: (a) as a first portion, at least one discrete molded triturate tablet comprising a therapeutically effective amount of at least one pharmaceutically active ingredient capable of intraoral administration; and (b) as a second portion located around the said first portion, a therapeutically effective amount of at least one pharmaceutically active ingredient capable of oral administration and which is releasable and orally ingestible by the patient after the molded triturate tablet has disintegrated or has dissolved intraorally.
摘要翻译：公开了单位剂量形式的新的药物组合物，用于向患者进行口内和口服给药，所述单位剂型被配置为置于所述患者的口内，其包括：（a）作为第一部分，至少一个离散的模制成型的片剂包括治疗有效量的至少一种能口内给药的药物活性成分; 和（b）作为位于所述第一部分周围的第二部分，治疗有效量的至少一种能够口服给药的药学活性成分，并且其在模制的特定片剂崩解或溶解之后由患者可释放和口服摄入口语

9. 发明授权

US07585520B2 Compositions containing both sedative and non-sedative antihistamines and sleep aids 有权
标题翻译：含有镇静和非镇静抗组胺药和睡眠辅助剂的组合物
公开(公告)号：US07585520B2
公开(公告)日：2009-09-08
申请号：US10943311
申请日：2004-09-17
申请人： Mark Hirsh , Jane Hirsh , Whe-Yong Lo
发明人： Mark Hirsh , Jane Hirsh , Whe-Yong Lo
IPC分类号： A61K9/24 , A61K9/20 , A61K9/22 , A61K9/28 , A61K9/14
CPC分类号： A61K45/06 , A61K9/209 , A61K9/5084 , A61K31/00 , A61K2300/00
摘要： Compositions containing both a sedative compound and a non-sedative antihistamine are provided. More particularly, compositions for administration at bedtime containing a sedating antihistamine or other sedating compound in immediate release form and a non-sedating antihistamine in delayed-release form are described. Alternatively, a composition, for administrating upon awakening, containing a non-sedating antihistamine in immediate release form, and a sedating antihistamine or other sedative in delayed-release form is described. Methods of inhibiting the release of histamines by administration of the compositions to a mammalian subject are also provided. The dosage forms may comprise other medications, such as leukotriene receptor antagonists, to enhance the suppression of histamine symptoms.
摘要翻译：提供了含有镇静化合物和非镇静抗组胺剂的组合物。更具体地，描述了在睡前给药的组合物，其含有立即释放形式的镇静抗组胺药或其他镇静化合物和延迟释放形式的非镇静抗组胺药。或者，描述了用于在觉醒时施用含有立即释放形式的非镇静抗组胺剂的组合物，以及缓释形式的镇静抗组胺药或其他镇静剂。还提供了通过将哺乳动物受试者施用组合物来抑制组胺释放的方法。剂型可以包含其他药物，例如白三烯受体拮抗剂，以增强组胺症状的抑制。

10. 发明申请

US20050123609A1 Pharmaceutical composition for compressed annular tablet with molded triturate tablet for both intraoral and oral administration 失效
标题翻译：用于口内和口服给药的具有模制的triturate片剂的压缩环形片剂的药物组合物
公开(公告)号：US20050123609A1
公开(公告)日：2005-06-09
申请号：US11041474
申请日：2005-01-24
申请人： Jane Hirsh , Kamal Midha , Mark Hirsh , Whe-Yong Lo
发明人： Jane Hirsh , Kamal Midha , Mark Hirsh , Whe-Yong Lo
IPC分类号： A61J3/10 , A61K9/00 , A61K9/22 , A61K9/24 , A61K9/26 , A61K9/30 , A61K9/36 , A61K9/42 , A61K45/00 , A61K47/12 , A61K47/14 , A61K47/16 , A61K47/32 , A61K47/36 , A61K47/38 , A61K47/44 , A61P9/00 , A61P19/00 , A61P25/00 , A61P37/00 , A61K9/20
CPC分类号： A61K9/209 , A61K9/0056
摘要： New pharmaceutical compositions in unit dosage form are disclosed for both intraoral and oral administration to a patient, said unit dosage form configured to be placed intraorally of said patient, which comprises: (a) as a first portion, at least one discrete molded triturate tablet comprising a therapeutically effective amount of at least one pharmaceutically active ingredient capable of intraoral administration; and (b) as a second portion located around the said first portion, a therapeutically effective amount of at least one pharmaceutically active ingredient capable of oral administration and which is releasable and orally ingestible by the patient after the molded triturate tablet has disintegrated or has dissolved intraorally.
摘要翻译：公开了单位剂量形式的新的药物组合物，用于向患者进行口内和口服给药，所述单位剂型被配置为置于所述患者的口内，其包括：（a）作为第一部分，至少一个离散的模制成型的片剂包括治疗有效量的至少一种能口内给药的药物活性成分; 和（b）作为位于所述第一部分周围的第二部分，治疗有效量的至少一种能够口服给药的药物活性成分，并且其在模制的沙粒片已经崩解或溶解之后由患者可释放和口服摄入口语

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式