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1. 发明授权

US06440931B1 Conjugated linoleic acid in treatment and prophylaxis of diabetes 有权
标题翻译：共轭亚油酸治疗和预防糖尿病
公开(公告)号：US06440931B1
公开(公告)日：2002-08-27
申请号：US09510059
申请日：2000-02-22
申请人： Jan Remmereit , Jan Wadstein , Jo Klaveness
发明人： Jan Remmereit , Jan Wadstein , Jo Klaveness
IPC分类号： A61K3828
CPC分类号： A61K31/64 , A23L33/12 , A23V2002/00 , A61K31/155 , A61K31/201 , A61K31/702 , A61K38/28 , Y10S426/807 , A61K2300/00 , A23V2250/1866
摘要： This invention provides method of treatment and prophylaxis of both insulin (Type I) and non-insulin dependent (type II) diabetes mellitus, by administration of conjugated linoleic acid (CLA) in the form of pure isomers, selected isomer mixtures or non-selected isomer mixtures. The conjugated linoleic acids may be administered alone, or in combination with other diabetes therapeutic regimes.
摘要翻译：本发明通过以纯异构体，选择的异构体混合物或未选择的形式施用共轭亚油酸（CLA），提供了治疗和预防胰岛素（I型）和非胰岛素依赖型（II型）糖尿病的方法异构体混合物。共轭亚油酸可以单独施用，或与其它糖尿病治疗方案组合施用。

2. 发明授权

US07947737B1 Method of treating hypertension and reducing serum lipase activity 失效
标题翻译：治疗高血压和降低血清脂肪酶活性的方法
公开(公告)号：US07947737B1
公开(公告)日：2011-05-24
申请号：US09410484
申请日：1999-09-30
申请人： Jan Wadstein , Jan Remmereit
发明人： Jan Wadstein , Jan Remmereit
IPC分类号： A61K31/20 , A61K47/12 , A61K31/19 , A01N37/00
CPC分类号： A61K31/20
摘要： This invention relates to a method of treating hypertension and reducing serum lipase activity by dietary supplementation with conjugated linoleic acid. The method comprises administering a safe and effective amount of conjugated linoleic acid to a human. The conjugated linoleic acid may be provided in the form of a free fatty acid or chemical derivatives thereof in a pill, or as a component of a prepared food product.
摘要翻译：本发明涉及通过膳食补充共轭亚油酸治疗高血压和降低血清脂肪酶活性的方法。该方法包括向人施用安全有效量的共轭亚油酸。共轭亚油酸可以以游离脂肪酸或其化学衍生物的形式提供在丸剂中，或作为制备的食品的组分。

3. 发明申请

US20100048521A1 COMBINATION OF A GLUCO-KORTICOID AND BETA-CYCLODEXTRIN CONJUGATED VITAMIN A-DERIVATE COMPLEX 审中-公开
标题翻译：葡聚糖和β-环糊精连接的维生素A衍生物复合物的组合
公开(公告)号：US20100048521A1
公开(公告)日：2010-02-25
申请号：US12441947
申请日：2007-09-20
申请人： Jan Wadstein , Erling Thom
发明人： Jan Wadstein , Erling Thom
IPC分类号： A61K31/57 , A61K31/07 , A61K31/58 , A61P17/00
CPC分类号： A61K31/07 , A61K31/56 , A61K31/724 , A61K2300/00
摘要： The present invention is related to a pharmaceutical combination of a glucocorticoid and a β-cyclodextrin conjugated vitamin A derivative complex as well as a pharmaceutical composition comprising the same. The combination and the composition of the invention can be used for reducing or eliminating skin atrophy induced by treatment with glucocorticoids (GC). Also comprised is a method for reducing or eliminating skin atrophy induced by GC treatment. Furthermore the invention concerns a kit comprising a glucocorticoid and a β-cyclodextrin conjugated vitamin A derivative complex.
摘要翻译：本发明涉及糖皮质激素和环糊精结合的维生素A衍生物复合物的药物组合以及包含其的药物组合物。本发明的组合和组合物可用于减少或消除用糖皮质激素（GC）治疗诱导的皮肤萎缩。还包括减少或消除由GC处理引起的皮肤萎缩的方法。此外，本发明涉及包含糖皮质激素和联合环糊精的维生素A衍生物复合物的试剂盒。

4. 发明授权

US4798595A Injection device 失效
标题翻译：注射装置
公开(公告)号：US4798595A
公开(公告)日：1989-01-17
申请号：US51958
申请日：1987-04-29
申请人： Ingvar Andersson , Jan Wadstein
发明人： Ingvar Andersson , Jan Wadstein
IPC分类号： A61M5/158 , A61M5/32
CPC分类号： A61M5/32 , A61M5/3291 , Y10S128/26
摘要： The present invention relates to an injection arrangement. This is characterized in that it comprises an injection needle (1) and a base plate (8). The needle (1) is curved so that at least one part of it exhibits a circular arc with a certain radius of curvature. The needle (1) is executed at one end with a solid, cutting point (2). The needle (1) has a central duct (3) which is closed in the area ahead of the tip (2) of the needle, and along the area in the form of a circular arc it has a number of openings (6) communicating with the duct (3). The base plate (8) has two curved ducts (11,12) passing through the plate (8) at an angle to one another and with the same radius of curvature as the needle (1). The base plate (8) also supports a cradle (13), to which the needle (1) is attached, which cradle is able to move in the base plate in such a way that the needle (1) is able to move in a normal plane to the plane of the base plate (8) in a reciprocating fashion about the center of the radius of curvature. During forward movement of this kind, the tip (2) of the needle (1) moves from a first end position down through the first curved duct (11) and then up through the second duct (12) to a second end position.
摘要翻译： PCT No.PCT / SE86 / 00396 Sec。 371日期1987年4月29日 102（e）1987年4月29日PCT PCT 1986年9月9日PCT公布。出版物WO87 / 01292 1987年3月12日公开本发明涉及一种注射装置。其特征在于，其包括注射针（1）和基板（8）。针（1）是弯曲的，使得其中至少一部分具有一定的曲率半径的圆弧。针（1）在一端执行固体切割点（2）。针（1）具有在针的尖端（2）前方的区域中闭合的中心管道（3），并且沿着圆弧形状的区域具有多个开口（6），其连通与管道（3）。基板（8）具有彼此成角度并且具有与针（1）相同的曲率半径的两个弯曲的管道（11,12），其穿过板（8）。基板（8）还支撑着一个支架（13），其上安装有针（1），支架能够在基板中移动，使得针（1）能够在一个以平行于基板（8）的平面的方式围绕曲率半径的中心往复运动。在这种向前运动期间，针（1）的尖端（2）从第一端部位置向下移动穿过第一弯曲管道（11），然后通过第二管道（12）向上移动到第二端部位置。

5. 发明授权

US07557094B2 Skin cream composition 失效
标题翻译：护肤霜组成
公开(公告)号：US07557094B2
公开(公告)日：2009-07-07
申请号：US10416671
申请日：2001-11-01
申请人： Jan Wadstein
发明人： Jan Wadstein
IPC分类号： A61K8/18 , A61K8/02 , A61K31/715 , A01N43/04
CPC分类号： A61K8/67 , A61K8/361 , A61K8/671 , A61K8/736 , A61K8/738 , A61K31/07 , A61K31/201 , A61K31/202 , A61K35/20 , A61K47/61 , A61K47/6951 , A61K2800/57 , A61Q19/00 , B82Y5/00 , A61K2300/00
摘要： The present invention is related to compositions containing chitosan conjugated CLA (conjugated linoleic acid) and a chitosan conjugated Vitamin A or a β-cyclodextrin conjugated vitamin A. The invention also concerns the preparation of the compositions. The compositions according to the invention can be used as topical and cosmetic compositions as well as pharmaceutical compositions for treatment of atopical dermatitis, psoriasis eczema as well as eczema of different origins and solar dermatitis.
摘要翻译：本发明涉及含有壳聚糖缀合的CLA（共轭亚油酸）和壳聚糖缀合的维生素A或β-环糊精缀合的维生素A的组合物。本发明还涉及组合物的制备。根据本发明的组合物可用作局部和化妆品组合物以及用于治疗特应性皮炎，牛皮癣湿疹以及不同来源和太阳皮炎的湿疹的药物组合物。

6. 发明授权

US5613955A Device for administration of fluid 失效
标题翻译：流体管理装置
公开(公告)号：US5613955A
公开(公告)日：1997-03-25
申请号：US432195
申请日：1995-05-04
申请人： Jan Wadstein
发明人： Jan Wadstein
IPC分类号： A61M25/00 , A61M25/02 , A61M5/32
CPC分类号： A61M25/02 , A61M2025/024 , A61M25/007
摘要： The invention relates to an arrangement for the administration of a fluid. The arrangement consists of a tube, preferably made of plastic, one end of which is executed with a cutting or tissue-displacing tip. The other end of the tube has a connection (1b) for an injection syringe or the like. Arranged in the tube is a rigid, elongated body so executed as to facilitate insertion of the tube into human tissue. The tube is sufficiently soft for it to be of essentially the same consistency as the surrounding tissue, in particular the subcutaneous tissue and musculator. It is also sealed at its tip and executed with a number of openings distributed over an area between the tip and the connection. The external surface of the tube is covered with a coating of titanium of sufficient thinness for the tube to retain its soft characteristics. The arrangement also comprises an attachment device (3) so arranged, after insertion of the tube and after withdrawal of the aforementioned rigid body, as to be applied between the ends of the tube in order to produce a rigid connection between same.
摘要翻译： PCT No.PCT / SE93 / 00924 Sec。 371日期：1995年5月4日 102（e）日期1995年5月4日PCT 1993年11月5日PCT公布。第WO94 / 11046号公报日期：1994年5月26日本发明涉及一种用于给予流体的装置。该装置由优选由塑料制成的管组成，其一端用切割或组织移位的尖端执行。管的另一端具有用于注射器等的连接（1b）。在管中排列的是刚性的细长的主体，以便于将管插入人体组织中。管足够柔软，使其具有与周围组织基本上相同的稠度，特别是皮下组织和肌肉。它的尖端也被密封，并且在尖端和连接之间的区域上分布有许多开口。管的外表面覆盖有足够薄的钛涂层，用于管，以保持其软特性。该装置还包括一个附接装置（3），该安装装置（3）在插入管之后并且在撤回上述刚体之后被布置成被施加在管的端部之间以在其之间产生刚性连接。

7. 发明授权

US4957485A Arrangement for the instillation of fluids in a urethra 失效
标题翻译：在尿道中滴注液体的布置
公开(公告)号：US4957485A
公开(公告)日：1990-09-18
申请号：US313185
申请日：1989-02-07
申请人： Ingvar Andersson , Jan Wadstein
发明人： Ingvar Andersson , Jan Wadstein
IPC分类号： A61M3/00 , A61M25/00 , A61M29/00 , A61M31/00
CPC分类号： A61M29/00
摘要： An arrangement for the instillation of fluids in a urethra comprising a tube of rigidity and diameter to be capable of being introduced into the urethra. The invention is characterized in that the length of the tube is a fraction of the length of the urethra, or approximately one decimeter. Along most of its length the tube is executed with an inflatable sac with elastic walls. This exhibits straight cylindrical form in its uninflated state, and in its inflated state has a slim, conical form, the base of which is situated at the end of the tube, and the tip of which is attached to a flange near the other end of the tube. Near the flange the sac has a connection via which the sac can be inflated with and emptied of air. The arrangement also comprises a device adapted to suit the opening of the urethra, made of an elastic material, and anchored to the flange. The device is executed with a connection leading to a vacuum source.
摘要翻译： PCT No.PCT / SE87 / 00361 Sec。 371日期1989年2月7日 102（e）1989年2月7日PCT PCT 1987年8月18日PCT公布。出版物WO88 / 01183 日期1988年2月25日。用于在尿道中滴注流体的装置，其包括刚性和直径的管能够被引入尿道。本发明的特征在于，管的长度是尿道长度的一部分，或大约一分米。沿其大部分长度，管被执行与具有弹性壁的充气囊。在其未膨胀的状态下呈现直的圆柱形状，并且在其膨胀状态下具有纤细的圆锥形，其基部位于管的端部，并且其尖端附接到靠近管的另一端的凸缘管子。在凸缘附近，囊具有连接，通过该连接可以使囊膨胀并排空空气。该装置还包括适于适合由弹性材料制成并且锚定到凸缘的尿道开口的装置。该装置通过连接到真空源的连接来执行。

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