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1. 发明申请

US20070224652A1 Blood Group Antigens of Different Types for Diagnostic and Therapeutic Applications 有权
标题翻译：用于诊断和治疗应用的不同类型的血液组抗原
公开(公告)号：US20070224652A1
公开(公告)日：2007-09-27
申请号：US11690616
申请日：2007-03-23
申请人： Jan Holgersson , Jining Liu , Linda Bjornstrom , Per Grufman
发明人： Jan Holgersson , Jining Liu , Linda Bjornstrom , Per Grufman
IPC分类号： G01N33/567 , C12M3/00
CPC分类号： G01N33/585 , C07K14/70596 , C07K2319/30 , G01N33/54313 , G01N33/80 , G01N2333/4725 , G01N2400/40 , G01N2800/245 , Y10T436/101666 , Y10T436/105831 , Y10T436/25125 , Y10T436/25375
摘要： The present invention provides compositions and methods for treating or preventing antibody mediated graft rejection and blood typing.
摘要翻译：本发明提供用于治疗或预防抗体介导的移植排斥和血型分型的组合物和方法。

2. 发明申请

US20110287556A1 BLOOD GROUP ANTIGENS OF DIFFERENT TYPES FOR DIAGNOSTIC AND THERAPEUTIC APPLICATIONS 有权
标题翻译：用于诊断和治疗应用的不同类型的血液组抗原
公开(公告)号：US20110287556A1
公开(公告)日：2011-11-24
申请号：US13036446
申请日：2011-02-28
申请人： Jan Holgersson , Jining Liu , Linda Lindberg , Per Grufman
发明人： Jan Holgersson , Jining Liu , Linda Lindberg , Per Grufman
IPC分类号： G01N33/566
CPC分类号： G01N33/585 , C07K14/70596 , C07K2319/30 , G01N33/54313 , G01N33/80 , G01N2333/4725 , G01N2400/40 , G01N2800/245 , Y10T436/101666 , Y10T436/105831 , Y10T436/25125 , Y10T436/25375
摘要： The present invention provides compositions and methods for treating or preventing antibody mediated graft rejection and blood typing.
摘要翻译：本发明提供用于治疗或预防抗体介导的移植排斥和血型分型的组合物和方法。

3. 发明授权

US07897328B2 Blood group antigens of different types for diagnostic and therapeutic applications 有权
标题翻译：用于诊断和治疗应用的不同类型的血型抗原
公开(公告)号：US07897328B2
公开(公告)日：2011-03-01
申请号：US11690616
申请日：2007-03-23
申请人： Jan Holgersson , Jining Liu , Linda Lindberg , Per Grufman
发明人： Jan Holgersson , Jining Liu , Linda Lindberg , Per Grufman
IPC分类号： G01N33/543 , A01N1/02 , A61K38/14 , C07K9/00
CPC分类号： G01N33/585 , C07K14/70596 , C07K2319/30 , G01N33/54313 , G01N33/80 , G01N2333/4725 , G01N2400/40 , G01N2800/245 , Y10T436/101666 , Y10T436/105831 , Y10T436/25125 , Y10T436/25375
摘要： The present invention provides compositions and methods for treating or preventing antibody mediated graft rejection and blood typing.
摘要翻译：本发明提供用于治疗或预防抗体介导的移植排斥和血型分型的组合物和方法。

4. 发明授权

US08404456B2 Blood group antigens of different types for diagnostic and therapeutic applications 有权
标题翻译：用于诊断和治疗应用的不同类型的血型抗原
公开(公告)号：US08404456B2
公开(公告)日：2013-03-26
申请号：US13036446
申请日：2011-02-28
申请人： Jan Holgersson , Jining Liu , Linda Lindberg , Per Grufman
发明人： Jan Holgersson , Jining Liu , Linda Lindberg , Per Grufman
IPC分类号： G01N33/00 , G01N1/18
CPC分类号： G01N33/585 , C07K14/70596 , C07K2319/30 , G01N33/54313 , G01N33/80 , G01N2333/4725 , G01N2400/40 , G01N2800/245 , Y10T436/101666 , Y10T436/105831 , Y10T436/25125 , Y10T436/25375
摘要： The present invention provides compositions and methods for treating or preventing antibody mediated graft rejection and blood typing.
摘要翻译：本发明提供用于治疗或预防抗体介导的移植排斥和血型分型的组合物和方法。

5. 发明授权

US07638323B2 Fusion proteins and methods of producing same 失效
标题翻译：融合蛋白及其生产方法
公开(公告)号：US07638323B2
公开(公告)日：2009-12-29
申请号：US10638820
申请日：2003-08-11
申请人： Jan Holgersson , Jining Liu , Anki Gustafsson
发明人： Jan Holgersson , Jining Liu , Anki Gustafsson
IPC分类号： C12N15/00 , C12P21/06
CPC分类号： C07K14/4727 , C07K2319/20 , C07K2319/40
摘要： The present invention provides compositions and methods for treating or preventing hyperacute rejection.
摘要翻译：本发明提供了用于治疗或预防超急性排斥反应的组合物和方法。

6. 发明授权

US07658919B2 Compositions and methods for inhibiting H. pylori adhesion and infection 失效
标题翻译：用于抑制幽门螺杆菌粘附和感染的组合物和方法
公开(公告)号：US07658919B2
公开(公告)日：2010-02-09
申请号：US11251140
申请日：2005-10-14
申请人： Jan Holgersson , Jining Liu , Anki Gustafsson , Jonas Lofling
发明人： Jan Holgersson , Jining Liu , Anki Gustafsson , Jonas Lofling
IPC分类号： C07K19/00
CPC分类号： C07K14/4727 , A61K38/00 , C07K14/70564 , C07K2319/30
摘要： The present invention provides compositions and methods for treating or preventing bacterial infections. Also provide by the invention are genetically modified cell expressing Lewisb carbohydrate epitope.
摘要翻译：本发明提供用于治疗或预防细菌感染的组合物和方法。本发明还提供了表达Lewisb碳水化合物表位的遗传修饰的细胞。

7. 发明申请

US20060177463A1 Compositions and methods for inhibiting H. pylori adhesion and infection 失效
标题翻译：用于抑制幽门螺杆菌粘附和感染的组合物和方法
公开(公告)号：US20060177463A1
公开(公告)日：2006-08-10
申请号：US11251140
申请日：2005-10-14
申请人： Jan Holgersson , Jining Liu , Anki Gustafsson , Jonas Lofling
发明人： Jan Holgersson , Jining Liu , Anki Gustafsson , Jonas Lofling
IPC分类号： C12N1/20 , C07K14/195 , C07H21/04 , C12P21/06 , A61K39/02 , C12N5/06 , C12N15/74
CPC分类号： C07K14/4727 , A61K38/00 , C07K14/70564 , C07K2319/30
摘要： The present invention provides compositions and methods for treating or preventing bacterial infections. Also provide by the invention are genetically modified cell expressing Lewisb carbohydrate epitope.
摘要翻译：本发明提供用于治疗或预防细菌感染的组合物和方法。本发明还提供了表达Lewis糖蛋白表位的遗传修饰的细胞。

8. 发明申请

US20050255099A1 Antigenic fusion protein carrying Galalpha 1,3Gal epitopes 审中-公开
标题翻译：携带Galalpha 1,3Gal表位的抗原融合蛋白
公开(公告)号：US20050255099A1
公开(公告)日：2005-11-17
申请号：US11153082
申请日：2005-06-15
申请人： Jan Holgersson , Jining Liu
发明人： Jan Holgersson , Jining Liu
IPC分类号： C12N15/09 , A61K31/00 , A61K35/16 , A61K38/00 , A61K39/395 , A61P37/00 , A61P37/06 , C07K14/47 , C07K19/00 , C12N5/10 , C12N9/10 , C12P21/02 , A61K39/00 , C07H21/04 , C12P21/06
CPC分类号： C07K14/47 , C07K14/4727 , C07K2319/30 , C07K2319/40
摘要： The present invention relates to an antigenic fusionprotein, which carries multiple Galα1,3Gal epitopes. The fusion protein according to the invention may also be comprised of a heavily glycosylated mucin part, which mediates binding to selecting, such as PSGL-1, and a part, which exhibits immunoglobulin properties, such as the Fc part of IgG. The fusionprotein according to the invention is preferably used as an absorber to prevent a hyperacute rejection of a xenotransplant, such as a pig tissue or organ transplanted into a human patient. In addition, the invention relates to a method for the prevention of a hyperacute rejection reaction in a patient who is to receive a xenotransplant.
摘要翻译：本发明涉及携带多种Galalpha1,3Gal表位的抗原融合蛋白。根据本发明的融合蛋白还可以由介导与选择结合的重糖基化的粘蛋白部分组成，例如PSGL-1，以及显示免疫球蛋白特性的部分，例如IgG的Fc部分。根据本发明的融合蛋白优选用作吸收剂以防止异种移植物例如移植到人类患者中的猪组织或器官的超急性排斥反应。此外，本发明涉及一种用于预防接受异种移植的患者中的超急性排斥反应的方法。

9. 发明申请

US20090286963A1 ANTIGENIC FUSION PROTEIN CARRYING GAL ALPHA1,3GAL EPITOPES 审中-公开
标题翻译：抗原融合蛋白携带GAL ALPHA1,3GAL EPITOPES
公开(公告)号：US20090286963A1
公开(公告)日：2009-11-19
申请号：US12507626
申请日：2009-07-22
申请人： Jan Holgersson , Jining Liu
发明人： Jan Holgersson , Jining Liu
IPC分类号： C07K19/00
CPC分类号： C07K14/47 , C07K14/4727 , C07K2319/30 , C07K2319/40
摘要： The present invention relates to an antigenic fusionprotein, which carries multiple Galα1,3Gal epitopes. The fusion protein according to the invention may also be comprised of a heavily glycosylated mucin part, which mediates binding to selectins, such as PSGL-1, and a part, which exhibits immunoglobulin properties, such as the Fc part of IgG. The fusionprotein according to the invention is preferably used as an absorber to prevent a hyperacute rejection of a xenotransplant, such as a pig tissue or organ transplanted into a human patient. In addition, the invention relates to a method for the prevention of a hyperacute rejection reaction in a patient who is to receive a xenotransplant.
摘要翻译：本发明涉及携带多种Galalpha1,3Gal表位的抗原融合蛋白。根据本发明的融合蛋白还可以由介导与选择蛋白结合的重糖基化粘蛋白部分（例如PSGL-1）和显示免疫球蛋白特性的部分（例如IgG的Fc部分）组成。根据本发明的融合蛋白优选用作吸收剂以防止异种移植物例如移植到人类患者中的猪组织或器官的超急性排斥反应。此外，本发明涉及一种用于预防接受异种移植的患者中的超急性排斥反应的方法。

10. 发明授权

US06943239B2 Antigenic fusionprotein carrying Galα1,3Gal epitopes 失效
标题翻译：携带Galalpha1,3Gal表位的抗原融合蛋白
公开(公告)号：US06943239B2
公开(公告)日：2005-09-13
申请号：US09194396
申请日：1998-03-26
申请人： Jan Holgersson , Jining Liu
发明人： Jan Holgersson , Jining Liu
IPC分类号： C12N15/09 , A61K31/00 , A61K35/16 , A61K38/00 , A61K39/395 , A61P37/00 , A61P37/06 , C07K14/47 , C07K19/00 , C12N5/10 , C12N9/10 , C12P21/02 , C07K1/00
CPC分类号： C07K14/47 , C07K14/4727 , C07K2319/30 , C07K2319/40
摘要： The present invention relates to an antigenic fusionprotein, which carries multiple Galα1,3Gal epitopes. The fusion protein according to the invention may also be comprised of a heavily glycosylated mucin part, which mediates binding to selectins, such as PSGL-1, and a part, which exhibits immunoglobulin properties, such as the Fc part of IgG. The fusionprotein according to the invention is preferably used as an absorber to prevent a hyperacute rejection of a xenotransplant, such as a pig tissue or organ transplanted into a human patient. In addition, the invention relates to a method for the prevention of hyperacute rejection reaction in a patient who is to receive a xenotransplant.
摘要翻译：本发明涉及携带多种Galalpha1,3Gal表位的抗原融合蛋白。根据本发明的融合蛋白还可以由介导与选择蛋白结合的重糖基化粘蛋白部分（例如PSGL-1）和显示免疫球蛋白特性的部分（例如IgG的Fc部分）组成。根据本发明的融合蛋白优选用作吸收剂以防止异种移植物例如移植到人类患者中的猪组织或器官的超急性排斥反应。此外，本发明涉及一种在接受异种移植的患者中预防超急性排斥反应的方法。

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