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1. 发明授权

US06453188B1 Method of magnetic resonance imaging 失效
标题翻译：磁共振成像方法
公开(公告)号：US06453188B1
公开(公告)日：2002-09-17
申请号：US09333910
申请日：1999-06-16
申请人： Jan Henrik Ardenkjaer-Larsen , Oskar Axelsson , Klaes Golman , Georg Hansson , Ib Leunbach , Stefan Petersson , Lars-Goran Wistrand
发明人： Jan Henrik Ardenkjaer-Larsen , Oskar Axelsson , Klaes Golman , Georg Hansson , Ib Leunbach , Stefan Petersson , Lars-Goran Wistrand
IPC分类号： A61B505
CPC分类号： G01R33/5601
摘要： The invention relates to a method of magnetic imaging (MR) of a living sample comprising the steps of hyperpolarizing a hyperpolarizable gas ex-vivo and transferring the nuclear polarization from the hyperpolarized gas to the nuclei of an MR imaging agent, that is not hyperpolarizable, that is exposed to a uniform magnetic field and that is introduced in contact to the hyperpolarizable gas, separating the hyperpolarizable gas from the MR imaging agent, administering the MR imaging agent to the living sample, exciting NMR transitions in the nuclei of the imaging agent and detecting an NMR signal thereof.
摘要翻译：本发明涉及一种活体样品的磁成像（MR）方法，包括以下步骤：离子超极化超极化气体，并将核极化从超极化气体转移到MR成像剂的核，其不是超极化的，暴露于均匀的磁场并且与超极化气体接触引入，将超极化气体与MR成像剂分离，将MR成像剂施用于活体样品，在显像剂的细胞核中激发NMR转变，以及检测其NMR信号。

2. 发明授权

US06466814B1 Method of magnetic resonance investigation 有权
标题翻译：磁共振研究方法
公开(公告)号：US06466814B1
公开(公告)日：2002-10-15
申请号：US09609153
申请日：2000-06-30
申请人： Jan Henrik Ardenkjaer-Larsen , Oskar Axelsson , Klaes Golman , Lars-Goran Wistrand , Georg Hansson , Ib Leunbach , Stefan Petersson
发明人： Jan Henrik Ardenkjaer-Larsen , Oskar Axelsson , Klaes Golman , Lars-Goran Wistrand , Georg Hansson , Ib Leunbach , Stefan Petersson
IPC分类号： A61B505
CPC分类号： G01R33/5601 , A61K49/08 , A61K49/10 , A61K49/18 , A61K49/1815 , G01R33/282 , G01R33/62
摘要： The present invention provides a method of magnetic resonance investigation of a sample, preferably of a human or non-human animal body. The method comprises the step of ex vivo polarization of a high T1 agent. The polarizing agent is optionally separated from the high T1 agent before the high T1 agent is administered to the sample.
摘要翻译：本发明提供一种样品，优选人或非人动物体的磁共振研究方法。该方法包括高T1试剂的离体极化步骤。在将高T1试剂施用于样品之前，任选地将偏振剂与高T1试剂分离。

3. 发明授权

US06311086B1 Overhauser magnetic resonance imaging (ORMI) method comprising ex vivo polarization of a magnetic resonance (MR) imaging agent 有权
标题翻译： Overhauser磁共振成像（ORMI）方法包括磁共振（MR）成像剂的离体极化
公开(公告)号：US06311086B1
公开(公告)日：2001-10-30
申请号：US09460094
申请日：1999-12-13
申请人： Jan Henrik Ardenkjaer-Larsen , Klaes Golman , Georg Hansson , Ib Leunbach , Stefan Petersson , Lars-Goran Wistrand , Oskar Axelsson
发明人： Jan Henrik Ardenkjaer-Larsen , Klaes Golman , Georg Hansson , Ib Leunbach , Stefan Petersson , Lars-Goran Wistrand , Oskar Axelsson
IPC分类号： A61B505
CPC分类号： A61K49/10 , A61K49/08 , A61K49/18 , A61K49/20 , G01R33/5601 , G01R33/62
摘要： This invention provides a method of MR investigation of a sample, the method comprising: (i) placing in a uniform magnetic field a composition comprising an OMRI contrast agent and an MR imaging agent containing nuclei (MR imaging nuclei) capable of emitting magnetic resonance signals (e.g. the primary magnetic field B0) and capable of exhibiting a T1 relaxation time of 6 s or more (at 37° C. in D2O in a field of 7T); (ii) exposing the composition to a first radiation of a frequency selected to excite electron spin transitions in the OMRI contrast agent; (iii) optionally but preferably separating the whole, substantially the whole, or a portion of said OMRI contrast agent from said MR imaging agent; (iv) administering said MR imaging agent to said sample, (v) exposing the sample to a second radiation of a frequency selected to excite nuclear spin transitions; (vi) detecting magnetic resonance signals from the sample; and (vii) optionally, generating an image or dynamic flow data from the detected signals.
摘要翻译：本发明提供了一种样品的MR研究方法，该方法包括：（i）在均匀的磁场中放置包含OMRI造影剂和含有能够发射磁共振信号的核（MR成像核）的MR成像剂的组合物（例如初级磁场B0），并且能够表现出6秒以上的T1弛豫时间（在7T的场中在D2O中为37℃）; （ii）将组合物暴露于在OMRI造影剂中激发电子自旋跃迁的频率的第一辐射; （iii）任选地但优选地将所述OMRI造影剂的全部，基本上全部或一部分与所述MR成像剂分离; （iv）向所述样品施用所述MR成像剂，（v）将所述样品暴露于选定为激发核自旋转变的频率的第二辐射; （vi）检测来自样品的磁共振信号; 和（vii）可选地，从检测到的信号生成图像或动态流量数据。

4. 发明授权

US6008644A Nuclear Polarization Enhanced Nuclear Magnetic Resonance Imaaging 失效
标题翻译：核极化增强核磁共振成像
公开(公告)号：US6008644A
公开(公告)日：1999-12-28
申请号：US888317
申请日：1997-07-03
申请人： Ib Leunbach , Ian Young , Gosta Ehnholm , Georg Hansson , Stefan Petersson , Lars-Goran Wistrand , Klaes Golman
发明人： Ib Leunbach , Ian Young , Gosta Ehnholm , Georg Hansson , Stefan Petersson , Lars-Goran Wistrand , Klaes Golman
IPC分类号： B82B1/00 , A61B5/055 , G01N24/12 , G01R33/28 , G01R33/62 , G01V3/00
CPC分类号： G01R33/5601 , G01R33/282 , G01R33/62
摘要： This invention relates to a method of electron spin resonance enhanced magnetic resonance imaging which relies on ex vivo dynamic nuclear polarisation of an MR imaging agent.
摘要翻译：本发明涉及依赖于MR成像剂的离体动态核极化的电子自旋共振增强磁共振成像方法。

5. 发明授权

US06278893B1 Method of magnetic resonance imaging of a sample with ex vivo polarization of an MR imaging agent 有权
标题翻译： MR成像剂离子极化的样品的磁共振成像方法
公开(公告)号：US06278893B1
公开(公告)日：2001-08-21
申请号：US09169148
申请日：1998-10-09
申请人： Jan Henrik Ardenkjær-Larson , Oskar Axelsson , Klaes Golman , Georg Hansson , Ib Leunbach , Stefan Petersson , Lars-Göran Wistrand
发明人： Jan Henrik Ardenkjær-Larson , Oskar Axelsson , Klaes Golman , Georg Hansson , Ib Leunbach , Stefan Petersson , Lars-Göran Wistrand
IPC分类号： A61B5055
CPC分类号： G01R33/5601 , A61K49/08 , A61K49/10 , A61K49/18 , A61K49/1815 , G01R33/282 , G01R33/62
摘要： The present invention provides a method of magnetic resonance investigation of a sample, preferably of a human or non-human animal body, said method comprising the step of ex vivo polarisation of a high T1 agent and wherein the polarising agent is optionally seperated from the high T1 agent before the high T1 agent is administered to the sample.
摘要翻译：本发明提供了一种优选人或非人动物体的样品的磁共振研究方法，所述方法包括高T1试剂的离体极化步骤，其中偏振剂可选地与高 T1试剂前高剂量施用T1试剂。

6. 发明申请

US20050152840A1 Process 有权
标题翻译：处理
公开(公告)号：US20050152840A1
公开(公告)日：2005-07-14
申请号：US11002864
申请日：2004-12-02
申请人： Oskar Axelsson , Charlotte Olofsson , Axel Morgenstjerne , Georg Hansson , Haukur Johannesson , Jan-Henrik Ardenkjaer-Larsen
发明人： Oskar Axelsson , Charlotte Olofsson , Axel Morgenstjerne , Georg Hansson , Haukur Johannesson , Jan-Henrik Ardenkjaer-Larsen
IPC分类号： A61K49/00 , A61K49/18 , C07C67/303 , C07C69/675 , G01R33/28 , G01R33/483
CPC分类号： A61K49/1815
摘要： The present invention provides a process for the preparation of an MR contrast agent, said process comprising: i) obtaining a solution in a solvent of a hydrogenatable, unsaturated substrate compound and a catalyst for the hydrogenation of said substrate compound; ii) introducing said solution in droplet form into a chamber containing hydrogen gas (H2) enriched in para-hydrogen (p-1H2) and/or ortho-deuterium (o-2H2) whereby to hydrogenate said substrate to form a hydrogenated imaging agent; iii) optionally subjecting said hydrogenated imaging agent to a magnetic field having a field strength below earth's ambient field strength; iv) optionally dissolving said imaging agent in an aqueous medium; v) optionally separating said catalyst from the solution of said imaging agent in said aqueous medium; vi) optionally separating said solvent from the solution of said imaging agent in said aqueous medium; and vii) optionally freezing the solution of said imaging agent in said aqueous medium.
摘要翻译：本发明提供了一种制备MR造影剂的方法，所述方法包括：i）获得在可氢化不饱和底物化合物的溶剂中的溶液和用于所述底物化合物氢化的催化剂; ii）将所述液滴形式的溶液引入含有富氢对二氢的氢气（H 2 S 2 H 2）的室中，）和/或邻 - 氘（o-2 H 2 H 2），由此氢化所述底物以形成氢化显像剂; iii）任选地使所述氢化成像剂经受场强低于地球环境场强的磁场; iv）任选地将所述成像剂溶解在水性介质中; v）任选地将所述催化剂与所述显影剂的溶液在所述水性介质中分离; vi）任选地将所述溶剂与所述显影剂的溶液在所述水性介质中分离; 和vii）任选地将所述成像剂的溶液冷冻在所述水性介质中。

7. 发明授权

US07459144B2 Process for preparation of MR contrast agents 有权
标题翻译：制备MR造影剂的方法
公开(公告)号：US07459144B2
公开(公告)日：2008-12-02
申请号：US11002864
申请日：2004-12-02
申请人： Oskar Axelsson , Charlotte Olofsson , Axel Morgenstjerne , Georg Hansson , Haukur Johannesson , Jan-Henrik Ardenkjaer-Larsen
发明人： Oskar Axelsson , Charlotte Olofsson , Axel Morgenstjerne , Georg Hansson , Haukur Johannesson , Jan-Henrik Ardenkjaer-Larsen
IPC分类号： A61B5/055 , B01J10/00
CPC分类号： A61K49/1815
摘要： The present invention provides a process for the preparation of an MR contrast agent, said process comprising: i) obtaining a solution in a solvent of a hydrogenatable, unsaturated substrate compound and a catalyst for the hydrogenation of said substrate compound; ii) introducing said solution in droplet form into a chamber containing hydrogen gas (H2) enriched in para-hydrogen (p-1H2) and/or ortho-deuterium (o-2H2) whereby to hydrogenate said substrate to form a hydrogenated imaging agent; iii) optionally subjecting said hydrogenated imaging agent to a magnetic field having a field strength below earth's ambient field strength; iv) optionally dissolving said imaging agent in an aqueous medium; v) optionally separating said catalyst from the solution of said imaging agent in said aqueous medium; vi) optionally separating said solvent from the solution of said imaging agent in said aqueous medium; and vii) optionally freezing the solution of said imaging agent in said aqueous medium.
摘要翻译：本发明提供了一种制备MR造影剂的方法，所述方法包括：i）获得在可氢化不饱和底物化合物的溶剂中的溶液和用于所述底物化合物氢化的催化剂; ii）将所述液滴形式的溶液引入含有富氢对二氢（p-1H 2）和/或邻 - 氘（o-2H 2）的氢气（H 2）的室中，从而氢化所述底物以形成氢化显像剂; iii）任选地使所述氢化成像剂经受场强低于地球环境场强的磁场; iv）任选地将所述成像剂溶解在水性介质中; v）任选地将所述催化剂与所述显影剂的溶液在所述水性介质中分离; vi）任选地将所述溶剂与所述显影剂的溶液在所述水性介质中分离; 和vii）任选地将所述成像剂的溶液冷冻在所述水性介质中。

8. 发明授权

US06872380B2 Process for preparation of MR contrast agents 有权
标题翻译：制备MR造影剂的方法
公开(公告)号：US06872380B2
公开(公告)日：2005-03-29
申请号：US09990537
申请日：2001-11-16
申请人： Oskar Axelsson , Charlotte Olofsson , Axel Morgenstjerne , Georg Hansson , Haukur Johannesson , Jan-Henrik Ardenkjaer-Larsen
发明人： Oskar Axelsson , Charlotte Olofsson , Axel Morgenstjerne , Georg Hansson , Haukur Johannesson , Jan-Henrik Ardenkjaer-Larsen
IPC分类号： A61K49/00 , A61K49/18 , C07C67/303 , C07C69/675 , G01R33/28 , G01R33/483 , A61B5/055 , C07C69/02
CPC分类号： A61K49/1815
摘要： The present invention provides a process for the preparation of an MR contrast agent, said process comprising: i) obtaining a solution in a solvent of a hydrogenatable, unsaturated substrate compound and a catalyst for the hydrogenation of said substrate compound; ii) introducing said solution in droplet form into a chamber containing hydrogen gas (H2) enriched in para-hydrogen (p-1H2) and/or ortho-deuterium (o-2H2) whereby to hydrogenate said substrate to form a hydrogenated imaging agent; iii) optionally subjecting said hydrogenated imaging agent to a magnetic field having a field strength below earth's ambient field strength; iv) optionally dissolving said imaging agent in an aqueous medium; v) optionally separating said catalyst from the solution of said imaging agent in said aqueous medium; vi) optionally separating said solvent from the solution of said imaging agent in said aqueous medium; and vii) optionally freezing the solution of said imaging agent in said aqueous medium.
摘要翻译：本发明提供一种制备MR造影剂的方法，所述方法包括：i）获得在可氢化不饱和底物化合物的溶剂中的溶液和用于所述底物化合物氢化的催化剂; ii）将所述溶液以液滴形式进入含有富氢对氢（对 - 氢）和/或邻 - 氘（o- 2 H 2）的氢气（H 2）和/或邻 - 氘（o- 2 H 2）的室中，由此氢化所述基底以形成氢化显像剂 iii）任选地使所述氢化显像剂经受场强低于地球环境场强的磁场; iv）任选地将所述成像剂溶解在水性介质中; v）任选地将所述催化剂与所述成像剂在所述水性介质; vi）任选地将所述溶剂与所述显影剂的溶液在所述水性介质中分离; 和任选地将所述显像剂的溶液冷冻在所述水性介质中。

9. 发明授权

US07372274B2 Methods and devices configured for dissolving hyperpolarised solid material with a solvent within a cryostat for NMR analyses 有权
标题翻译：配置用于将超极化固体物质溶解在低温恒温器内用于NMR分析的方法和装置
公开(公告)号：US07372274B2
公开(公告)日：2008-05-13
申请号：US10415968
申请日：2001-11-02
申请人： Jan Henrik Ardenkjaer-Larsen , Oskar H. E. Axelsson , Klaes Koppel Golman , Georg Hansson , Haukur Johannesson , Rolf Servin , Mikkel Thaning , Lennart Hansson
发明人： Jan Henrik Ardenkjaer-Larsen , Oskar H. E. Axelsson , Klaes Koppel Golman , Georg Hansson , Haukur Johannesson , Rolf Servin , Mikkel Thaning , Lennart Hansson
IPC分类号： G01V3/00 , A61B5/055
CPC分类号： G01R33/282 , G01N1/44 , G01R33/307 , G01R33/5601 , G01R33/62
摘要： The present invention relates to devices and method for dissolving solid polarised material while retaining a high level of polarisation. In an embodiment of the present invention a material is polarised in a strong magnetic field in a cryostat 2 and then brought into solution while still inside the cryostat 2.
摘要翻译：本发明涉及用于溶解固体极化材料同时保持高水平偏振的装置和方法。在本发明的一个实施例中，材料在低温恒温器2中的强磁场中极化，然后在仍然在低温恒温器2内部的同时进入溶液中。

10. 发明申请

US20100310467A1 COMPOSITION AND METHOD FOR GENERATING A METABOLIC PROFILE USING 13C-MR DETECTION 审中-公开
标题翻译：使用13C-MR检测产生代谢谱的组合物和方法
公开(公告)号：US20100310467A1
公开(公告)日：2010-12-09
申请号：US12747929
申请日：2008-12-18
申请人： Anna Gisselsson , Georg Hansson , Sven Mansson , Rene In't Zandt , Magnus Karlsson , Pernille R. Jensen , Mathilde H. Lerche
发明人： Anna Gisselsson , Georg Hansson , Sven Mansson , Rene In't Zandt , Magnus Karlsson , Pernille R. Jensen , Mathilde H. Lerche
IPC分类号： A61K49/06 , C12Q1/02 , C07C57/13 , G01R33/48
CPC分类号： A61K49/10 , A61K49/20
摘要： The invention relates to a method of 13C-MR detection using an imaging medium comprising hyperpolarised 13C-fumarate and imaging media comprising hyperpolarised 13C-fumarate for use in said method.
摘要翻译：本发明涉及使用包含超极化13C-富马酸盐的成像介质和包含超极化13 C-富马酸盐的成像介质的13C-MR检测方法，用于所述方法。

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