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1. 发明授权

US08802872B2 Process for preparing glycidyl esters of branched monocarboxylic acids 有权
标题翻译：制备支化单羧酸缩水甘油酯的方法
公开(公告)号：US08802872B2
公开(公告)日：2014-08-12
申请号：US13377470
申请日：2010-06-02
申请人： Jan Gouman , Sandra Rens-van der Lee , Robert van t Sand
发明人： Jan Gouman , Sandra Rens-van der Lee , Robert van t Sand
IPC分类号： C07D301/27
CPC分类号： C07D303/16
摘要： Accordingly, the invention relates to a process for the preparation of a glycidyl ester of a branched monocarboxylic acid by reacting an aliphatic monocarboxylic acid of the formula R1R2R3CCOOH, wherein R1, R2, and R3 each independently represent an alkyl radical of normal or branched structure containing from 1 to 20 carbon atoms and an epoxyalkyl halide containing from 3 to 13 carbon atoms in the presence of a catalyst, wherein a greater than stoichiometric amount of epoxyalkyl halide is reacted with the acid (e.g., preferably in the molar ratio of epoxyalkyl halide to acid that is in the range of from 1.02:1 to 1.50:1) to form an intermediate reaction product comprising a halohydrin, the epoxyalkyl halide is added to the acid with appropriate cooling of the reactants and/or the reaction mixture to keep the temperature of the reaction mixture below 80° C., whereupon the epoxyalkyl halide and the acid are reacted at a temperature below 80° C. (preferably in the range of from 55 to 75° C.) for a time sufficient to reduce the amount of acid to no more than 2 wt % but no less than 0.1 wt % calculated on the initial amount of acid, optionally removing any excess epoxyalkyl halide from the reaction product prior to the ring closure reaction, subjecting the reaction product to a ring closure reaction (DHC) and optionally to one or more after treatments (ADHC) for removal of any remaining halo functionality.
摘要翻译：因此，本发明涉及通过使式R1R2R3CCOOH的脂肪族一元羧酸反应制备支链一元羧酸的缩水甘油酯的方法，其中R1，R2和R3各自独立地表示含有正构或支链结构的烷基， 1至20个碳原子和含有3至13个碳原子的环氧烷基卤化物，在催化剂存在下，其中大于化学计量的环氧烷基卤化物与酸反应（例如，优选以环氧烷基卤化物与酸，其范围为1.02:1至1.50:1）以形成包含卤代醇的中间反应产物，将环氧烷基卤化物加入到酸中，同时适当冷却反应物和/或反应混合物以保持温度的反应混合物低于80℃，于是环氧烷基卤化物和酸在低于80℃的温度下反应（优选在55至7的范围内 5℃）持续一段足以将酸的量减少到不超过2wt％但不小于0.1wt％的酸的时间，所述时间基于酸的初始量计算，任选地在反应产物之前除去任何过量的环氧烷基卤化物闭环反应，使反应产物进行闭环反应（DHC）并任选地进行一次或多次处理（ADHC）以除去任何剩余的卤素官能团。

2. 发明申请

US20120095244A1 PROCESS FOR PREPARING GLYCIDYL ESTERS OF BRANCHED MONOCARBOXYLIC ACIDS 有权
标题翻译：制备分支单环羧酸的甘氨酸酯的方法
公开(公告)号：US20120095244A1
公开(公告)日：2012-04-19
申请号：US13377470
申请日：2010-06-02
申请人： Jan Gouman , Sandra Rens-van der Lee , Robert van t Sand
发明人： Jan Gouman , Sandra Rens-van der Lee , Robert van t Sand
IPC分类号： C07D301/30
CPC分类号： C07D303/16
摘要： Accordingly, the invention relates to a process for the preparation of a glycidyl ester of a branched monocarboxylic acid by reacting an aliphatic monocarboxylic acid of the formula R1R2R3COOH, wherein R1, R2, and R3 each independently represent an alkyl radical of normal or branched structure containing from 1 to 20 carbon atoms and an epoxyalkyl halide containing from 3 to 13 carbon atoms in the presence of a catalyst, wherein a greater than stoichiometric amount of epoxyalkyl halide is reacted with the acid (e.g., preferably in the molar ratio of epoxyalkyl halide to acid that is in the range of from 1.02:1 to 1.50:1) to form an intermediate reaction product comprising a halohydrin, the epoxyalkyl halide is added to the acid with appropriate cooling of the reactants and/or the reaction mixture to keep the temperature of the reaction mixture below 80° C., whereupon the epoxyalkyl halide and the acid are reacted at a temperature below 80° C. (preferably in the range of from 55 to 75° C.) for a time sufficient to reduce the amount of acid to no more than 2 wt % but no less than 0.1 wt % calculated on the initial amount of acid, optionally removing any excess epoxyalkyl halide from the reaction product prior to the ring closure reaction, subjecting the reaction product to a ring closure reaction (DHC) and optionally to one or more after treatments (ADHC) for removal of any remaining halo functionality.
摘要翻译：因此，本发明涉及通过使式R 1 R 2 R 3 COOH的脂肪族单羧酸反应制备支链一元羧酸的缩水甘油酯的方法，其中R 1，R 2和R 3各自独立地表示含有正丁基或支链结构的烷基 1至20个碳原子和含有3至13个碳原子的环氧烷基卤化物，在催化剂存在下，其中大于化学计量的环氧烷基卤化物与酸反应（例如，优选以环氧烷基卤化物与酸，其范围为1.02:1至1.50:1）以形成包含卤代醇的中间反应产物，将环氧烷基卤化物加入到酸中，同时适当冷却反应物和/或反应混合物以保持温度的反应混合物低于80℃，于是环氧烷基卤化物和酸在低于80℃的温度下反应（优选在55至75的范围内 ℃）足以将酸的量减少至不超过基于酸的初始量计算的2重量％但不小于0.1重量％的时间，任选地在环之前从反应产物中除去任何过量的环氧烷基卤化物封闭反应，使反应产物进行闭环反应（DHC），并任选进行一次或多次处理（ADHC）以除去任何剩余的卤素官能团。

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